公开(公告)号：US20120121572A1

公开(公告)日：2012-05-17

申请号：US13320000

申请日：2010-05-14

申请人： Matteo D'Este ,  Giovanni Gennari

发明人： Matteo D'Este ,  Giovanni Gennari

IPC分类号： A61K31/737 ,  A61P17/00 ,  A61P17/06 ,  A61P29/00 ,  A61P11/06 ,  A61K38/47 ,  A61P35/00 ,  A61K38/02 ,  A61P31/22 ,  A61P7/02 ,  A61K38/43 ,  A61K38/48 ,  C08B37/08 ,  A61P37/06

CPC分类号： C08B37/00 ,  A61K8/735 ,  A61K9/0014 ,  A61K9/007 ,  A61K31/136 ,  A61K31/737 ,  A61K38/47 ,  A61K45/06 ,  A61Q1/06 ,  A61Q11/00 ,  C12Y302/01035 ,  A61K2300/00

摘要： The object of the present invention relates to the new and surprising use of sulfated hyaluronic acid (HAS) as regulator agent of the cytokine activity (pro- and anti-inflammatory) and consequently the use of HAS for the preparation of a new medicine for topic use in the prevention and treatment of pathologies associated with the activation and/or deficiency of cytokines of a pro- and anti-inflammatory nature. The Applicant has in fact discovered the exclusive capacity of HAS in modulating the activity of these particular proteins, it has studied the action mechanism and demonstrated the substantial difference between the different sulfated types known in the state of the art, but above all it has demonstrated an unexpectedly high activity of HAS vs different types and strains of Herpes virus, Cytomegalovirus and the virus of vesicular stomatitis. Finally, a further object of the present invention is the use of HAS as a skin absorption promoter of drugs of an anti-inflammatory nature.

摘要翻译： 本发明的目的涉及硫酸化透明质酸（HAS）作为细胞因子活性（促炎和消炎）的调节剂的新颖且令人惊奇的用途，因此使用HAS来制备用于主题的新药 用于预防和治疗与促炎和抗炎性质的细胞因子的活化和/或缺乏相关的病理学。 申请人实际上已经发现HAS在调节这些特定蛋白质的活性方面的排他能力，已经研究了作用机制，并证明了现有技术中已知的不同硫酸化类型之间的显着差异，但首先它已经证实 HAS对疱疹病毒，巨细胞病毒和水泡性口炎病毒的不同类型和毒株的意想不到的高活性。 最后，本发明的另一个目的是使用HAS作为抗炎性质的药物的皮肤吸收促进剂。

公开(公告)号：US20120114609A1

公开(公告)日：2012-05-10

申请号：US13380971

申请日：2010-06-29

申请人： Lanfranco Callegaro ,  Anna Maria Zanellato

发明人： Lanfranco Callegaro ,  Anna Maria Zanellato

IPC分类号： A61K35/48 ,  A61K35/28 ,  A61P19/08 ,  A61K35/16 ,  A61P19/02 ,  A61P19/00 ,  A61K35/12 ,  A61P17/02

CPC分类号： A61K35/19 ,  A61K9/0014 ,  A61K9/0024 ,  A61K9/06 ,  A61K35/16 ,  A61K35/28 ,  A61K47/36 ,  A61K47/38 ,  A61L27/20 ,  A61L27/3616 ,  A61L27/3834 ,  A61L27/60

摘要： The present invention regards a biological material comprising: a) a liquid carrier comprising a viscous solution containing at least one natural and/or semisynthetic polysaccharide, and having a Dynamic viscosity measured at 20° C. and at shear rate of D=350 s−1, comprised between 100 and 250 c Poise and/or a Kinematic viscosity comprised between 99 and 248cSt (measured at the same conditions); b) a culture of mesenchymal stem cells, and/or c) a platelet-rich hemo-derivative. This type of material in form of viscous liquid is particularly suitable for the therapy of osteoarthrosis, ligament damage, in particular tendon and cartilage damage) and may be administered intra-articularly, intradermally or directly applied in situ without altering the properties of the mesenchymal stem cells and/or platelets contained therein.

摘要翻译： 本发明涉及一种生物材料，其包括：a）液体载体，其包含含有至少一种天然和/或半合成多糖的粘稠溶液，并且具有在20℃下测得的动态粘度和D = 350s- 1，在100和250c之间Poise和/或运动粘度在99和248cSt之间（在相同条件下测量）; b）间充质干细胞的培养，和/或c）富含血小板的血红素衍生物。 这种粘稠液体形式的材料特别适用于治疗骨关节炎，韧带损伤，特别是肌腱和软骨损伤），并且可以在原位进行关节内，皮内或直接施用，而不改变间充质干细胞的性质 细胞和/或血小板。

公开(公告)号：US20100197631A1

公开(公告)日：2010-08-05

申请号：US12665151

申请日：2008-06-25

申请人： Davide Renier ,  Matteo D'este

发明人： Davide Renier ,  Matteo D'este

IPC分类号： A61K31/728 ,  C07H1/00

CPC分类号： A61K31/728 ,  A61K9/0014 ,  A61K9/0021 ,  A61K45/06 ,  A61K47/36 ,  A61K47/61 ,  C08B37/0072

摘要： Disclosed are hyaluronic acid derivatives functionalised with S-nitrosothiol groups of the general formula: wherein HA indicates hyaluronic acid and G indicates a suitable spacer.

摘要翻译： 本发明公开了具有以下通式的S-亚硝基硫醇官能化的透明质酸衍生物：其中HA表示透明质酸，G表示合适的间隔基。

公开(公告)号：US06884818B1

公开(公告)日：2005-04-26

申请号：US10009689

申请日：2000-06-13

申请人： Carla Bevilacqua ,  Giuseppe Di Sante ,  Mario Finesso

发明人： Carla Bevilacqua ,  Giuseppe Di Sante ,  Mario Finesso

IPC分类号： A61K31/37 ,  A61K31/35

CPC分类号： A61K31/37

摘要： The present invention concerns the use of cloricromene (8-chloro-3(β-diethylaminoethyl)-4-methyl-7-ethoxycarbonylmethoxy coumarin) base and the salts thereof to prepare pharmaceutical compositions with cholesterol-lowering activity.

摘要翻译： 本发明涉及氯碱（8-氯-3（β-二乙氨基乙基）-4-甲基-7-乙氧基羰基甲氧基香豆素）碱及其盐在制备具有降胆固醇活性的药物组合物中的用途。

公开(公告)号：US20240217166A1

公开(公告)日：2024-07-04

申请号：US17909787

申请日：2021-03-16

申请人： FIDIA FARMACEUTICI S.p.A.

发明人： Devis GALESSO ,  Riccardo BENINATTO ,  Mauro PAVAN ,  Alba DI LUCIA

IPC分类号： B29C64/106 ,  B33Y70/10 ,  C08B37/00 ,  C08B37/08

CPC分类号： B29C64/106 ,  B33Y70/10 ,  C08B37/006 ,  C08B37/0072

摘要： A bio-ink for use in 3D printing, the related conjugate and the preparation process of an intermediate consisting of a bifunctional photoreactive linker are described. Said bio-inks are used for the manufacturing of constructs by 3D printing.

公开(公告)号：US20230148151A1

公开(公告)日：2023-05-11

申请号：US17917653

申请日：2021-04-15

申请人： FIDIA FARMACEUTICI S.p.A.

发明人： Monica CAMPISI ,  Cristian GUARISE ,  Carlo PIZZOCARO

IPC分类号： A61K47/61 ,  A61K31/337

CPC分类号： A61K47/61 ,  A61K31/337

摘要： An industrial synthesis process of a hyaluronic acid-paclitaxel conjugate obtained by introducing the 4-bromobutyric acid spacer/linker between the hyaluronic acid and the paclitaxel, said conjugate being characterized by a high purity, the related pharmaceutical compositions for use in the treatment of multiple cancer forms are described.

公开(公告)号：US11040089B2

公开(公告)日：2021-06-22

申请号：US15423208

申请日：2017-02-02

申请人： Fidia Farmaceutici S.p.A.

发明人： Susanna Vaccaro ,  Giovanni Gennari ,  Lanfranco Callegaro ,  Antonio Giannelli ,  Salvatore Caruso

IPC分类号： A61K38/48 ,  A61K31/728 ,  A61K47/06 ,  A61K47/10 ,  A61K47/26 ,  A61K47/36 ,  A61K47/44 ,  A61K9/00

摘要： The present invention concerns new compositions containing hyaluronic acid or the derivatives thereof in association with the proteolytic enzyme collagenase (and relative pharmaceutical formulations) for the preparation of a dressing for topical treatment of various kinds of wounds, burns of varying depth, pressure sores, vascular ulcers and diabetic foot ulcers as well as for the treatment of hypertrophic and keloid scars.

公开(公告)号：US10849925B2

公开(公告)日：2020-12-01

申请号：US16313409

申请日：2017-07-27

申请人： FIDIA FARMACEUTICI S.p.A.

发明人： Mara Pittarello ,  Francesco Borile ,  Vincenza Corsa

IPC分类号： C08B37/08 ,  C12P19/04 ,  A61K31/728 ,  A61P41/00 ,  A61P19/02 ,  A61P27/00

摘要： The present invention concerns a process for the preparation and purification of the sodium salt of HA from the fermentation broth of Streptococcus or Bacillus or from rooster combs, the sodium salt of HA obtained and purified with said process and pharmaceutical, cosmetic and nutritional compositions comprising said sodium salt of HA.

公开(公告)号：US20200289604A1

公开(公告)日：2020-09-17

申请号：US16753152

申请日：2018-10-03

申请人： FIDIA FARMACEUTICI S.P.A.

发明人： Antonella SCHIAVINATO ,  Valentina GRECO ,  Luciano MESSINA ,  Susanna VACCARO ,  Enrico RIZZARELLI ,  Sebastiano SCIUTO

IPC分类号： A61K38/05 ,  A61K31/728 ,  A61P19/02 ,  A61P19/10 ,  A61K47/64

摘要： Pharmaceutical compositions are described containing Hyaluronic Acid and Carnosine for use in the treatment and prevention of osteoarthritis (OA) and for the treatment of rheumatoid arthritis (RA).

公开(公告)号：US20190321390A1

公开(公告)日：2019-10-24

申请号：US16344449

申请日：2017-11-13

申请人： FIDIA FARMACEUTICI S.P.A.

发明人： Cristian GUARISE ,  Stefano PLUDA ,  Devis GALESSO

IPC分类号： A61K31/728 ,  A61K31/138 ,  A61K47/36 ,  A61K47/55

摘要： Disclosed is grade 2 sulphated hyaluronic acid having 2 to 60% molar, preferably 15 to 35%, and even more preferably between 20 and 25%, of the carboxyl groups functionalized with dopamine conjugated directly via an amide bond or by means of a spacer having an amino group for the formation of an amide bond with the carboxyl groups of hyaluronic acid and of a carboxyl group for the formation of an amide bond with the amino group of dopamine.