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公开(公告)号:US20210121539A1
公开(公告)日:2021-04-29
申请号:US17257764
申请日:2019-07-04
Applicant: LEMPO THERAPEUTICS LTD , RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Anat KAHANA , Rotem VOLKMAN , Ben Zion GARTY , Daniel OFFEN
Abstract: The present invention relates to methods of modulating the expression and/or activity of Myeloperoxidase (MPO) in a mammalian subject, by modulating ex vivo and/or in vivo MPO levels and/or activity in undifferentiated bone marrow (BM) cells of the subject. The invention further provide therapeutic methods and compositions for treating MPO-related disorders.
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公开(公告)号:US20210116442A1
公开(公告)日:2021-04-22
申请号:US16767221
申请日:2018-11-29
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Yosi SHACHAM-DIAMAND , Adi AVINI , Richa PANDEY
IPC: G01N33/50 , G01N27/327
Abstract: A sensing system comprises an electrochemical chip having an arrangement of electrodes configured for electrochemical sensing; a microfluidic system having fluidic channels leading to ports on a surface of the sensing system, for delivering to a plant part a substrate for a reporter enzyme expressed by the plant; and an attachment system for attaching the surface of the sensing system to a surface of the plant part in a manner that the fluidic ports contact the surface of the plant part.
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公开(公告)号:US10973902B2
公开(公告)日:2021-04-13
申请号:US16783597
申请日:2020-02-06
Applicant: The Trustees of Columbia University in the City of New York , Ramot at Tel-Aviv University Ltd. , Kimron Veterinary Institute
Inventor: W. Ian Lipkin , Thomas Briese , Nischay Mishra , Eran Bacharach , Avi Eldar
IPC: A61K39/12 , C07K14/005 , C12Q1/70
Abstract: The invention is directed to isolated Tilapia Lake Virus or TiLV, and isolated nucleic acids sequences and polypeptides thereof. The invention also relates to probes and primers, and to antibodies against antigens from TiLV, and use of these reagents for detecting the presence or absence of TiLV in an animal. The invention also relates to iRNAs which target nucleic acid sequences of TiLV. The invention is also related to immunogenic compositions, including antibodies and vaccines, for inducing an immune response against TiLV in an animal. The invention is also related to gene constructs and cells comprising TiLV and isolated nucleic acids sequences and polypeptides thereof for use in developing prophylactic and therapeutic agents.
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公开(公告)号:US20210090182A1
公开(公告)日:2021-03-25
申请号:US16579454
申请日:2019-09-23
Applicant: International Business Machines Corporation , TRUSTEES OF TUFTS COLLEGE , Ramot at Tel-Aviv University Ltd.
Inventor: Lior Horesh , Osman Asif Malik , Shashanka Ubaru , Misha E. Kilmer , Haim Avron
IPC: G06Q50/00 , G06F16/901 , G06N20/00 , G06F17/16
Abstract: A computer-implemented method for analyzing a time-varying graph is provided. The time-varying graph includes nodes representing elements in a network, edges representing transactions between elements, and data associated with the nodes and the edges. The computer-implemented method includes constructing, using a processor, adjacency and feature matrices describing each node and edge of each time-varying graph for stacking into an adjacency tensor and describing the data of each time-varying graph for stacking into a feature tensor, respectively. The adjacency and feature tensors are partitioned into adjacency and feature training tensors and into adjacency and feature validation tensors, respectively. An embedding model and a prediction model are created using the adjacency and feature training tensors. The embedding and prediction models are validated using the adjacency and feature validation tensors to identify an optimized embedding-prediction model pair.
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公开(公告)号:US10912485B2
公开(公告)日:2021-02-09
申请号:US15784263
申请日:2017-10-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Yaniv Assaf , Daniel Barazany
Abstract: A method of identifying brain structures is disclosed. The method comprises imaging the cortex of the brain via inversion recovery magnetic resonance imaging, such that at least two areas are zeroed in terms of their longitudinal relaxation times, and associating the two areas with different brain structures, thereby identifying brain structures.
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公开(公告)号:US20200380687A1
公开(公告)日:2020-12-03
申请号:US16959693
申请日:2019-01-03
Applicant: Ramot at Tel-Aviv University Ltd. , Tel HaShomer Medical Research Infrastrastructure and Services Ltd.
Inventor: Yitzhak AVITAL , Nahum KIRYATI , Eli KONEN , Arnaldo MAYER
Abstract: There is provided a computer implemented method of automatic segmentation of three dimensional (3D) anatomical region of interest(s) (ROI) that includes predefined anatomical structure(s) of a target individual, comprising: receiving 3D images of a target individual, each including the predefined anatomical structure(s), each 3D image is based on a different respective imaging modality. In one implementation, each respective 3D image is inputted into a respective processing component of a multi-modal neural network, wherein each processing component independently computes a respective intermediate, and the intermediate outputs are inputted into a common last convolutional layer(s) for computing the indication of segmented 3D ROI(s). In another implementation, each respective 3D image is inputted into a respective encoding-contracting component a multi-modal neural network, wherein each encoding-contracting component independently computes a respective intermediate output. The intermediate outputs are inputted into a single common decoding-expanding component for computing the indication of segmented 3D ROI(s).
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公开(公告)号:US20200371173A1
公开(公告)日:2020-11-26
申请号:US16992160
申请日:2020-08-13
Applicant: Tel HaShomer Medical Research Infrastructure and Services Ltd. , Ramot at Tel-Aviv University Ltd.
Inventor: Yael MARDOR , Leor ZACH , David GUEZ , David LAST , Dianne DANIELS ELMAKIAS
IPC: G01R33/28 , A61B5/055 , G01R33/56 , A61B5/00 , G06T7/00 , G16H40/40 , G16H30/40 , G16H40/63 , G01R33/48
Abstract: Apparatus for operating MRI is disclosed. The apparatus comprises: a control for operating an MRI scanner to carry out an MRI scan; an input for receiving first and second MRI scans respectively at the beginning and end of a predetermined time interval post contrast administration; a subtraction map former for forming a subtraction map from the first and the second MRI scans by analyzing the scans to distinguish between a population in which contrast clearance from the tissue is slower than contrast accumulation, and a population in which clearance is faster than accumulation; and an output to provide an indication of distribution of the populations. The control is configured to carry out the first scan at least five minutes and no more than twenty minutes post contrast administration and to carry out the second scan such that the predetermined time period is at least twenty minutes.
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公开(公告)号:US10822375B2
公开(公告)日:2020-11-03
申请号:US16161504
申请日:2018-10-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Illana Gozes , Saar Oz , Jacqueline Woang Cheing Tiong
Abstract: This invention provides novel compounds and methods for promoting cell survival and/or plasticity, especially in neuronal cells, by targeting the microtubule End Binding (EB) proteins and other associated proteins (e.g., drebrin). Methods for identifying potential modulators of cell death/plasticity are also described.
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公开(公告)号:US10816614B2
公开(公告)日:2020-10-27
申请号:US16077497
申请日:2017-02-14
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Alexander Gerber , Gil Markovich , Leah Ben Gur , Einat Tirosh
Abstract: A magnetic field sensor system comprises an electrically conducting film of ferromagnetic nanoparticles printed directly on a supporting structure, and electrically conducting contacts coupled to the film for injecting an electric current into the film and measuring a voltage generated across said film responsive to said injected current in a direction that is generally perpendicular to the current direction in the plane of the film.
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公开(公告)号:US20200308232A1
公开(公告)日:2020-10-01
申请号:US15929356
申请日:2020-04-28
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Jonathan GERSHONI , Natalia T. FREUND
IPC: C07K14/005 , A61K39/215 , A61K39/12 , A61P31/14
Abstract: Provided are polypeptides derived from the coronaviruses (CoVs) Spike protein (S) characterized by high affinity and specificity the S receptor and its neutralizing antibodies. Further provided are compositions and vaccines, and vaccine-based therapies targeting CoVs, and SARS and MERS viruses in particular.
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