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    Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug
    17.
    发明授权
    Methods of forming ciclopirox or derivatives thereof in a subject by administration of prodrug 有权
    通过给药前药在受试者中形成环吡酮或其衍生物的方法

    公开(公告)号：US09545413B2

    公开(公告)日：2017-01-17

    申请号：US14966323

    申请日：2015-12-11

    申请人： The University of Kansas

    发明人： Mehmet Tanol ,  Scott Weir

    IPC分类号： A01N57/00 ,  A61K31/675 ,  C07F9/58 ,  C07F9/59 ,  C07F9/09 ,  C07F9/11

    CPC分类号： A61K31/675 ,  C07F9/091 ,  C07F9/094 ,  C07F9/11 ,  C07F9/58 ,  C07F9/59 ,  C07F9/6596

    摘要： A method of forming a compound in a subject can include: providing a composition having a prodrug compound represented by a structure of Formula 1 or stereoisomer thereof or pharmaceutically acceptable salt thereof; and administering the composition to a subject such that the prodrug compound has a phosphoryloxyalkyl prodrug moiety removed therefrom to form the compound in the subject and to form the separate phosphoryloxyalkyl compound. The prodrug can be included in a pharmaceutical composition for use in treatment of fungus, various cancers (e.g., bladder, breast, etc.), dermatitis, superficial mycoses; inflammation, tinea pedis, tinea cruris, and tinea corporis, Trichophyton rubrum, Trichophyton mentagrophytes, Epidermophyton floccosum, and Microsporum canis, candidiasis (moniliasis), Candida albicans, tinea (pityriasis) vesicolor, Malassezia furfur, acute myeloid leukemia, acute lymphoid leukemia, chronic myelogenous leukemia, lymphoma or multiple myeloma.

    摘要翻译： 在受试者中形成化合物的方法可以包括：提供具有由式1的结构或其立体异构体或其药学上可接受的盐表示的前药化合物的组合物; 以及将所述组合物施用于受试者，使得所述前药化合物具有从其中除去的磷酰氧基烷基前药部分以在受试者中形成化合物并形成分离的磷酰氧基烷基化合物。 前药可以包括在药物组合物中，用于治疗真菌，各种癌症（例如膀胱，乳房等），皮炎，浅表性真菌病; 癣菌，癣菌，癣菌，癣菌，癣菌和癣菌，红色毛癣菌，癣菌和小孢子癣菌，念珠菌病（moniliasis），白色念珠菌，癣（糠疹），糠疹马拉色菌，急性淋巴细胞性白血病， 慢性骨髓性白血病，淋巴瘤或多发性骨髓瘤。