公开(公告)号：US20210341486A1

公开(公告)日：2021-11-04

申请号：US17378829

申请日：2021-07-19

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Zvi FISHELSON ,  Zoltan PROHASZKA

IPC: G01N33/574

Abstract: Provided are methods of determining a presence or level of soluble mortalin in a body fluid of a subject, and predicting prognosis of a subject diagnosed with cancer (e.g., solid tumor) by determining the presence or level of soluble mortalin in a body fluid of the subject. Also provided are kits for determining presence and/or level of soluble mortalin in a body fluid of the subject and/or predicting prognosis of a subject diagnosed with cancer, comprising at least two distinct antibodies to mortalin directed against different epitopes of said mortalin.

公开(公告)号：US20210340601A1

公开(公告)日：2021-11-04

申请号：US17272961

申请日：2019-09-03

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Noam SHOMRON ,  Tom RABINOWITZ

IPC: C12Q1/6827 ,  C12Q1/6883 ,  G16B20/00 ,  G16B40/20 ,  G16B30/10

Abstract: A method of fetal genotyping, comprises receiving maternal genomic DNA (gDNA) data, maternal cell-free DNA (cfDNA) data, and paternal gDNA data of a pair parenting to a fetus. The data are analyzed to identify a first set of sites at which the parents are homozygous for different alleles, and a second set at which at least one of the parents has a mutation. For each site of the first set, a probability that a respective portion of the maternal cfDNA data is derived from the fetus is determined. Each site of the second set is classified according to the determined probabilities as being either fetal or maternal to genotype the fetus.

公开(公告)号：US11161801B2

公开(公告)日：2021-11-02

申请号：US15751786

申请日：2016-08-03

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Yoram Cohen ,  Micha Fridman ,  Roymon Joseph ,  Alissa Naugolny ,  Mark Feldman ,  Ido M. Herzog ,  Dana Kaizerman

IPC: C02F1/50 ,  C07C217/54 ,  C07D233/60 ,  C07F9/54 ,  C09D5/16 ,  A61K31/138 ,  A61K31/4178 ,  A61K31/66 ,  A61K45/06

Abstract: The present invention provides cationic pillar[n]arenes, e.g., positively charged poly-ammonium, poly-phosphonium and poly-imidazolium pillar[5-6]arene derivatives, capable of inhibiting or preventing biofilm formation, and facilitating existing biofilm decomposition; as well as compositions thereof and methods of use.

公开(公告)号：US20210325346A1

公开(公告)日：2021-10-21

申请号：US17270016

申请日：2019-08-20

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Itzhak KHAIT ,  Raz SHARON ,  Yosef YOVEL ,  Lilach HADANY

IPC: G01N29/14 ,  G01N29/26 ,  G01N29/44 ,  G01N33/00

Abstract: A system for monitoring plants, the system comprising: one or more sound collectors configured to receive and generate signals based on sounds that plants make; and a computer system configured to receive and process the signals to provide a profile of a plant producing the sounds.

公开(公告)号：US11118182B2

公开(公告)日：2021-09-14

申请号：US16461941

申请日：2017-11-16

Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.

Inventor： Dan Canaani ,  Ronni Aram ,  Iris Dotan ,  Pnina Gottfried Komlosh

IPC: C07H21/04 ,  C12N15/113 ,  A61P17/02 ,  A61P35/04 ,  A61K9/127 ,  C12Q1/6886 ,  G01N33/50 ,  G01N33/52

Abstract: The invention provides modulators of human cancer and tumor metastasis in particular. More specifically the present disclosure relates to modulators of SKAI1BC, an antisense long non-coding RNA which was found to be an epigenetic suppressor of the metastasis suppressor gene KAI1/CD82, compositions, methods and uses thereof for decreasing metastasis, invasion and possibly also proliferation of cancer cells.

公开(公告)号：US11105809B2

公开(公告)日：2021-08-31

申请号：US14434164

申请日：2013-10-09

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Zvi Fishelson ,  Zoltan Prohaszka

IPC: G01N31/00 ,  G01N33/53 ,  G01N33/574

Abstract: Provided are methods of determining a presence or level of soluble mortalin in a body fluid of a subject, and predicting prognosis of a subject diagnosed with cancer (e.g., solid tumor) by determining the presence or level of soluble mortalin in a body fluid of the subject. Also provided are kits for determining presence and/or level of soluble mortalin in a body fluid of the subject and/or predicting prognosis of a subject diagnosed with cancer, comprising at least two distinct antibodies to mortalin directed against different epitopes of said mortalin.

公开(公告)号：US11091793B2

公开(公告)日：2021-08-17

申请号：US16424523

申请日：2019-05-29

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Yuval Ebenstein ,  Micha Fridman

IPC: C12P19/30 ,  C12Q1/6806 ,  G01N21/64

Abstract: Methodologies for labeling the epigenetic modification 5-hydroxymethylcytosine (5hmC) along a DNA molecule, and for determining a presence or a level of this epigenetic modification based on a ratio of fluorescence intensity of a labeled DNA sample to absorption intensity of the DNA sample at 260 nm are disclosed. Related compositions and reagents, and methods of preparing same are also disclosed.

公开(公告)号：US20210214766A1

公开(公告)日：2021-07-15

申请号：US17058623

申请日：2019-05-24

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Doron SHABAT ,  Michal Eli ROTH-KONFORTI ,  Nir HANANYA ,  Ori GREEN ,  Urs SPITZ ,  Lukas WICK ,  Julian IHSSEN ,  Raffael VORBERG ,  Riccardo CRIBIU ,  Zuzana BABJAKOVÀ ,  Chunyan YAO

IPC: C12Q1/10 ,  C07D407/04 ,  C07D321/00 ,  C12Q1/44 ,  C12Q1/04 ,  C12Q1/14 ,  C12Q1/22 ,  C12Q1/54 ,  G01N21/76

Abstract: Dioxetane compounds can be used in the detection of presence or absence, quantification and identification of microorganisms including bacteria, bacterial fragments (e.g., LPS, endotoxin), viruses, fungi as well as other pathogens by means of chemiluminescence and to corresponding methods. A method for the detection of a target analyte, a target microorganism or a target metabolite includes providing a medium including one or more target analytes, target microorganisms or target metabolites, adding a dioxetane compound to the medium so that the compound emits light, and detecting the emitted light.

公开(公告)号：US20210214607A1

公开(公告)日：2021-07-15

申请号：US17058453

申请日：2019-05-24

Applicant: NEMIS Technologies AG ,  Ramot at Tel-Aviv University Ltd.

Inventor： Julian IHSSEN ,  Urs SPITZ ,  Doron SHABAT ,  Ori GREEN ,  Nir HANANYA

IPC: C09K11/06 ,  C07F5/04 ,  C07D405/10 ,  C07D321/00 ,  G01N33/58 ,  G01N21/76

Abstract: Improved long wavelength-emitting chemiluminescent probes are easy to synthesize and are well-suited for both in vitro and in vivo applications, but are particularly well-suited for in vivo applications. The wavelengths of the emissions of the probes include those in the orange, red or NIR range. Dioxetane compounds and phenolic ester compounds are included.

公开(公告)号：US20210166359A1

公开(公告)日：2021-06-03

申请号：US17177319

申请日：2021-02-17

Applicant: Ramot at Tel-Aviv University Ltd.

Inventor： Iftach KLAPP ,  David MENDLOVIC

IPC: G06T5/00 ,  G02B27/42 ,  G02B27/46 ,  H04N5/232 ,  G02B27/00 ,  G02B26/06 ,  H04N5/225

Abstract: An imaging device is presented for use in an imaging system capable of improving the image quality. The imaging device has one or more optical systems defining an effective aperture of the imaging device. The imaging device comprises a lens system having an algebraic representation matrix of a diagonalized form defining a first Condition Number, and a phase encoder utility adapted to effect a second Condition Number of an algebraic representation matrix of the imaging device, smaller than said first Condition Number of the lens system.