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    MULTI-LAYER ORAL THIN FILM
    21.
    发明申请
    MULTI-LAYER ORAL THIN FILM 有权

    公开(公告)号：US20210030668A1

    公开(公告)日：2021-02-04

    申请号：US16964351

    申请日：2019-01-28

    申请人： LTS LOHMANN THERAPIE-SYSTEME AG

    发明人： Christoph SCHMITZ ,  Michael LINN

    IPC分类号： A61K9/00

    摘要： Described are: a multi-layer oral thin film, comprising at least two layers arranged one on top of the other, which each comprise at least one water-soluble polymer, these at least two layers being connected to one another by at least one sealing, characterised in that the at least one sealing is not provided over the entire surface; a method for producing same; and use thereof as a medicament.

    Medical active substance patch with reduced optical conspicuousness on the skin
    26.
    发明授权
    Medical active substance patch with reduced optical conspicuousness on the skin 有权

    公开(公告)号：US10653636B2

    公开(公告)日：2020-05-19

    申请号：US10553708

    申请日：2004-04-08

    申请人： Stefan Bracht

    发明人： Stefan Bracht

    IPC分类号： A61K9/70

    摘要： A medical active substance patch comprising a matrix of monolayer or multilayer configuration with at least one active substance-containing layer and comprising a backing layer connected with the matrix. The active substance patch is transparent or at least translucent, and in the state of having been applied to the skin of a first person, the patch has a lightness colour value L1 at a place of the skin covered by the patch which is not less than 50% and not more than 200% of a lightness colour value L2, L2 being the lightness value of the region of the skin of the same person which surrounds the applied patch. The same is true of the skin of a second or any other person, provided that for all the persons mentioned L2 is in the range from 5° to 100°, namely from 20° to 90°.

    CONTROL OF ADHESIVE DOMAINS
    27.
    发明申请
    CONTROL OF ADHESIVE DOMAINS 审中-公开

    公开(公告)号：US20200071571A1

    公开(公告)日：2020-03-05

    申请号：US16318430

    申请日：2017-07-19

    申请人： LTS LOHMANN THERAPIE-SYSTEME AG ,  DOW SILICONES CORPORATION

    发明人： Marco EMGENBROICH

    IPC分类号： C09J7/38 ,  C08G77/442 ,  C08G77/20 ,  C09J183/10 ,  C09J11/06 ,  C09J183/04 ,  C08G77/06 ,  C08G77/382 ,  A61K9/70

    摘要： A method of inverting the phase arrangement of the silicone phase and the acrylic phase in a silicone acrylic hybrid composition, the silicone acrylic hybrid composition comprising: a) a silicone acrylic hybrid pressure sensitive adhesive, and b) a solvent, wherein the phase arrangement of the silicone phase and the acrylic phase in the initial silicone acrylic hybrid composition forming a continuous external phase and a discontinuous internal phase is determined by the solvent, comprising the step of adding an activator to the silicone acrylic hybrid composition, wherein the activator a) is liquid at 20° C. and 1013 mbar, b) has a boiling point which is higher than the boiling point of the solvent and/or has a vapor pressure at 20° C. which is lower than the vapor pressure of the solvent contained in the silicone acrylic hybrid composition, and c) provides better dissolution properties for the inner phase of the initial silicone acrylic hybrid composition than the solvent contained in the silicone acrylic hybrid composition.

    Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine
    29.
    发明授权
    Polyvinylpyrrolidone for the stabilization of a solid dispersion of the non-crystalline form of rotigotine 有权

    公开(公告)号：US10130589B2

    公开(公告)日：2018-11-20

    申请号：US15884587

    申请日：2018-01-31

    申请人： UCB Pharma GmbH

    发明人： Hans-Michael Wolff ,  Christoph Arth ,  Luc Quere ,  Walter Müller

    IPC分类号： A61K31/381 ,  A61K9/70

    摘要： The present invention relates to a method for stabilizing rotigotine, the method comprising providing a solid dispersion comprising polyvinylpyrrolidone and a non-crystalline form of rotigotine, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6. The present invention also relates to a solid dispersion comprising a dispersing agent and a dispersed phase, said dispersed phase comprising rotigotine and polyvinylpyrrolidone, wherein the weight ratio of rotigotine to polyvinylpyrrolidone is in a range from about 9:3.5 to about 9:6, a pharmaceutical composition comprising such a solid dispersion, in particular a transdermal therapeutic system, as well as a method for the preparation thereof.

    Microneedle system and method for the production thereof
    30.
    发明授权
    Microneedle system and method for the production thereof 有权

    公开(公告)号：US10105526B2

    公开(公告)日：2018-10-23

    申请号：US15231097

    申请日：2016-08-08

    申请人： LTS LOHMANN THERAPIE-SYSTEME AG

    发明人： Sebastian Scherr ,  Karsten Heuser

    IPC分类号： A61M37/00 ,  A61B5/15 ,  A61B17/20

    摘要： A microneedle system and method for production thereof. From a board a web grating is produced which has a plurality of grating nodes each defined by three apertures and which has web grating wedges. The microneedle system comprising a board and a plurality of openings delimited circumferentially by a web grating, having at each opening at least one web grating wedge having a needle-shaped tip which projects from the board and which is oriented at least approximately normal to the board. Web grating wedges having needle-shaped tips protrude into each aperture from at least three different directions. In order to produce openings, at least all the web grating wedges which protrude into an aperture are bent by a punch and the needle-shaped tips thereof are oriented normal to the plane of the web grating. At least two web grating wedges are arranged at each opening.