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    ORALLY DISPERSIBLE TABLET
    243.
    发明申请
    ORALLY DISPERSIBLE TABLET 审中-公开

    公开(公告)号：US20130060052A1

    公开(公告)日：2013-03-07

    申请号：US13557794

    申请日：2012-07-25

    Applicant: Yutaka Tanoue ,  Tetsuya Matsuura ,  Yutaka Yamagata ,  Naoki Nagahara

    Inventor： Yutaka Tanoue ,  Tetsuya Matsuura ,  Yutaka Yamagata ,  Naoki Nagahara

    IPC: C07D307/93

    CPC classification number: A61K9/0056 ,  A61K9/006 ,  A61K9/1623 ,  A61K9/2018 ,  A61K9/2027 ,  A61K9/2054 ,  A61K9/2059 ,  A61K47/38

    Abstract: The present invention provides a preparation with improved disintegration property, a preparation showing improved bioavailability of a medicament, production methods thereof and the like. A rapidly disintegrating preparation comprising granules comprising a medicament coated with a coating layer containing sugar or sugar alcohol; and a disintegrant. A production method of a rapidly disintegrating preparation including a step of producing granules comprising a medicament, a step of forming a coating layer containing sugar or sugar alcohol on the obtained granules and a step of mixing the coated granules with a disintegrant and molding the mixture.

    Abstract translation: 本发明提供了具有改善的崩解性的制剂，显示药物的生物利用度提高的制剂，其制备方法等。 一种快速崩解制剂，其包含颗粒，其包含涂覆有含有糖或糖醇的涂层的药物; 和崩解剂。 一种快速崩解制剂的制备方法，包括生产颗粒的步骤，其包括药物，在所得颗粒上形成含有糖或糖醇的包衣层的步骤，以及将包衣颗粒与崩解剂混合并模制该混合物的步骤。

    Nitrogenated 5-membered heterocyclic compound
    247.
    发明授权
    Nitrogenated 5-membered heterocyclic compound 失效
    氮化五元杂环化合物

    公开(公告)号：US08349886B2

    公开(公告)日：2013-01-08

    申请号：US12937820

    申请日：2009-04-15

    Applicant: Tsuneo Yasuma ,  Osamu Ujikawa

    Inventor： Tsuneo Yasuma ,  Osamu Ujikawa

    IPC: A61K31/426 ,  C07D401/04

    CPC classification number: C07D405/14 ,  C07D417/14 ,  C07D471/04

    Abstract: The purpose of the present invention is to provide a glucokinase activator which is useful as a pharmaceutical agent such as agents for the prophylaxis or treatment of diabetes, obesity and the like, and the like.The present invention is a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof.

    Abstract translation: 本发明的目的是提供可用作药剂的糖激酶活化剂，例如用于预防或治疗糖尿病，肥胖症等的药剂。 本发明是由式（I）表示的化合物：其中各符号如说明书中所定义，或其盐。

    1-heterocyclylsulfonyl, 3-aminomethyl, 5-(hetero-)aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors
    249.
    发明授权
    1-heterocyclylsulfonyl, 3-aminomethyl, 5-(hetero-)aryl substituted 1-H-pyrrole derivatives as acid secretion inhibitors 有权
    1-杂环基磺酰基，3-氨基甲基，5-（杂）芳基取代的1 H-吡咯衍生物作为酸分泌抑制剂

    公开(公告)号：US08338461B2

    公开(公告)日：2012-12-25

    申请号：US13037690

    申请日：2011-03-01

    Applicant: Masahiro Kajino ,  Atsushi Hasuoka ,  Haruyuki Nishida

    Inventor： Masahiro Kajino ,  Atsushi Hasuoka ,  Haruyuki Nishida

    IPC: C07D401/02 ,  A61K31/444

    CPC classification number: C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D409/14 ,  C07D417/12 ,  C07D487/04

    Abstract: The present invention provides a compound having a superior acid secretion inhibitory effect and showing an antiulcer activity and the like. The present invention provides a compound represented by the formula (I) wherein R1 is a nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle, the nitrogen-containing monocyclic heterocyclic group optionally condensed with a benzene ring or a heterocycle optionally has substituent(s), R2 is an optionally substituted C6-14 aryl group, an optionally substituted thienyl group or an optionally substituted pyridyl group, R3 and R4 are each a hydrogen atom, or one of R3 and R4 is a hydrogen atom and the other is an optionally substituted lower alkyl group, an acyl group, a halogen atom, a cyano group or a nitro group, and R5 is an alkyl group or a salt thereof.

    Abstract translation: 本发明提供具有优异的酸分泌抑制作用并显示出抗溃疡活性等的化合物。 本发明提供由式（I）表示的化合物，其中R 1是任选与苯环或杂环稠合的含氮单环杂环基，任选地与苯环或杂环稠合的含氮单环杂环基 具有取代基，R 2为任选取代的C 6-14芳基，任选取代的噻吩基或任选取代的吡啶基，R 3和R 4各自为氢原子，或者R 3和R 4中的一个为氢原子， 另一个是任选取代的低级烷基，酰基，卤素原子，氰基或硝基，R 5是烷基或其盐。

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