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公开(公告)号:US11679133B2
公开(公告)日:2023-06-20
申请号:US15780153
申请日:2016-11-28
Applicant: Kadimastem Ltd. , Yeda Research and Development Co. Ltd.
Inventor: Kfir Molakandov , Neta Lavon , Avital Beck , Michel Revel , Ofer Elhanani , Yoav Soen , Michael Walker , Arik Hasson
CPC classification number: A61K35/39 , A61P3/10 , A61P5/50 , C12N5/0676 , C12N2500/25 , C12N2500/34 , C12N2500/38 , C12N2501/599 , C12N2506/02 , C12N2506/45
Abstract: The present invention relates to compositions and methods comprising cell surface markers for pluripotent-derived cells, in particular, pancreatic endoderm-type cells, derived from pluripotent stem cells.
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公开(公告)号:US11406670B2
公开(公告)日:2022-08-09
申请号:US16281490
申请日:2019-02-21
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Michel Revel , Judith Chebath , Michal Izrael , Rosalia Kaufman
IPC: A61K35/30 , C12N5/0793 , C12N5/079 , G01N33/50
Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
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3.
公开(公告)号:US20190175658A1
公开(公告)日:2019-06-13
申请号:US16281490
申请日:2019-02-21
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Michel Revel , Judith Chebath , Michal Izrael , Rosalia Kaufman
IPC: A61K35/30 , C12N5/079 , C12N5/0793
Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
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公开(公告)号:US10258651B2
公开(公告)日:2019-04-16
申请号:US15468020
申请日:2017-03-23
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Michel Revel , Judith Chebath , Michal Izrael , Rosalia Kaufman
IPC: A61K48/00 , A61K35/30 , C12N5/0793 , C12N5/079 , G01N33/50
Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
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5.
公开(公告)号:US20170362570A1
公开(公告)日:2017-12-21
申请号:US15468020
申请日:2017-03-23
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Michel Revel , Judith Chebath , Michal Izrael , Rosalia Kaufman
IPC: C12N5/079 , G01N33/50 , A61K35/30 , C12N5/0793
CPC classification number: A61K35/30 , C12N5/0619 , C12N5/0622 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/385 , C12N2501/41 , C12N2506/02 , C12N2533/52 , C12N2533/90 , G01N33/5058
Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
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公开(公告)号:US09631175B2
公开(公告)日:2017-04-25
申请号:US14329510
申请日:2014-07-11
Applicant: Yeda Research and Development Co. Ltd.
Inventor: Michel Revel , Judith Chebath , Michal Izrael , Rosalia Kaufman
IPC: A01N63/00 , C12N5/079 , C12N5/0793 , A61K35/30 , G01N33/50
CPC classification number: C12N5/0622 , A61K35/30 , C12N5/0619 , C12N2501/11 , C12N2501/115 , C12N2501/155 , C12N2501/385 , C12N2501/41 , C12N2506/02 , C12N2533/52 , C12N2533/90 , G01N33/5058
Abstract: A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating Bone Morphogenic Protein activity.
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