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公开(公告)号:US12296094B1
公开(公告)日:2025-05-13
申请号:US17239880
申请日:2021-04-26
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor: Moshe Ashkenazi , Gil Sokol , Ori Efrati , Itzik Mashiach , Diana Sverdlov , Ortal Shtayman , Imry Ben Avi , Daniel Sorkin
Abstract: Pulmonary treatment methods and systems. During pulmonary treatment breath cycles, a hold period of elevated inspiration pressure may promote lung region filling (and potentially recruitment) via collateral airways. Expectoration is promoted by dropping from the inspiration pressure to an undershoot pressure; de-recruitment (e.g., by airway collapse) is mitigated by raising the undershoot pressure to a positive expiratory pressure (PEP) during expiration phase. Breath cycles with a period of post-PEP suction may also be administered. Respiratory therapy systems may be programmed or re-programmed to administer this pressure protocol. In some embodiments, a system includes a hand-held unit including a patient mouthpiece, a base unit which provides pressurized gas to the mouthpiece, an electronically controllable valve in the hand-held unit for providing therapy maneuvers such as PEP (Positive Expiratory Pressure) through the mouthpiece, and a computing unit which instructs the hand-held unit to perform therapy maneuvers.
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公开(公告)号:US12294387B2
公开(公告)日:2025-05-06
申请号:US18223121
申请日:2023-07-18
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Yoni Choukroun , Lior Wolf
Abstract: Disclosed herein are systems and method for training neural network based decoders for decoding error correction codes, comprising obtaining a plurality of training samples comprising one or more codewords encoded using an error correction code and transmitted over a transmission channel where the training samples are subject to gradual interference over a plurality of time steps and associate the encoded codeword(s) with an interference level and a parity check syndrome at each of the plurality of time steps, using the training samples to train a neural network based decoder to decode codewords encoded using an error correction code by (1) estimating a multiplicative interference included in the encoded codeword(s) based on reverse diffusion applied to the encoded codeword(s) across the time steps, (2) computing an additive interference included in the encoded codewords based on the multiplicative interference, and (3) recovering the codeword(s) by removing the additive interference.
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公开(公告)号:US12274678B2
公开(公告)日:2025-04-15
申请号:US17611093
申请日:2020-05-17
Inventor: David Meiri , Elazar Besser , Igal Louria-Hayon , Paula Berman , Gil Moshe Lewitus , Limor Broday
Abstract: The present invention provides a pharmaceutical composition including a combination of at least two cannabinoids, and methods of using same, such as for treating a NOTCH 1-related disease.
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公开(公告)号:US20250107745A1
公开(公告)日:2025-04-03
申请号:US18846301
申请日:2023-03-10
Inventor: Oded SHOR , Felix BENNINGER , Andrei KHRENNIKOV
Abstract: There is provided a method of diagnosing a medical state associated with a neuro-psychiatric disorder in a subject, comprising: receiving EEG datasets from EEG electrodes monitoring a head of the subject, computing events for the EEG datasets, clustering the events into clusters, computing a p-adic representation of the clusters, extracting a p-adic topology from the p-adic representation of the clusters, computing a personal universal dendrogramic holographic signature (PUDHS) of the p-acid topology relative to a personalized threshold that separates between a relative large distance between events and a relatively small distance between events, the PUDHS denoting number of events below the personalized threshold, and diagnosing the medical state associated with the neuro-psychiatric disorder according to the PUDHS relative to a medical threshold that separates between presence of the medical state and non-presence of the medical state.
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公开(公告)号:US12221621B2
公开(公告)日:2025-02-11
申请号:US17059236
申请日:2019-06-04
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Tal Dvir , Assaf Shapira
Abstract: Provided herein is a see-through transparent, stable, safe and (bio)degradable hydrogel-based particulate support medium, made of calcium alginate particles. The calcium alginate particles, or hybrid hydrogel particles, are characterized by a substantially homogeneous average particle size that ranges from 0.1 micrometer to 5 micrometer.
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公开(公告)号:US20250032581A1
公开(公告)日:2025-01-30
申请号:US18552266
申请日:2022-03-25
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Illana GOZES
IPC: A61K38/18 , C07K14/475
Abstract: Compositions and articles comprising an ADNF polypeptide are provided. Accordingly, there is provided an article of manufacture comprising as active ingredients an ADNF polypeptide and a SIRT1 activator. Also provided are methods of treating a disease that can benefit from the article of manufacture.
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公开(公告)号:US20240420504A1
公开(公告)日:2024-12-19
申请号:US18713653
申请日:2022-11-30
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: David Mendlovic , Dan Raviv , Lior Gelberg , Khen Cohen , Mor-Avi Azulay , Menahem Koren
Abstract: Systems, methods, and computer readable media for identifying a person in a video are disclosed. Systems, methods, devices, and non-transitory computer readable media may include at least one processor that may be configured to generate a spatiotemporal emotion data compendium (STEM-DC) from the video and to process the STEM-DC using a deep fully adaptive graph convolutional network (FAGC) to determine a first person representation vector that represents the person in the video.
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公开(公告)号:US20240398839A1
公开(公告)日:2024-12-05
申请号:US18694614
申请日:2022-09-22
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Daniel OFFEN , Nataly YOM-TOV
Abstract: Provided is a cannabinoid-phospholipid conjugate where the cannabinoid is covalently linked, via a cleavable linker, to a polar head group of the phospholipid. Also provided is a method of obtaining the conjugate, the method comprising (a) reacting the phospholipid (PL) dissolved in an organic solvent with maleic anhydride (MA) to obtain PL-MA intermediate; and (b) reacting said PL-MA intermediate with the cannabinoid in the presence of a carboxyl activating agent and an esterification agent to obtain a reaction mixture comprising said conjugate. Uses of the conjugate are also disclosed.
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公开(公告)号:US20240368700A1
公开(公告)日:2024-11-07
申请号:US18562317
申请日:2022-05-19
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Tamir TULLER , Tal GUTMAN
IPC: C12Q1/6886 , G16B20/00 , G16B40/20
Abstract: Methods of determining a type of cancer in a subject or estimating survival time after diagnosis of a subject comprising employing a machine learning model to evaluate mutations that are not exonic non-synonymous mutations are provided. Methods comprising training a machine learning model are also provided.
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公开(公告)号:US20240361320A1
公开(公告)日:2024-10-31
申请号:US18768074
申请日:2024-07-10
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Ella BORBERG , Eran GRANOT , Fernando PATOLSKY
IPC: G01N33/569 , G01N27/327 , G01N33/543
CPC classification number: G01N33/56983 , G01N27/3271 , G01N33/5438 , G01N2469/10
Abstract: A functionalized electrode capable of selectively interacting with a viral biomarker, an electrochemical system comprising the electrode and methods utilizing same for, for example, determining a presence of a viral infection in a subject are provided.
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