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公开(公告)号：US06521460B1
公开(公告)日：2003-02-18
申请号：US09180806
申请日：1999-02-08
IPC分类号： G01N3386
CPC分类号： G01N33/50 , G01N33/86 , G01N2333/815 , Y10T436/108331
摘要： The present invention relates to a method of carrying out blood tests. The invention is based on the finding that clinico-chemical blood parameters can be determined using not only blood serum but also blood plasma. Therefore, freshly taken blood samples, which are mixed with at least one thrombin inhibitor, can be used for determining both clinico-chemical parameters and hematological parameters. The clinico-chemical parameters can thus be determined using blood plasma, a separation of coagulable components being not required any more.
摘要翻译： 本发明涉及进行血液检查的方法。 本发明是基于不仅可以使用血清而且可以使用血浆来确定临床化学血液参数的发现。 因此，与至少一种凝血酶抑制剂混合的新鲜采集的血液样品可用于确定临床化学参数和血液学参数。 因此，可以使用血浆来确定临床化学参数，不再需要分离凝结组分。
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公开(公告)号：US06245573B1
公开(公告)日：2001-06-12
申请号：US09022449
申请日：1998-02-12
申请人： Charles R. Spillert
发明人： Charles R. Spillert
IPC分类号： G01N3386
摘要： This invention relates to diagnostic methods and test kits for rapidly assessing the coagulant activity of blood by measuring the rate of blood clotting in the presence of certain metal ions. A modulator of coagulation may also be included. The coagulation activity of the blood of the patient in the presence of metal ions and an optional modulator is an indication of the presence or development of certain pathological conditions relating to the procoagulant activity of blood, including platelet function. The effect of metal ions on the viscosity of blood is also diagnostically useful.
摘要翻译： 本发明涉及用于通过在某些金属离子的存在下测量血液凝固速率来快速评估血液凝血活性的诊断方法和测试试剂盒。 还可以包括凝血调节剂。 在金属离子和任选的调节剂存在下，患者的血液的凝血活性指示与血液的促凝血活性（包括血小板功能）有关的某些病理状况的存在或发展。 金属离子对血液粘度的影响在诊断上也是有用的。
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公开(公告)号：US06797519B2
公开(公告)日：2004-09-28
申请号：US09974044
申请日：2001-10-10
IPC分类号： G01N3386
摘要： A system and method for diagnosing hemostasis utilizing a communication network. A blood hemostasis analyzer tests a blood sample and provides a parameter indicative of hemostasis. The blood hemostasis analyzer is communicatively coupled via the communication network to an analysis tool. The analysis tool includes an algorithm operable on the parameter to provide a result. The diagnostic result may indicate normal hemostasis, a coagulopathy or other condition, and may provide a recommended course of treatment.
摘要翻译： 一种利用通信网络诊断止血的系统和方法。 血液止血分析仪测试血液样品并提供指示止血的参数。 血液止血分析仪通过通信网络与分析工具进行通信耦合。 分析工具包括可以在参数上操作以提供结果的算法。 诊断结果可能表明正常止血，凝血病或其他病症，并可提供推荐疗程。
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公开(公告)号：US06686204B2
公开(公告)日：2004-02-03
申请号：US10226714
申请日：2002-08-23
IPC分类号： G01N3386
CPC分类号： B01L3/5082 , A61B5/15003 , A61B5/150351 , A61B5/150755 , A61B5/154 , B01L2300/161
摘要： The present invention is a container assembly that includes a coating composition on an interior surface of the container assembly and more particularly a coating composition for rapid clotting of a blood sample within a blood collection tube. The coating composition includes an intrinsic coagulation activator and an extrinsic coagulation activator for activating intrinsic and extrinsic pathways for promoting the rapid clotting of the blood sample. In addition, the present invention includes a barrier package for enclosing the container assembly.
摘要翻译： 本发明是一种容器组件，其在容器组件的内表面上包括涂料组合物，更具体地说是用于在采血管内快速凝固血液样品的涂料组合物。 涂层组合物包括内在凝固活化剂和外在凝固活化剂，用于激活用于促进血液样品快速凝固的内在和外在途径。 此外，本发明包括用于封闭容器组件的屏障包装。
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公开(公告)号：US06541262B1
公开(公告)日：2003-04-01
申请号：US09560470
申请日：2000-04-28
IPC分类号： G01N3386
CPC分类号： G01N33/86
摘要： A method and device for testing a sample of fresh whole blood. In particular the present invention provides a method and device for testing a sample of fresh whole blood to determine whether a patient would benefit from the administration of a blood factor (such as AT III.)
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公开(公告)号：US06524861B1
公开(公告)日：2003-02-25
申请号：US09235530
申请日：1999-01-22
申请人： Eric S. Anderson
发明人： Eric S. Anderson
IPC分类号： G01N3386
CPC分类号： G01N33/86 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/115831 , Y10T436/12
摘要： One method and apparatus for analyzing clotting characteristics of a blood sample includes the use of a non-linear equation having coefficients capable of being related to the underlying clotting processes. The non-linear equation is curve fit to a waveform of a clotting sample to provide values for the coefficients of the non-linear function. Once the coefficients are obtained, an inference engine may be used to evaluate the non-linear relationship between the coefficients and factor concentrations within the blood sample. Advantageously, the waveform of the actual sample may be detrended to extract a residual oscillatory component to aid in the determination of initial coefficients for simplifying the curve fit operation. The non-linear equation may additionally be used for providing simulated clotting waveforms for testing clot analysis instruments. A residual oscillatory component may advantageously be extracted from the clotting signal. The oscillatory components may be used to provide a high quality clot time indicator for the sample. In addition, the oscillatory component may be used to correct for clot anomalies by correlating the frequency of the oscillatory to various physical characteristics of the blood clot. The oscillatory component may be used to provide initial estimates for values of the coefficients of the logistic. The logistic, because it represents knowledge as to the underlying chemistry of the clotting process, may also be used to provide initial estimates for coefficients of the logistic, and may also be used to enhance the accuracy of existing polynomial template clot analysis techniques. The logistic model may also be used to verify the operation of clot analysis tools.
摘要翻译： 用于分析血液样本的凝血特征的一种方法和装置包括使用具有能够与潜在凝血过程相关的系数的非线性方程式。 非线性方程曲线拟合到凝血样本的波形，以提供非线性函数系数的值。 一旦获得了系数，就可以使用推理机来评估血样中系数和因子浓度之间的非线性关系。 有利地，可以将实际样品的波形去除以提取残余振荡分量，以帮助确定初始系数以简化曲线拟合操作。 非线性方程可另外用于提供用于测试凝块分析仪器的模拟凝血波形。 可以有利地从凝血信号中提取残留振荡成分。 振荡组分可用于为样品提供高质量的凝血时间指示剂。 此外，通过将振荡频率与血块的各种物理特征相关联，振荡组件可用于校正血块异常。 振荡分量可用于为物流系数的值提供初始估计。 因为它代表关于凝血过程的基础化学的知识的逻辑，也可以用于提供逻辑系数的初始估计，并且还可以用于增强现有多项式模板凝块分析技术的准确性。 物流模型也可用于验证凝块分析工具的操作。
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公开(公告)号：US06482653B1
公开(公告)日：2002-11-19
申请号：US09604271
申请日：2000-06-26
申请人： Michael Kraus , Carsten Schelp , Andreas Wiegand
发明人： Michael Kraus , Carsten Schelp , Andreas Wiegand
IPC分类号： G01N3386
CPC分类号： G01N33/86
摘要： The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.
摘要翻译： 本发明涉及一种用于检测止血障碍的方法和诊断剂，其中，由于血小板聚集，凝块形成和/或凝块溶解的结果，使物质彼此间隔一段距离，这允许或阻止相互作用， 特别是物质之间的能量转移，并且测量相互作用的程度。
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18.发明授权Method for predicting the presence of haemostatic dysfunction in a patient sample 有权用于预测患者样品中止血功能障碍的存在的方法公开(公告)号：US06429017B1
公开(公告)日：2002-08-06
申请号：US09372954
申请日：1999-08-12
申请人： Cheng Hock Toh , Colin Downey , Timothy J. Fischer
发明人： Cheng Hock Toh , Colin Downey , Timothy J. Fischer
IPC分类号： G01N3386
CPC分类号： G01N33/4905 , G01N30/96 , G01N33/86
摘要： A method which may be used to determine haemostatic dysfunction in a patient is carried out by (a) adding a reagent to a test sample, wherein the test sample includes at least a component of a blood sample from a patient; and then (b) measuring the formation of a precipitate due to the reaction of the test sample and the reagent, over time so as to derive a time-dependent measurement profile, the reagent forming a precipitate in the test sample without causing substantial fibrin polymerization.
摘要翻译： 可以用于确定患者止血功能障碍的方法是通过（a）向试验样品中加入试剂，其中所述测试样品至少包括来自患者的血样的成分; 然后（b）随着时间的推移测量由于测试样品和试剂的反应而产生的沉淀物的形成，从而导出时间依赖性测量曲线，试剂在测试样品中形成沉淀物而不引起显着的纤维蛋白聚合 。
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公开(公告)号：US06406672B1
公开(公告)日：2002-06-18
申请号：US09494072
申请日：2000-01-28
IPC分类号： G01N3386
CPC分类号： B01L3/502753 , B01L3/50273 , B01L2300/0645 , B01L2300/0681 , B01L2300/0816 , B01L2400/0406 , G01N33/491 , Y10T436/25125 , Y10T436/25375
摘要： A capillary hematocrit separation structure is included within a housing having a fluid inlet port, a reaction region, and a capillary pathway connecting the inlet port and the reaction region. The capillary pathway is dimensioned so that the driving force for the movement of liquid through the capillary pathway arises from capillary pressure. A plurality of obstructions are fixed in the capillary pathway, each obstruction having a concave portion facing toward the vented reaction region on the down stream side of the obstructions as viewed with reference to a liquid flowing from the inlet port to the reaction region. The capillary pathway in a hematocrit separation structure for a single drop sample size includes about 105 obstructions, each obstruction including a concave portion having a volume of between about 10−4 to 10−5 &mgr;l for selectively receiving hematocrit.
摘要翻译： 毛细管血细胞比容分离结构包括在具有连接入口和反应区域的流体入口，反应区域和毛细管道的壳体内。 毛细管路径的尺寸被设计成使得液体通过毛细通路的运动的驱动力由毛细管压力引起。 多个障碍物固定在毛细管路径中，每个阻塞件相对于从入口流向反应区域的液体观察，在障碍物的下游侧具有面向通气的反应区域的凹部。 用于单滴样品尺寸的血细胞比容分离结构中的毛细血管通路包括约105个障碍物，每个梗阻包括体积在约10-4至10-5μm之间的凹部，用于选择性地接受血细胞比容。
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公开(公告)号：US06403381B1
公开(公告)日：2002-06-11
申请号：US09327806
申请日：1999-06-08
IPC分类号： G01N3386
CPC分类号： G01N33/86 , G01N2333/811
摘要： The present invention provides methods for inhibiting blood clotting. In general, the methods include adding corn trypsin inhibitor (CTI) to blood or a blood product in an amount sufficient to inhibit the clotting. The CTI can be used alone or in combination with other anti-coagulants. In one aspect, the invention features plasma clotting assays featuring substantially prolonged clotting times. Clotting assays using whole or minimally altered blood are also provided. Further provided are methods for storing blood or blood products at low temperature with the CTI.
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