公开(公告)号：US3835124A

公开(公告)日：1974-09-10

申请号：US32556373

申请日：1973-01-22

Applicant: SNIA VISCOSA

Inventor： GIUFFRE L ,  SIOLI G ,  MATTONE R

IPC: C07D201/02 ,  C07C67/00 ,  C07C201/00 ,  C07C207/00 ,  C07C239/00 ,  C07C251/46 ,  C07D201/04 ,  C07D201/10 ,  C07D205/08 ,  C07D207/263 ,  C07D223/02 ,  C07D41/06

CPC classification number: C07D201/10

Abstract: A method for the preparation of omega lactams is disclosed, more particularly epsilon caprolactam or a precursor thereof (such as cyclohexanone oxime), using as the starting material a cyclomethylene ketene, with the simultaneous formation of side products such as cyclohexanecarboxylic acid, wherein an adduct is preliminarly formed between cyclomethylene ketene and sulphur dioxide. The adduct is then reacted with a nitrosating agent so as to obtain, under the appropriate reaction conditions, the expected lactam, more specifically epsilon caprolactam.

Abstract translation: 公开了制备ω内酰胺的方法，更特别的是ε己内酰胺或其前体（例如环己酮肟），其以起始材料为环亚甲基乙烯酮，同时形成副产物如环己烷羧酸，其中加合物 在环亚甲基乙烯酮和二氧化硫之间初步形成。 然后将加合物与亚硝化剂反应，以在适当的反应条件下获得预期的内酰胺，更具体地是ε己内酰胺。

公开(公告)号：US3792078A

公开(公告)日：1974-02-12

申请号：US3792078D

申请日：1971-05-28

Applicant: CITIES SERVICE CO

Inventor： OLECHOWSKI J ,  NEWCOMBE J ,  DOTSON A

IPC: B01J31/20 ,  C07C31/133 ,  C07D201/10 ,  C07C69/74

CPC classification number: C07D201/10 ,  B01J31/20 ,  B01J2231/321 ,  B01J2231/643 ,  B01J2531/0211 ,  B01J2531/845 ,  C07C31/133 ,  C07C45/50 ,  C07C69/74 ,  C07C2601/20 ,  C07C47/33

Abstract: CYCLODODECYLMETHYL CYCLODOECANECARBOXYLATE IS DISCLOSED AS A NOVEL COMPOSITION OF MATTER WHICH MAY BE NITROSATED WITH NITROSYLSULFURIC ACID TO LAURINLACTAM. THE LACTAM IS CONVERTED BY CONVENTIONAL METHODS INTO NYLON 12. NYLON 12 IS BECOMING AN INCREASINGLY IMPORTANT POLYMER COMPOSITION FOR THE MANUFACTURE OF MOLDED ARTICLES, FIBERS AND THE LIKE. THE PRESENT INVENTION RELATES TO A NOVEL ESTER COMPOSITION OF MATTER WHICH MAY BE EMPLOYED IN THE SYNTHESIS OF LAURINLACTAM WHICH IN TURN IS USED IN THE MANFACTURE OF NYLON 12. THE PRESENT INVENTION ALSO RELATES TO A METHOD FOR MANUFACTURING SUCH ESTER COMPOSITIONS.

公开(公告)号：US3652552A

公开(公告)日：1972-03-28

申请号：US3652552D

申请日：1967-12-18

Applicant: STAMICARBON

Inventor： GARRITSEN JOHAN W ,  HOFMAN JOHANNES H A

IPC: C07D201/10 ,  C07D29/16

CPC classification number: C07D201/10

Abstract: A PROCESS FOR PRODUCING LACTAMS FROM CYCLOALKANES IS DISCLOSED. CYCLOALKANES ARE REACTED WITH NITROSYL CHLORIDE WHILE SUBJECTED TO IRRADIATION, IN THE PRESENCE OF A NITRILE WHICH DOES NOT CONTAIN ANY METHYLENE GROUPS CAPABLE OF REACTING WITH NITROSYL UNDER THE REACTION CONDITIONS. WLACTAMS ARE DIRECTLY PRODUCED BY HEATING THE REACTION PRODUCT.

公开(公告)号：US3449326A

公开(公告)日：1969-06-10

申请号：US3449326D

申请日：1966-11-04

Applicant: HALCON INTERNATIONAL INC

Inventor： NAGLIERI ANTHONY N ,  WINNICK CHARLES N

IPC: C07D201/10 ,  C07D41/04 ,  C07D41/00

CPC classification number: C07D201/10

公开(公告)号：US3427303A

公开(公告)日：1969-02-11

申请号：US3427303D

申请日：1964-07-23

Applicant: ORGANICO SOC

Inventor： GENAS MICHAILAS ,  KERN RENE

IPC: C07D201/10

CPC classification number: C07D201/10

公开(公告)号：US08980873B2

公开(公告)日：2015-03-17

申请号：US13133297

申请日：2009-12-09

Applicant: Brian Dymock ,  Cheng H. Lee ,  Anthony D. William

Inventor： Brian Dymock ,  Cheng H. Lee ,  Anthony D. William

IPC: C07D498/04 ,  C07D201/10

CPC classification number: C07D498/08 ,  C07B2200/13 ,  C07C55/22 ,  C07D201/10 ,  C07D498/04

Abstract: The present invention relates to certain salts of a 11-(2-pyrrolidin-1-yl-ethoxy)-14,19-dioxa-5,7,26-triaza-tetracyclo[19.3.1.1(2,6).1(8,12)]heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene (Compound I) which have been found to have improved properties. In particular the present invention relates to the citrate salt of this compound. The invention also relates to pharmaceutical compositions containing the citrate salt and methods of use of the citrate salt in the treatment of certain medical conditions.

Abstract translation: 本发明涉及11-（2-吡咯烷-1-基 - 乙氧基）-14,19-二氧杂-5,7,26-三氮杂 - 四环[19.3.1.1（2,6）.1（ 8,12）]，已被发现具有改善的性能的十七酸-1（25），2（26），3,5,8,10,12（27），16,21,23-十氢烯（化合物I）。 特别地，本发明涉及该化合物的柠檬酸盐。 本发明还涉及含有柠檬酸盐的药物组合物和柠檬酸盐在使用某些医疗条件下的使用方法。

公开(公告)号：US06333411B1

公开(公告)日：2001-12-25

申请号：US09221211

申请日：1998-12-24

Applicant: Diego Fernandez Echegaray ,  Antonio Augusto M. Velloso ,  Matthew Lincoln Wagner

Inventor： Diego Fernandez Echegaray ,  Antonio Augusto M. Velloso ,  Matthew Lincoln Wagner

IPC: C07D20104

CPC classification number: C07D201/06 ,  C07D201/10

Abstract: A method for production of caprolactam. The method involves: (a) reacting air with ammonia gas in an ammonia conversion zone to produce nitric oxide; (b) oxidizing at least a portion of the nitric oxide to nitrogen dioxide to produce an NOx-rich process gas stream; (c) reactively absorbing the NOx-rich gas stream with phosphoric acid containing solution in an absorption zone to form nitrate ions; (d) contacting the nitrate ions with air in a degassing zone to produce a nitrate-rich aqueous process stream; (e) reducing the nitrate-rich aqueous stream with hydrogen in the presence of phosphoric acid to produce hydroxylammonium phosphate; (f) oximating the hydroxylammonium phosphate with cyclohexanone to produce cyclohexanone oxime; and (g) converting the cyclohexanone oxime to caprolactam. According to the invention, supplemental oxygen is added downstream of the ammonia conversion zone to increase the quantity and rate of formation of nitrogen dioxide in the NOx-rich process gas stream.

Abstract translation: 一种生产己内酰胺的方法。 该方法包括：（a）在氨转化区中使空气与氨气反应以产生一氧化氮;（b）将至少一部分一氧化氮氧化成二氧化氮以产生富含NO x的工艺气流;（c） 在吸收区中用含磷酸溶液反应性吸收富含NO x的气流，形成硝酸根离子;（d）使硝酸根离子与脱气区的空气接触，产生富含硝酸盐的含水工艺流;（e） 富含硝酸盐的含水流在磷酸存在下用氢气生成磷酸羟铵;（f）用环己酮肟化磷酸羟铵以制备环己酮肟; 并且（g）将环己酮肟转化为己内酰胺。根据本发明，在氨转化区的下游添加补充氧以增加富氮过程气流中二氧化氮的形成量和速率。

公开(公告)号：US3816410A

公开(公告)日：1974-06-11

申请号：US20619971

申请日：1971-12-08

Applicant: TEXACO INC

Inventor： DURANLEAU R ,  LOVE R

IPC: C07C205/51 ,  C07D201/02 ,  C07D201/10 ,  C07D41/06

CPC classification number: C07D201/02 ,  C07C201/12 ,  C07D201/10 ,  Y02P20/582 ,  C07C205/51

Abstract: A METHOD FOR PREPARAING LACTAMS BY THE STEPS OF (1) CLEAVING AND ESTERIFYING A CYCLIC ALPHA-NITROKETONE WITH AN ALCOHOL TO FORM AN ALKYL OMEGA-NITROESTER AND (2) CATALYST HYDROGENATING AND CYCLIZING THE NITROESTER TO A LACTAM.

公开(公告)号：US3391137A

公开(公告)日：1968-07-02

申请号：US46301965

申请日：1965-06-10

Applicant: STAMICARBON

Inventor： BIGOT JOHAN A ,  KERKHOFFS PIETER L

IPC: C07D201/10

CPC classification number: C07D201/10

公开(公告)号：US3297684A

公开(公告)日：1967-01-10

申请号：US34085564

申请日：1964-01-21

Applicant: TOYO RAYON CO LTD

Inventor： YOSHIKAZU ITO ,  KUNIO SHIJI ,  SAIHEI NOMURA ,  RYO ENDO ,  AKIO IKEYAMA ,  FUMINO NISHIKAWA

IPC: C01B7/00 ,  C01B7/01 ,  C07D201/10

CPC classification number: C07D201/10 ,  C01B7/01