Devices and methods for treating lung diseases

    公开(公告)号:US12296094B1

    公开(公告)日:2025-05-13

    申请号:US17239880

    申请日:2021-04-26

    Abstract: Pulmonary treatment methods and systems. During pulmonary treatment breath cycles, a hold period of elevated inspiration pressure may promote lung region filling (and potentially recruitment) via collateral airways. Expectoration is promoted by dropping from the inspiration pressure to an undershoot pressure; de-recruitment (e.g., by airway collapse) is mitigated by raising the undershoot pressure to a positive expiratory pressure (PEP) during expiration phase. Breath cycles with a period of post-PEP suction may also be administered. Respiratory therapy systems may be programmed or re-programmed to administer this pressure protocol. In some embodiments, a system includes a hand-held unit including a patient mouthpiece, a base unit which provides pressurized gas to the mouthpiece, an electronically controllable valve in the hand-held unit for providing therapy maneuvers such as PEP (Positive Expiratory Pressure) through the mouthpiece, and a computing unit which instructs the hand-held unit to perform therapy maneuvers.

    Decoding of error correction codes based on reverse diffusion

    公开(公告)号:US12294387B2

    公开(公告)日:2025-05-06

    申请号:US18223121

    申请日:2023-07-18

    Abstract: Disclosed herein are systems and method for training neural network based decoders for decoding error correction codes, comprising obtaining a plurality of training samples comprising one or more codewords encoded using an error correction code and transmitted over a transmission channel where the training samples are subject to gradual interference over a plurality of time steps and associate the encoded codeword(s) with an interference level and a parity check syndrome at each of the plurality of time steps, using the training samples to train a neural network based decoder to decode codewords encoded using an error correction code by (1) estimating a multiplicative interference included in the encoded codeword(s) based on reverse diffusion applied to the encoded codeword(s) across the time steps, (2) computing an additive interference included in the encoded codewords based on the multiplicative interference, and (3) recovering the codeword(s) by removing the additive interference.

    PERSONAL UNIVERSAL DENDROGRAMIC HOLOGRAPHIC SIGNATURE FROM EEG DATA ANALYSIS FOR DIAGNOSIS OF NEURO-PSYCHIATRIC DISEASES

    公开(公告)号:US20250107745A1

    公开(公告)日:2025-04-03

    申请号:US18846301

    申请日:2023-03-10

    Abstract: There is provided a method of diagnosing a medical state associated with a neuro-psychiatric disorder in a subject, comprising: receiving EEG datasets from EEG electrodes monitoring a head of the subject, computing events for the EEG datasets, clustering the events into clusters, computing a p-adic representation of the clusters, extracting a p-adic topology from the p-adic representation of the clusters, computing a personal universal dendrogramic holographic signature (PUDHS) of the p-acid topology relative to a personalized threshold that separates between a relative large distance between events and a relatively small distance between events, the PUDHS denoting number of events below the personalized threshold, and diagnosing the medical state associated with the neuro-psychiatric disorder according to the PUDHS relative to a medical threshold that separates between presence of the medical state and non-presence of the medical state.

    CANNABINOID-LIPID CONJUGATES, METHODS FOR PRODUCING THE SAME AND USES THEREOF

    公开(公告)号:US20240398839A1

    公开(公告)日:2024-12-05

    申请号:US18694614

    申请日:2022-09-22

    Abstract: Provided is a cannabinoid-phospholipid conjugate where the cannabinoid is covalently linked, via a cleavable linker, to a polar head group of the phospholipid. Also provided is a method of obtaining the conjugate, the method comprising (a) reacting the phospholipid (PL) dissolved in an organic solvent with maleic anhydride (MA) to obtain PL-MA intermediate; and (b) reacting said PL-MA intermediate with the cannabinoid in the presence of a carboxyl activating agent and an esterification agent to obtain a reaction mixture comprising said conjugate. Uses of the conjugate are also disclosed.

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