利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

28 条记录 (耗时 0.018 秒)

    Method for the treatment of osteoarthritis
    22.
    发明授权
    Method for the treatment of osteoarthritis 有权

    公开(公告)号：US11123354B2

    公开(公告)日：2021-09-21

    申请号：US16467207

    申请日：2017-12-06

    申请人： ABIOGEN PHARMA S.P.A.

    发明人： Fabio Neggiani ,  Silvia Trasciatti

    IPC分类号： A61K31/663 ,  A61P19/02 ,  A61K9/00 ,  A61K9/08 ,  A61K47/02

    摘要： The present invention relates to a composition for use in the treatment of osteoarthritis (OA), wherein said composition comprises from 5 to 40 mg of sodium chlodronate, or an equivalent amount of chlodronic acid, or other pharmaceutically acceptable salts thereof, and wherein said composition is administered intra-articularly in a unitary dosage form once monthly, once biweekly or once weekly. Single-dose medicaments and kits comprising them are also described.

    PROCESS FOR PREPARING A CRYSTALLINE FORM COMPOUND OF 3-BENZYL-2-METHYL-2,3,3a,4,5,6,7,7a-OCTAHYDROBENZO[d]ISOXAZOL-4-ONE
    26.
    发明申请
    PROCESS FOR PREPARING A CRYSTALLINE FORM COMPOUND OF 3-BENZYL-2-METHYL-2,3,3a,4,5,6,7,7a-OCTAHYDROBENZO[d]ISOXAZOL-4-ONE 审中-公开
    制备3-苄基-2-甲基-2,3,3a，4,5,6,7,7a-八氢噻吩并[d]异恶唑-4-酮的晶体形式化合物的方法

    公开(公告)号：US20110039902A1

    公开(公告)日：2011-02-17

    申请号：US12989069

    申请日：2009-04-23

    申请人： Fabio Neggiani ,  Elio Napolitano ,  Simone Basagni ,  Barbara Politi

    发明人： Fabio Neggiani ,  Elio Napolitano ,  Simone Basagni ,  Barbara Politi

    IPC分类号： A61K31/423 ,  C07D261/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/08 ,  A61P25/30

    CPC分类号： C07D261/20

    摘要： A process for preparing a crystalline form compound of 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one is described, comprising the step of reacting 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydroben-zo[d]isoxazol-4-one with oxalic acid in one or more solvents, wherein at least one solvent is a solvent having a carbon atom number of from 3 to 6, said solvent being non-halogenated and having a dielectric constant ∈ within the range from 4 to 25. The process of the invention enables a co-crystal comprising 3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one and oxalic acid to be obtained.

    摘要翻译： 描述了制备3-苄基-2-甲基-2,3,3a，4,5,6,7,7a-八氢苯并[d]异恶唑-4-酮的结晶形式化合物的方法，包括使 3-苄基-2-甲基-2,3,3a，4,5,6,7,7a-八氢苯并[d]异恶唑-4-酮与一种或多种溶剂中的草酸反应，其中至少一种溶剂是 碳原子数为3至6的溶剂，所述溶剂是非卤化的并且介电常数ε在4至25的范围内。本发明的方法使得能够包含3-苄基-2- 甲基-2,3,3a，4,5,6,7,7a-八氢苯并[d]异恶唑-4-酮和草酸。

    SALT OF 3-BENZYL-2-METHYL-2,3,3A,4,5,6,7, 7A- OCTAHYDROBENZO[D]ISOXAZOL-4-ONE
    27.
    发明申请
    SALT OF 3-BENZYL-2-METHYL-2,3,3A,4,5,6,7, 7A- OCTAHYDROBENZO[D]ISOXAZOL-4-ONE 审中-公开
    3-苯甲基-2-甲基-2,3,3a，4,5,6,7,7a-八氢噻吩并[D]异恶唑-4-酮的盐

    公开(公告)号：US20100069451A1

    公开(公告)日：2010-03-18

    申请号：US12513352

    申请日：2007-10-31

    申请人： Fabio Neggiani ,  Laura Dini

    发明人： Fabio Neggiani ,  Laura Dini

    IPC分类号： A61K31/423 ,  C07D261/20 ,  A61P25/00

    CPC分类号： C07D261/20

    摘要： The present invention relates to oxalate salt of the compound of formula (I) in all its stereochemical configurations, a process for its preparation and its use in treating mood disorders, disorders of anxiety, depression and convulsive conditions, in the improvement of learning ability, in the reversal of amnesia, in resolving the abstinence syndrome from drugs and drugs of abuse. Preferably, the invention concerns oxalate salt of rel-(3R,3aS,7aS)-3-benzyl-2-methyl-2,3,3a,4,5,6,7,7a-octahydrobenzo[d]isoxazol-4-one.

    摘要翻译： 本发明涉及其所有立体化学构型的式（I）化合物的草酸盐，其制备方法及其在治疗情绪障碍，焦虑障碍，抑郁和惊厥症状中的用途，提高学习能力， 在解除戒毒综合症药物和药物滥用的情况下进行健忘症的逆转。 优选地，本发明涉及rel-（3R，3aS，7aS）-3-苄基-2-甲基-2,3,3a，4,5,6,7,7a-八氢苯并[d]异恶唑-4-甲酸的草酸盐 一。