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    Diagnosis and treatment of cancer using anti-EREG antibody
    3.
    发明授权
    Diagnosis and treatment of cancer using anti-EREG antibody 有权
    使用抗EREG抗体诊断和治疗癌症

    公开(公告)号：US09017684B2

    公开(公告)日：2015-04-28

    申请号：US12444916

    申请日：2007-10-12

    申请人： Hiroyuki Aburatani ,  Hirotaka Ito ,  Kenji Yoshida

    发明人： Hiroyuki Aburatani ,  Hirotaka Ito ,  Kenji Yoshida

    IPC分类号： C07K16/22 ,  A61K39/395 ,  A61K51/10 ,  G01N33/574 ,  C07K16/30

    CPC分类号： G01N33/57407 ,  A61K51/1045 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/485

    摘要： Methods that entail detection of an epiregulin (EREG) protein for cancer diagnosis are disclosed. In colon cancer, lung adenocarcinoma, pancreatic cancer, stomach cancer, and kidney cancer, the gene and protein expressions of EREG were frequently found to be elevated. Antibodies that recognize an EREG protein are used for diagnosing or treating cancer in the present invention. Pharmaceutical compositions, cell proliferation inhibitors, and anticancer agents containing an EREG-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in EREG-expressing cells and methods of suppressing the proliferation of EREG-expressing cells by contacting the EREG-expressing cells with EREG-binding antibodies are also disclosed.

    摘要翻译： 公开了检测外周调蛋白（EREG）蛋白用于癌症诊断的方法。 在结肠癌，肺腺癌，胰腺癌，胃癌和肾癌中，经常发现EREG的基因和蛋白质表达升高。 识别EREG蛋白的抗体用于诊断或治疗本发明的癌症。 还公开了含有EREG结合抗体作为活性成分的药物组合物，细胞增殖抑制剂和抗癌剂。 还公开了在表达EREG的细胞中诱导细胞损伤的方法以及通过使EREG表达细胞与EREG结合抗体接触来抑制表达EREG的细胞增殖的方法。

    Diagnosis and Treatment of Cancer Using Anti-EREG Antibody
    4.
    发明申请
    Diagnosis and Treatment of Cancer Using Anti-EREG Antibody 有权
    使用抗EREG抗体诊断和治疗癌症

    公开(公告)号：US20090324491A1

    公开(公告)日：2009-12-31

    申请号：US12444916

    申请日：2007-10-12

    申请人： Hiroyuki Aburatani ,  Hirotaka Ito ,  Kenji Yoshida

    发明人： Hiroyuki Aburatani ,  Hirotaka Ito ,  Kenji Yoshida

    IPC分类号： C07K16/22 ,  A61K39/395 ,  C07K16/46 ,  G01N33/53 ,  A61K51/10 ,  C12Q1/68 ,  A61P35/04

    CPC分类号： G01N33/57407 ,  A61K51/1045 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  G01N2333/485

    摘要： Methods that entail detection of an epiregulin (EREG) protein for cancer diagnosis are disclosed. In colon cancer, lung adenocarcinoma, pancreatic cancer, stomach cancer, and kidney cancer, the gene and protein expressions of EREG were frequently found to be elevated. Antibodies that recognize an EREG protein are used for diagnosing or treating cancer in the present invention. Pharmaceutical compositions, cell proliferation inhibitors, and anticancer agents containing an EREG-binding antibody as an active ingredient are also disclosed. Methods of inducing cell damage in EREG-expressing cells and methods of suppressing the proliferation of EREG-expressing cells by contacting the EREG-expressing cells with EREG-binding antibodies are also disclosed.

    摘要翻译： 公开了检测外周调蛋白（EREG）蛋白用于癌症诊断的方法。 在结肠癌，肺腺癌，胰腺癌，胃癌和肾癌中，经常发现EREG的基因和蛋白质表达升高。 识别EREG蛋白的抗体用于诊断或治疗本发明的癌症。 还公开了含有EREG结合抗体作为活性成分的药物组合物，细胞增殖抑制剂和抗癌剂。 还公开了在表达EREG的细胞中诱导细胞损伤的方法以及通过使EREG表达细胞与EREG结合抗体接触来抑制表达EREG的细胞增殖的方法。

    DOT PATTERN
    9.
    发明申请
    DOT PATTERN 审中-公开

    公开(公告)号：US20160335528A1

    公开(公告)日：2016-11-17

    申请号：US15218841

    申请日：2016-07-25

    申请人： Kenji Yoshida

    发明人： Kenji Yoshida

    IPC分类号： G06K19/06

    CPC分类号： G06K19/06037 ,  G06F3/03545 ,  G06K19/06

    摘要： To realize a dot pattern which can be read even by a frame buffer of which algorithm for search is simple and of which resolution is low without sacrificing an information dot for defining a direction of a block. There is provided a dot pattern, wherein a plurality of reference points is provided in an area of a block having a predetermined information dot arranged thereon; a plurality of virtual reference points to be defined is arranged from the reference points (for example, a central point of a grid area); an information dot is arranged, of which information is defined by a distance and a direction from the virtual reference point; and at least the information dot at the predetermined position is made into a direction dot showing the direction of the block by a direction from the virtual reference point.

    INPUT PROCESSING SYSTEM FOR INFORMATION PROCESSING DEVICE
    10.
    发明申请
    INPUT PROCESSING SYSTEM FOR INFORMATION PROCESSING DEVICE 审中-公开
    用于信息处理设备的输入处理系统

    公开(公告)号：US20160320861A1

    公开(公告)日：2016-11-03

    申请号：US15204668

    申请日：2016-07-07

    申请人： Kenji Yoshida

    发明人： Kenji Yoshida

    IPC分类号： G06F3/03 ,  H04N21/422 ,  G06F3/039 ,  G06F3/0488 ,  G06F3/02 ,  G06F3/0354

    CPC分类号： G06F3/0321 ,  G06F3/0219 ,  G06F3/03545 ,  G06F3/0395 ,  G06F3/04886 ,  H04N21/42222

    摘要： New input systems, that is, a paper icon, a paper controller, a paper keyboard, and a mouse pad capable of inputting letters, characters or the like to a computer and performing operations with easy manipulation and replacing hardware devices such as a keyboard, a mouse, and a tablet are provided. By providing an icon formed on a medium for reading a dot pattern formed on a surface of the medium using a scanner connected to an information processing device, for converting the dot pattern into each of or one of a code value and a coordinate value defined by the dot pattern, and for outputting a voice, an image, a moving image, a letter or character or a program corresponding to each of or one of the code value and the coordinate value stored in the information processing device or for outputting information on an access to a website corresponding to each of or one of the code value and the coordinate value stored in the information processing device, it is possible to realize information on the voice, image, moving image or letter or character prepared in advance, start of the program, access to the website or the like.

    摘要翻译： 新的输入系统，即纸图标，纸张控制器，纸键盘和鼠标垫，其能够向计算机输入字母，字符等，并且通过易于操作和更换诸如键盘的硬件设备来执行操作， 提供鼠标和平板电脑。 通过使用连接到信息处理装置的扫描仪提供在介质上形成的用于读取形成在介质表面上的点阵图形的图标，用于将点图案转换成代码值和由 点图案，并且用于输出与存储在信息处理装置中的代码值和坐标值中的每一个或对应的语音，图像，运动图像，字母或字符或程序，或用于输出关于 访问对应于存储在信息处理设备中的代码值和坐标值中的每个或其中之一的网站，可以实现关于预先准备的语音，图像，运动图像或字母或字符的信息， 程序，访问网站等。