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公开(公告)号：US20240279158A1
公开(公告)日：2024-08-22
申请号：US18604045
申请日：2024-03-13
发明人： Ho Wan HAM , Hyun Cheol AN , Dong Jun KIM , Dong Hyun LEE , Ja Eun ANN , Dong Yuel KWON , Sung Kyu LEE , Tae Jin LEE , Yeong Rong PARK , Dae Woong LEE , Il Soo OH , Bo Ra LEE , Hyeon Jeong IM , Ill Hun CHO
IPC分类号： C07C233/58 , C07C211/53 , C07C233/59 , C07C233/60 , C07C233/62 , C07C255/46 , C07C323/40 , C07D211/16 , C07D295/32 , C07F7/08 , H10K50/858
CPC分类号： C07C233/58 , C07C211/53 , C07C233/59 , C07C233/60 , C07C233/62 , C07C255/46 , C07C323/40 , C07D211/16 , C07D295/32 , C07F7/081 , C07C2601/14 , C07C2601/16 , C07C2601/18 , C07C2602/42 , C07C2602/44 , C07C2603/74 , H10K50/858
摘要： A novel compound for a capping layer, and an organic light emitting device containing the same are disclosed. The compound for a capping layer is represented by Formula 1 below:
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公开(公告)号：US11857550B2
公开(公告)日：2024-01-02
申请号：US16953201
申请日：2020-11-19
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , The United States Government as represented by the Department of Veterans Affairs
发明人： Beibei Chen , Rama K. Mallampalli
IPC分类号： A61K31/506 , A61K31/137 , C07D239/26 , C07D403/12 , A61P3/10 , A61P11/06 , A61P19/00 , A61P25/00 , A61P35/00 , C07D231/12 , C07D233/61 , A61K31/341 , A61K31/381 , A61K31/402 , A61K31/4155 , A61K31/427 , A61K31/4418 , A61K31/5375 , C07D213/36 , C07C211/01 , C07C211/53 , C07C229/38 , C07D207/06 , C07D211/14 , C07D213/06 , C07D213/38 , C07D265/30 , C07D277/28 , A61K31/4178 , A61K31/435 , A61K31/444 , C07D233/64 , C07D401/12 , C07D295/135
CPC分类号： A61K31/506 , A61K31/137 , A61K31/341 , A61K31/381 , A61K31/402 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/435 , A61K31/444 , A61K31/4418 , A61K31/5375 , A61P3/10 , A61P11/06 , A61P19/00 , A61P25/00 , A61P35/00 , C07C211/01 , C07C211/53 , C07C229/38 , C07D207/06 , C07D211/14 , C07D213/06 , C07D213/36 , C07D213/38 , C07D231/12 , C07D233/61 , C07D233/64 , C07D239/26 , C07D265/30 , C07D277/28 , C07D295/135 , C07D401/12 , C07D403/12 , Y02A50/30
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:
wherein X is a divalent linking moiety; and
R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.-
公开(公告)号：US20170204036A1
公开(公告)日：2017-07-20
申请号：US15313474
申请日：2015-05-26
发明人： Declan GILHEANY , Bartosz BIESZCZAD
IPC分类号： C07C45/69 , C07C41/30 , C07D235/12 , C07D311/76 , C07C215/64 , C07C211/53 , C07C215/50 , C07C29/40 , C07C211/36
CPC分类号： C07C45/69 , C07B2200/07 , C07C29/40 , C07C41/30 , C07C211/36 , C07C211/53 , C07C215/50 , C07C215/64 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07C2602/18 , C07D235/12 , C07D311/76 , C07C33/20 , C07C31/125 , C07C33/46 , C07C35/32 , C07C43/23 , C07C49/213 , C07C33/30 , C07C33/24 , C07C33/18 , C07C31/1355 , C07C35/23 , C07C35/36
摘要： A process for the stereoselective preparation of a chiral alcohol or a chiral amine, the process comprising reacting a first prochiral reactant selected from the group consisting of a ketone, an aldehyde, and an imine, with a second reactant comprising a Grignard reagent, in the presence of a chiral trans-diamine of formula (1) as defined herein: Also provided is the use of the chiral trans-diamine of formula (1) in a Grignard reaction and the chiral trans-diamines per se.
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4.发明申请公开(公告)号：US20170037008A1
公开(公告)日：2017-02-09
申请号：US15101385
申请日：2014-11-06
发明人： Zhiyong Zhang , Mengchao Cui , Chunping Lin , Boli Liu , Yuzhi Guo
IPC分类号： C07D213/64 , C07C201/12 , C07C43/205 , C07C319/20 , C07C217/86 , C07C213/02 , C07C323/20 , C07C205/37 , C07C41/18
CPC分类号： C07D213/64 , A61K51/04 , A61K51/0406 , C07B2200/05 , C07C41/18 , C07C43/2055 , C07C43/225 , C07C43/23 , C07C201/12 , C07C205/37 , C07C211/53 , C07C213/02 , C07C217/86 , C07C319/20 , C07C323/20 , C07D213/65 , C07F7/2208
摘要： Parts of compounds, after being labeled by radionuclide, of the phenyl benzyl ether derivative, are used as Aβ plaque imaging agent. The structural formula of the phenyl benzyl ether derivative is shown by formula (I). The present invention develops a kind of brand new phenyl benzyl ether derivative which has high affinity with Aβ plaques in brains of AD patients. The chemical structure of the phenyl benzyl ether derivative is different from that of compounds disclosed in the prior art and the phenyl benzyl ether derivative belongs to a brand new compound for diagnosing and treating AD. The obtained Aβ plaque imaging agent has the advantages that the in-vivo stability is good, the fat solubility is low, the removal speed for the brain is fast, the problem of removing the radionuclide in vivo does not exist, and the application prospect and the market value are great.
摘要翻译： 本发明涉及苯基苄基醚衍生物及其制备方法和用途，一部分化合物在放射性核素标记后作为Aβ斑块显像剂，苯基苄基醚衍生物用于制备 用于诊断和治疗阿尔茨海默病（AD）的药物。 苯基苄基醚衍生物具有式（I）所示的结构式; 本发明开发了一种对AD患者大脑中的Aβ斑块具有高亲和力的全新苯基苄基醚衍生物，其化学结构与现有技术公开的化合物的化学结构不同，属于 用于诊断和治疗阿尔茨海默病的全新化合物; 得到的Aβ噬菌斑显像剂体内稳定性好，脂质溶解度低，使得脑部消除速度快，体内不含放射性核素的去除问题，具有广阔的应用前景， 市场价值。
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5.发明授权Organo-amine acid gas adsorption-desorption polymers, processes for preparing same, and uses thereof 有权有机胺酸性气体吸附 - 解吸聚合物，其制备方法及其应用公开(公告)号：US09533248B2
公开(公告)日：2017-01-03
申请号：US14791800
申请日：2015-07-06
IPC分类号： C08L79/00 , C07C209/06 , B01J20/22 , B01J20/26 , B01D53/02 , B01D53/62 , C08G73/02 , C08J9/26 , C08J9/28 , B01J20/28 , B01J20/30 , B01J20/34 , C08G73/00 , B01D53/40 , C07C211/53 , C08J9/14
CPC分类号： B01D53/02 , B01D53/40 , B01D53/62 , B01D2251/80 , B01D2253/202 , B01D2253/311 , B01D2256/24 , B01D2257/504 , B01D2258/0283 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/3085 , B01J20/3425 , B01J20/3483 , B01J20/3491 , B01J2220/56 , C07C211/53 , C08G73/00 , C08G73/02 , C08G73/0206 , C08J9/141 , C08J9/26 , C08J9/28 , C08J2201/026 , C08J2201/0502 , C08J2203/14 , C08J2379/02 , Y02C10/04 , Y02C10/08 , Y02P20/152 , Y10T428/2982
摘要： An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having a weight average molecular weight of from about 500 to about 1×106, a total pore volume of from about 0.2 cubic centimeters per gram (cc/g) to about 2.0 cc/g, and an adsorption capacity of at least about 0.2 millimoles of CO2 adsorbed per gram of adsorption-desorption material, and linear organo-amine polymeric materials having a weight average molecular weight of from about 160 to about 1×106, a total pore volume of from about 0.2 cubic centimeters per gram (cc/g) to about 2.0 cc/g, and an adsorption capacity of at least about 0.2 millimoles of CO2 adsorbed per gram of adsorption-desorption material. This disclosure also relates in part to processes for preparing the crosslinked organo-amine materials and linear organo-amine materials. This disclosure further relates in part to the selective removal of CO2 and/or other acid gases from a gaseous stream containing one or more of these gases using the adsorption-desorption materials.
摘要翻译： 吸附解吸材料，特别是重均分子量为约500至约1×10 6的交联有机胺聚合物材料，总孔体积为约0.2立方厘米每克（cc / g）至约 2.0cc / g，每克吸附 - 解吸材料吸附至少约0.2毫摩尔二氧化碳的吸附能力，重均分子量为约160至约1×106的线性有机胺聚合物， 总孔体积为约0.2立方厘米每克（cc / g）至约2.0cc / g，吸附能力为每克吸附 - 解吸材料吸附至少约0.2毫摩尔二氧化碳。 本公开还部分涉及制备交联的有机胺材料和线性有机胺材料的方法。 本公开还部分地涉及使用吸附 - 解吸材料从含有一种或多种这些气体的气流中选择性除去CO 2和/或其它酸性气体。
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公开(公告)号：US09359284B2
公开(公告)日：2016-06-07
申请号：US14406189
申请日：2013-03-13
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education , The United States Government as represented by the Department of Veterans Affairs
发明人： Beibei Chen , Rama K. Mallampalli
IPC分类号： C07D239/26 , C07D213/36 , C07D295/135 , C07C211/01 , A61K31/137 , A61K31/341 , A61K31/381 , A61K31/402 , A61K31/4155 , A61K31/427 , A61K31/4418 , A61K31/506 , A61K31/5375 , C07D231/12 , C07D233/61 , C07C211/53 , C07C229/38 , C07D207/06 , C07D211/14 , C07D213/06 , C07D213/38 , C07D265/30 , C07D277/28 , C07D403/12 , C07D401/12
CPC分类号： A61K31/506 , A61K31/137 , A61K31/341 , A61K31/381 , A61K31/402 , A61K31/4155 , A61K31/4178 , A61K31/427 , A61K31/435 , A61K31/4418 , A61K31/444 , A61K31/5375 , A61P3/10 , A61P11/06 , A61P19/00 , A61P25/00 , A61P35/00 , C07C211/01 , C07C211/53 , C07C229/38 , C07D207/06 , C07D211/14 , C07D213/06 , C07D213/36 , C07D213/38 , C07D231/12 , C07D233/61 , C07D233/64 , C07D239/26 , C07D265/30 , C07D277/28 , C07D295/135 , C07D401/12 , C07D403/12 , Y02A50/411 , Y02A50/473
摘要： A compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of: wherein X is a divalent linking moiety; and R1-R10 are each individually H, optionally-substituted alkyl, optionally-substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, halogen, amino, or hydroxy, provided that at least one of R3 or R8 is an optionally-substituted alkyl, a substituted alkoxy, optionally-substituted aryl, optionally-substituted cycloalkyl, optionally-substituted heterocyclic, or halogen.
摘要翻译： 具有以下结构的化合物或其药学上可接受的盐或酯：其中X是二价连接部分; 和R 1 -R 10各自独立地为H，任选取代的烷基，任选取代的烷氧基，任选取代的芳基，任选取代的环烷基，任选取代的杂环，卤素，氨基或羟基，条件是R 3或R 8中的至少一个 是任选取代的烷基，取代的烷氧基，任选取代的芳基，任选取代的环烷基，任选取代的杂环或卤素。
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7.发明申请Tricyclic Amino Containing Compounds for Treatment or Prevention of Symptoms Associated with Endocrine Dysfunction 审中-公开用于治疗或预防与内分泌功能障碍有关的症状的三环氨基含有化合物公开(公告)号：US20160058761A1
公开(公告)日：2016-03-03
申请号：US14934715
申请日：2015-11-06
IPC分类号： A61K31/506 , A61K45/06
CPC分类号： A61K31/506 , A61K31/137 , A61K31/138 , A61K31/167 , A61K31/4166 , A61K31/444 , A61K31/505 , A61K31/57 , A61K31/575 , A61K31/58 , A61K38/2073 , A61K45/06 , C07C211/27 , C07C211/52 , C07C211/53 , C07C229/60 , C07C233/11 , C07C233/58 , C07C233/64 , C07C233/65 , C07C233/75 , C07C237/40 , C07C255/58 , C07C279/04 , C07C279/18 , C07D213/72 , C07D213/74 , C07D239/42 , C07D401/12 , C07D403/12 , A61K2300/00
摘要： The disclosure provides methods of use of certain compounds that are useful for treating certain symptoms of endocrine disturbances, and in particular those associated with hot flashes.
摘要翻译： 本公开提供了可用于治疗某些内分泌紊乱症状的某些化合物的使用方法，特别是与潮热相关的化合物。
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8.发明申请ORGANO-AMINE ACID GAS ADSORPTION-DESORPTION POLYMERS, PROCESSES FOR PREPARING SAME, AND USES THEREOF 有权有机酸酸气体吸收分解聚合物，其制备方法及其用途公开(公告)号：US20150307661A1
公开(公告)日：2015-10-29
申请号：US14791772
申请日：2015-07-06
IPC分类号： C08G73/02 , C07C211/53 , B01D53/02
CPC分类号： B01D53/02 , B01D53/40 , B01D53/62 , B01D2251/80 , B01D2253/202 , B01D2253/311 , B01D2256/24 , B01D2257/504 , B01D2258/0283 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/3085 , B01J20/3425 , B01J20/3483 , B01J20/3491 , B01J2220/56 , C07C211/53 , C08G73/00 , C08G73/02 , C08G73/0206 , C08J9/141 , C08J9/26 , C08J9/28 , C08J2201/026 , C08J2201/0502 , C08J2203/14 , C08J2379/02 , Y02C10/04 , Y02C10/08 , Y02P20/152 , Y10T428/2982
摘要： An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having a weight average molecular weight of from about 500 to about 1×106, a total pore volume of from about 0.2 cubic centimeters per gram (cc/g) to about 2.0 cc/g, and an adsorption capacity of at least about 0.2 millimoles of CO2 adsorbed per gram of adsorption-desorption material, and linear organo-amine polymeric materials having a weight average molecular weight of from about 160 to about 1×106, a total pore volume of from about 0.2 cubic centimeters per gram (cc/g) to about 2.0 cc/g, and an adsorption capacity of at least about 0.2 millimoles of CO2 adsorbed per gram of adsorption-desorption material. This disclosure also relates in part to processes for preparing the crosslinked organo-amine materials and linear organo-amine materials. This disclosure further relates in part to the selective removal of CO2 and/or other acid gases from a gaseous stream containing one or more of these gases using the adsorption-desorption materials.
摘要翻译： 吸附解吸材料，特别是重均分子量为约500至约1×10 6的交联有机胺聚合物材料，总孔体积为约0.2立方厘米每克（cc / g）至约 2.0cc / g，每克吸附 - 解吸材料吸附至少约0.2毫摩尔二氧化碳的吸附能力，重均分子量为约160至约1×106的线性有机胺聚合物， 总孔体积为约0.2立方厘米每克（cc / g）至约2.0cc / g，吸附能力为每克吸附 - 解吸材料吸附至少约0.2毫摩尔二氧化碳。 本公开还部分涉及制备交联的有机胺材料和线性有机胺材料的方法。 本公开还部分地涉及使用吸附 - 解吸材料从含有一种或多种这些气体的气流中选择性除去CO 2和/或其它酸性气体。
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9.发明申请公开(公告)号：US20150306542A1
公开(公告)日：2015-10-29
申请号：US14791868
申请日：2015-07-06
CPC分类号： B01D53/02 , B01D53/40 , B01D53/62 , B01D2251/80 , B01D2253/202 , B01D2253/311 , B01D2256/24 , B01D2257/504 , B01D2258/0283 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28057 , B01J20/28069 , B01J20/28078 , B01J20/3085 , B01J20/3425 , B01J20/3483 , B01J20/3491 , B01J2220/56 , C07C211/53 , C08G73/00 , C08G73/02 , C08G73/0206 , C08J9/141 , C08J9/26 , C08J9/28 , C08J2201/026 , C08J2201/0502 , C08J2203/14 , C08J2379/02 , Y02C10/04 , Y02C10/08 , Y02P20/152 , Y10T428/2982
摘要： An adsorption-desorption material, in particular, crosslinked organo-amine polymeric materials having a weight average molecular weight of from about 500 to about 1×106, a total pore volume of from about 0.2 cubic centimeters per gram (cc/g) to about 2.0 cc/g, and an adsorption capacity of at least about 0.2 millimoles of CO2 adsorbed per gram of adsorption-desorption material, and linear organo-amine polymeric materials having a weight average molecular weight of from about 160 to about 1×106, a total pore volume of from about 0.2 cubic centimeters per gram (cc/g) to about 2.0 cc/g, and an adsorption capacity of at least about 0.2 millimoles of CO2 adsorbed per gram of adsorption-desorption material. This disclosure also relates in part to processes for preparing the crosslinked organo-amine materials and linear organo-amine materials. This disclosure further relates in part to the selective removal of CO2 and/or other acid gases from a gaseous stream containing one or more of these gases using the adsorption-desorption materials.
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10.发明申请公开(公告)号：US20090292129A1
公开(公告)日：2009-11-26
申请号：US12278268
申请日：2007-02-01
IPC分类号： C07D207/16 , C07D207/09 , C07D307/24 , C07C255/41 , C07C61/35
CPC分类号： C07D207/06 , C07C211/27 , C07C211/53 , C07C215/08 , C07C233/83 , C07C237/04 , C07C237/06 , C07C311/19 , C07D207/09 , C07D207/16
摘要： A process for resolving a compound in racemic form comprising the following steps is described: a) reacting a compound in racemic form with a resolving agent, b) forming a diastereoisomeric complex of the resolving agent and an enantiomer of interest, c) separating the enantiomer of interest from the obtained diastereoisomer, wherein such a process is characterized in that said resolving agent is a compound of Formula (I). A diastereoisomeric complex between the resolving agent of Formula (I) and the enantiomer of interest is also described. The process according to the invention allows acid and basic racemic mixtures to be separated.
摘要翻译： 描述了一种拆分含外消旋形式的化合物的方法，包括以下步骤：a）使外消旋形式的化合物与拆分剂反应，b）形成拆分剂和目的对映异构体的非对映异构体复合物，c）分离对映异构体 所获得的非对映异构体感兴趣，其中这种方法的特征在于所述拆分剂是式（I）的化合物。 还描述了式（I）的拆分剂与目标对映异构体之间的非对映异构复合物。 根据本发明的方法允许酸和碱性外消旋混合物分离。
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