公开(公告)号：US06600030B2

公开(公告)日：2003-07-29

申请号：US09131827

申请日：1998-08-10

Applicant: Michael Dean ,  Stephen J. O'Brien ,  Michael Smith ,  Mary Carrington

Inventor： Michael Dean ,  Stephen J. O'Brien ,  Michael Smith ,  Mary Carrington

IPC: A61K3817

CPC classification number: C12Q1/703 ,  A01K2217/05 ,  A61K38/00 ,  A61K48/00 ,  C07K14/7158 ,  C12Q1/6883 ,  C12Q2600/156

Abstract: The present invention relates to a CCR2 deletion mutant, designated “CCR2-64I.” CCR2 is a C—C chemokine receptor and has been implicated as a co-receptor for HIV-1. It has been discovered that the presence of the CCR2-64I allele correlates with a postponement of AIDS outcomes, and that infected individuals who have the CCR2-64I allele are at a reduced risk for progression from HIV-1 infection to the development of clinical AIDS and death. Isolated nucleic acid molecule encoding CCR2-64I and the establishment of cell lines that express CCR2-64I provides valuable tools for continuing research on HIV infection. Diagnostic methods for analysis of the allelic frequency of CCR2 wild-type and 64I genes are provided. In addition, antibodies which bind to CCR2-64I, CCR2-64I variants, and CCR2 binding agents represent potential anti-HIV agents.

Abstract translation: 本发明涉及CCR2缺失突变体，命名为“CCR2-64I”。 CCR2是C-C趋化因子受体，并且被认为是HIV-1的共受体。 已经发现，CCR2-64I等位基因的存在与艾滋病结局的推迟相关，并且具有CCR2-64I等位基因的感染个体具有从HIV-1感染进展到临床艾滋病发展的风险降低 和死亡。 编码CCR2-64I的分离的核酸分子和表达CCR2-64I的细胞系的建立为继续研究HIV感染提供了宝贵的工具。 提供了分析CCR2野生型和64I基因等位基因频率的诊断方法。 此外，结合CCR2-64I，CCR2-64I变体和CCR2结合剂的抗体代表潜在的抗HIV剂。

公开(公告)号：US06503516B1

公开(公告)日：2003-01-07

申请号：US09434130

申请日：1999-11-05

Applicant: Terry Van Liew ,  Olga Alonzo ,  Michael Smith

Inventor： Terry Van Liew ,  Olga Alonzo ,  Michael Smith

IPC: A61K700

CPC classification number: A61K8/894 ,  A61K8/02 ,  A61K8/31 ,  A61K8/39 ,  A61K8/8111 ,  A61K8/86 ,  A61K8/922 ,  A61K8/927 ,  A61Q1/02 ,  A61Q1/06 ,  A61Q1/10 ,  Y10S424/05

Abstract: A composition which can be molded in the form of a stick or hot-poured, comprising at least one wax having a melting point of greater than 95° C. and a penetration of from 1 to 7.5 mm, and at least one organically modified beeswax having a penetration of greater than 7.5 mm, wherein the waxes are present in a combined amount sufficient to provide stability and a creamy texture to a molded stick or to a product resulting from hot-pouring, and a process for caring for and/or making-up the eyes, lips, or skin using this composition.

Abstract translation: 可以以棒状或热浇注的形式模制的组合物，其包含熔点大于95℃和渗透度为1至7.5mm的至少一种蜡，以及至少一种有机改性的蜂蜡，其具有 渗透度大于7.5mm，其中蜡以足以为模塑棒或由热浇注产生的产品提供稳定性和乳状质地的组合量存在，以及用于照料和/或化妆的方法 使用这种组合物的眼睛，嘴唇或皮肤。

公开(公告)号：US06405134B1

公开(公告)日：2002-06-11

申请号：US09650732

申请日：2000-08-30

Applicant: Michael Smith ,  Bill Vincent

Inventor： Michael Smith ,  Bill Vincent

IPC: G01V16900

CPC classification number: G01S13/86 ,  G01S13/951 ,  Y02A90/18

Abstract: The invention provides a system and method for predicting areas where lightning strikes are likely to occur by evaluating radar and temperature data. Radar volume data is analyzed to locate cloud tops that extend above a height corresponding to a temperature line of about −10° C. Areas where cloud tops extend above the height of the −10° C. line and that have a radar composite reflectivity greater than 30 dBZ are designated as probable lightning threat areas. Radar movement is tracked across at least two time periods, and a correlation algorithm predicts the future location of lightning threat areas at predetermined time periods (e.g., 10 minutes, 20 minutes, and 30 minutes) based on predicted radar values. A computer display shows the predicted location of the lightning threat areas for the future time periods. In one variation, selected structures or areas (e.g., power lines, factories, or the like) are superimposed on a computer display with predicted lightning threat areas to illustrate where lightning damage is likely to occur.

Abstract translation: 本发明提供一种用于通过评估雷达和温度数据来预测可能发生雷击的区域的系统和方法。 分析雷达体积数据以定位云顶顶部，其高度对应于约-10℃的温度线。云顶部延伸超过-10℃线的高度并且雷达复合反射率更大的区域 超过30 dBZ被指定为可能的雷电威胁区域。 在至少两个时间段内跟踪雷达移动，并且相关算法基于预测的雷达值预测在预定时间段（例如，10分钟，20分钟和30分钟）的雷电威胁区域的未来位置。 计算机显示屏显示未来时间段的雷电威胁区域的预测位置。 在一个变型中，选择的结构或区域（例如，电力线，工厂等）被叠加在具有预测的闪电威胁区域的计算机显示器上，以示出可能发生雷击的可能性。

公开(公告)号：USD450529S1

公开(公告)日：2001-11-20

申请号：US29136609

申请日：2001-02-02

Applicant: Michael Smith

Designer： Michael Smith

公开(公告)号：US5762855A

公开(公告)日：1998-06-09

申请号：US639743

申请日：1996-04-29

Applicant: James E. Betters ,  Michael Smith

Inventor： James E. Betters ,  Michael Smith

IPC: B29C45/00 ,  B29C45/28 ,  B29C45/18

CPC classification number: B29C45/0025 ,  B29C45/2806 ,  B29C45/77 ,  B29C2045/0032 ,  B29C2045/0089 ,  B29C45/2701 ,  B29C45/2725 ,  B29L2031/3044

Abstract: A system for injection molding of large components is disclosed that provides for the production of higher quality large molded components with a reduction in both molding cycle time and molding costs. Plasticized material communicates with a mold, having at least one single cavity, through a manifold that has at least two spaced valve gates that are independently opened and closed as directed by a controller to selectively communicate plasticized material to the mold cavity at separate locations in the mold cavity. The controller directs the valve gates to sequentially open and close during the filling phase so as to achieve the desired melt front advancement within the mold cavity. Once the mold cavity has been filled as desired, the valve gates are closed to effectively seal the manifold from the mold cavity. The plasticized material within the manifold is held in compression while the mold cavity is open, so as to prevent appreciable expansion of the material that has been found to result in molded part imperfections. Additional material may be plasticized and held in compression while the mold cavity is open, resulting in a further reduction in overall cycle time.

Abstract translation: 公开了一种用于大型部件的注射成型的系统，其提供了更高质量的大型模制部件的生产，同时缩短成型周期时间和成型成本。 增塑材料与具有至少一个单个空腔的模具连通，该模具具有至少两个间隔开的阀门，所述歧管独立地由控制器打开和关闭，以在塑料模具的不同位置选择性地将增塑材料连接到模腔 模腔。 控制器在填充阶段引导阀门依次打开和关闭，以便在模具腔内实现期望的熔体前进。 一旦根据需要填充了模腔，就关闭阀门以有效地将歧管与模腔密封。 歧管内的增塑材料在模腔打开时保持压缩，以防止发现导致模制部件缺陷的材料的明显膨胀。 另外的材料可以塑化并且在模腔打开时保持压缩，导致整个循环时间的进一步减少。

公开(公告)号：US5613787A

公开(公告)日：1997-03-25

申请号：US617255

申请日：1996-03-18

Applicant: Barry E. Passer ,  Michael Smith ,  Robert Delaney

Inventor： Barry E. Passer ,  Michael Smith ,  Robert Delaney

IPC: B41J15/02 ,  B41J15/04 ,  B41J15/06 ,  G07G1/00 ,  G07G5/00

CPC classification number: B41J15/042 ,  B41J15/02 ,  B41J15/06 ,  G07G1/0018 ,  G07G5/00

Abstract: A journal printing apparatus is disclosed for a journal receipt printing machine. The apparatus semi-automatically loads the journal paper onto the take-up spool. The machine is also characterized by drop-in loading for the journal paper supply roll. The journal printing apparatus utilizes a duckbill take-up core or spool that is bifurcated into stationary and movable sections. The bifurcated spool is spring loaded, and is caused to bias closed by movement of a cam. The leader of the journal paper is placed over the stationary section of the spool and a gear train causes the cam to rotate again. The gear train then forces the duckbill spool shut against its biasing, thus capturing the paper between the spool sections. In this fashion, the procedure of journal paper resupply is accomplished without the user having to thread paper.

Abstract translation: 公开了一种日记收据印刷机的日记印刷装置。 设备半自动将日志纸装载到卷取卷轴上。 该机器的特征还在于日志供纸辊的下降载荷。 日记印刷设备利用鸭嘴卷芯或线轴分成静止和可移动部分。 分叉的卷轴是弹簧加载的，并且由于凸轮的运动而被偏置关闭。 日志纸的引导件放置在卷轴的静止部分上，齿轮系使凸轮再次旋转。 然后，齿轮系迫使鸭嘴阀芯阻止其偏压，从而将纸张捕获在卷轴部分之间。 以这种方式，在用户不必使用纸的情况下，完成了日记纸补充的过程。

公开(公告)号：US5403342A

公开(公告)日：1995-04-04

申请号：US080830

申请日：1993-06-21

Applicant: H. Jonathan Tovey ,  Ernie Aranyi ,  Thomas D. Guy ,  Joseph Pasqualucci ,  H. Allan Alward ,  Michael Smith

Inventor： H. Jonathan Tovey ,  Ernie Aranyi ,  Thomas D. Guy ,  Joseph Pasqualucci ,  H. Allan Alward ,  Michael Smith

IPC: A61B17/28

CPC classification number: A61B17/29 ,  A61B17/2909 ,  A61B2017/2905 ,  A61B2017/2927 ,  A61B2017/2929 ,  A61B2017/2936

Abstract: A surgical instrument is provided for performing a variety of endoscopic or laparoscopic procedures including the electrocauterization of tissue. The instrument includes a handle assembly, a tubular body extending from the handle assembly therein defining a longitudinal axis, a tool assembly associated with a distal end of the tubular body including a tool base and tool members, an electrical connector electrically associated with the tool members, electrical insulation being provided in association with electrical conducting components, a first mechanism for effectuating remote articulation of the tool assembly with respect to the longitudinal axis of the tubular body, and a second mechanism for effectuating remote rotation of the tool assembly about the longitudinal axis of the tubular body.

Abstract translation: 提供外科器械用于执行各种内窥镜或腹腔镜手术，包括组织的电灼。 所述器械包括手柄组件，从所述手柄组件在其中延伸限定纵向轴线的管状体，与所述管状主体的远端相关联的工具组件，所述工具组件包括工具基座和工具构件，与所述工具构件电连接的电连接器 电气绝缘与导电部件相关联地设置，用于实现工具组件相对于管状体的纵向轴线的远程铰接的第一机构，以及用于实现工具组件围绕纵向轴线的远程旋转的第二机构 的管状体。

公开(公告)号：US5237310A

公开(公告)日：1993-08-17

申请号：US807997

申请日：1991-12-16

Applicant: Michael Smith

Inventor： Michael Smith

IPC: F04B49/10 ,  F04D15/02 ,  G07C3/00 ,  G08B21/20

CPC classification number: G08B21/187 ,  F04B49/10 ,  F04D15/02 ,  G07C3/00 ,  F04B2205/05 ,  F04B2205/063

Abstract: A monitor (10) includes a transducer (20) registered with a pump (22) for generating electrical signals reflecting the status of the pump (22). The output of the transducer (20) is conditioned by a pump monitor circuit (16) to indicate the status (18) of the pump (22) and for subsequent delivery to an alarm processing unit (C) and alarm condition (D). The monitor (10) reports both normal and abnormal pump (22) conditions.

Abstract translation: 监视器（10）包括与泵（22）对准的换能器（20），用于产生反映泵（22）的状态的电信号。 传感器（20）的输出由泵监视器电路（16）调节以指示泵（22）的状态（18）并随后传送到报警处理单元（C）和报警状态（D）。 监视器（10）报告正常和异常泵（22）条件。

公开(公告)号：US4388375A

公开(公告)日：1983-06-14

申请号：US324507

申请日：1981-11-24

Applicant: Michael J. Hopper ,  Michael R. Martin ,  Lawrence Bolt ,  Michael Smith ,  Ali Tavasolian

Inventor： Michael J. Hopper ,  Michael R. Martin ,  Lawrence Bolt ,  Michael Smith ,  Ali Tavasolian

IPC: B32B27/08 ,  G02B5/30 ,  B32B27/40 ,  G02F1/13

CPC classification number: B32B27/08 ,  G02B5/3033 ,  Y10T428/31565 ,  Y10T428/31797 ,  Y10T428/31928 ,  Y10T428/31935

Abstract: A polarizer having increased hydrolytic stability is produced by impregnating a polyvinyl alcohol substrate with an iodine containing composition and then subjecting the substrate to both concentrated infrared and ultraviolet radiation treatments sufficient to substantially increase the hydrolytic stability of the thusly formed polarizer. The polyvinyl alcohol film had been laminated to a polyester support with a dispersed, aqueous composition of polyvinyl alcohol or polyurethane on its surface.

Abstract translation: 具有增加的水解稳定性的偏振片通过用含碘组合物浸渍聚乙烯醇基材，然后对基材进行浓缩红外和紫外线辐射处理，足以显着提高如此形成的偏振片的水解稳定性。 聚乙烯醇膜已经在其表面上层压到具有聚乙烯醇或聚氨酯的分散的水性组合物的聚酯载体上。

公开(公告)号：US3959152A

公开(公告)日：1976-05-25

申请号：US559141

申请日：1975-03-17

Applicant: Jay A. Seifert ,  Donald R. Hill ,  Michael Smith

Inventor： Jay A. Seifert ,  Donald R. Hill ,  Michael Smith

IPC: B01D21/06 ,  B01D21/14

CPC classification number: B01D21/06 ,  B01D21/0003 ,  B01D21/0042 ,  B01D21/18 ,  B01D21/2405 ,  B01D21/2427 ,  B01D21/245

Abstract: A large sedimentation tank having a traction-driven composite sludge raking mechanism provided with lift capability, and comprising a rotary traction-driven drive arm of girder-like construction exposed above the liquid level, and draft-connected to an inner load yielding self-liftable rake arm operating in the central sludge accumulation zone in the tank, and also connected to an outer complementary rake structure operating in an outer annular zone to move sludge therefrom into the central accumulation zone.

Abstract translation: 具有提升能力的牵引驱动复合污泥耙机构的大型沉淀池，包括暴露在液面以上的大梁式结构的旋转牵引驱动驱动臂，并且牵引连接到产生自升式的内部载荷 耙臂在罐中的中央污泥积聚区中操作，并且还连接到在外部环形区域中操作的外部互补的耙式结构，以将污泥从其中移入中央堆积区。