Abstract:
The present invention provides DNAzymes which specifically cleaves mRNA transcribed from a member of the bcl-2 gene family selected from the group consisting of bcl-2, bcl-xl, bcl-w, bfl-1, brag-1, Mcl-1 and A1. The DNAzymes comprise (a) a catalytic domain that has the nucleotide sequence GGCTAGCTACAACGA (SEQ ID NO.1) and cleaves mRNA at any purine: pyrimidine cleavage site at which it is directed, (b) a binding domain contiguous with the 5′ end of the catalytic domain, and (c) another binding domain contiguous with the 3′ end of the catalytic domain. The binding domains are complementary to, and therefore hybridise with, the two regions immediately flanking the purine residue of the cleavage site within the bcl-2 gene family mRNA, at which DNAzyme-catalysed cleavage is desired. Each binding domain is at least six nucleotides in length, and both binding domains have a combined total length of at least 14 nucleotides.
Abstract translation:本发明提供了特异性切割从bcl-2基因家族成员转录的mRNA的DNA酶,其选自bcl-2,bcl-xl,bcl-w,bfl-1,brag-1,Mcl-1和 A1。 DNAzymes包含(a)具有核苷酸序列GGCTAGCTACAACGA(SEQ ID NO.1)的催化结构域,并在任何嘌呤:其所针对的嘧啶切割位点处切割mRNA,(b)与5'端连接的结合结构域 的催化结构域,和(c)与催化结构域的3'末端相邻的另一个结合结构域。 结合结构域与bcl-2基因家族mRNA内的切割位点的嘌呤残基紧邻的两个区域互补,并因此杂交,需要DNA酶催化切割。 每个结合结构域的长度至少为6个核苷酸,两个结合结构域的总长度至少为14个核苷酸。
Abstract:
An electronic business device on web page for flower shops which provides instant sound and image. This electronic business device allows electronic purchasing and it not only provides the convenience of web page order but also provides direct selection of flower product by consumers. The consumers can directly communicate with the flower shop to proceed with interaction. The electronic business device allows the consumer to process with ordering and purchasing similar to purchasing on the spot.
Abstract:
Improved designs of fiber collimators that include an asymmetric sleeve are disclosed. According to one embodiment of the present invention, the asymmetric sleeve is so shaped that, when arranged next to each other, two collimators with the asymmetric sleeve achieves a lateral distance shorter than the outer diameter of the collimators, which makes it possible to design smaller optical components without effecting the performance and characteristics thereof.
Abstract:
In an implantable pacemaker/cardioverter/defibrillator, a system for correlating the delivery of a cardioversion therapy to an optimum point or phase of the respiratory cycle of the patient to effect delivery of the therapy when the impedance between the cardioversion electrodes is minimized. In a first application for use with cardioversion electrodes located substantially in contact with the heart chamber, the optimum point or phase is at the end of inspiration. In a second application for use with at least one cardioversion electrode located remotely from the heart chamber, the optimum point or phase is at end expiration or beginning of inspiration. The cardioversion therapy is delivered in synchrony with a ventricular sense event, if present. If the optimum point or phase of the respiratory cycle cannot be determined during a therapy time, a pre-shock may be delivered to elicit a respiration cycle through a stimulated contraction of the diaphragm.
Abstract:
A process for chemical bath deposition of selenide and sulfide salts as films and powders employable as precursors for the fabrication of solar cell devices. The films and powders include (1) Cu.sub.x Se.sub.n, wherein x=1-2 and n=1-3; (2) Cu.sub.x Ga.sub.y Se.sub.n, wherein x=1-2, y=0-1 and n=1-3; (3) Cu.sub.x In.sub.y Se.sub.n, wherein x=1-2.27, y=0.72-2 and n=1-3; (4) Cu.sub.x (InGa).sub.y Se.sub.n, wherein x=1-2.17, y=0.96-2 and n=1-3; (5) In.sub.y Se.sub.n, wherein y=1-2.3 and n=1-3; (6) Cu.sub.x S.sub.n, wherein x=1-2 and n=1-3; and (7) Cu.sub.x (InGa).sub.y (SeS).sub.n, wherein x=1-2, y=0.07-2 and n=0.663-3. A reaction vessel containing therein a substrate upon which will form one or more layers of semiconductor material is provided, and relevant solution mixtures are introduced in a sufficient quantity for a sufficient time and under favorable conditions into the vessel to react with each other to produce the resultant salt being prepared and deposited as one or more layers on the substrate and as a powder on the floor of the vessel. Hydrazine is present during all reaction processes producing non-gallium containing products and optionally present during reaction processes producing gallium-containing products to function as a strong reducing agent and thereby enhance reaction processes.
Abstract:
The instant invention provides an olefin polymerization catalyst comprising chromium and titanium supported on silica. The catalyst is prepared with a low sodium ammonia-stabilized silica sol which has an average silicate particle size of from about 2 to about 6 nm. The catalyst produces polyethylene or a copolymer of ethylene and another olefin selected from the group consisting of the C.sub.3 to C.sub.8 mono 1-olefins, the polymer having a high melt index and a narrow molecular weight distribution.
Abstract:
FIG. 1 is a front perspective view of a lamp, showing my new design; FIG. 2 is a rear perspective view thereof; FIG. 3 is a perspective view of the lamp in an alternate state thereof; FIG. 4 is a front view thereof; FIG. 5 is a rear view thereof; FIG. 6 is a left side view thereof; FIG. 7 is a right side view thereof; FIG. 8 is a top view thereof; and, FIG. 9 is a bottom view.
Abstract:
FIG. 1 is a first perspective view of a wireless charger showing my new design; FIG. 2 is a second perspective view thereof; FIG. 3 is a front view thereof; FIG. 4 is a back view thereof; FIG. 5 is a left side view thereof FIG. 6 is a right side view thereof; FIG. 7 is a top view thereof; FIG. 8 is a bottom view thereof; FIG. 9 is a perspective view of another state of the wireless charger thereof; and, FIG. 10 is a perspective view of another state of the wireless charger thereof. The broken lines shown in the drawings depict portions of the wireless charger that form no part of the claimed design.
Abstract:
FIG. 1 is a first perspective view of a wireless charger showing my new design; FIG. 2 is a second perspective view thereof; FIG. 3 is a front view thereof; FIG. 4 is a back view thereof; FIG. 5 is a left side view thereof; FIG. 6 is a right side view thereof; FIG. 7 is a top view thereof; FIG. 8 is a bottom view thereof; FIG. 9 is a perspective view of another state of the wireless charger thereof; and, FIG. 10 is a perspective view of another state of the wireless charger thereof. The broken lines shown in the drawings depict portions of the wireless charger that form no part of the claimed design.
Abstract:
Provided are a semiconductor device and a method of manufacturing the same. The semiconductor device includes a substrate and a PIP capacitor located. The PIP capacitor includes a first polysilicon layer, a metallic silicide layer, a protective layer, a dielectric layer, and a second polysilicon layer, which have a lower conductive plate pattern and are successively arranged. The method includes: providing a substrate; successively forming a first polysilicon layer, a metallic silicide, and a protective layer on the substrate; transferring a lower conductive plate pattern into the first polysilicon layer, the metallic silicide layer, and the protective layer, thus forming the first polysilicon layer, the metallic silicide layer, and the protective layer having the lower conductive plate pattern; successively forming a dielectric layer and a second polysilicon layer having a lower conductive plate pattern on the protective layer. The capacitance and reliability of the PIP capacitor are improved.