公开(公告)号：US06750032B2

公开(公告)日：2004-06-15

申请号：US10255632

申请日：2002-09-27

Applicant: Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

Inventor： Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

IPC: C12Q152

CPC classification number: G01N33/86

Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.

Abstract translation: 本发明涉及一种用于检测止血障碍的方法和诊断剂，其中，由于血小板聚集，凝块形成和/或凝块溶解的结果，使物质彼此间隔一段距离，这允许或阻止相互作用， 特别是物质之间的能量转移，并且测量相互作用的程度。

公开(公告)号：US06482653B1

公开(公告)日：2002-11-19

申请号：US09604271

申请日：2000-06-26

Applicant: Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

Inventor： Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

IPC: G01N3386

CPC classification number: G01N33/86

Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.

Abstract translation: 本发明涉及一种用于检测止血障碍的方法和诊断剂，其中，由于血小板聚集，凝块形成和/或凝块溶解的结果，使物质彼此间隔一段距离，这允许或阻止相互作用， 特别是物质之间的能量转移，并且测量相互作用的程度。

公开(公告)号：US5783455A

公开(公告)日：1998-07-21

申请号：US542026

申请日：1995-10-12

Applicant: Andreas Wiegand ,  Rudolf Schmidtberger

Inventor： Andreas Wiegand ,  Rudolf Schmidtberger

IPC: G01N33/543 ,  G01N33/553

CPC classification number: G01N33/543 ,  G01N33/553 ,  Y10S435/97 ,  Y10S436/81

Abstract: The present invention relates to a method for carrying out immunochemical reactions and to regenerable solid phases which can be used for this purpose. When use is made of precious metals, preferably gold, as the solid phase, and also of certain reducing agents or oxidizing agents, such as, for example, sodium borohydride and tetrabutylammonium hydroxide, with or without the addition of detergents, the solid phase can be employed repeatedly, following regeneration.

Abstract translation: 本发明涉及一种用于进行免疫化学反应的方法和可再生固相，可用于此目的。 当使用贵金属，优选金作为固相，以及某些还原剂或氧化剂，例如硼氢化钠和四丁基氢氧化铵时，加入或不添加洗涤剂，固相可以 重复使用，再生。

公开(公告)号：US06187594B1

公开(公告)日：2001-02-13

申请号：US09215167

申请日：1998-12-18

Applicant: Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

Inventor： Michael Kraus ,  Carsten Schelp ,  Andreas Wiegand

IPC: G01N3386

CPC classification number: G01N33/86

Abstract: The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or prevents an interaction, in particular an energy transfer, between the substances, and the extent of the interaction is measured.

Abstract translation: 本发明涉及一种用于检测止血障碍的方法和诊断剂，其中，由于血小板聚集，凝块形成和/或凝块溶解的结果，使物质彼此间隔一段距离，这允许或阻止相互作用， 特别是物质之间的能量转移，并且测量相互作用的程度。

公开(公告)号：US07179660B1

公开(公告)日：2007-02-20

申请号：US10220623

申请日：2000-03-06

Applicant: Hrair Kirakossian ,  John S. Pease ,  Carsten Schelp ,  Marcel R. Pirio ,  Uwe Stöhr ,  Andreas Wiegand

Inventor： Hrair Kirakossian ,  John S. Pease ,  Carsten Schelp ,  Marcel R. Pirio ,  Uwe Stöhr ,  Andreas Wiegand

IPC: G01N33/548

CPC classification number: G01N33/548 ,  Y10S435/969 ,  Y10S436/827 ,  Y10T428/2991

Abstract: A polysaccharide coated carrier having a coating of at least two successive layers of polysaccharide. The first polysaccharide layer spontaneously associates with a second polysaccharide layer and, optionally, the carrier. Each successive layer of polysaccharide spontaneously associates with a preceding layer. Spontaneous association occurs due to the presence of oppositely charged functional groups on each layer of polysaccharide or due to a spontaneous reaction between the functional groups the layers. The carrier may be any surface such as a tube, microtitration plate, bead, particle or the like and is suitable for use in diagnostic or therapeutic methods.

Abstract translation: 具有至少两层连续多层多糖的涂层的多糖涂覆的载体。 第一多糖层自发地与第二多糖层和任选的载体结合。 每个连续的多糖多层自发地与前一层相关联。 由于在多层多层上存在相反电荷的官能团，或由于各层之间的官能团之间的自发反应，发生自发缔合。 载体可以是诸如管，微量滴定板，珠粒，颗粒等的任何表面，并且适用于诊断或治疗方法。

公开(公告)号：US6087187A

公开(公告)日：2000-07-11

申请号：US771249

申请日：1996-12-20

Applicant: Andreas Wiegand ,  Norbert Madry ,  Carsten Schelp ,  Paul Meller ,  Michael Mohlen

Inventor： Andreas Wiegand ,  Norbert Madry ,  Carsten Schelp ,  Paul Meller ,  Michael Mohlen

IPC: G01N33/531 ,  G01N5/02 ,  G01N33/543 ,  G01N33/553

CPC classification number: G01N33/54373

Abstract: The present invention relates to a piezoelectric sensor for use in diagnostic and analytic processes, in particular for the immunochemical detection of diagnostically relevant specific binding partners.

Abstract translation: 本发明涉及一种用于诊断和分析过程的压电传感器，特别是用于诊断相关特异性结合配偶体的免疫化学检测。