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    Systems and methods for replacing signal artifacts in a glucose sensor data stream
    1.
    发明授权
    Systems and methods for replacing signal artifacts in a glucose sensor data stream 有权

    公开(公告)号：US11589823B2

    公开(公告)日：2023-02-28

    申请号：US16540000

    申请日：2019-08-13

    申请人： DexCom, Inc.

    发明人： Paul V. Goode ,  James H. Brauker ,  Arpurv U. Kamath ,  James Patrick Thrower ,  Victoria Carr-Brendel

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1473 ,  A61B5/1495

    摘要： Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as ischemia, pH changes, temperatures changes, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system replaces some or the entire data stream continually or intermittently including signal estimation methods that particularly address transient signal artifacts. The system is also capable of detecting the severity of the signal artifacts and selectively applying one or more signal estimation algorithm factors responsive to the severity of the signal artifacts, which includes selectively applying distinct sets of parameters to a signal estimation algorithm or selectively applying distinct signal estimation algorithms.

    OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES
    9.
    发明申请
    OXYGEN ENHANCING MEMBRANE SYSTEMS FOR IMPLANTABLE DEVICES 有权
    用于可植入设备的氧气增强膜系统

    公开(公告)号：US20150057514A1

    公开(公告)日：2015-02-26

    申请号：US14529034

    申请日：2014-10-30

    申请人： DexCom, Inc.

    发明人： James R. Petisce ,  Mark A. Tapsak ,  Peter C. Simpson ,  Victoria Carr-Brendel ,  James H. Brauker

    IPC分类号： A61B5/1486 ,  A61B5/1473

    CPC分类号： A61B5/1473 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1468 ,  A61B5/14735 ,  A61B5/14865

    摘要： The present invention relates generally to systems and methods for increasing oxygen availability to implantable devices. The preferred embodiments provide a membrane system configured to provide protection of the device from the biological environment and/or a catalyst for enabling an enzymatic reaction, wherein the membrane system includes a polymer formed from a high oxygen soluble material. The high oxygen soluble polymer material is disposed adjacent to an oxygen-utilizing source on the implantable device so as to dynamically retain high oxygen availability to the oxygen-utilizing source during oxygen deficits. Membrane systems of the preferred embodiments are useful for implantable devices with oxygen-utilizing sources and/or that function in low oxygen environments, such as enzyme-based electrochemical sensors and cell transplantation devices.

    摘要翻译： 本发明一般涉及用于增加可植入装置的氧气可用性的系统和方法。 优选的实施方案提供了一种膜系统，其被配置为提供该装置与生物环境的保护和/或用于实现酶反应的催化剂，其中所述膜系统包括由高氧可溶性材料形成的聚合物。 高氧可溶性聚合物材料与可植入装置上的氧气源相邻设置，以便在缺氧期间动态地保持氧利用源的高氧可利用性。 优选实施方案的膜系统对于具有氧利用源的可植入装置和/或在低氧环境中起作用，例如基于酶的电化学传感器和细胞移植装置是有用的。