公开(公告)号：US08722858B2

公开(公告)日：2014-05-13

申请号：US12666418

申请日：2008-06-25

Applicant: Kenji Yoshida

Inventor： Kenji Yoshida

IPC: C12P21/08 ,  C07K16/00

CPC classification number: C07K16/2896 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72

Abstract: Disclosed are antibodies that bind to Prominin-1 and have ADCC activity and/or CDC activity, and pharmaceutical compositions containing those antibodies. Recombinant antibodies were produced by cloning a nucleotide sequence of the AC133 antibody variable region and it was discovered that the ADCC/CDC-inducing effect which does not exist in the original AC133 antibody is imparted to the recombinant antibodies. In the human chimeric antibody/human effector cell combination, the chimeric antibody whose constant region sequence had been converted to human IgG1/κ was found to induce strong ADCC. Humanized antibodies were prepared by grafting the AC133 antibody CDRs to a human antibody sequence, producing humanized antibodies having binding activities equivalent to the activity of the chimeric antibody. Also disclosed are unlabeled AC133 human chimeric antibodies and humanized antibodies having antitumor effects.

Abstract translation: 公开了结合Prominin-1并具有ADCC活性和/或CDC活性的抗体，以及含有这些抗体的药物组合物。 通过克隆AC133抗体可变区的核苷酸序列产生重组抗体，发现在原始AC133抗体中不存在的ADCC / CDC诱导作用被赋予重组抗体。 在人嵌合抗体/人效应细胞组合中，其恒定区序列已转化为人IgG1 / 被发现诱导强ADCC。 通过将AC133抗体CDR移植到人抗体序列来制备人源化抗体，产生具有与嵌合抗体活性相当的结合活性的人源化抗体。 还公开了未标记的AC133人嵌合抗体和具有抗肿瘤作用的人源化抗体。

公开(公告)号：US20140029062A1

公开(公告)日：2014-01-30

申请号：US14047759

申请日：2013-10-07

Applicant: Kenji Yoshida

Inventor： Kenji Yoshida

IPC: G06K7/14 ,  G06K19/06

CPC classification number: G06K7/1417 ,  G06K19/06037 ,  G06K2019/06234

Abstract: A dot pattern including a block defined as a rectangular area of a square or a rectangle of a medium face, such as printed matter. A straight line in a vertical direction and a horizontal direction configuring a frame of the block each are defined as a standard grid line. Virtual reference grid points are provided at predetermined intervals on the reference grid line. Reference grid point dots are placed on respective virtual reference grid points. Straight lines that connect the virtual reference grid points to each other and are parallel to the reference grid lines are defined as grid lines. A point of intersection of grid lines is defined as a virtual grid point. A dot pattern is generated by arranging one or a plurality of information dots, each of which has a distance and a direction around the virtual grid point.

Abstract translation: 点阵图形，其包括被定义为中等面的正方形或矩形的矩形区域的块，例如印刷物。 在构成块的框架的垂直方向和水平方向上的直线被定义为标准网格线。 以参考网格线上的预定间隔提供虚拟参考网格点。 参考网格点点放置在相应的虚拟参考网格点上。 将虚拟参考网格点彼此连接并平行于参考网格线的直线定义为网格线。 将网格线的交点定义为虚拟网格点。 通过布置一个或多个信息点来生成点图案，每个信息点具有围绕虚拟网格点的距离和方向。

公开(公告)号：US08584932B2

公开(公告)日：2013-11-19

申请号：US13393872

申请日：2010-09-03

Applicant: Kenji Yoshida

Inventor： Kenji Yoshida

IPC: G06K17/00

CPC classification number: G06F3/03545 ,  G06F3/0321 ,  G06K9/228 ,  G06K2009/226

Abstract: Continuous output of content data is aimed in output of content data using a dot pattern. In the information processing method of the invention, by storing a content data file that stores content data or a dot code signified by a dot pattern and also has a function as instruction information that indicates other content data to be continuously output after outputting the desired content data, the content data can be continuously output.

Abstract translation: 内容数据的连续输出旨在使用点图案输出内容数据。 在本发明的信息处理方法中，通过存储存储由点图案表示的内容数据或点代码的内容数据文件，并且还具有作为指示信息的功能，该指令信息在输出所需内容之后指示要连续输出的其他内容数据 数据，内容数据可以连续输出。

公开(公告)号：US08553284B2

公开(公告)日：2013-10-08

申请号：US13589767

申请日：2012-08-20

Applicant: Kenji Yoshida

Inventor： Kenji Yoshida

IPC: G06K15/00

CPC classification number: G06K7/1417 ,  G06K19/06037 ,  G06K2019/06234

Abstract: A dot pattern including a block defined as a rectangular area of a square or a rectangle of a medium face, such as printed matter. A straight line in a vertical direction and a horizontal direction configuring a frame of the block each are defined as a standard grid line. Virtual reference grid points are provided at predetermined intervals on the reference grid line. Reference grid point dots are placed on respective virtual reference grid points. Straight lines that connect the virtual reference grid points to each other and are parallel to the reference grid lines are defined as grid lines. A point of intersection of grid lines is defined as a virtual grid point. A dot pattern is generated by arranging one or a plurality of information dots, each of which has a distance and a direction around the virtual grid point.

Abstract translation: 点阵图形，其包括被定义为中等面的正方形或矩形的矩形区域的块，例如印刷物。 在构成块的框架的垂直方向和水平方向上的直线被定义为标准网格线。 以参考网格线上的预定间隔提供虚拟参考网格点。 参考网格点点放置在相应的虚拟参考网格点上。 将虚拟参考网格点彼此连接并平行于参考网格线的直线定义为网格线。 将网格线的交点定义为虚拟网格点。 通过布置一个或多个信息点来生成点图案，每个信息点具有围绕虚拟网格点的距离和方向。

公开(公告)号：US08547346B2

公开(公告)日：2013-10-01

申请号：US12440011

申请日：2007-09-04

Applicant: Kenji Yoshida

Inventor： Kenji Yoshida

IPC: G06F3/041

CPC classification number: G06F3/0425 ,  A63F13/02 ,  A63F13/2145 ,  A63F13/426 ,  A63F2300/1068 ,  G06F3/0321 ,  G06F3/0421 ,  G06F3/0428

Abstract: An information output device includes a touch panel chassis having a touch panel with a medium on which a coordinate value based on a predetermined rule and a dot pattern signifying a code value are printed. The medium is placed on the touch panel with a surface on which the dot pattern is printed facing the touch panel. The device includes a coordinate recognition unit for recognizing a position on the medium of the touch panel. The device also includes an imaging unit for imaging via an imaging portion disposed on a predetermined location in the touch panel chassis. The device further includes a control unit for computing the coordinate value, the code value, and an orientation signified by the dot pattern and for inputting coordinate information from the coordinate recognition unit of the touch panel. An output unit outputs multimedia information according to an instruction from the control unit.

Abstract translation: 信息输出装置包括具有触摸面板的触摸面板底盘，该触摸面板具有基于预定规则的坐标值和表示代码值的点图案的介质。 将介质放置在触摸面板上，其上印刷有点图案的表面面向触摸面板。 该装置包括用于识别触摸面板的介质上的位置的坐标识别单元。 该装置还包括用于经由设置在触摸面板底盘中的预定位置的成像部分进行成像的成像单元。 该装置还包括控制单元，用于计算坐标值，代码值和由点图案表示的取向，以及用于从触摸面板的坐标识别单元输入坐标信息。 输出单元根据来自控制单元的指令输出多媒体信息。

公开(公告)号：US08523081B2

公开(公告)日：2013-09-03

申请号：US12672579

申请日：2008-08-08

Applicant: Kenji Yoshida

Inventor： Kenji Yoshida

IPC: G06K7/10

CPC classification number: G06F3/0317 ,  G02B5/208 ,  G06F3/0321 ,  G06F3/03545 ,  G06F3/0412

Abstract: The technical objective is to provide a simple and low-cost information input help sheet and an information processing system which exhibit a significantly high input accuracy and input efficiency without limiting a mounting object. The information input help sheet comprises an infrared reflection layer which reflects infrared rays from one side and transmits visible light, and a dot pattern layer provided on one side of the infrared reflection layer and on which dots generated by a dot-code generating algorithm and formed with material having an infrared absorbing characteristic are arranged according to a predetermined rule, in order to perform a variety of multimedia information output and/or operation instructions.

公开(公告)号：US08429508B2

公开(公告)日：2013-04-23

申请号：US13174596

申请日：2011-06-30

Applicant: Yosuke Kondo ,  Kenji Yoshida

Inventor： Yosuke Kondo ,  Kenji Yoshida

IPC: H03M13/00

CPC classification number: H03M13/19 ,  H03M13/616 ,  H03M13/618 ,  H03M13/6575

Abstract: According to one embodiment, an encoder/decoder apparatus includes an encoder module, a decoder module, and a transposing module. The encoder module is configured to generate a Hamming code from the input data, in accordance with a check matrix having a specific regularity. The decoder module is configured to detect an error position in the output data composed of the Hamming code, in accordance with the check matrix. The transposing module is configured to perform a transposing process of transposing some of the columns of the check matrix, while maintaining the regularity of the check matrix, and to change the error position in accordance with the transposing process, during the decoding process.

Abstract translation: 根据一个实施例，编码器/解码器装置包括编码器模块，解码器模块和转置模块。 编码器模块被配置为根据具有特定规则性的校验矩阵从输入数据生成汉明码。 解码器模块被配置为根据校验矩阵来检测由汉明码组成的输出数据中的错误位置。 移调模块被配置为执行转置处理，以便在维持校验矩阵的规律性的同时，在校验矩阵的一些列转置，并且在解码过程期间根据转置处理改变错误位置。

公开(公告)号：US20130093733A1

公开(公告)日：2013-04-18

申请号：US13640979

申请日：2011-04-13

Applicant: Kenji Yoshida

Inventor： Kenji Yoshida

IPC: G06F3/0354 ,  G09G3/30

CPC classification number: G06F3/03545 ,  G06F3/0321 ,  G06F3/0428 ,  G09G3/30

Abstract: A handwriting input board whereby handwritten characters can be erased, and erased characters can be stored. The handwriting input board includes: a display panel provided with a writing area in which dot patterns, in which coordinates and/or code values are repeatedly defined, are arranged; and a scanner pen which can be used to draw on or touch the display panel to draw a trail. The scanner pen includes: an optical reading unit that optically reads the dot pattern provided on the display panel; and a dot code analysis unit. When the scanner pen is used to draw on or touch the display panel, the scanner pen sequentially images the dot pattern, the dot code analysis unit analyzes the dot pattern and outputs coordinates and/or code values, and a trail is displayed visibly on the display panel. The handwriting input board also includes an erasure unit for erasing the displayed trail.

Abstract translation: 可以存储可以擦除手写字符并且擦除字符的手写输入板。 手写输入板包括：设置有写入区域的显示面板，其中布置了重复定义坐标和/或代码值的点图案; 以及可用于绘制或触摸显示面板以绘制轨迹的扫描笔。 扫描笔包括：光学读取单元，其光学地读取设置在显示面板上的点图案; 和点代码分析单元。 当扫描笔用于绘制或触摸显示面板时，扫描笔顺序成像点图案，点码分析单元分析点图案并输出坐标和/或代码值，并且轨迹可视地显示在 显示面板。 手写输入板还包括用于擦除所显示的轨迹的擦除单元。

公开(公告)号：US08343761B2

公开(公告)日：2013-01-01

申请号：US13187677

申请日：2011-07-21

Applicant: Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

Inventor： Masayuki Tsuchiya ,  Masami Suzuki ,  Kenji Yoshida ,  Etsuko Fujii ,  Miho Watanabe ,  Koichi Matsubara ,  Yu Jau Chen ,  Juliana Sim

IPC: C12N5/06 ,  A01K67/00 ,  C12N5/00

CPC classification number: A01K67/027 ,  A01K2267/01 ,  A61K35/16 ,  C07K16/00 ,  C07K16/30

Abstract: An objective of the present invention is to facilitate the acquisition of antibody-producing cells that are infiltrating virus-infected cells, cancer cells, abnormal cells forming a benign hyperplasia, and the like, and to improve the efficiency of the production of antibodies as well as nucleic acids encoding them from the antibody-producing cells.The present inventors discovered that, when cancer tissues comprising infiltrating lymphocytes are transplanted into highly immunodeficient animals that do not have T cells, B cells, and NK cells and further exhibit a low IFN production ability, the differentiation and proliferation of infiltrating lymphocytes are unexpectedly promoted, and the number of plasma cells that produce antibodies recognizing cancer tissues increases dramatically, plasma cells can be separated easily, and antibodies or nucleic acids encoding them can be easily prepared from the plasma cells.

Abstract translation: 本发明的目的是便于获得渗透病毒感染细胞的抗体产生细胞，癌细胞，形成良性增生的异常细胞等，以及提高抗体生产的效率 作为从抗体产生细胞编码它们的核酸。 本发明人发现，当将包含浸润性淋巴细胞的癌组织移植到不具有T细胞，B细胞和NK细胞的高度免疫缺陷的动物中并且进一步表现出低的IFN产生能力时，意外地促进了浸润性淋巴细胞的分化和增殖 并且产生识别癌组织的抗体的浆细胞的数量急剧增加，可以容易地分离浆细胞，并且可以容易地从浆细胞制备抗体或编码它们的核酸。

公开(公告)号：US20120328624A1

公开(公告)日：2012-12-27

申请号：US13575861

申请日：2011-01-28

Applicant: Kenji Yoshida ,  Hiroyuki Aburatani ,  Shumpei Ishikawa

Inventor： Kenji Yoshida ,  Hiroyuki Aburatani ,  Shumpei Ishikawa

IPC: A61K39/395 ,  C07K16/18 ,  A61P35/00 ,  G01N33/574

CPC classification number: C07K16/3023 ,  A61K2039/505 ,  C07K16/28 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2319/30 ,  C12Q1/6886 ,  C12Q2600/118 ,  G01N33/574 ,  G01N2333/4703

Abstract: It is intended to disclose an antibody which binds to DLL3 protein. Preferably, the antibody of the present invention recognizes a region from amino acids 216 to 492 in human DLL3 having the amino acid sequence as set forth in SEQ ID NO: 1. The present invention also provides a pharmaceutical composition, for example, an anticancer agent, comprising the antibody of the present invention as an active ingredient. The present invention further discloses a method for diagnosing cancer using the antibody of the present invention and a diagnostic drug for cancer comprising the antibody of the present invention.

Abstract translation: 旨在公开结合DLL3蛋白的抗体。 优选地，本发明的抗体识别具有SEQ ID NO：1所示的氨基酸序列的人DLL3中的氨基酸216至492的区域。本发明还提供药物组合物，例如抗癌剂 ，其包含本发明的抗体作为活性成分。 本发明还公开了使用本发明的抗体和包含本发明的抗体的癌症诊断药物诊断癌症的方法。