公开(公告)号：US09206102B2

公开(公告)日：2015-12-08

申请号：US14400036

申请日：2013-05-10

Applicant: RHODIA OPERATIONS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： Astrid Tay ,  Floryan Decampo ,  Xiaoshuang Feng ,  Wenjuan Zhou ,  Jean Marc Clacens

IPC: C07C41/09 ,  C07C41/34

CPC classification number: C07C41/09 ,  C07C41/34 ,  C07C43/1782 ,  C07C43/11

Abstract: A process for the preparation of an ether compound is disclose, wherein the ether compound is prepared via a reaction from at least an alcohol (I) and an alcohol (II), optionally using a catalyst X, wherein alcohol (I) and alcohol (II) are forming a biphasic liquid system when mixed together; comprising at least the following steps: a) Producing an alcohol (I)/alcohol (II) emulsion by using as stabilizing species amphiphilic solid particles of nanometric dimension; optionally comprising a catalyst X; b) Proceeding to the reaction of the ether compound by setting temperature, and c) Isolating the ether compound.

Abstract translation: 公开了制备醚化合物的方法，其中醚化合物通过至少一种醇（I）和醇（II）的反应制备，任选地使用催化剂X，其中醇（I）和醇（ II）当混合在一起时形成双相液体体系; 包括至少以下步骤：a）通过使用纳米尺寸的稳定剂两亲固体颗粒来生产醇（I）/醇（II）乳液; 任选地包含催化剂X; b）通过设定温度进行醚化合物的反应，和c）分离醚化合物。

公开(公告)号：US20150340708A1

公开(公告)日：2015-11-26

申请号：US14409155

申请日：2013-06-20

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE DE POITIERS

Inventor： Nicolas ALONSO-VANTE ,  Jiwei MA ,  Aldo GAGO

IPC: H01M4/92 ,  H01M8/10 ,  H01M4/88

CPC classification number: H01M4/921 ,  H01M4/8882 ,  H01M4/923 ,  H01M4/926 ,  H01M4/928 ,  H01M8/1011 ,  H01M2004/8689 ,  Y02E60/523

Abstract: The invention relates to a process for preparing nanoparticles of a catalyst for cathodic reduction and which is tolerant to methanol, these nanoparticles comprising a metallic centre and a submonolayer of a chalcogen.

Abstract translation: 本发明涉及一种制备用于阴极还原的催化剂的纳米颗粒并且耐甲醇的方法，这些纳米颗粒包含金属中心和硫属元素的亚单层。

公开(公告)号：US20150303019A1

公开(公告)日：2015-10-22

申请号：US14437739

申请日：2013-10-22

Applicant: ECOLE POLYTECHNIQUE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (INRS)

Inventor： Julien FUCHS ,  Bruno ALBERTAZZI ,  Henri PEPIN ,  Emmanuel D'HUMIERES

IPC: H01J3/22

CPC classification number: H01J3/22 ,  G21K1/093

Abstract: The invention relates to a method for generating a focused charged-particle beam, comprising at least the steps of: a) generating a charged-particle beam (10); b) emitting a laser pulse (40); c) generating a focusing magnetic field structure in a target (50) by means of an interaction between the laser pulse and the target; and d) making the charged-particle beam penetrate the focusing magnetic field structure at least partially.

Abstract translation: 本发明涉及一种产生聚焦带电粒子束的方法，至少包括以下步骤：a）产生带电粒子束（10）; b）发射激光脉冲（40）; c）通过激光脉冲和目标之间的相互作用在目标（50）中产生聚焦磁场结构; 以及d）使带电粒子束至少部分地穿透聚焦磁场结构。

公开(公告)号：US09156800B2

公开(公告)日：2015-10-13

申请号：US14424255

申请日：2013-09-02

Applicant: UNIVERSITÉ D'AIX-MARSEILLE ,  UNIVERSITÉ DE NANTES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Olivier Siri ,  Zhongrui Chen ,  Denis Jacquemin

IPC: C07D257/02 ,  C07D257/10 ,  C07F15/00 ,  H01L51/00 ,  H01G9/20 ,  H01L51/44

CPC classification number: C07D257/10 ,  A61K41/0071 ,  C07F15/0093 ,  C09B47/00 ,  H01G9/2059 ,  H01L51/0077 ,  H01L51/0087 ,  H01L51/42 ,  H01L51/441 ,  H01L2251/301 ,  H01L2251/303 ,  Y02E10/542 ,  Y02E10/549

Abstract: The present invention relates to compound of formula (I), their method of preparation and use thereof in particular in the fields of optoelectronic, photonic, photovoltaics and biology.

Abstract translation: 本发明涉及式（I）化合物，其制备方法及其应用，特别是在光电子，光子，光伏和生物学领域。

公开(公告)号：US20150285833A1

公开(公告)日：2015-10-08

申请号：US14438601

申请日：2013-10-17

Applicant: UNIVERSITÉ D'AIX-MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Franck Ruffier ,  Fabien Expert

IPC: G01P3/38 ,  G01S11/12 ,  G01P3/68

CPC classification number: G01P3/38 ,  G01P3/68 ,  G01S11/12

Abstract: A motion sensor assembly is adapted to determine an angular velocity of a moving contrast in its field of view. The motion sensor assembly includes: a motion sensor with a first and a second analog photoreceptor each adapted for observing the moving contrast, the first and the second photoreceptors being separated by a predetermined interreceptor angle; and an angular velocity calculating unit connected to the first and second photoreceptors for calculating the angular velocity of the moving contrast based on a first and a second analog signal delivered by the first and the second photoreceptors, respectively. The first and the second analog signals delivered by the first and the second photoreceptors at are sampled a given sampling frequency to obtain a first and a second digital signal, respectively. An interpolator is configured to interpolate the first and the second digital signals upon their crossing a predetermined threshold between successive samples.

Abstract translation: 运动传感器组件适于在其视场中确定移动对比度的角速度。 运动传感器组件包括：具有第一和第二模拟感光体的运动传感器，每个适于观察运动对比度，第一和第二感光体被预定的接触器角度分隔; 以及角速度计算单元，连接到第一和第二感光体，用于基于由第一和第二感光体传送的第一和第二模拟信号来计算运动对比度的角速度。 由第一和第二感光体传送的第一和第二模拟信号在给定采样频率下被采样，以分别获得第一和第二数字信号。 内插器被配置为在第一数字信号和第二数字信号跨越连续样本之间的预定阈值时插值。

公开(公告)号：US20150246091A1

公开(公告)日：2015-09-03

申请号：US14713477

申请日：2015-05-15

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT PASTEUR ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITÈ PARIS-SUD

Inventor： Jerome ESTAQUIER ,  Mireille Laforge ,  Anna Senik

IPC: A61K38/05 ,  A61K45/06 ,  C07K5/062

CPC classification number: A61K38/05 ,  A61K31/404 ,  A61K31/4525 ,  A61K31/47 ,  A61K31/496 ,  A61K31/7072 ,  A61K38/005 ,  A61K45/06 ,  C07K5/06052 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/463 ,  Y02A50/465

Abstract: A compound is provided which has a structure I: A-B-C and a method for administering the compound is also provided for use in the prophylaxis and/or treatment of a viral infection, and in particular for preventing and/or inhibiting viral replication, in which A is a quinoline or quinoline-like group, B is a sole amino acid or a peptide or polypeptide having a given amino acid sequence, and C is an O-phenoxy group. According to one embodiment, the compound is a protease inhibitor such as a caspase inhibitor, and the inhibitor can be Q-VD-OPh (N-(2-(quinolyl)valylaspartyl-(2,6-difluorophenoxyl)methyl ketone), optionally in an O-methylated form. Antiviral compositions and kits are also provided.

Abstract translation: 提供了具有结构I：ABC的化合物，并且还提供了用于施用化合物的方法用于预防和/或治疗病毒感染，特别是用于预防和/或抑制病毒复制，其中A 是喹啉或喹啉类基团，B是唯一的氨基酸或具有给定氨基酸序列的肽或多肽，C是O-苯氧基。 根据一个实施方案，化合物是蛋白酶抑制剂，例如胱天蛋白酶抑制剂，并且抑制剂可以是Q-VD-OPh（N-（2-（喹啉基）缬氨酰天竺葵酰基 - （2,6-二氟苯氧基）甲基酮），任选地 还提供了抗病毒组合物和试剂盒。

公开(公告)号：US20150232489A1

公开(公告)日：2015-08-20

申请号：US14412878

申请日：2013-07-08

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER ,  UNIVERSITE MONTPELLIER 2, SCIENCES ET TECHNIQUES

Inventor： Michel Wong Chi Man ,  Xavier Cattoen ,  Nirmalya Moitra ,  Kristyna Burglova ,  Jana Hodacova

IPC: C07F7/18

CPC classification number: C07F7/1804

Abstract: The present invention concerns a funtionalisable polysilylated organosilane precursors with formula (I): in which: Z1 represents a moiety with formula (a) and Z2 represents a moiety with formula (b) Z1 and Z2 simultaneously represent a moiety chosen from the moieties R7R8Si(OH), R9Si(OH)2, Si(OH)3, R7R8SiO1/2, R9SiO or Si03/2; U represents a moiety chosen from the moieties with formulas (U1), (U2), (U3), (U4), (U5), (U6), (U7), (U8).

Abstract translation: 本发明涉及具有式（I）的无定形聚硅烷基化的有机硅烷前体：其中：Z1表示具有式（a）的部分，Z2表示具有式（b）的部分，Z1和Z2同时表示选自部分R7R8Si OH），R9Si（OH）2，Si（OH）3，R7R8SiO1 / 2，R9SiO或Si03 / 2; U表示选自具有式（U1），（U2），（U3），（U4），（U5），（U6），（U7），（U8）的部分的部分。

公开(公告)号：US20150168507A1

公开(公告)日：2015-06-18

申请号：US14414430

申请日：2013-07-12

Applicant: Université de Montpellier ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Férial Terki ,  Azzedine Bousseksou ,  Quang Hung Tran ,  Souleyman Kamara ,  CheolGi Kim ,  Kun Woo Kim ,  Philippe Gandit

IPC: G01R33/07 ,  G01R33/09

CPC classification number: G01R33/072 ,  B82Y25/00 ,  G01N27/745 ,  G01R33/091 ,  G01R33/096 ,  G01R33/1269

Abstract: A micromagnetometry system for detecting the presence of very small quantities of magnetic particles comprises a first magnetic hybrid AMR/PHR multi-ring sensor using a Wheastone bridge electrical configuration, a first current source, a first voltage measurement device, a set of at least one magnetic particles deposited on the first magnetic sensor and a processing unit for detecting from a set of different measured differential voltages a magnetic flux shift representative of the presence of a least one deposited magnetic particle.The micromagnetometry system comprises means for creating a magnetic excitation field HAC to make produce by each motionless magnetic particle a stray magnetic field oscillating along the time at a constant frequency ω ranging from 10 Hz to 3 KHz.

Abstract translation: 用于检测非常少量的磁性颗粒的存在的微量计量系统包括使用Wheastone电桥构造的第一磁性混合AMR / PHR多环传感器，第一电流源，第一电压测量装置，至少一个 沉积在第一磁传感器上的磁性颗粒和用于从一组不同测量的差分电压中检测表示存在至少一个沉积的磁性颗粒的磁通量位移的处理单元。 微量测量系统包括用于产生磁激励场HAC以通过每个静止磁体产生杂散磁场的装置，该杂散磁场沿着10Hz至3KHz的恒定频率ω的时间振荡。

公开(公告)号：US20150152079A1

公开(公告)日：2015-06-04

申请号：US14413527

申请日：2013-07-10

Applicant: RHODIA OPERATIONS ,  UNIVERSITE CLAUDE BERNARD LYON 1 ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  FONDS DE DEVELOPPEMENT DES FILIERES DES OLEAGINEUX ET PROTEAGINEUX FIDOP

Inventor： Gerard Mignani ,  Julien Debray ,  Eric Da Silva ,  Marc Lemaire ,  Yann Raoul

IPC: C07D317/36

CPC classification number: C07D317/36

Abstract: The invention relates to a method for producing a compound of fonnula (I), comprising the reaction, in the presence of a catalytic system comprising a single rare earth oxide or a mixture of rare earth oxides, of an alkyl carbonate or an alkylene carbonate with a polyol of fonnula (II), wherein p is a whole number between 2 and 10.

Abstract translation: 本发明涉及一种制备式（I）化合物的方法，其包括在包含单一稀土氧化物或稀土氧化物的混合物的碳酸亚烷基酯或碳酸亚烷基酯的催化体系存在下的反应， （II）的多元醇，其中p是2至10之间的整数。

公开(公告)号：US20150139901A1

公开(公告)日：2015-05-21

申请号：US14399305

申请日：2013-05-14

Applicant: Institut National de la Sante et de la Recherche Medicale (INSERM) ,  CHU Nantes ,  Universite de Nantes ,  Centre National de la Recherche Scientifique (C.N.R.S.) ,  Universite d'Angers

Inventor： Alain Faivre-Chauvet ,  Holisoa Rajaerison ,  Jean-Francois Gestin

IPC: C07F15/00 ,  A61K47/48

CPC classification number: C07F15/0073 ,  A61K47/549

Abstract: The present invention concerns radioactive rhodium complexes, their preparation methods, and their use for the radiolabelling of biomolecules, especially monoclonal antibodies.

Abstract translation: 本发明涉及放射性铑配合物，其制备方法及其在生物分子，特别是单克隆抗体的放射性标记中的应用。