公开(公告)号：US11737692B2

公开(公告)日：2023-08-29

申请号：US16882334

申请日：2020-05-22

Applicant: DexCom, Inc.

Inventor： Naresh C. Bhavaraju ,  Sebastian Bohm ,  Robert J. Boock ,  Daiting Rong ,  Peter C. Simpson

IPC: A61B5/145 ,  A61B5/1495 ,  A61B5/1473 ,  A61B5/1459 ,  A61B5/00 ,  A61B5/1486

CPC classification number: A61B5/1495 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/7278 ,  A61B2562/04

Abstract: Disclosed herein are devices, systems, and methods for a continuous analyte sensor, such as a continuous glucose sensor. In certain embodiments disclosed herein, various in vivo properties of the sensor's surroundings can be measured. In some embodiments, the measured properties can be used to identify a physiological response or condition in the body. This information can then be used by a patient, doctor, or system to respond appropriately to the identified condition.

公开(公告)号：US20210353185A1

公开(公告)日：2021-11-18

申请号：US17444148

申请日：2021-07-30

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Paul V. Neale ,  Sebastian Böhm ,  Matthew D. Wightlin ,  Jack Pryor ,  Jason Mitchell ,  Jeff Jackson ,  Kaushik Patel ,  Antonio C. Llevares

IPC: A61B5/1473 ,  A61B5/1486 ,  B05C3/12 ,  B05C3/02 ,  A61B5/145 ,  B05C3/10

Abstract: Analyte sensors and methods of manufacturing same are provided, including analyte sensors comprising multi-axis flexibility. For example, a multi-electrode sensor system 800 comprising two working electrodes and at least one reference/counter electrode is provided. The sensor system 800 comprises first and second elongated bodies E1, E2, each formed of a conductive core or of a core with a conductive layer deposited thereon, insulating layer 810 that separates the conductive layer 820 from the elongated body, a membrane layer deposited on top of the elongated bodies E1, E2, and working electrodes 802′, 802″ formed by removing portions of the conductive layer 820 and the insulating layer 810, thereby exposing electroactive surface of the elongated bodies E1, E2.

公开(公告)号：US20210345916A1

公开(公告)日：2021-11-11

申请号：US17330265

申请日：2021-05-25

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Monica Rixman Swinney

IPC: A61B5/145 ,  A61B5/1486 ,  A61B5/00 ,  C08L83/04

Abstract: Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

公开(公告)号：US20210231602A1

公开(公告)日：2021-07-29

申请号：US17163083

申请日：2021-01-29

Applicant: DexCom, Inc.

Inventor： Michael J. Estes ,  Jennifer Blackwell ,  Sebastian Bohm ,  Robert J. Boock ,  Jack Pryor ,  Peter C. Simpson ,  Matthew D. Wightlin

IPC: G01N27/403 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495

Abstract: Systems and methods for compensating for effects of temperature on implantable sensors are provided. In some embodiments, systems and methods are provided for measuring a temperature to determine a change in temperature in a sensor environment. In certain embodiments, a temperature compensation factor is determined based on a change in temperature of the sensor environment. The temperature compensation factor can be used in processing raw data of an analyte signal to report a more accurate analyte concentration.

公开(公告)号：US20200146598A1

公开(公告)日：2020-05-14

申请号：US16739617

申请日：2020-01-10

Applicant: DexCom, Inc.

Inventor： Phil Mayou ,  Hari Hampapuram ,  David Price ,  Keri Weindel ,  Kostantyn Snisarenko ,  Michael Robert Mensinger ,  Leif N. Bowman ,  Robert J. Boock ,  Apurv Ullas Kamath ,  Eli Reihman ,  Peter C. Simpson

IPC: A61B5/145 ,  G16H50/70 ,  G16H50/20 ,  G16H15/00

Abstract: Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.

公开(公告)号：US10376143B2

公开(公告)日：2019-08-13

申请号：US14145404

申请日：2013-12-31

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Mark C. Brister ,  Monica A. Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth R. Brunner ,  Arthur Chee ,  Melissa A. Nicholas ,  Matthew D. Wightlin ,  Jack Pryor ,  Dubravka Markovic

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473

Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US10052051B2

公开(公告)日：2018-08-21

申请号：US15796163

申请日：2017-10-27

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Monica Rixman Swinney

IPC: A61B5/00 ,  A61B5/145 ,  C08L83/04 ,  A61B5/1486 ,  C08G77/20 ,  C08G77/46 ,  C08G77/12 ,  B33Y70/00

CPC classification number: A61B5/14532 ,  A61B5/14865 ,  A61B5/6848 ,  B33Y70/00 ,  C08G77/12 ,  C08G77/20 ,  C08G77/46 ,  C08L83/04 ,  C08L2666/14

Abstract: Membrane systems incorporating silicone polymers are described for use in implantable analyte sensors. Some layers of the membrane system may comprise a blend of a silicone polymer with a hydrophilic polymer, for example, a triblock poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) polymer. Such polymeric blends provide for both high oxygen solubility and aqueous analyte solubility.

公开(公告)号：US20180008173A1

公开(公告)日：2018-01-11

申请号：US15711863

申请日：2017-09-21

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  Matthew Wightlin ,  Mark C. Shults

IPC: A61B5/1473 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486

CPC classification number: A61B5/1473 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/14865 ,  A61B5/6848 ,  A61B2562/028

Abstract: Systems and methods of use involving sensors having a particle-containing domain are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US09763609B2

公开(公告)日：2017-09-19

申请号：US13732848

申请日：2013-01-02

Applicant: DexCom, Inc.

Inventor： Peter C. Simpson ,  Robert J. Boock ,  James R. Petisce ,  Mark C. Brister ,  Monica A. Rixman ,  Kum Ming Woo ,  Lisa Nguyen ,  Seth R. Brunner ,  Arthur Chee ,  Melissa A. Nicholas ,  Matthew D. Wightlin ,  Jack Pryor ,  Dubravka Markovic

IPC: A61B5/05 ,  A61B5/1473 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/00

CPC classification number: A61B5/14735 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6848 ,  A61B5/7203

Abstract: Systems and methods of use involving sensors having a signal-to-noise ratio that is substantially unaffected by non-constant noise are provided for continuous analyte measurement in a host. In some embodiments, a continuous analyte measurement system is configured to be wholly, transcutaneously, intravascularly or extracorporeally implanted.

公开(公告)号：US09693721B2

公开(公告)日：2017-07-04

申请号：US14742137

申请日：2015-06-17

Applicant: DexCom, Inc.

Inventor： Robert J. Boock ,  Monica A. Rixman ,  Huashi Zhang ,  Michael J. Estes ,  Kristina Lawrence

IPC: A61B5/1486 ,  A61B5/1468 ,  G01N27/40 ,  A61B5/1473 ,  A61B5/145 ,  C12Q1/00 ,  A61B5/00

CPC classification number: A61B5/14865 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/7203 ,  B33Y70/00 ,  C12Q1/006 ,  G01N27/40

Abstract: Devices and methods are described for providing continuous measurement of an analyte concentration. In some embodiments, the device has a sensing mechanism and a sensing membrane that includes at least one surface-active group-containing polymer and that is located over the sensing mechanism. The sensing membrane may have a bioprotective layer configured to substantially block the effect and/or influence of non-constant noise-causing species.