公开(公告)号：US11717801B2

公开(公告)日：2023-08-08

申请号：US17625349

申请日：2020-08-05

申请人： Academia Sinica

发明人： Michael Hsiao ,  Ming-Che Hsieh ,  Zhen Bao ,  Ming-Hsien Chan ,  Ru-Shi Liu ,  An-Bang Wang ,  Chia-Chih Chu

IPC分类号： B01J19/00

CPC分类号： B01J19/0093 ,  B01J2219/00873 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00972

摘要： Disclosed herein is a micro-reactor for synthesizing a molecule, for example, compound, a nanoparticle, or a quantum dot. According to embodiments of the present disclosure, the apparatus comprises a processor, a storage unit, a reaction unit, a detector, and a collector, in which the storage unit and the reaction unit are independently controlled by the process. Optionally, the present micro-reactor further comprises a diagnostic device for performing a diagnostic test on a biological sample by use of the molecule. Also disclosed wherein are methods of diagnosing and treating a disease in a subject with the aid of the present micro-reactor.

公开(公告)号：US20110004345A1

公开(公告)日：2011-01-06

申请号：US12819427

申请日：2010-06-21

申请人： William Allen Rogers, JR. ,  Chistopher Paul Weil ,  Robert Dwayne Litt ,  Ronald Chester Pasadyn ,  George Bradley Smith ,  Charles Robert Miele ,  Thomas Peter Forte ,  Jimmy Glen Pelham

发明人： William Allen Rogers, JR. ,  Chistopher Paul Weil ,  Robert Dwayne Litt ,  Ronald Chester Pasadyn ,  George Bradley Smith ,  Charles Robert Miele ,  Thomas Peter Forte ,  Jimmy Glen Pelham

IPC分类号： C07C1/04

CPC分类号： B01J19/0093 ,  B01J3/046 ,  B01J2219/0081 ,  B01J2219/00817 ,  B01J2219/00835 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  C01B3/382 ,  C01B3/384 ,  C01B2203/0227 ,  C01B2203/0283 ,  C01B2203/0811 ,  C01B2203/1604 ,  C07C1/0475 ,  C07C1/0485 ,  C10G2/00 ,  C10G2300/4031 ,  Y02P20/52 ,  Y10T29/49345 ,  Y10T29/49815 ,  Y10T29/49826 ,  Y10T29/49948 ,  Y10T137/0335

摘要： A process unit comprising: (a) a first microchannel module comprising: (i) a first unit operation including microchannels, in which at least a portion of a unit operation takes place, adapted to be in fluid communication with a first inlet stream and a first outlet stream, and (ii) a second unit operation including microchannels adapted to be in thermal communication with the first unit operation, the second unit operation adapted to be in fluid communication with a second inlet stream and a second outlet stream; and (b) a pressurized vessel at least partially containing the first microchannel module adapted to be concurrently occupied by a compressive medium in thermal communication with the first microchannel module.

摘要翻译： 一种处理单元，包括：（a）第一微通道模块，包括：（i）包括微通道的第一单元操作，其中发生单元操作的至少一部分，适于与第一入口流和 第一出口流，和（ii）包括适于与第一单元操作热连通的微通道的第二单元操作，所述第二单元操作适于与第二入口流和第二出口流流体连通; 和（b）至少部分地包含第一微通道模块的加压容器，其适于由与第一微通道模块热连通的压缩介质同时占据。

公开(公告)号：US20100320121A1

公开(公告)日：2010-12-23

申请号：US12521753

申请日：2007-12-29

申请人： Richard F BAUMAN ,  Rocco A FIATO

发明人： Richard F BAUMAN ,  Rocco A FIATO

IPC分类号： C10G45/72

CPC分类号： B01J19/0093 ,  B01J19/0046 ,  B01J2219/00015 ,  B01J2219/00286 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00707 ,  B01J2219/00747 ,  B01J2219/00788 ,  B01J2219/00835 ,  B01J2219/0086 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00981 ,  C10G49/26 ,  C40B60/12

摘要： A method for determining a set of operating parameters for a commercial scale plug flow catalytic process and reactor system for hydroprocessing dirty feedstocks, comprises the steps of: feeding selected partial pressures of said feedstock and hydrogen to the inlet the first reactor stage of a first composite multi-stage series-connected laboratory scale plug flow reactor including at least three reactor stages, the catalyst beds of each of said reactor stages including catalyst particles capable of catalyzing the removal by hydrogen of heteroatoms from said heterocyclic molecules; sampling the effluents of each of said reactor stages; measuring the concentration of heterocyclic molecules in said dirty feedstock in the concentrations of heterocyclic molecules and intermediate and final products and by products of the catalytic reaction in the effluents of each of said reactor stages.

摘要翻译： 一种用于确定用于加氢处理脏原料的商业规模的塞式流动催化过程和反应器系统的一组操作参数的方法包括以下步骤：将选择的所述原料和氢气的分压送入第一复合材料的第一反应器阶段的入口 包括至少三个反应器阶段的多级串联实验室规模的活塞式流动反应器，每个所述反应器级的催化剂床包括能够催化氢从所述杂环分子中除去杂原子的催化剂颗粒; 对每个所述反应器级的流出物进行取样; 以杂质分子和中间产物和最终产物的浓度以及每个反应器阶段的流出物中的催化反应产物测量所述脏进料中杂环分子的浓度。

公开(公告)号：US07614135B2

公开(公告)日：2009-11-10

申请号：US11927156

申请日：2007-10-29

申请人： John T. Santini, Jr. ,  Norman F. Sheppard, Jr. ,  Robert S. Langer ,  Chung Chang Young

发明人： John T. Santini, Jr. ,  Norman F. Sheppard, Jr. ,  Robert S. Langer ,  Chung Chang Young

IPC分类号： H01R3/00

CPC分类号： B01L3/50853 ,  A61B5/00 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14865 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0097 ,  A61K47/6957 ,  A61K49/0002 ,  B01J19/0093 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00783 ,  B01J2219/00819 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00907 ,  B01J2219/00925 ,  B01J2219/00952 ,  B01J2219/00957 ,  B01J2219/00966 ,  B01J2219/0097 ,  B01J2219/00984 ,  B01J2219/00986 ,  B01L2200/12 ,  B01L2300/023 ,  B01L2300/049 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2400/0677 ,  C40B60/14 ,  G01N2035/00158 ,  G01N2035/00247 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T436/25

摘要： Methods are provided for making a reservoir-based sensor device. The method may include fabricating a first substrate portion which comprises an upper surface, an opposed lower surface, a plurality of through holes defining reservoirs between said upper surface and said lower surface, and a plurality of reservoir caps closing off one end of said through holes at said upper surface; fabricating a plurality of sensors on an upper surface of a second substrate portion; aligning the first and second substrate portions such that each of said plurality of sensors is in alignment with each of said plurality of reservoirs; and bonding together the lower surface of said first substrate portion and the upper surface of said second substrate portion to seal each of said sensors inside the reservoir with which it is aligned.

摘要翻译： 提供了制备基于储液器的传感器装置的方法。 该方法可以包括制造第一衬底部分，其包括上表面，相对的下表面，在所述上表面和所述下表面之间限定储存器的多个通孔，以及封闭所述通孔的一端的多个贮存器盖 在所述上表面; 在第二基板部分的上表面上制造多个传感器; 对准所述第一和第二基板部分，使得所述多个传感器中的每一个与所述多个储存器中的每一个对齐; 以及将所述第一基板部分的下表面和所述第二基板部分的上表面接合在一起，以密封与所述第二基板部分对准的所述储存器内的每个所述传感器。

公开(公告)号：US20090275115A1

公开(公告)日：2009-11-05

申请号：US12347579

申请日：2008-12-31

申请人： Andrey Zarur Jury ,  Mark D. Angelino

发明人： Andrey Zarur Jury ,  Mark D. Angelino

IPC分类号： C12M3/00

CPC分类号： B01F13/0064 ,  B01F5/0256 ,  B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0094 ,  B01F15/00935 ,  B01F2005/0621 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00835 ,  B01J2219/00862 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00907 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00966 ,  C12M23/16

摘要： Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of the reactors can be readily formed from a variety of materials. For example, they can be etched from silicon. Components are connectable to and separable from each other to form a variety of types of reactors, and the reactors can be attachable to and separable from each other to add significant flexibility in parallel and/or series reactor operation.

摘要翻译： 提供化学和生物反应堆，包括微反应器。 示例性反应器包括可并行操作的多个反应器，其中每个反应器具有小体积，并且一起反应器产生大体积的产物。 反应系统可以包括混合室，加热/分散单元，反应室和分离单元。 反应器的组分可以容易地由各种材料形成。 例如，它们可以从硅上蚀刻。 组件可彼此连接并可分离以形成各种类型的反应器，并且反应器可以彼此附接和分离，以在并联和/或串联反应器操作中增加显着的灵活性。

公开(公告)号：US07485454B1

公开(公告)日：2009-02-03

申请号：US09707852

申请日：2000-11-07

申请人： Andrey Zarur Jury ,  Mark D. Angelino

发明人： Andrey Zarur Jury ,  Mark D. Angelino

IPC分类号： C12M1/12

CPC分类号： B01F13/0064 ,  B01F5/0256 ,  B01F5/061 ,  B01F5/0646 ,  B01F5/0647 ,  B01F13/0094 ,  B01F15/00935 ,  B01F2005/0621 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00828 ,  B01J2219/00835 ,  B01J2219/00862 ,  B01J2219/00871 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00907 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00966 ,  C12M23/16

摘要： Chemical and biological reactors, including microreactors, are provided. Exemplary reactors include a plurality of reactors operable in parallel, where each reactor has a small volume and, together, the reactors produce a large volume of product. Reaction systems can include mixing chambers, heating/dispersion units, reaction chambers, and separation units. Components of the reactors can be readily formed from a variety of materials. For example, they can be etched from silicon. Components are connectable to and separable from each other to form a variety of types of reactors, and the reactors can be attachable to and separable from each other to add significant flexibility in parallel and/or series reactor operation.

摘要翻译： 提供化学和生物反应堆，包括微反应器。 示例性反应器包括可并行操作的多个反应器，其中每个反应器具有小体积，并且一起反应器产生大体积的产物。 反应系统可以包括混合室，加热/分散单元，反应室和分离单元。 反应器的组分可以容易地由各种材料形成。 例如，它们可以从硅上蚀刻。 组件可彼此连接并可分离以形成各种类型的反应器，并且反应器可以彼此附接和分离，以在并联和/或串联反应器操作中增加显着的灵活性。

公开(公告)号：US20080274557A1

公开(公告)日：2008-11-06

申请号：US11817436

申请日：2006-03-03

申请人： Pilsoo Kang ,  Yehia S. Mechref ,  Milos V. Novotny

发明人： Pilsoo Kang ,  Yehia S. Mechref ,  Milos V. Novotny

IPC分类号： G01N33/00 ,  B01J19/00 ,  C07H1/00

CPC分类号： B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00824 ,  B01J2219/00835 ,  B01J2219/00837 ,  B01J2219/00891 ,  B01J2219/00916 ,  B01J2219/00957 ,  C07K1/1077 ,  G01N30/02 ,  Y10T436/11 ,  Y10T436/143333 ,  Y10T436/25 ,  B01D15/325

摘要： A solid-phase permethylation procedure is described. For example, solid-phase permethylation can be utilized to prepare permethylated linear and branched, neutral and sialylated oligosaccharides, which can be analyzed by MALDI-MS.

摘要翻译： 描述了固相去甲基化方法。 例如，可以使用固相甲基化来制备可以通过MALDI-MS分析的二甲基化的直链和支链，中性和唾液酸化寡糖。

公开(公告)号：US20050214202A1

公开(公告)日：2005-09-29

申请号：US11077849

申请日：2005-03-11

申请人： Christopher Weil ,  Robert Litt ,  W. Rogers ,  Richard Bennett ,  Elizabeth De Lucia

发明人： Christopher Weil ,  Robert Litt ,  W. Rogers ,  Richard Bennett ,  Elizabeth De Lucia

IPC分类号： B01J3/00 ,  B01J8/02 ,  B01J8/04 ,  B01J10/00 ,  B01J19/00 ,  B01J19/24 ,  C01B3/24 ,  C01B3/38 ,  C07C27/00

CPC分类号： B01J19/0093 ,  B01J3/046 ,  B01J2219/0081 ,  B01J2219/00817 ,  B01J2219/00835 ,  B01J2219/00867 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00957 ,  B01J2219/00961 ,  B01J2219/00963 ,  B01J2219/00986 ,  C01B3/382 ,  C01B3/384 ,  C01B2203/0227 ,  C01B2203/0283 ,  C01B2203/0811 ,  C01B2203/1604 ,  C07C1/0475 ,  C07C1/0485 ,  C10G2/00 ,  C10G2300/4031 ,  Y02P20/52 ,  Y10T29/49345 ,  Y10T29/49815 ,  Y10T29/49826 ,  Y10T29/49948 ,  Y10T137/0335

摘要： A method of starting up and shutting down a microchannel process is provided. Included are the steps of providing a first multi-planar process unit, preferably adapted to process an endothermic reaction, a second multi-planar process unit, preferably adapted to process an exothermic reaction, providing a containment vessel, the containment vessel containing at least a portion of the first, and preferably the second, process unit. In startup, the microchannel process is first checked for pressure integrity by pressurizing and checking the important components of the process for leaks. Subsequently, the process units are heated by introducing a dilute low-thermal energy density material, preferably to the second process unit, followed by the introduction of a dilute high-thermal energy density material, and adjusting the proportion of high-thermal energy density material as required. In shutdown, a purge material from the containment vessel is introduced into the first, and preferably the second, process unit.

摘要翻译： 提供了一种启动和关闭微通道过程的方法。 包括提供优选适于处理吸热反应的第一多平面处理单元的步骤，优选地适于处理放热反应的第二多平面处理单元，提供容纳容器，该容纳容器至少包含一个 第一，最好是第二个处理单元的部分。 在启动时，首先通过对渗漏过程的重要组件进行加压和检查来检查微通道过程的压力完整性。 随后，通过将稀释的低热能密度材料引入到第二处理单元中，然后引入稀释的高热能密度材料并调节高热能密度材料的比例来加热处理单元 按要求。 在关闭时，来自容纳容器的吹扫材料被引入第一，最好是第二个处理单元。

公开(公告)号：US20050124979A1

公开(公告)日：2005-06-09

申请号：US11039048

申请日：2005-01-19

申请人： John Santini ,  Norman Sheppard

发明人： John Santini ,  Norman Sheppard

IPC分类号： G01N21/64 ,  A61K9/00 ,  A61K38/28 ,  A61P3/10 ,  B01J19/00 ,  B01L3/00 ,  B01L99/00 ,  B81B1/00 ,  C40B60/14 ,  G01N21/27 ,  G01N21/41 ,  G01N27/12 ,  G01N27/28 ,  G01N27/327 ,  G01N27/416 ,  G01N33/66 ,  G01N35/00 ,  C12Q1/68 ,  A61K9/22 ,  C12M1/34 ,  G01N33/543

CPC分类号： B01L3/50853 ,  A61B5/00 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1473 ,  A61B5/14865 ,  A61K9/0004 ,  A61K9/0009 ,  A61K9/0097 ,  A61K47/6957 ,  A61K49/0002 ,  B01J19/0093 ,  B01J2219/00317 ,  B01J2219/00351 ,  B01J2219/00783 ,  B01J2219/00819 ,  B01J2219/00822 ,  B01J2219/00824 ,  B01J2219/00828 ,  B01J2219/00831 ,  B01J2219/00833 ,  B01J2219/00835 ,  B01J2219/00844 ,  B01J2219/00853 ,  B01J2219/00873 ,  B01J2219/00889 ,  B01J2219/00907 ,  B01J2219/00925 ,  B01J2219/00952 ,  B01J2219/00957 ,  B01J2219/00966 ,  B01J2219/0097 ,  B01J2219/00984 ,  B01J2219/00986 ,  B01L2200/12 ,  B01L2300/023 ,  B01L2300/049 ,  B01L2300/0627 ,  B01L2300/0654 ,  B01L2300/0819 ,  B01L2400/0677 ,  C40B60/14 ,  G01N2035/00158 ,  G01N2035/00247 ,  Y10T29/49007 ,  Y10T29/49117 ,  Y10T436/25

摘要： Devices are provided for controlled release of chemical molecules, such as drugs or diagnostic agents. The devices comprises a substrate; a plurality of discrete reservoirs located in the substrate, wherein the reservoirs each have at least one opening at a surface of the substrate; chemical molecules, for release, disposed in the reservoirs; a rupturable barrier layer closing the at least one opening; and a pressure generating material disposed in the reservoirs, the pressure generating material being selected from the group consisting of water-swellable materials, osmotic pressure generating materials, and combinations thereof, wherein the chemical molecules can be selectively released from each reservoir by rupturing of the barrier layer, due to pressure generated by the pressure generating material.

摘要翻译： 提供了用于控制释放化学分子的装置，例如药物或诊断剂。 所述装置包括基板; 位于所述基板中的多个分立的储存器，其中所述储存器各自在所述基板的表面具有至少一个开口; 用于释放的化学分子，放置在储存器中; 封闭所述至少一个开口的可破裂阻挡层; 以及设置在所述储存器中的压力产生材料，所述压力产生材料选自水溶胀性材料，渗透压产生材料及其组合，其中所述化学分子可以通过破裂所述化学分子而被选择性地从每个储存器释放 阻挡层，由于压力产生材料产生的压力。

公开(公告)号：US06495016B1

公开(公告)日：2002-12-17

申请号：US09532157

申请日：2000-03-21

申请人： Bernd Nawracala

发明人： Bernd Nawracala

IPC分类号： C02F140

CPC分类号： B01L3/5027 ,  B01F13/0001 ,  B01F13/0059 ,  B01F15/00298 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00826 ,  B01J2219/00828 ,  B01J2219/0093 ,  B01J2219/00957 ,  B01J2219/00995 ,  B01L3/502784 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2400/0415 ,  B01L2400/0487

摘要： A microfluidic microchip includes a channel structure having a delivery channel connected in a substance conductive manner to a separation channel. Laterally offset discharge channels are at connection points displaced from a connection point between the delivery and separation channels. Between the connection points on the one hand and the connection point on the other are channel sections having concordant channel lengths. By imposing suitable electrical potentials along these channel sections, the filling volumes present in the channel sections are satisfactorily homogenous after a certain period of time to form a representative part of a substance specimen. Substance volume units are formed in these channel sections. The lengths of the volume units are determined exclusively by the lengths of the channel sections. Pulse-shaped substance volume sequences are injected into the separation channel. The signal-to-noise ratio of the measurement results is substantially improved by generating substance volume sequences on the basis of pseudo-randomly scattered binary digit sequences similar to Hadamard sequences, and by a cross-correlation analysis of spectra measured on the basis of such substance volume sequences.

摘要翻译： 微流体微芯片包括具有以物质导电方式连接到分离通道的输送通道的通道结构。 在从输送和分离通道之间的连接点移位的连接点处的横向偏移排出通道。 一方面的连接点和另一方的连接点是具有一致的通道长度的通道部分。 通过沿着这些通道部分施加合适的电势，存在于通道部分中的填充体积在一段时间之后令人满意地均匀，以形成物质样品的代表性部分。 在这些通道部分中形成物质体积单位。 体积单位的长度仅由通道段的长度确定。 将脉冲物质体积序列注入分离通道。 通过基于类似于Hadamard序列的伪随机分散的二进制数字序列产生物质体积序列，并且通过基于这样的方法测量的光谱的互相关分析，实质上改善了测量结果的信噪比 物质体积序列。