公开(公告)号：US20190192034A1

公开(公告)日：2019-06-27

申请号：US16229224

申请日：2018-12-21

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  MEDTRONIC, INC. ,  ALLINA HEALTH SYSTEM

Inventor： Subham Ghosh ,  Antonia E. Curtin ,  Alan J. Bank ,  Ryan M. Gage ,  Kevin V. Burns ,  Jeffrey M. Gillberg ,  Juan Du

IPC: A61B5/0408 ,  A61B5/04 ,  A61N1/39

CPC classification number: A61B5/04087 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/04085 ,  A61B5/0452 ,  A61B5/046 ,  A61B5/0464 ,  A61B5/0472 ,  A61B5/6805 ,  A61B5/6823 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3904 ,  A61N1/3956

Abstract: The exemplary systems, methods, and interfaces may obtain and analyze electrode signals from a plurality of external electrodes. The electrode signals may include at least an anterior set of electrode signals and a posterior set of electrode signals. The anterior and posterior sets of electrode signals may be used to generate, or provide, various metrics of cardiac electrical heterogeneity and various graphical depictions that may be useful in assessing a patient's cardiac functionality.

公开(公告)号：US20190183370A1

公开(公告)日：2019-06-20

申请号：US16279709

申请日：2019-02-19

Applicant: Medtronic, Inc.

Inventor： Jeffrey Gillberg ,  Subham Ghosh

IPC: A61B5/0408 ,  A61B5/0452 ,  A61N1/368 ,  G16H20/40 ,  G16H50/70 ,  G16H50/30 ,  G16H40/63 ,  A61B5/044 ,  A61N1/37 ,  A61B5/00 ,  A61B5/0402

CPC classification number: A61B5/0408 ,  A61B5/0402 ,  A61B5/04085 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/0472 ,  A61B5/1107 ,  A61B5/6823 ,  A61B5/743 ,  A61N1/3627 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3702 ,  G06F19/00 ,  G06F19/3481 ,  G16H20/40 ,  G16H40/63 ,  G16H50/30 ,  G16H50/70

Abstract: Systems, methods, and interfaces are described herein for assisting a user in noninvasive evaluation of patients for cardiac therapy and noninvasive evaluation of cardiac therapy being delivered. The systems, methods, and interfaces may provide graphical representations of cardiac electrical activation times about one or more portions of human anatomy and one or more cardiac health metrics.

公开(公告)号：US20180263522A1

公开(公告)日：2018-09-20

申请号：US15915995

申请日：2018-03-08

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  D'Anne Kudlik ,  Ya-Jian Cheng

IPC: A61B5/0456 ,  A61B5/0408 ,  A61B5/00

Abstract: The exemplary systems and methods may be configured to generate a dispersion signal from a plurality of cardiac signals and determine a QRS onset time value and a QRS offset time value from the plurality of cardiac signals. The QRS onset and offset time values may be used to measure, or capture, activation times.

公开(公告)号：US20180250514A1

公开(公告)日：2018-09-06

申请号：US15909585

申请日：2018-03-01

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61N1/368 ,  A61N1/365 ,  A61N1/37

Abstract: A cardiac pacemaker is disclosed for pacing cardiac tissue to improve synchrony between the atria and ventricles and/or between the left and right ventricles. A pulse generator is configured to deliver a pacing pulse to a patient's ventricle at an atrioventricular (AV) delay following a preceding atrial event. A sensing circuitry configured to sense a signal from the patient's ventricle following delivery of a said pacing pulse. A processing circuitry coupled to the pulse generator and the sensing circuitry and configured to control the pulse generator, the processing circuitry further configured to: (1) acquire from the sensed signal a set of features; (2) determine whether the ventricular pacing pulse effectively captures the patient's ventricle using the set of features; (3) determine whether one or more tissue latency conditions are present. The one or more pacing pulse parameters are adjusted, in response to determining that tissue latency is present.

公开(公告)号：US10065043B2

公开(公告)日：2018-09-04

申请号：US15618311

申请日：2017-06-09

Applicant: Medtronic, Inc.

Inventor： Richard M. T. Lu ,  Subham Ghosh ,  Robert W. Stadler

IPC: A61N1/37 ,  A61B5/046 ,  A61N1/368 ,  A61N1/362

Abstract: The present disclosure pertains to cardiac pacing methods and systems, and, more particularly, to cardiac resynchronization therapy (CRT). In particular, the present disclosure pertains to determining whether a patient is experiencing atrial fibrillation (AF). If the patient is experiencing AF, the efficacy of CRT is determined. A signal is sensed in response to a ventricular pacing stimulus. Through signal processing, a number of features are parsed from the signal and a determination is made as to whether the ventricular pacing stimulus evoked a response from the ventricle.

公开(公告)号：US09999775B2

公开(公告)日：2018-06-19

申请号：US15223703

申请日：2016-07-29

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61N1/36 ,  A61N1/368 ,  A61N1/365 ,  A61N1/372 ,  A61N1/375 ,  A61N1/39

CPC classification number: A61N1/3688 ,  A61N1/36578 ,  A61N1/37205 ,  A61N1/37288 ,  A61N1/3756 ,  A61N1/3962

Abstract: An implantable medical device system operates in an atrial synchronized ventricular pacing mode and switches to an atrial-asynchronous pacing mode when pacing mode switching criteria are met. A control circuit of the system detects a cycle length change between two atrial cycle lengths determined from a cardiac signal that includes far-field atrial events. If the cycle length change is greater than a change, threshold the control circuit determines if the pacing mode switching criteria are satisfied subsequent to detecting the cycle length change.

公开(公告)号：US09931048B2

公开(公告)日：2018-04-03

申请号：US14227962

申请日：2014-03-27

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Jeffrey Gillberg

IPC: A61B5/04 ,  A61B5/044 ,  A61N1/37 ,  A61N1/362 ,  A61N1/372 ,  A61N1/08

CPC classification number: A61B5/044 ,  A61N1/362 ,  A61N1/371 ,  A61N1/37247 ,  A61N2001/083

Abstract: Systems, methods, and interfaces are described herein for identification of effective electrodes to be used in sensing and/or therapy. Two or more portions of a signal monitored using an electrode may be compared to determine whether the electrode is effective. The two or more portions may correspond to the same portion or window of a cardiac cycle. Further, signals from a first electrode and from a second electrode located proximate the first electrode may be compared to determine whether one or both of the electrodes are effective.

公开(公告)号：US20180020938A1

公开(公告)日：2018-01-25

申请号：US15720119

申请日：2017-09-29

Applicant: Medtronic, Inc.

Inventor： Juan Du ,  Subham Ghosh ,  Jeffrey M. Gillberg

IPC: A61B5/04 ,  A61B5/0408 ,  A61B5/00 ,  A61B5/0456

CPC classification number: A61B5/04012 ,  A61B5/04085 ,  A61B5/0456 ,  A61B5/6823 ,  A61B5/7221 ,  A61B5/7239 ,  A61B5/7435 ,  A61N1/36507

Abstract: A system and associated method for determining whether a signal is ambiguous, wherein the system includes a plurality of electrodes configured to be located proximate tissue of a patient. A display apparatus thereof includes a graphical user interface configured to present information to a user. A computing apparatus thereof is configured to determine maximums for beats of signals from the electrodes.

公开(公告)号：US09855430B2

公开(公告)日：2018-01-02

申请号：US14926359

申请日：2015-10-29

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh ,  Kushagr Gupta

IPC: A61N1/00 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37 ,  A61N1/372 ,  A61N1/39

CPC classification number: A61N1/36514 ,  A61N1/365 ,  A61N1/36507 ,  A61N1/368 ,  A61N1/3702 ,  A61N1/37288 ,  A61N1/3956

Abstract: A medical device system for controlling ventricular pacing therapy during cardiac resynchronization therapy that includes a sensing device to sense a cardiac signal and emit a trigger signal in response to the sensed cardiac signal, a therapy delivery device to deliver the ventricular pacing in response to the emitted trigger signal, and a processor configured to identify a fiducial point of the cardiac signal sensed in real-time, set a window comprising a start point positioned a first distance prior to the fiducial point and an endpoint positioned a second distance less than the first distance subsequent to the fiducial point, determine a signal characteristic of the cardiac signal within the window, determine whether a P-wave is detected in response to the signal characteristic, determine whether an atrio-ventricular interval timer has expired, and emit a trigger signal to deliver the ventricular pacing timed off of the local maximum in response to the P-wave being detected and not timed off of the local maximum in response to the timer being expired.

公开(公告)号：US09750941B2

公开(公告)日：2017-09-05

申请号：US15004487

申请日：2016-01-22

Applicant: Medtronic, Inc.

Inventor： Subham Ghosh

IPC: A61N1/00 ,  A61N1/368 ,  A61N1/365 ,  A61B5/0452

CPC classification number: A61N1/3684 ,  A61B5/04085 ,  A61B5/0452 ,  A61B5/0464 ,  A61N1/36514 ,  A61N1/3682

Abstract: A system and method for identifying whether local tissue latency is present. The system and method comprises an implanted lead having a first electrode for cardiac pacing and sensing. A sensing module for sensing heart activity with the first electrode to produce an electrogram (EGM) waveform. A processor is configured to receive the EGM waveform and extract two or more features from the EGM waveform representative of heart activity in response to monoventricular or biventricular pacing stimulus at the electrode and identify local tissue latency at a site of the first electrode based upon at least two of the extracted features indicating local tissue latency.