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    Homogeneous detection method
    1.
    发明授权
    Homogeneous detection method 有权
    均匀检测方法

    公开(公告)号：US08399209B2

    公开(公告)日：2013-03-19

    申请号：US11443270

    申请日：2006-05-31

    Applicant: Carsten Schelp ,  Michael Trier ,  Hrair Kirakossian

    Inventor： Carsten Schelp ,  Michael Trier ,  Hrair Kirakossian

    IPC: G01N33/00

    CPC classification number: G01N33/00 ,  G01N33/5306 ,  G01N33/536 ,  G01N33/542 ,  G01N33/582 ,  Y10S435/975

    Abstract: The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is associated with a component of a signal-forming system while a second analyte-specific binding partner R2 comprises more than one specific binding point for a specific binding partner Y which is also associated with a component of a signal-forming system.

    Abstract translation: 本发明涉及用于在测定中定量或定性检测分析物的方法及其适用的试剂，特别是均匀结合试验。 根据本发明，分析物特异性结合配偶体R1包括与信号形成系统的组分相关的特异性结合配偶体X的多于一个特异性结合点，而第二分析物特异性结合配偶体R2包含多于一个 特定结合对象Y的特异性结合点，其也与信号形成系统的组分相关联。

    Homogeneous detection method
    2.
    发明申请
    Homogeneous detection method 有权
    均匀检测方法

    公开(公告)号：US20070082346A1

    公开(公告)日：2007-04-12

    申请号：US11443270

    申请日：2006-05-31

    Applicant: Carsten Schelp ,  Michael Trier ,  Hrair Kirakossian

    Inventor： Carsten Schelp ,  Michael Trier ,  Hrair Kirakossian

    IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/544

    CPC classification number: G01N33/00 ,  G01N33/5306 ,  G01N33/536 ,  G01N33/542 ,  G01N33/582 ,  Y10S435/975

    Abstract: The invention relates to methods for the quantitative or qualitative detection of an analyte in an assay and adequate reagents therefor, particularly a homogeneous binding test. According to the invention, an analyte-specific binding partner R1 comprises more than one specific binding point for a specific binding partner X that is associated with a component of a signal-forming system while a second analyte-specific binding partner R2 comprises more than one specific binding point for a specific binding partner Y which is also associated with a component of a signal-forming system.

    Abstract translation: 本发明涉及用于在测定中定量或定性检测分析物的方法及其适用的试剂，特别是均匀结合试验。 根据本发明，分析物特异性结合配偶体R1包括与信号形成系统的组分相关的特异性结合配偶体X的多于一个特异性结合点，而第二分析物特异性结合配偶体R2包含多于一个 特定结合对象Y的特异性结合点，其也与信号形成系统的组分相关联。

    Method and diagnostic agent for hemostasis diagnosis
    4.
    发明授权
    Method and diagnostic agent for hemostasis diagnosis 有权
    止血诊断方法和诊断剂

    公开(公告)号：US06187594B1

    公开(公告)日：2001-02-13

    申请号：US09215167

    申请日：1998-12-18

    Applicant: Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

    Inventor： Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

    IPC: G01N3386

    CPC classification number: G01N33/86

    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.

    Abstract translation: 本发明涉及一种用于检测止血障碍的方法和诊断剂，其中，由于血小板聚集，凝块形成和/或凝块溶解的结果，使物质彼此间隔一段距离，这允许或阻止相互作用， 特别是物质之间的能量转移，并且测量相互作用的程度。

    Reduction of non-specific binding in assays
    5.
    发明授权
    Reduction of non-specific binding in assays 有权
    在测定中减少非特异性结合

    公开(公告)号：US07172906B2

    公开(公告)日：2007-02-06

    申请号：US10989677

    申请日：2004-11-16

    Applicant: Zhu Teng ,  Jeffrey L. Moore ,  Alan R. Craig ,  Gary Hickey ,  Carsten Schelp ,  Tie Quan Wei

    Inventor： Zhu Teng ,  Jeffrey L. Moore ,  Alan R. Craig ,  Gary Hickey ,  Carsten Schelp ,  Tie Quan Wei

    IPC: G01N33/548 ,  G01N33/544 ,  G01N33/547 ,  G01N33/53 ,  G01N1/17

    CPC classification number: G01N33/548 ,  G01N33/54393

    Abstract: Methods and compositions are disclosed for reducing non-specific binding in a binding assay for the determination of an analyte in a sample where one of the reagents for conducting the binding assay comprises a solid support comprising a polysaccharide. The method comprises including in an assay medium for conducting the binding assay a soluble compound comprising a protein linked to a polysaccharide. Also disclosed are methods and compositions for determining the presence and/or amount of an analyte in a sample suspected of containing the analyte. The methods include as reagents a solid support comprising a polysaccharide and a soluble compound comprising a protein linked to a polysaccharide.

    Abstract translation: 公开了用于在用于测定样品中分析物的结合测定中的非特异性结合的方法和组合物，其中用于进行结合测定的试剂之一包含含有多糖的固体支持物。 该方法包括在用于进行结合测定的测定培养基中包含可与多糖连接的蛋白质的可溶性化合物。 还公开了用于确定疑似含有分析物的样品中分析物的存在和/或量的方法和组合物。 所述方法包括作为试剂的固体支持物，其包含多糖和包含与多糖连接的蛋白质的可溶性化合物。

    Method and diagnostic agent for hemostasis diagnosis
    6.
    发明授权
    Method and diagnostic agent for hemostasis diagnosis 有权
    止血诊断方法和诊断剂

    公开(公告)号：US06750032B2

    公开(公告)日：2004-06-15

    申请号：US10255632

    申请日：2002-09-27

    Applicant: Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

    Inventor： Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

    IPC: C12Q152

    CPC classification number: G01N33/86

    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.

    Abstract translation: 本发明涉及一种用于检测止血障碍的方法和诊断剂，其中，由于血小板聚集，凝块形成和/或凝块溶解的结果，使物质彼此间隔一段距离，这允许或阻止相互作用， 特别是物质之间的能量转移，并且测量相互作用的程度。

    Detection and determination of solid phase-associated factors
    7.
    发明授权
    Detection and determination of solid phase-associated factors 有权
    固相相关因素的检测和测定

    公开(公告)号：US06632599B1

    公开(公告)日：2003-10-14

    申请号：US09215209

    申请日：1998-12-18

    Applicant: Michael Kraus ,  Carsten Schelp ,  Wilhelm Schuy

    Inventor： Michael Kraus ,  Carsten Schelp ,  Wilhelm Schuy

    IPC: C12Q100

    CPC classification number: G01N33/554 ,  G01N33/54313 ,  G01N2333/295 ,  Y10S435/81 ,  Y10S435/962 ,  Y10S435/968

    Abstract: The present invention relates to procedures for the detection or for the determination of solid phase-associated factors, which are multiply associated with the same solid phase. According to the invention, the sample is brought into contact with a transmitter particle, on which at least one ligand having binding affinity for a solid phase-associated factor and a transmitter are immobilized, and a receiver particle, on which at least one ligand having binding affinity for said solid phase-associated factor and a receiver is immobilized, and then the signal is determined which results when transmitter and receiver are brought sufficiently close to one another. In particular, the invention relates to the detection of cell surface receptors which can be used for the typing of cells or for the determination of cell activation states. It is thus possible to replace the hitherto widely customary flow cytometry by a more simple procedure.

    Abstract translation: 本发明涉及用于检测固相相关因子的测定方法，其与相同的固相相关联。 根据本发明，使样品与其上固定有至少一种与固相相关因子和发射体具有结合亲和力的配体的发射体颗粒和接收剂颗粒接触，其中至少一种配体具有 对所述固相关因子和接收器的结合亲和力被固定，然后确定当发送器和接收器彼此充分接近时导致的信号。 特别地，本发明涉及可用于细胞分型或确定细胞活化状态的细胞表面受体的检测。 因此，可以通过更简单的程序来替代迄今广泛使用的流式细胞术。

    Method and diagnostic agent for hemostasis diagnosis
    8.
    发明授权
    Method and diagnostic agent for hemostasis diagnosis 有权
    止血诊断方法和诊断剂

    公开(公告)号：US06482653B1

    公开(公告)日：2002-11-19

    申请号：US09604271

    申请日：2000-06-26

    Applicant: Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

    Inventor： Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

    IPC: G01N3386

    CPC classification number: G01N33/86

    Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.

    Abstract translation: 本发明涉及一种用于检测止血障碍的方法和诊断剂，其中，由于血小板聚集，凝块形成和/或凝块溶解的结果，使物质彼此间隔一段距离，这允许或阻止相互作用， 特别是物质之间的能量转移，并且测量相互作用的程度。

    Carriers coated with polysaccharides, their preparation and use
    10.
    发明授权
    Carriers coated with polysaccharides, their preparation and use 有权
    载体涂多糖，其制备和用途

    公开(公告)号：US07179660B1

    公开(公告)日：2007-02-20

    申请号：US10220623

    申请日：2000-03-06

    Applicant: Hrair Kirakossian ,  John S. Pease ,  Carsten Schelp ,  Marcel R. Pirio ,  Uwe Stöhr ,  Andreas Wiegand

    Inventor： Hrair Kirakossian ,  John S. Pease ,  Carsten Schelp ,  Marcel R. Pirio ,  Uwe Stöhr ,  Andreas Wiegand

    IPC: G01N33/548

    CPC classification number: G01N33/548 ,  Y10S435/969 ,  Y10S436/827 ,  Y10T428/2991

    Abstract: A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spontaneously associates with a preceding layer. Spontaneous association occurs due to the presence of oppositely charged functional groups on each layer of polysaccharide or due to a spontaneous reaction between the functional groups the layers. The carrier may be any surface such as a tube, microtitration plate, bead, particle or the like and is suitable for use in diagnostic or therapeutic methods.

    Abstract translation: 具有至少两层连续多层多糖的涂层的多糖涂覆的载体。 第一多糖层自发地与第二多糖层和任选的载体结合。 每个连续的多糖多层自发地与前一层相关联。 由于在多层多层上存在相反电荷的官能团，或由于各层之间的官能团之间的自发反应，发生自发缔合。 载体可以是诸如管，微量滴定板，珠粒，颗粒等的任何表面，并且适用于诊断或治疗方法。

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