公开(公告)号：US11406670B2

公开(公告)日：2022-08-09

申请号：US16281490

申请日：2019-02-21

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michel Revel ,  Judith Chebath ,  Michal Izrael ,  Rosalia Kaufman

IPC: A61K35/30 ,  C12N5/0793 ,  C12N5/079 ,  G01N33/50

Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.

公开(公告)号：US20220211758A1

公开(公告)日：2022-07-07

申请号：US17574626

申请日：2022-01-13

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rachel Lea EISENBACH ,  Yosi GOZLAN ,  Esther TZEHOVAL

IPC: A61K35/17 ,  C07K14/725 ,  C12N15/10 ,  C12N15/63 ,  C12N15/85 ,  C12N5/0783 ,  C12N5/10 ,  C07K14/705

Abstract: The present invention relates to methods and systems for increasing the affinity of a T cell receptor (TCR) to its ligand by subjecting the TCR gene to somatic hypermutation. The present invention further relates to use of affinity maturated TCRs to create T cells reactive against a selected antigen.

公开(公告)号：US20220202919A1

公开(公告)日：2022-06-30

申请号：US17397298

申请日：2021-08-09

Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD. AT THE WEIZMANN INSTITUTE OF SCIENCE

Inventor： Edward H. Schuchman ,  Erich Gulbins ,  Anthony Futerman ,  Yael Pewzner-Jung

IPC: A61K38/50 ,  A61K9/12 ,  A61K9/00 ,  A61K45/06

Abstract: The present invention relates to a method for treating or preventing pathogenic infections in a subject having Cystic Fibrosis, COPD, and/or an open wound. This method involves selecting a subject having Cystic Fibrosis, COPD, and/or an open wound and administering to the selected subject a ceramidase under conditions effective to reduce ceramide and to treat or prevent the pathogenic infection. The method also involves the use of a ceramidase in combination with other drugs to reduce infection, reduce ceramide, or improve lung function in Cystic Fibrosis, COPD, and/or open wound patients.

公开(公告)号：US20220184148A1

公开(公告)日：2022-06-16

申请号：US17579638

申请日：2022-01-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran ELINAV ,  Eran SEGAL

IPC: A61K35/741 ,  A61B5/00 ,  C12Q1/02 ,  C12Q1/04 ,  G01N33/68 ,  C12Q1/6883

Abstract: A method of determining tolerance to an agent in a healthy subject is disclosed. The method comprises: (a) determining a signature of a microbiome in a sample of the healthy subject who has been subjected to the agent or condition; and (b) comparing the signature of the microbiome of the healthy subject to at least one reference signature of a pathological microbiome, wherein when the signature of the microbiome of the healthy subject is statistically significantly similar to the reference signature of the pathological microbiome, it is indicative that the healthy subject is intolerant to the agent.

公开(公告)号：US20220170939A1

公开(公告)日：2022-06-02

申请号：US17670467

申请日：2022-02-13

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Zvi LIVNEH ,  Tamar PAZ-ELIZUR

IPC: G01N33/574 ,  G01N33/68 ,  A61K31/7088

Abstract: A method of selecting a treatment for a subject having cancer is disclosed. The method comprises: (a) determining a level of catalytic activity of at least one DNA repair enzyme in a biological sample of the subject; and (b) selecting an immune checkpoint regulator as a treatment for a subject having a statistically significant different level of catalytic activity of said DNA repair enzyme as compared to the catalytic activity of said DNA repair enzyme in a biological sample of a healthy subject.

公开(公告)号：US20220106405A1

公开(公告)日：2022-04-07

申请号：US17429672

申请日：2020-02-10

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Irit SAGI ,  Vishnu MOHAN

IPC: C07K16/40 ,  C07K16/30 ,  A61P35/00 ,  A61K31/282 ,  A61K31/7068

Abstract: An antibody comprising an antigen recognition region which binds a catalytic site of MMP-7, having complementarity determining region (CDR) amino acid sequences as set forth in: SEQ ID NOs: 3 (CDR1), 4 (CDR2) and 5 (CDR3), sequentially arranged from N to C on a light chain of the antibody; and SEQ ID NOs: 6 (CDR1), 7 (CDR2) and 8 (CDR3), sequentially arranged from N to C on a heavy chain of the antibody.

公开(公告)号：US20220100150A1

公开(公告)日：2022-03-31

申请号：US17426304

申请日：2020-02-05

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Roee OZERI ,  Yehonatan DALLAL ,  Yotam SHAPIRA ,  Adiel STERN

IPC: G04F5/14 ,  G01R33/24

Abstract: An atomic vector magnetometer and magnetometric methods based on atomic clock transitions unaffected by magnetic field strength for increased quantum coherency time, resulting in improved sensitivity over conventional Zeeman-based atomic magnetometry, where coherency is restricted by sensitivity to magnetic fields. Instead of measuring magnetic field strength in the direction of the quantization axis, as in Zeeman magnetometry, magnetic field strength is measured substantially orthogonal to the quantization axis, via determining the angular displacement of the quantization axis by the magnetic signal field, which is detected by changes in atomic state populations as the quantization axis is rotated relative to the excitation polarization. In addition, the present invention measures magnetic fields instantaneously rather than via accumulated phase shift over time, as in Zeeman magnetometry, thereby providing measurement and spectral analysis of time-varying magnetic fields.

公开(公告)号：US20220073733A1

公开(公告)日：2022-03-10

申请号：US17416766

申请日：2019-12-26

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Reshef TENNE ,  Hila SHALOM ,  Noa LACHMAN SENESH

IPC: C08L67/04 ,  B29C64/118 ,  B29C71/02

Abstract: This invention is directed to nanocomposite comprising biodegradable polymers and inorganic nanoparticles or nanotubes, methods of preparation and uses thereof.

公开(公告)号：US11254947B2

公开(公告)日：2022-02-22

申请号：US15753024

申请日：2016-08-16

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Avihai Danon ,  Erez Eliyahu ,  Vivekanand Tiwari

IPC: C12N15/82 ,  C07K14/415 ,  C12N9/02

Abstract: The present invention provides compositions for attenuating the function of atypical CYS HIS rich thioredoxin 4 (ACHT4), a light-regulated protein expressed in plants and algae that controls starch storage in chloroplast, and methods for increasing plant and algae growth and yield.

公开(公告)号：US11236352B2

公开(公告)日：2022-02-01

申请号：US16208640

申请日：2018-12-04

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Mark Safro ,  Liron Klipcan ,  Inbar Maymon ,  Igal Finarov

IPC: C12N15/82 ,  C12N9/00

Abstract: Transgenic plants resistant to bio-herbicides, particularly to phytotoxic non-protein amino acids including the meta-tyrosine (m-tyrosine) amino acid analog and salts thereof, means and methods for producing the transgenic plants.