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公开(公告)号：US20050037059A1
公开(公告)日：2005-02-17
申请号：US10641654
申请日：2003-08-15
申请人： Kenneth Miller
发明人： Kenneth Miller
CPC分类号： A61M35/00 , A61F2013/0296 , A61K9/703 , A61K9/7084
摘要： Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.
摘要翻译： 用于将一种或多种活性剂施用于主体的皮肤或粘膜的装置形成为双盘补片的性质。 一个外层用作将贴剂粘附到主体上的主要粘合剂层。 另一个内层含有至少一种要施用于宿主的活性剂。 内层通过提供在插入的活性剂不渗透释放层中的开口结合到外层。 释放层将含有内层的活性剂的周边部分与外部粘合剂层分离，以抑制活性剂在其间的迁移。
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22.发明授权Transdermal systems containing multilayer adhesive matrices to modify drug delivery 有权包含多层粘合剂基质以改变药物递送的透皮系统公开(公告)号：US09492401B2
公开(公告)日：2016-11-15
申请号：US12979120
申请日：2010-12-27
CPC分类号： A61K9/7092 , A61F13/00 , A61F2013/00646 , A61F2013/00655 , A61F2013/0071 , A61F2013/00906 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/565 , A61K31/567 , A61M37/00 , Y10T156/10
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译： 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。
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公开(公告)号：US20140249492A1
公开(公告)日：2014-09-04
申请号：US14278486
申请日：2014-05-15
IPC分类号： A61M35/00
CPC分类号： A61M35/00 , A61F2013/0296 , A61K9/703 , A61K9/7084
摘要： Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.
摘要翻译： 用于将一种或多种活性剂施用于宿主皮肤或粘膜的装置形成为双盘补片的性质。 一个外层用作将贴剂粘附到主体上的主要粘合剂层。 另一个内层含有至少一种要施用于宿主的活性剂。 内层通过提供在插入的活性剂不渗透释放层中的开口结合到外层。 释放层将含有内层的活性剂的周边部分与外部粘合剂层分离，以抑制活性剂在其间的迁移。
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公开(公告)号：US08524272B2
公开(公告)日：2013-09-03
申请号：US10641654
申请日：2003-08-15
CPC分类号： A61M35/00 , A61F2013/0296 , A61K9/703 , A61K9/7084
摘要： Devices for administration of one or more active agents to the skin or mucosa of a host are formed in the nature of a double-disk patch. One outer layer functions as the primary adhesive layer for adhering the patch to the host. The other inner layer contains at least one active agent to be administered to the host. The inner layer is bonded to the outer layer through an opening provided in an interposed active agent impermeable release layer. The release layer separates a circumferential portion of the active agent containing inner layer from the outer adhesive layer to inhibit migration of the active agent therebetween.
摘要翻译： 用于将一种或多种活性剂施用于主体的皮肤或粘膜的装置形成为双盘补片的性质。 一个外层用作将贴剂粘附到主体上的主要粘合剂层。 另一个内层含有至少一种要施用于宿主的活性剂。 内层通过提供在插入的活性剂不渗透释放层中的开口结合到外层。 释放层将含有内层的活性剂的周边部分与外部粘合剂层分离，以抑制活性剂在其间的迁移。
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25.发明申请TRANSDERMAL SYSTEMS CONTAINING MULTILAYER ADHESIVE MATRICES TO MODIFY DRUG DELIVERY 有权包含多层粘合剂基体的变态系统修改药物递送公开(公告)号：US20110151003A1
公开(公告)日：2011-06-23
申请号：US12979120
申请日：2010-12-27
IPC分类号： A61K9/14 , A61K31/56 , A61K31/445 , B32B38/10 , B32B37/02
CPC分类号： A61K9/7092 , A61F13/00 , A61F2013/00646 , A61F2013/00655 , A61F2013/0071 , A61F2013/00906 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/565 , A61K31/567 , A61M37/00 , Y10T156/10
摘要： A transdermal drug-containing dosage unit comprises: a backing layer substantially impervious to the drug to be delivered transdermally; a first polymeric adhesive matrix, in contact with the backing layer, having dispersed therein the drug and having a first delivery profile of the drug; a second polymeric adhesive matrix, in contact with said first polymeric adhesive matrix, having dispersed therein the drug and having a second delivery profile of the drug, wherein said second delivery profile is different from said first delivery profile; and a release liner in contact with the second polymeric adhesive matrix.The first polymeric adhesive matrix can release the drug more quickly or more slowly than the second polymeric adhesive matrix. Through the selection of the two matrices, the delivery profile of the drug through the skin can be selectively modified and controlled.
摘要翻译： 含透皮药物的剂量单位包括：基本上不透过经皮递送的药物的背衬层; 与背衬层接触的第一聚合物粘合剂基质，其中分散有药物并具有药物的第一递送曲线; 与所述第一聚合物粘合剂基质接触的第二聚合物粘合剂基质，其中分散有药物并具有药物的第二递送分布，其中所述第二递送分布与所述第一递送分布不同; 以及与第二聚合物粘合剂基质接触的剥离衬垫。 第一聚合物粘合剂基质可以比第二聚合物粘合剂基质更快或更慢地释放药物。 通过选择两个基质，可以选择性地改变和控制药物通过皮肤的递送特征。
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公开(公告)号：US07638140B2
公开(公告)日：2009-12-29
申请号：US10730561
申请日：2003-12-08
申请人： Sharad K. Govil , Ludwig J. Weimann
发明人： Sharad K. Govil , Ludwig J. Weimann
IPC分类号： A61K9/14
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/138 , A61K31/4402 , A61K45/06 , A61K47/32
摘要： Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
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公开(公告)号：US20090234308A1
公开(公告)日：2009-09-17
申请号：US12454782
申请日：2009-05-22
CPC分类号： A61K9/7061 , A61F13/0276 , A61F13/0283 , A61F13/0289 , A61F2013/0296 , A61K9/7053 , A61K9/7092 , A61K31/00 , A61K31/137 , A61K31/565 , A61K47/10 , A61K47/12
摘要： Transdermal delivery systems are disclosed including a backing layer, a polymer membrane within the backing layer, an adhesive layer for attaching the delivery system to the patient's skin or mucosa, and a releasable layer covering the adhesive layer prior to use, the polymer membrane impregnated with sufficient fluid medium to alter the rate of transmission of an active agent through the polymer membrane, with the amount of fluid medium being greater than the amount retained by the fluid membrane upon drying.
摘要翻译： 公开了透皮递送系统，其包括背衬层，背衬层内的聚合物膜，用于将递送系统附着到患者皮肤或粘膜的粘合剂层，以及在使用之前覆盖粘合剂层的可释放层，所述聚合物膜浸渍 足够的流体介质来改变活性剂通过聚合物膜的传播速率，流体介质的量大于干燥时由流体膜保留的量。
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公开(公告)号：US20070156076A1
公开(公告)日：2007-07-05
申请号：US11594224
申请日：2006-11-08
申请人： Kristin Jackson , Kenneth Miller
发明人： Kristin Jackson , Kenneth Miller
IPC分类号： A61F15/00
CPC分类号： A61L15/44 , A61K9/7061 , A61L15/585 , A61L2300/602
摘要： A medical grade adhesive comprises a mixture of at least one cross-linkable pressure sensitive adhesive component and at least one non-cross-linkable pressure-sensitive adhesive component, wherein the amount of each of said components is such that the resultant adhesive can adhere to human skin for a period of up to about 7-10 days but can be removed without causing trauma to the skin.
摘要翻译： 医用级粘合剂包括至少一种可交联压敏粘合剂组分和至少一种不可交联的压敏粘合剂组分的混合物，其中每种所述组分的量使得所得粘合剂可以粘附到 人体皮肤长达约7-10天，但可以去除而不会对皮肤造成伤害。
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公开(公告)号：US07150881B2
公开(公告)日：2006-12-19
申请号：US08883075
申请日：1997-06-26
申请人： Sharad K. Govil , Ludwig J. Weimann
发明人： Sharad K. Govil , Ludwig J. Weimann
IPC分类号： A61F13/00
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/138 , A61K31/4402 , A61K45/06 , A61K47/32
摘要： Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
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公开(公告)号：US07070808B2
公开(公告)日：2006-07-04
申请号：US09754909
申请日：2001-01-05
申请人： Sharad K. Govil , Ludwig J. Weimann
发明人： Sharad K. Govil , Ludwig J. Weimann
CPC分类号： A61K9/7061 , A61K31/137 , A61K31/138 , A61K31/4402 , A61K45/06 , A61K47/32
摘要： Transdermal drug delivery patches and methods of their production are described. The patches can be made such that the accommodate highly plasticizing drugs such as selegiline and/or the use of protonated forms of various drugs.
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