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    CLEC2 FUSION PROTEIN AND USES THEREOF
    261.
    发明公开
    CLEC2 FUSION PROTEIN AND USES THEREOF 审中-公开

    公开(公告)号：US20230365640A1

    公开(公告)日：2023-11-16

    申请号：US18028747

    申请日：2021-09-29

    Applicant: Academia Sinica

    Inventor： Shie-Liang HSIEH ,  Pei-Shan SUNG

    IPC: C07K14/47 ,  A61P31/14 ,  A61P31/16

    CPC classification number: C07K14/4726 ,  A61P31/14 ,  A61P31/16 ,  A61K38/00

    Abstract: Disclosed herein is a CLEC2 fusion protein comprising a first polypeptide and a second polypeptide coupled to the upstream of the first polypeptide. According to embodiments of the present disclosure, the first and the second polypeptides respectively comprise the amino acid sequences of SEQ ID NOs: 1 and 2. Also disclosed therein are uses of the CLEC2 fusion protein in treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and treating influenza virus infection.

    METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES
    266.
    发明公开
    METHODS OF USING 4(1H)-QUINOLONE DERIVATIVES 审中-公开

    公开(公告)号：US20230233549A1

    公开(公告)日：2023-07-27

    申请号：US18184364

    申请日：2023-03-15

    Applicant: Academia Sinica

    Inventor： Rong-Jie CHEIN ,  Pan-Chyr YANG ,  Chi-Huey WONG ,  Ming-Shiu LIN ,  Ting-Jen CHENG ,  Ting-Hung Rachel CHOU

    IPC: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

    CPC classification number: A61K31/47 ,  A61P35/00 ,  A61K45/06 ,  C07D215/233

    Abstract: Provided herein are compounds of Formula (I). The disclosure provides new compounds, compositions, and methods for treating, delaying, and/or preventing the adverse effects of proliferative diseases, such as cancers including, for example, lung cancer, breast cancer, ovarian cancer, prostate cancer, head cancer, neck cancer, head and neck cancer, or leukemia (e.g., cancer resistant to treatment by one or more microtubule-targeting agents (e.g., cancer resistant to multiple drugs associated with P-glycoprotein (P-gp) overexpression)). Provided are methods of inhibiting polymerization of a cancer cell microtubule in a subject in need thereof or a cell, tissue, or biological sample, binding β-tubulin, inhibiting microtubule assembly and, inducing apoptosis in a cancer cell resistant to multiple drugs in a tissue, biological sample, or subject. Also provided in the present disclosure are pharmaceutical compositions, kits, and methods of using the compounds for treating any of the target diseases described herein.

    DETECTION METHOD AND DETECTION SYSTEM
    267.
    发明公开
    DETECTION METHOD AND DETECTION SYSTEM 审中-公开

    公开(公告)号：US20230204508A1

    公开(公告)日：2023-06-29

    申请号：US18084997

    申请日：2022-12-20

    Applicant: ACADEMIA SINICA

    Inventor： Pei-Kuen WEI ,  Sheng-Hann WANG ,  Ting-Wei CHANG

    IPC: G01N21/552

    CPC classification number: G01N21/554 ,  G01N2021/177

    Abstract: A detection method and a detection system for detecting objects of interest attached to a surface of a plurality of reporters, wherein the plurality of reporters are flowing in a microfluidic chip and illuminated by a light source. The detection method has following steps: obtaining a plurality of local surface plasmon resonance (LSPR) spectral images of each the plurality of the reporters individually, wherein each of the LSPR spectral images has a brightness of a long wavelength band (BA) and a brightness of a short wavelength band (BB); calculating a spectral image brightness contrast γ for each of the LSPR spectral images, wherein





    γ
    =



    B
    A

    -

    B
    B




    B
    A

    +

    B
    B




    ;




    and, defining a positive threshold for |γ|≥0.1.

    APPROACHES TO DRAMATICALLY INCREASE RICE PRODUCTIVITY
    268.
    发明公开
    APPROACHES TO DRAMATICALLY INCREASE RICE PRODUCTIVITY 审中-公开

    公开(公告)号：US20230203521A1

    公开(公告)日：2023-06-29

    申请号：US17923455

    申请日：2021-04-29

    Applicant: Academia Sinica

    Inventor： Su-Ying Yeh ,  Hsin-Hung Lin ,  Maurice S. B. Ku ,  Wen-Hsiung Li

    IPC: C12N15/82

    CPC classification number: C12N15/8269 ,  C12N15/8265

    Abstract: A transgenic rice plant containing in its genome a recombinant DNA construct that includes a first nucleic acid having a sequence of a first Golden 2-like transcription factor (GLK) gene operably linked to its natural promoter and 5′ untranslated region (5′UTR), and a second nucleic acid having a sequence of a second GLK gene operably linked to its natural promoter and 5′UTR, the second GLK gene being distinct from the first GLK gene. The first GLK gene and the second GLK gene are both from a C4 plant and the transgenic rice plant exhibits a 65-106% increase in shoot biomass and a 50-95% increase in grain yield, as compared to an untransformed wild-type rice plant. Also provided is a method for producing the transgenic rice plant and a recombinant DNA construct that can be used in the method.

    Capture, purification, and release of biological substances using a surface coating
    269.
    发明授权
    Capture, purification, and release of biological substances using a surface coating 有权

    公开(公告)号：US11674958B2

    公开(公告)日：2023-06-13

    申请号：US16832396

    申请日：2020-03-27

    Applicant: Academia Sinica

    Inventor： Ying-Chih Chang ,  Han-Chung Wu ,  Po-Yuan Tseng ,  Jen-Chia Wu

    IPC: G01N33/543 ,  G01N33/574 ,  G01N1/40 ,  C07K17/14 ,  C07K16/30

    CPC classification number: G01N33/54386 ,  C07K16/30 ,  C07K17/14 ,  G01N1/405 ,  G01N33/54393 ,  G01N33/57492

    Abstract: This invention relates to a surface coating for capture circulating rare cells, comprising a nonfouling composition to prevent the binding of non-specific cells and adsorption of serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the nonfouling and bioactive compositions. The invention also provide a surface coating for capture and purification of a biological substance, comprising a releasable composition to release the non-specific cells and other serum components; a bioactive composition for binding the biological substance, such as circulating tumor cells; with or without a linker composition that binds the releasable and bioactive compositions. The present invention also discloses a novel microfluidic chip, with specific patterned microstructures to create a flow disturbance and increase the capture rate of the biological substance.

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