公开(公告)号：US20080094620A1

公开(公告)日：2008-04-24

申请号：US11584020

申请日：2006-10-20

Applicant: Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

Inventor： Zhiyong Li ,  Wei Wu ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01J3/44 ,  G01N21/658

Abstract: Raman spectroscopy systems include an analyte, a radiation source configured to emit incident radiation having a wavelength, and a detector that is capable of detecting only radiation having wavelengths within a detectable range that includes at least one wavelength corresponding to hyper Raman scattered radiation scattered by the analyte. The wavelength of the incident radiation is outside the detectable range. In particular systems, all wavelengths of radiation that are scattered in the direction of the detector impinge on the detector. Raman spectroscopy methods include providing an analyte and irradiating the analyte with incident radiation having a wavelength, providing a detector capable of detecting only wavelengths of radiation within a detectable range that does not include the wavelength of the incident radiation, and detecting Raman scattered radiation scattered by the analyte. A continuous path free of radiation filters may be provided between the analyte and the detector.

公开(公告)号：US07359048B2

公开(公告)日：2008-04-15

申请号：US11413910

申请日：2006-04-28

Applicant: Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

Inventor： Shih-Yuan Wang ,  R. Stanley Williams ,  Raymond G. Beausoleil ,  Theodore I. Kamins ,  Zhiyong Li ,  Wei Wu

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658 ,  G01J3/44

Abstract: Raman systems include a radiation source, a radiation detector, and a Raman device or signal-enhancing structure. Raman devices include a tunable resonant cavity and a Raman signal-enhancing structure coupled to the cavity. The cavity includes a first reflective member, a second reflective member, and an electro-optic material disposed between the reflective members. The electro-optic material exhibits a refractive index that varies in response to an applied electrical field. Raman signal-enhancing structures include a substantially planar layer of Raman signal-enhancing material having a major surface, a support structure extending from the major surface, and a substantially planar member comprising a Raman signal-enhancing material disposed on an end of the support structure opposite the layer of Raman signal-enhancing material. The support structure separates at least a portion of the planar member from the layer of Raman signal-enhancing material by a selected distance of less than about fifty nanometers.

Abstract translation: 拉曼系统包括辐射源，辐射检测器和拉曼器件或信号增强结构。 拉曼器件包括耦合到空腔的可调谐谐振腔和拉曼信号增强结构。 空腔包括第一反射构件，第二反射构件和设置在反射构件之间的电光材料。 电光材料表现出响应于所施加的电场而变化的折射率。 拉曼信号增强结构包括具有主表面的基本平坦的拉曼信号增强材料层，从主表面延伸的支撑结构和包括设置在支撑结构的端部上的拉曼信号增强材料的基本上平面的构件 与拉曼信号增强材料层相对。 支撑结构将平面构件的至少一部分与拉曼信号增强材料层分开小于约五十纳米的选定距离。

公开(公告)号：US07342656B2

公开(公告)日：2008-03-11

申请号：US11252134

申请日：2005-10-17

Applicant: M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

Inventor： M. Saif Islam ,  Shih-Yuan Wang ,  R. Stanley Williams ,  Philip J. Kuekes ,  Wei Wu ,  Zhiyong Li

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A NERS-active structure includes a deformable, active nanoparticle support structure for supporting a first nanoparticle and a second nanoparticle that is disposed proximate the first nanoparticle. The nanoparticles each comprise a NERS-active material. The deformable, active nanoparticle support structure is configured to vary the distance between the first nanoparticle and the second nanoparticle while performing NERS. Various active nanoparticle support structures are disclosed. A NERS system includes such a NERS-active structure, a radiation source for generating radiation scatterable by an analyte located proximate the NERS-active structure, and a radiation detector for detecting Raman scattered radiation scattered by the analyte. A method for performing NERS includes providing such a NERS-active structure, providing an analyte at a location proximate the NERS-active structure, irradiating the NERS-active structure and the analyte with radiation, varying the distance between the nanoparticles, and detecting Raman scattered radiation scattered by the analyte.

Abstract translation: NERS活性结构包括用于支撑第一纳米颗粒的可变形的活性纳米颗粒支撑结构和邻近第一纳米颗粒设置的第二纳米颗粒。 纳米颗粒各自包含NERS-活性材料。 可变形的活性纳米颗粒支撑结构被配置为在执行NERS的同时改变第一纳米颗粒和第二纳米颗粒之间的距离。 公开了各种活性纳米颗粒载体结构。 NERS系统包括这样的NERS-活性结构，用于产生由位于NERS-活性结构附近的分析物可散射的辐射的辐射源，以及用于检测被分析物散射的拉曼散射辐射的辐射检测器。 执行NERS的方法包括提供这样的NERS活性结构，在靠近NERS-活性结构的位置提供分析物，用辐射照射NERS-活性结构和分析物，改变纳米颗粒之间的距离并检测拉曼散射 被分析物散射的辐射。

公开(公告)号：US07339666B2

公开(公告)日：2008-03-04

申请号：US10942079

申请日：2004-09-14

Applicant: Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

Inventor： Shih-Yuan Wang ,  Zhiyong Li ,  M. Saif Islam

IPC: G01J3/44

CPC classification number: G01N21/658

Abstract: Structures for amplifying light include a resonant cavity in which an analyte may be positioned. The structures for amplifying light may be used to amplify the incident light employed in surface enhanced Raman spectroscopy (SERS). SERS systems employing the structures for amplifying light of the present invention and methods of performing SERS are also disclosed.

Abstract translation: 用于放大光的结构包括其中可以定位分析物的谐振腔。 用于放大光的结构可以用于放大表面增强拉曼光谱（SERS）中使用的入射光。 还公开了采用本发明的光放大结构的SERS系统和执行SERS的方法。

公开(公告)号：US07294526B2

公开(公告)日：2007-11-13

申请号：US10917751

申请日：2004-08-12

Applicant: Zhiyong Li ,  Yong Chen ,  Sean Xiao-An Zhang

Inventor： Zhiyong Li ,  Yong Chen ,  Sean Xiao-An Zhang

IPC: H01L51/40 ,  H01L21/00

CPC classification number: H01L51/42 ,  H01L51/005 ,  H01L51/0071 ,  H01L51/0077 ,  H01L51/428 ,  Y02E10/549 ,  Y10S977/954

Abstract: An optical sensor is provided, comprising (a) a silicon nanowire of finite length having an electrical contact pad at each end thereof; and (b) a plurality of self-assembled molecules on a surface of the silicon nanowire, the molecules serving to modulate electrical conductivity of the silicon nanowire by either a reversible change in dipole moment of the molecules or by a reversible molecule-assisted electron/energy transfer from the molecules onto the silicon nanowire. Further, a method of making the optical sensor is provided. The concept of molecular self-assembly is applied in attaching functional molecules onto silicon nanowire surfaces, and the requirement of molecule modification (hydroxy group in molecules) is minimal from the point view of synthetic difficulty and compatibility. Self-assembly will produce well-ordered ultra-thin films with strong chemical bonding on a surface that cannot be easily achieved by other conventional methods.

Abstract translation: 提供了一种光学传感器，其包括（a）有限长度的硅纳米线，其每端具有电接触焊盘; 和（b）在硅纳米线的表面上的多个自组装分子，所述分子用于通过分子的偶极矩的可逆变化或通过可逆分子辅助电子/分子调制硅纳米线的导电性， 能量从分子转移到硅纳米线上。 此外，提供了制造光学传感器的方法。 分子自组装的概念应用于将功能分子附着在硅纳米线表面上，从合成难度和相容性的观点来看，分子修饰（分子中的羟基）的要求是最小的。 自组装将产生在表面上具有强化学键合的良好有序的超薄膜，其不能通过其它常规方法实现。

公开(公告)号：US20070259189A1

公开(公告)日：2007-11-08

申请号：US11827480

申请日：2007-07-11

Applicant: Gun Jung ,  Zhiyong Li ,  Richard Williams ,  Sivapackia Ganapathlappan

Inventor： Gun Jung ,  Zhiyong Li ,  Richard Williams ,  Sivapackia Ganapathlappan

IPC: B32B17/06

CPC classification number: G03F7/0002 ,  B05D1/185 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  Y10T428/31612 ,  Y10T428/31692 ,  Y10T428/31855 ,  Y10T428/31935 ,  Y10T428/31938

Abstract: A method for increasing adhesion between a substrate and a polymeric imprintable material during an imprinting procedure. The method includes chemically bonding a plurality of molecules to a surface of a substrate to form a self-assembled monolayer thereon. A monomer is copolymerized with the self-assembled monolayer to form a polymeric imprintable material that is chemically bonded to the self-assembled monolayer. Adhesion between the polymeric imprintable material and the substrate is substantially increased by the self-assembled monolayer.

公开(公告)号：US20070254377A1

公开(公告)日：2007-11-01

申请号：US11413516

申请日：2006-04-28

Applicant: Zhiyong Li ,  William Tong ,  R. Williams

Inventor： Zhiyong Li ,  William Tong ,  R. Williams

IPC: G01N21/62

CPC classification number: G01N21/658 ,  Y10T428/218 ,  Y10T428/28

Abstract: Packaged NERS-active structures are disclosed that include a NERS substrate having a NERS-active structure thereon, and a packaging substrate over the NERS substrate having an opening therethrough, the opening in alignment with the NERS-active structure. A membrane may cover the opening in the packaging substrate. In order to perform nanoenhanced Raman spectroscopy, the membrane may be removed, and an analyte placed on the NERS substrate adjacent the NERS-active structure. The membrane may be replaced with another membrane after the analyte has been placed on the substrate. The membrane may maintain the pristine state of the substrate before it is deployed, and the replacement membrane may preserve the substrate and analyte for archival purposes. Also disclosed are methods for performing NERS with packaged NERS-active structures.

Abstract translation: 公开了封装的NERS-活性结构，其包括其上具有NERS-活性结构的NERS衬底和在NERS衬底上的具有穿过其中的开口的封装衬底，该开口与NERS-活性结构对准。 膜可以覆盖封装衬底中的开口。 为了进行纳米增强拉曼光谱，可以去除膜，并将分析物放置在邻近NERS-活性结构的NERS衬底上。 在将分析物放置在基底上之后，膜可以用另一膜替代。 膜可以在其被部署之前保持基材的原始状态，并且替换膜可以保留底物和分析物用于归档目的。 还公开了使用封装的NERS-活性结构来执行NERS的方法。

公开(公告)号：US20070178507A1

公开(公告)日：2007-08-02

申请号：US11655388

申请日：2007-01-19

Applicant: Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wong ,  Duncan Stewart

Inventor： Wei Wu ,  Zhiyong Li ,  Shih-Yuan Wong ,  Duncan Stewart

IPC: C12Q1/68 ,  G01N33/53 ,  C12M3/00

CPC classification number: G01N33/48721 ,  C12Q1/6825 ,  C12Q1/6869 ,  G01N27/414 ,  G01N33/54373 ,  C12Q2565/631 ,  C12Q2565/601

Abstract: A molecular analysis device comprises a molecule sensor and a nanopore that passes through, partially through, or substantially near the molecule sensor. The molecule sensor may comprise a single electron transistor including a first terminal, a second terminal, and a nanogap or at least one quantum dot positioned between the first terminal and the second terminal. The molecular sensor may also comprise a nanowire that operably couples a first and a second terminal. A nitrogenous material that may be disposed on at least part of the molecule sensor is configured for a chemical interaction with an identifiable configuration of a molecule. The molecule sensor develops an electronic effect responsive to a molecule or responsive to a chemical interaction.

Abstract translation: 分子分析装置包括分子传感器和穿过分子传感器部分通过或基本上接近分子传感器的纳米孔。 分子传感器可以包括单电子晶体管，其包括位于第一端子和第二端子之间的第一端子，第二端子和纳米隙隙或至少一个量子点。 分子传感器还可以包括可操作地连接第一和第二端子的纳米线。 可以设置在分子传感器的至少一部分上的含氮材料被配置为与分子的可识别构型的化学相互作用。 分子传感器产生响应于分子或响应于化学相互作用的电子效应。

公开(公告)号：US07245370B2

公开(公告)日：2007-07-17

申请号：US11030733

申请日：2005-01-06

Applicant: Alexandre Bratkovski ,  M. Salf Islam ,  Theodore I. Kamins ,  Zhiyong Li ,  Shih-Yuan Wang

Inventor： Alexandre Bratkovski ,  M. Salf Islam ,  Theodore I. Kamins ,  Zhiyong Li ,  Shih-Yuan Wang

IPC: G01J3/44 ,  G01N21/65

CPC classification number: G01N21/658

Abstract: A SERS-active structure is disclosed that includes a substrate and at least two nanowires disposed on the substrate. Each of the at least two nanowires has a first end and a second end, the first end being attached to the substrate and the second end having a SERS-active tip. A SERS system is also disclosed that includes a SERS-active structure. Also disclosed are methods for forming a SERS-active structure and methods for performing SERS with SERS-active structures.

Abstract translation: 公开了一种SERS-活性结构，其包括衬底和设置在衬底上的至少两个纳米线。 所述至少两个纳米线中的每一个具有第一端和第二端，所述第一端附接到所述基底，所述第二端具有SERS活性末端。 还公开了包括SERS活性结构的SERS系统。 还公开了形成SERS活性结构的方法和用SERS活性结构进行SERS的方法。

公开(公告)号：US20060275779A1

公开(公告)日：2006-12-07

申请号：US11144588

申请日：2005-06-03

Applicant: Zhiyong Li ,  Shih-Yuan Wang ,  Wei Wu ,  M. Islam

Inventor： Zhiyong Li ,  Shih-Yuan Wang ,  Wei Wu ,  M. Islam

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N33/48721 ,  B82Y5/00 ,  B82Y15/00

Abstract: Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a nanowire operably coupling a first terminal and a second terminal and a nitrogenous material disposed on the nanowire. The nitrogenous material is configured to interact with an identifiable configuration of a molecule such that the molecule sensor develops a conductance change responsive to the interaction. The molecule guide is configured for guiding at least a portion of the molecule near the molecule sensor to enable the interaction.

Abstract translation: 公开了用于检测生物聚合物的组成部分的装置和方法。 分子分析装置包括分子传感器和分子引导件。 分子传感器包括可操作地耦合第一端子和第二端子的纳米线和设置在纳米线上的含氮材料。 含氮材料被配置为与分子的可识别构型相互作用，使得分子传感器响应于相互作用产生电导变化。 分子引导件被配置用于引导分子传感器附近的分子的至少一部分以实现相互作用。