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136 条记录 (耗时 0.05 秒)

    METHOD FOR MAKING CUSTOMISED NANOPARTICLES, NANOPARTICLES AND USES THEREOF
    11.
    发明申请
    METHOD FOR MAKING CUSTOMISED NANOPARTICLES, NANOPARTICLES AND USES THEREOF 审中-公开
    制备定制纳米颗粒的方法，纳米颗粒及其用途

    公开(公告)号：US20160220503A1

    公开(公告)日：2016-08-04

    申请号：US15095511

    申请日：2016-04-11

    申请人： ETH ZURICH

    发明人： Davide MOSCATELLI ,  Marco LATTUADA ,  Massimo MORBIDELI ,  Yingchuan YU

    IPC分类号： A61K9/51 ,  C08F222/10

    CPC分类号： A61K9/5192 ,  A61K9/146 ,  A61K9/513 ,  A61K9/5138 ,  A61K47/32 ,  C08F222/10 ,  Y10T428/2982

    摘要： A method for the production of biodegradable nanoparticles with an average particle size of less than 400 nm. In a first step, a macromonomer is prepared in a ring opening polymerization process between a hydrophilic acrylate compound (A) as an initiator and hydrophobic cyclic monomers (B), wherein the macromonomer comprises at least two repetitive units based on the cyclic monomer. In a second step, this macromonomer or a mixture of macromonomers and/or commercial biocompatible monomers is polymerized, e.g. in a starved, miniemulsion or emulsion radical polymerization in water in the presence of a surfactant to the nanoparticle without necessitating additional subsequent steps for the actual production of the nanoparticles. The correspondingly made nanoparticles and uses thereof also are disclosed.

    摘要翻译： 一种生产平均粒径小于400nm的可生物降解纳米颗粒的方法。 在第一步骤中，在作为引发剂的亲水性丙烯酸酯化合物（A）和疏水性环状单体（B）之间的开环聚合方法中制备大分子单体，其中大分子单体包含至少两个基于环状单体的重复单元。 在第二步中，将该大分子单体或大分子单体和/或商业生物相容性单体的混合物聚合，例如， 在表面活性剂存在下在水中的饥饿，微乳液或乳液自由基聚合到纳米颗粒，而不需要额外的后续步骤用于实际制备纳米颗粒。 相应制备的纳米颗粒及其用途也被公开。

    VIRAL VECTOR NANOCAPSULE FOR TARGETING GENE THERAPY AND ITS PREPARATION
    13.
    发明申请
    VIRAL VECTOR NANOCAPSULE FOR TARGETING GENE THERAPY AND ITS PREPARATION 审中-公开
    用于靶向基因治疗的病毒载体及其制备

    公开(公告)号：US20150320693A1

    公开(公告)日：2015-11-12

    申请号：US14651945

    申请日：2013-12-16

    申请人： Yunfeng LU ,  Ming YAN ,  Irvin S.Y. CHEN ,  Min LIANG ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Yunfeng LU ,  Ming YAN ,  Irvin S.Y. CHEN ,  Min LIANG

    IPC分类号： A61K9/51 ,  A61K31/7088

    CPC分类号： A61K9/513 ,  A61K9/5184 ,  A61K9/5192 ,  A61K31/7088 ,  A61K47/62 ,  A61K47/6925 ,  C12N15/86 ,  C12N2740/15045 ,  C12N2760/20245 ,  C12N2810/80 ,  C12N2810/859

    摘要： The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation in vivo, and an ability to infect dividing and non-dividing cells with high efficiencies.

    摘要翻译： 本发明提供可用于产生具有改变的组织和细胞靶向能力的病毒载体的新颖方法，材料和系统。 在本发明的说明性实施方案中，慢病毒载体的特异性由通过原位合成并与病毒包膜偶联的薄聚合物壳调制。 聚合物壳可以通过诸如与聚合物壳耦合的环状RGD（cRGD）肽的试剂赋予新的靶向能力。 这些聚合物包封的病毒载体表现出许多高度期望的特征，包括较高的热稳定性，体内血清失活的抗性，以及以高效率感染分裂和非分裂细胞的能力。