公开(公告)号：US20200146600A1

公开(公告)日：2020-05-14

申请号：US16742793

申请日：2020-01-14

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Apurv Ullas Kamath ,  Paul V. Goode, JR. ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1473

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

公开(公告)号：US20190320953A1

公开(公告)日：2019-10-24

申请号：US16457688

申请日：2019-06-28

Applicant: DexCom, Inc.

Inventor： Jack Pryor ,  Apurv Ullas Kamath ,  Paul V. Goode, JR. ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/1473

Abstract: Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor.

公开(公告)号：US10265000B2

公开(公告)日：2019-04-23

申请号：US15668541

申请日：2017-08-03

Applicant: DexCom, Inc.

Inventor： Mark C. Shults ,  Rathbun K. Rhodes ,  Stuart J. Updike ,  James H. Brauker

IPC: A61B5/05 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/15

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous and subcutaneous measurement of glucose in a host.

公开(公告)号：US20190021596A1

公开(公告)日：2019-01-24

申请号：US16137411

申请日：2018-09-20

Applicant: DexCom, Inc.

Inventor： Mark Brister ,  Paul V. Neale ,  Peter C. Simpson ,  James H. Brauker ,  James Patrick Thrower ,  Mark Shults ,  Rathbun K. Rhodes ,  Paul V. Goode, JR. ,  Arnold L. Holmquist

IPC: A61B5/00 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/07

Abstract: The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.

公开(公告)号：US20180303394A1

公开(公告)日：2018-10-25

申请号：US16017668

申请日：2018-06-25

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Peter C. Simpson ,  Robert J. Boock ,  Monica Rixman Swinney ,  Mark C. Brister

IPC: A61B5/1486 ,  A61B5/145 ,  A61B5/00 ,  C12Q1/00 ,  G01N33/543

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/418 ,  A61B5/6848 ,  A61B2562/08 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  Y02A50/55 ,  Y02A50/58

Abstract: The present invention relates generally to biointerface membranes utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, the invention relates to novel biointerface membranes, to devices and implantable devices including these membranes, methods for forming the biointerface membranes on or around the implantable devices, and to methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device.

公开(公告)号：US20180296164A1

公开(公告)日：2018-10-18

申请号：US16011414

申请日：2018-06-18

Applicant: DexCom, Inc.

Inventor： Paul V. Goode ,  James H. Brauker ,  Arpurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/1473

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

公开(公告)号：US20180296144A1

公开(公告)日：2018-10-18

申请号：US16007725

申请日：2018-06-13

Applicant: DexCom, Inc.

Inventor： Mark C. Brister ,  James H. Brauker

IPC: A61B5/145 ,  A61B5/00 ,  A61B5/1486 ,  A61B5/15 ,  A61B5/1468

Abstract: The present invention relates generally to variable stiffness transcutaneous medical devices including a distal portion designed to be more flexible than a proximal portion. The variable stiffness can be provided by a variable pitch in one or more wires of the device, a variable cross-section in one or more wires of the device, and/or a variable hardening and/or softening in one or more wires of the device.

公开(公告)号：US20180289298A1

公开(公告)日：2018-10-11

申请号：US16000621

申请日：2018-06-05

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode, JR. ,  Apurv Ullas Kamath ,  James Patrick Thrower ,  Ben Xavier

IPC: A61B5/145 ,  G06F19/00 ,  A61M5/172 ,  A61B5/00 ,  A61B5/1495 ,  A61B5/1486 ,  A61B5/1468 ,  A61B5/1473

Abstract: Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

公开(公告)号：US20180279959A1

公开(公告)日：2018-10-04

申请号：US15997509

申请日：2018-06-04

Applicant: DexCom, Inc.

Inventor： Apurv Ullas Kamath ,  James H. Brauker ,  Aarthi Mahalingam ,  Ying Li

IPC: A61B5/00 ,  A61B5/01 ,  A61B5/145 ,  A61B5/1486

Abstract: Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.

公开(公告)号：US20180242894A1

公开(公告)日：2018-08-30

申请号：US15967338

申请日：2018-04-30

Applicant: DexCom, Inc.

Inventor： James H. Brauker ,  Robert J. Boock ,  Monica A. Rixman ,  Peter C. Simpson ,  Mark C. Brister ,  Mark C. Shults

IPC: A61B5/1486 ,  G01N33/66 ,  A61B5/145 ,  C12Q1/00 ,  A61B5/00 ,  G01N33/543 ,  A61B5/1473

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/1473 ,  A61B5/411 ,  A61B5/418 ,  A61B5/6848 ,  A61B2562/08 ,  C12Q1/006 ,  G01N33/54366 ,  G01N33/66 ,  Y02A50/55 ,  Y02A50/58

Abstract: Biointerface membranes are provided which can be utilized with implantable devices, such as devices for the detection of analyte concentrations in a biological sample. More particularly, methods for monitoring glucose levels in a biological fluid sample using an implantable analyte detection device incorporating such membranes are provided.