利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

2 条记录 (耗时 0.027 秒)

    VIRAL VECTOR NANOCAPSULE FOR TARGETING GENE THERAPY AND ITS PREPARATION
    1.
    发明申请
    VIRAL VECTOR NANOCAPSULE FOR TARGETING GENE THERAPY AND ITS PREPARATION 审中-公开
    用于靶向基因治疗的病毒载体及其制备

    公开(公告)号：US20150320693A1

    公开(公告)日：2015-11-12

    申请号：US14651945

    申请日：2013-12-16

    申请人： Yunfeng LU ,  Ming YAN ,  Irvin S.Y. CHEN ,  Min LIANG ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

    发明人： Yunfeng LU ,  Ming YAN ,  Irvin S.Y. CHEN ,  Min LIANG

    IPC分类号： A61K9/51 ,  A61K31/7088

    CPC分类号： A61K9/513 ,  A61K9/5184 ,  A61K9/5192 ,  A61K31/7088 ,  A61K47/62 ,  A61K47/6925 ,  C12N15/86 ,  C12N2740/15045 ,  C12N2760/20245 ,  C12N2810/80 ,  C12N2810/859

    摘要： The invention provides novel methods, materials and systems that can be used to generate viral vectors having altered tissue and cell targeting abilities. In illustrative embodiments of the invention, the specificity of lentiviral vectors was modulated by a thin polymer shell that synthesized and coupled to the viral envelope in situ. The polymer shell can confers such vectors with new targeting ability via agents such as cyclic RGD (cRGD) peptides that are coupled to the polymer shell. These polymer encapsulated viral vectors exhibit a number of highly desirable characteristics including a higher thermal stability, resistance to serum inactivation in vivo, and an ability to infect dividing and non-dividing cells with high efficiencies.

    摘要翻译： 本发明提供可用于产生具有改变的组织和细胞靶向能力的病毒载体的新颖方法，材料和系统。 在本发明的说明性实施方案中，慢病毒载体的特异性由通过原位合成并与病毒包膜偶联的薄聚合物壳调制。 聚合物壳可以通过诸如与聚合物壳耦合的环状RGD（cRGD）肽的试剂赋予新的靶向能力。 这些聚合物包封的病毒载体表现出许多高度期望的特征，包括较高的热稳定性，体内血清失活的抗性，以及以高效率感染分裂和非分裂细胞的能力。