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    VARIANT AIM
    1.
    发明公开
    VARIANT AIM 审中-公开

    公开(公告)号：US20230212238A1

    公开(公告)日：2023-07-06

    申请号：US18050245

    申请日：2022-10-27

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki ,  Satoko Arai

    IPC分类号： C12P21/02 ,  C07K14/705

    CPC分类号： C12P21/02 ,  C07K14/70596

    摘要： The present invention relates to the provision of a recombinant AIM that maintains functions, does not multimerize, and is not inactivated by IgM (e.g., a protein containing an amino acid sequence wherein cysteine at amino acid number 168 of the amino acid sequence shown in SEQ ID NO: 1 is substituted with another amino acid, and the like).

    Preventive or therapeutic agent for kidney disease
    2.
    发明授权
    Preventive or therapeutic agent for kidney disease 有权

    公开(公告)号：US11253571B2

    公开(公告)日：2022-02-22

    申请号：US16509161

    申请日：2019-07-11

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki

    IPC分类号： A61K38/17 ,  A61K38/00 ,  C07K14/435 ,  A61K45/06 ,  G01N33/68 ,  A61K31/7088 ,  A01K67/027

    摘要： The present invention provides a prophylactic or therapeutic agent for a kidney disease, comprising Apoptosis Inhibitor of Macrophage (AIM) or a partial peptide thereof, or a nucleic acid comprising a base sequence encoding the same, or a screening method for a prophylactic or therapeutic agent for a kidney disease, comprising using an animal obtained by subjecting a non-human mammal deficient in AIM expression to unilateral ureteral obstruction or transient kidney ischemia/reperfusion and the like.

    Tire
    4.
    发明授权
    Tire 有权
    胎

    公开(公告)号：US08754159B2

    公开(公告)日：2014-06-17

    申请号：US13386322

    申请日：2010-07-21

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki

    IPC分类号： B60C1/00 ,  C08K3/36 ,  C08L7/00

    CPC分类号： B60C1/00 ,  B60C1/0016 ,  C08K3/36 ,  C08L7/00 ,  C08L15/00 ,  C08L2666/08

    摘要： In order to provide a tire which is excellent in processability and which is excellent as well in a low fuel consumption, abrasion resistance and fracture resistance, assumed is such a constitution that used for a tire member is a rubber composition which contains a modified natural rubber having a polar group in the rubber molecule and precipitated silica, wherein a cetyltrimethylammonium bromide-adsorbing specific surface area (CTAB) (m2/g) of the precipitated silica and the mode Aac in diameters (nm) of primary aggregates thereof determined by acoustic measurement of particle size distribution satisfy an equation: Aac≧−0.76×(CTAB)+274.

    摘要翻译： 为了提供加工性优异且低油耗，耐磨性和耐断裂性优异的轮胎，假定轮胎构件使用的是含有改性天然橡胶的橡胶组合物 在橡胶分子中具有极性基团和沉淀二氧化硅，其中通过声学测量确定沉淀二氧化硅的十六烷基三甲基溴化铵吸附比表面积（CTAB）（m2 / g）和初级聚集体的直径（nm）中的模式Aac 的粒度分布满足下式：Aac≥-0.76×（CTAB）+274。

    Receiver, program recording controller, program recording control method and program recording system
    6.
    发明申请
    Receiver, program recording controller, program recording control method and program recording system 有权
    接收器，程序记录控制器，程序记录控制方法和程序记录系统

    公开(公告)号：US20060280440A1

    公开(公告)日：2006-12-14

    申请号：US11442293

    申请日：2006-05-30

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki

    IPC分类号： H04N5/91

    CPC分类号： H04N5/913 ,  H04N7/1675 ,  H04N21/2541 ,  H04N21/4334 ,  H04N21/43622 ,  H04N21/4367 ,  H04N21/4408 ,  H04N21/4627 ,  H04N21/835 ,  H04N2005/91364

    摘要： An embodiment of the receiver of the invention includes an output unit to output program data to a recording appliance so as to record a copyright-protected service, a first copyright protective mechanism and a second copyright protective mechanism to protect copyright. The receiver further includes a system manager to detect whether or not a copyright protective mechanism of a recording appliance connected to the output unit is present and switch over between the first and second copyright protective mechanisms in accordance with the detection result to output the program data to the output unit.

    摘要翻译： 本发明的接收机的一个实施例包括输出单元，用于将程序数据输出到记录设备，以便记录受版权保护的服务，第一版权保护机制和第二版权保护机制以保护版权。 接收机还包括系统管理器，用于检测连接到输出单元的记录设备的版权保护机制是否存在，并根据检测结果在第一和第二版权保护机制之间切换以将程序数据输出到 输出单元。

    METHOD FOR PREVENTION OR TREATMENT OF METABOLIC SYNDROME
    10.
    发明申请
    METHOD FOR PREVENTION OR TREATMENT OF METABOLIC SYNDROME 审中-公开
    预防或治疗代谢综合征的方法

    公开(公告)号：US20130115220A1

    公开(公告)日：2013-05-09

    申请号：US13698881

    申请日：2011-05-20

    申请人： Toru Miyazaki

    发明人： Toru Miyazaki

    IPC分类号： A61K39/395

    CPC分类号： A61K39/3955 ,  A61K31/7088 ,  A61K31/713 ,  A61K38/17 ,  C07K16/2851 ,  C07K16/2896 ,  C07K2317/76

    摘要： The present invention aims to provide a method for the prophylaxis or treatment of metabolic syndrome, which can discontinue the domino effect-like chain of diseases in metabolic syndrome in the upstream by suppressing infiltration of macrophage into the adipose tissues. The present invention provides a method for the prophylaxis or treatment of a metabolic syndrome, including a step of administering an AIM inhibitor to a subject.

    摘要翻译： 本发明旨在提供一种预防或治疗代谢综合征的方法，其可以通过抑制巨噬细胞浸入脂肪组织中断上游代谢综合征中的多米诺效应样疾病链。 本发明提供了一种预防或治疗代谢综合征的方法，包括向受试者施用AIM抑制剂的步骤。