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251.发明申请公开(公告)号：US20220230306A1
公开(公告)日：2022-07-21
申请号：US17614179
申请日：2020-05-27
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Natan Tzvi SHAKED , Gili DARDIKMAN
Abstract: A reconstruction system is presented for reconstructing morphology of biological cells. The system includes data input and output utilities, memory, and a data processor, and is configured for data communication with an image data provider to receive raw image data comprising a sequence of image frames acquired from the cell during a movement of the cell and being indicative of optical path delay (OPD) of light propagation through the biological cell. The data processor is configured and operable to process the raw image data and determine 3D dynamic morphological data of the cell. The data processor includes: a modeling utility; a position recovery module; and an analyzer module.
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公开(公告)号：US20220226348A1
公开(公告)日：2022-07-21
申请号：US17610276
申请日：2020-05-13
Applicant: ICHILOV TECH LTD , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Eli SPRECHER , Ofer SARIG , Janan MOHAMAD , Alon PELED
Abstract: The present invention provides a method and a pharmaceutical composition for treatment of skin diseases associated with accelerated comeodesmosomes degradation and/or weaker cell-cell adhesion, such as a peeling skin syndrome, Netherton syndrome, and atopic dermatitis.
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公开(公告)号：US11374120B2
公开(公告)日：2022-06-28
申请号：US16870980
申请日：2020-05-10
Inventor： Zohar Shaked , Yakov Roizin , Menachem Vofsy , Alexey Heiman , Yossi Rosenwaks , Klimentiy Shimanovich , Yhonatan Vaknin
IPC: H01L29/775 , G01N27/414 , H01L29/10 , H01L27/12 , H01L29/66 , H01L29/423
Abstract: For example, an Electrostatically Formed Nanowire (EFN) may include a source region; at least one drain region; a wire region configured to drive a current between the source and drain regions via a conductive channel; a first lateral-gate area extending along a first surface of the wire region between the source and drain regions; a second lateral-gate area extending along a second surface of the wire region between the source and drain regions; and a sensing area in opening in a backside of a silicon substrate under the wire region and the first and second lateral-gate areas, the sensing area configured to, in reaction to a predefined substance, cause a change in a conductivity of the conductive channel.
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公开(公告)号：US20220160790A1
公开(公告)日：2022-05-26
申请号：US17584508
申请日：2022-01-26
Inventor： Oded RECHAVI , Shahar BRACHA , Lilach SHEINER
Abstract: Provided are nucleic acid constructs, Toxoplasma comprising same, pharmaceutical compositions comprising same and methods using same for delivering a protein-of-interest to a tissue-of-interest of a subject, such as the CNS and further treating a pathology which is treatable by administration of a therapeutic polypeptide in a central nervous system of the subject.
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公开(公告)号：US11338042B2
公开(公告)日：2022-05-24
申请号：US16701184
申请日：2019-12-03
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Ranit Kedmi , Dan Peer
Abstract: A pharmaceutical composition comprising an immunoparticle is provided. The pharmaceutical composition comprising a monoclonal secondary antibody immunocomplexed with a primary antibody, wherein said monoclonal secondary antibody is coupled on an outer surface of a particle and wherein said particle is loaded with a pharmaceutical agent.
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Patent Agency Ranking
公开(公告)号：US11261230B2
公开(公告)日：2022-03-01
申请号：US16914388
申请日：2020-06-28
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor： Genady Kostenich , Mor Oron-Herman , Arie Orenstein , Talia Shekhter Zahavi , Ehud Gazit , Yoseph Salitra , Ludmila Buzhansky
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号：US20220031720A1
公开(公告)日：2022-02-03
申请号：US17296504
申请日：2019-11-21
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor： Vered PADLER-KARAVANI , Eliran Moshe REUVEN , Shani LEVIATAN BEN-ARYE
IPC: A61K31/7012 , A61K9/127 , A61K39/39 , A61K39/00 , A61P35/00 , A61K39/395
Abstract: The present invention provides an active cancer vaccine and specifically an immunogenic compositions of membrane vesicles that serve as biomimetic nanoparticles derived from eukaryotic cell membranes that bear N-glycolylneuraminic acid glycoconjugates. These compositions can elicit beneficial immunological responses for treatment of Neu5Gc-positive tumors. The present invention provides methods of generating and using Neu5Gc-conjugated nanoparticles from eukaryotic cells membranes designated nano-ghosts.
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公开(公告)号：US11213609B2
公开(公告)日：2022-01-04
申请号：US16061675
申请日：2016-12-15
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor： Tal Dvir , Assaf Shapira , Michal Shevach , Idan Gal
Abstract: A spherical particle comprising decellularized omentum being between 1 nM-300 μM in diameter is disclosed. In some embodiments, the particle comprises biological cells. In other embodiments, the particle comprises a biomolecule. Uses of the particles are also disclosed.
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公开(公告)号：US20210357540A1
公开(公告)日：2021-11-18
申请号：US16874819
申请日：2020-05-15
Inventor： Lior Horesh , Oguzhan Murat Onen , Haim Avron , Tayfun Gokmen , Vasileios Kalantzis , Shashanka Ubaru
IPC: G06F30/10
Abstract: A computer-implemented method is presented for performing matrix sketching by employing an analog crossbar architecture. The method includes low rank updating a first matrix for a first period of time, copying the first matrix into a dynamic correction computing device, switching to a second matrix to low rank update the second matrix for a second period of time, as the second matrix is low rank updated, feeding the first matrix with first stochastic pulses to reset the first matrix back to a first matrix symmetry point, copying the second matrix into the dynamic correction computing device, switching back to the first matrix to low rank update the first matrix for a third period of time, and as the first matrix is low rank updated, feeding the second matrix with second stochastic pulses to reset the second matrix back to a second matrix symmetry point.
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公开(公告)号：US11170508B2
公开(公告)日：2021-11-09
申请号：US16959693
申请日：2019-01-03
Applicant: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastructure and Services Ltd.
Inventor： Yitzhak Avital , Nahum Kiryati , Eli Konen , Arnaldo Mayer
Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).
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