公开(公告)号：US20230059381A1

公开(公告)日：2023-02-23

申请号：US17967676

申请日：2022-10-17

申请人： KYUSHU UNIVERSITY ,  NIPPON CHEMIPHAR CO., LTD.

发明人： Toshiyasu IMAI ,  Toru KAWASAKI ,  Toru OGAWA ,  Kazuhide INOUE

IPC分类号： A61K31/551 ,  A61K31/137 ,  A61K31/138 ,  A61K31/15 ,  A61K31/335 ,  A61K31/343 ,  A61K31/451 ,  A61K31/4525 ,  A61K31/495 ,  A61K31/55 ,  C07D403/10

摘要： A P2X4 receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating neuropathic pain associated with Guillain-Barré syndrome: wherein R1 is hydrogen, a C1-8 alkyl group, or the like; each R2 and R3 is hydrogen, a C1-8 alkyl group, or the like; each of R4 and R5 is hydrogen or the like; and W is a five-membered or six-membered heterocyclic ring optionally having one or more substituents and comprising one to four nitrogen atoms as the members of the ring.

公开(公告)号：US11559487B2

公开(公告)日：2023-01-24

申请号：US16707833

申请日：2019-12-09

申请人： SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED

发明人： Ajay Jaysingh Khopade ,  Arindam Halder ,  Shivam Umeshkumar Upadhyay

IPC分类号： A61K9/14 ,  A61K9/00 ,  A61K9/20 ,  A61K9/10 ,  A61K9/06 ,  A61K31/135 ,  A61K31/196 ,  A61K31/335 ,  A61K31/498 ,  A61K31/519 ,  A61K31/65 ,  B82Y5/00 ,  A61K47/38 ,  A61K47/32

摘要： The present invention relates to nano-resin particles that are suitable for pharmaceutical use and their use in the pharmaceutical field. The present invention provides nano-sized resin particles having a particle size distribution characterized in that D90 value is between 200 nanometers to 900 nanometer and D10 value is not less than 50 nanometers, wherein the nano-resin particles are in pure form and safe for pharmaceutical use. The present invention further relates to pharmaceutical compositions comprising these purified nano-resin particles and their use in the treatment of diseases.
The present invention further provides a process for preparing purified, nano-sized resin particles that are suitable for pharmaceutical use, the process comprising steps of: (i) washing an ion exchange resin and suspending in an aqueous liquid, (ii) subjecting the suspension of (i) to wet milling for a period such that the particles have a particle size distribution characterized in that the D90 value is between 200 nanometers to 900 nanometers and D10 value is not less than 50 nanometers, (iii) subjecting the suspension of (ii) to purification to remove impurities, (iv) drying the purified suspension to obtain nano-resin particles in the form of dry powder.

公开(公告)号：US11406701B2

公开(公告)日：2022-08-09

申请号：US16901185

申请日：2020-06-15

申请人： Seqirus UK Limited

发明人： Giuseppe Del Giudice ,  Rino Rappuoli ,  Steven Black ,  Uwe Nicolay

IPC分类号： A61K39/00 ,  C12N9/64 ,  A61K31/335 ,  A61K31/34 ,  A61K31/35 ,  A61K39/145 ,  A61K39/39 ,  A61K39/12 ,  C12N7/00

摘要： Disclosed herein are methods for enhancing immune responses to a vaccine in immunocompromised individuals, including those receiving a statin therapy. Related products are also provided.

公开(公告)号：US20220133640A1

公开(公告)日：2022-05-05

申请号：US17512139

申请日：2021-10-27

申请人： BLUEBERRY THERAPEUTICS LIMITED

发明人： John RIDDEN ,  Michael DAVIES ,  Liam GOOD

IPC分类号： A61K9/51 ,  A61K31/7048 ,  A61K31/4375 ,  A61K31/137 ,  A61K31/335 ,  A61K31/496 ,  A61P31/10

摘要： The present invention relates nanoparticles formed of a polymer and an antifungal agent, wherein the polymer is selected from the group consisting of linear or branched or cyclic polymonoguanide/polyguanidine, polybiguanide, analogues or derivatives thereof, or mixtures thereof. The nanoparticles are particularly suited for the treatment of fungal nail or skin infections.

公开(公告)号：US11291647B2

公开(公告)日：2022-04-05

申请号：US16557294

申请日：2019-08-30

申请人： NISARGA BIOTECH PRIVATE LIMITED

发明人： Girish Sudhakar Soman

IPC分类号： A61K36/00 ,  A61K31/343 ,  A61K36/58 ,  A61K31/08 ,  A61K31/58 ,  A61K31/335 ,  A61K9/00

摘要： The present invention discloses process for preparation of a CO2 extract of Azadirachta indica and herbal compositions thereof for the treatment of Oral and Colon cancers. More particularly, the invention discloses a process for preparation of a standardized SCO2 extract of Azadirachta indica leaves and herbal compositions of the same for oral use.

公开(公告)号：US11273131B2

公开(公告)日：2022-03-15

申请号：US15724234

申请日：2017-10-03

申请人： AQUESTIVE THERAPEUTICS, INC.

发明人： Alexander Mark Schobel ,  Stephanie Marie Varjan ,  Stephen Paul Wargacki

IPC分类号： A61K9/70 ,  A61K31/085 ,  A61K31/05 ,  A61K31/36 ,  A61K36/61 ,  A61K31/137 ,  A61K31/335 ,  A61K9/00 ,  A61K47/26 ,  A61K47/12 ,  A61K31/5513 ,  A61K31/5517 ,  A61K47/10 ,  A61K47/14 ,  A61K47/38 ,  A61M37/00

摘要： Pharmaceutical compositions having enhanced active component permeation properties are described.

公开(公告)号：US20210393567A1

公开(公告)日：2021-12-23

申请号：US17467360

申请日：2021-09-06

申请人： Currax Pharmaceuticals LLC

发明人： Cara Baron Casseday ,  Elizabeth Ludington ,  Michael Skinner ,  Susan E. Dubé ,  Roberta L. Rogowski ,  Philip Jochelson ,  Robert Mansbach

IPC分类号： A61K31/335 ,  A61K31/55

摘要： Methods of improving the pharmacokinetics of doxepin in a patient.

公开(公告)号：US11197854B1

公开(公告)日：2021-12-14

申请号：US16684445

申请日：2019-11-14

申请人： National Technology & Engineering Solutions of Sandia, LLC

发明人： Michael S. Kent ,  Susan Rempe ,  Juan M. Vanegas

IPC分类号： A61K31/69 ,  A61K31/435 ,  A61K31/335 ,  A61K31/35 ,  A61P31/14 ,  A61K31/4745 ,  G01N33/68 ,  A61K45/06 ,  A61K31/351 ,  A61K31/366 ,  A61K31/7032 ,  A61K31/12 ,  A61K31/121 ,  A61K31/122 ,  A61K31/201

摘要： The present invention relates to methods for identifying candidate therapeutics for a disease caused by a viral envelope protein. In particular, the method can include contacting a test envelope protein with the candidate and determining its activity.

公开(公告)号：US11110076B2

公开(公告)日：2021-09-07

申请号：US16793861

申请日：2020-02-18

申请人： CASE WESTERN RESERVE UNIVERSITY

发明人： Alagramam N. Kumar ,  Suhasini Gopal Ramanujam

IPC分类号： A61K31/12 ,  A61K31/34 ,  A61K31/335 ,  A61K31/435 ,  A61K33/00 ,  A61K31/357 ,  A61P27/16 ,  A61K31/343

摘要： A method of treating a glycosylation-defective protein associated disease or disorder in a subject, the method includes administering to the subject a therapeutically effective amount of a Sarco/ER ATPase (SERCA) inhibitor.

公开(公告)号：US20210228538A1

公开(公告)日：2021-07-29

申请号：US17226781

申请日：2021-04-09

申请人： Indiana University Research and Technology Corporation

发明人： Timothy William Corson ,  Rania Sulaiman

IPC分类号： A61K31/353 ,  A61K31/343 ,  A61K31/335 ,  A61P27/02 ,  A61K39/395

摘要： Compositions including the combination of cremastranone analogs and anti-angiogenic agents and the use of the compositions for targeting ocular angiogenesis such as seen in neovascular eye diseases are disclosed.