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21.发明申请公开(公告)号：US20040175822A1
公开(公告)日：2004-09-09
申请号：US10740188
申请日：2003-12-18
发明人： Aaron T. Timperman
IPC分类号： C12M001/34 , G01N033/553
CPC分类号： G01N33/54326 , B01L3/502753 , B01L2300/0867 , B01L2400/0409 , B01L2400/0418 , B01L2400/0421 , B01L2400/0487 , C07K1/128 , G01N33/6818
摘要： An apparatus and method for Edman degradation using a microfluidic system to identify and characterize peptides is disclosed. A microfluidic device comprises an entrance channel through which a substantially purified polypeptide is accepted, a reaction channel engaging the entrance channel wherein the substantially purified polypeptide is digested, producing a digestion product, a reagent reservoir engaging the reaction channel, the reagent reservoir capable of delivering a reagent to the reaction channel, and an exit channel extending from the reaction channel, wherein the digestion product travels through the exit channel upon leaving the reaction channel. Protein digestion on the device comprises delivering a substantially purified polypeptide to a reaction channel, confining the polypeptide in the reaction channel, digesting the polypeptide in the reaction channel producing a digestion product, and removing the digestion product from the reaction channel, wherein the last two steps are repeated until the polypeptide is substantially digested.
摘要翻译： 公开了使用微流体系统鉴定和表征肽的Edman降解的装置和方法。 微流体装置包括入口通道，基本上纯化的多肽被接受，入口通道的反应通道，其中基本上纯化的多肽被消化，产生消化产物，与反应通道接合的试剂储存器，能够递送的试剂储存器 反应通道的试剂和从反应通道延伸的出口通道，其中消除产物在离开反应通道时通过出口通道。 在装置上的蛋白质消化包括将基本上纯化的多肽递送至反应通道，将多肽限制在反应通道中，消化产生消化产物的反应通道中的多肽，以及从反应通道中除去消化产物，其中最后两个 重复步骤直到多肽被基本消化。
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公开(公告)号：US20040175067A1
公开(公告)日：2004-09-09
申请号：US10695551
申请日：2003-10-28
发明人： John L. Loth
IPC分类号： F16C019/24
摘要： Rollers used on conveyors and inside the zinc-pot of a steel-sheet galvanizing line are usually driven by friction between the roller and the belt or sheet. To keep rollers from stalling, the bearing diameter is minimized. The allowable bending stress in the bearing shaft limits its length. Rollers operating in high temperature furnaces or in a hot zinc pot of a steel galvanizing line often have limited or non-existent bearing lubrication. In such cases, bearings of small diameter and limited length result in high contact pressure and short lifetime. Inside a zinc-pot, bearing life often does not exceed one week of operation. Most of these bearings are designed to have a stationary bearing housing with the roller shaft rotating inside. For small diameter rollers such shafts are an integral part of the roller. For cylindrical shell type rollers, short shafts are welded to plugs, which are then welded to each end of the roller. The herein disclosed nullBearing Life Extender For Conveyor Type Submerged Rollersnull utilizes bearings, which are smaller in diameter and longer, without an increase in shaft bending momentnull This is made possible by changing from a rotating cantilevered shaft to a stationary shaft strengthened to be substantially non-deflecting on either side of the bearings. Such a stationary shaft can be smaller in diameter to reduce bearing friction torque and stall problems. In addition such a shaft can have increased bearing contact area and assure bearing alignment, all of which contribute to increased bearing life.
摘要翻译： 用于输送机的滚筒和钢板镀锌线的锌锅内部的辊通常由辊和带或片之间的摩擦驱动。 为了保持滚筒停止，轴承直径最小化。 轴承轴的允许弯曲应力限制其长度。 在高温炉或钢镀锌线的热锌锅中操作的辊通常具有有限的或不存在的轴承润滑。 在这种情况下，小直径和有限长度的轴承导致高接触压力和短的使用寿命。 在锌锅内，轴承寿命通常不超过一周的运行。 大多数这些轴承设计成具有固定的轴承壳体，辊轴在内部旋转。 对于小直径辊，这些轴是辊的组成部分。 对于圆柱形壳型辊，短轴焊接到插头上，然后将其焊接到辊的每一端。 本文所公开的“用于输送机型浸没辊的轴承寿命延长器”使用直径更小且更长的轴承，而不增加轴弯矩！ 这可以通过从旋转的悬臂轴转变为固定轴来实现，该固定轴被加强以在轴承的任一侧基本上不偏转。 这样的固定轴的直径可以更小，以减少轴承摩擦扭矩和失速问题。 此外，这种轴可以具有增加的轴承接触面积并确保轴承对准，所有这些都有助于增加轴承寿命。
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公开(公告)号：US10207922B2
公开(公告)日：2019-02-19
申请号：US15415640
申请日：2017-01-25
发明人： Alfred H. Stiller
摘要： A method for producing elemental carbon and hydrogen gas directly from a hydrocarbon (for example, natural gas or methane) using a chemical reaction or series of reactions. In an aspect, other materials involved such as, for example, elemental magnesium, remain unchanged and function as a catalyst.
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公开(公告)号：US10144648B2
公开(公告)日：2018-12-04
申请号：US15618802
申请日：2017-06-09
发明人： Alfred H. Stiller
IPC分类号： C01B32/25 , C01B32/26 , C01B32/942 , C01B32/914 , C01F11/28 , C01F7/58 , C01B32/05 , C01B32/184 , C01B32/36
摘要： The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at low temperatures below about 600° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
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公开(公告)号：US10035709B2
公开(公告)日：2018-07-31
申请号：US15618804
申请日：2017-06-09
发明人： Alfred H. Stiller
IPC分类号： C01B32/25 , C01F7/58 , C01B32/942 , C01B32/36 , C01F11/28
CPC分类号： C01B32/25 , B01J19/24 , C01B32/05 , C01B32/184 , C01B32/26 , C01B32/36 , C01B32/914 , C01B32/942 , C01F7/58 , C01F11/28
摘要： The disclosure provides for methods of oxidizing carbide anions, or negative ions, from salt like carbides at temperatures from about 150° C. to about 750° C. In another aspect, the disclosure provides for reactions with intermediate transition metal carbides. In yet another aspect, the disclosure provides for a system of reactions where salt-like carbide anions and intermediate carbide anions are oxidized to produce pure carbon of various allotropes.
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26.发明授权公开(公告)号：US09909222B2
公开(公告)日：2018-03-06
申请号：US14886319
申请日：2015-10-19
IPC分类号： C01B31/02 , C25B1/00 , C25B11/12 , H01B1/04 , C01B32/00 , C01B32/05 , C01B32/20 , C01B32/182 , C01B32/184 , C01B32/25 , B82Y40/00
CPC分类号： C25B1/00 , B82Y40/00 , C01B32/00 , C01B32/05 , C01B32/182 , C01B32/184 , C01B32/20 , C01B32/25 , C01B2204/22 , C25B11/12 , H01B1/04
摘要： Method comprising providing at least one solid carbide chemical compound and reducing a metal cation with use of the solid carbide chemical compound. A method comprising producing elemental carbon material from the oxidation of carbide in at least one carbide chemical compound (e.g., calcium carbide) in at least one anode of an electrochemical cell apparatus, such as a galvanic cell apparatus. The cathode can be a variety of metals such as zinc or tin. The reaction can be carried out at room temperature and normal pressure. An external voltage also can be applied, and different forms of carbon can be produced depending on the reactants used and voltage applied. For carrying out the method, an apparatus comprising at least one galvanic cell comprising: at least one anode comprising at least one carbide chemical compound, and at least one cathode. For carrying out the method and constructing the apparatus, an electrode structure comprising at least one carbide chemical compound, wherein the carbide chemical compound is a salt-like carbide; and at least one electronically conductive element different from the carbide. Carbon compositions of various forms are also prepared by the methods and apparatus and with use of the electrode structure. Large pieces of pure carbon can be produced. Post-reaction processing of the carbon can be carried out such as exfoliation.
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公开(公告)号：US20090261815A1
公开(公告)日：2009-10-22
申请号：US12388987
申请日：2009-02-19
CPC分类号： G01R1/30 , B81B3/0021 , B82B3/00 , B82Y30/00 , B82Y40/00 , C09K19/02 , Y10S977/773 , Y10S977/84 , Y10S977/932
摘要： Disclosed are various embodiments of methods and systems related to stimulus responsive nanoparticles. In one embodiment includes a stimulus responsive nanoparticle system, the system includes a first electrode, a second electrode, and a plurality of elongated electro-responsive nanoparticles dispersed between the first and second electrodes, the plurality of electro-responsive nanorods configured to respond to an electric field established between the first and second electrodes.
摘要翻译： 公开了与刺激响应纳米颗粒相关的方法和系统的各种实施方案。 在一个实施方案中包括刺激响应纳米颗粒系统，所述系统包括分散在第一和第二电极之间的第一电极，第二电极和多个细长的电响应纳米棒，所述多个电响应纳米棒被配置为响应于 在第一和第二电极之间建立电场。
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公开(公告)号：US5629344A
公开(公告)日：1997-05-13
申请号：US453201
申请日：1995-05-30
申请人： Judie P. Charlton , Ivan R. Schwab
发明人： Judie P. Charlton , Ivan R. Schwab
IPC分类号： A61K31/17 , A61K31/197 , A61K31/4166
CPC分类号： A61K31/4166 , A61K31/17 , A61K31/197 , Y10S514/912
摘要： A topical ophthalmic preparation utilizing a urea and/or urea derivative or mixtures thereof as the principle active ingredient within a range of about 0.01% by weight to about 30% by weight and a method of using the same. When applied to a mammalian eye affected with an abnormal ophthalmological surface problem resulting in epithelial cell loss, keratinization, and/or scarring, the present invention will heal epithelial defects, soften keratin, decrease scarring, enhance hydration, and have anti-mucolytic activity. The present invention provides a method for treating ocular conditions such as dryness, noninfectious keratitis, corneal or conjunctival epithelial irregularities, ocular scarring and subjective irritations.
摘要翻译： 使用尿素和/或尿素衍生物或其混合物作为主要活性成分的约0.01重量％至约30重量％范围内的局部眼用制剂及其使用方法。 当应用于导致上皮细胞丢失，角质化和/或瘢痕形成的异常眼科表面问题的哺乳动物眼睛时，本发明将治愈上皮缺陷，软化角蛋白，减少瘢痕形成，增强水合，并具有抗粘液分解活性。 本发明提供了治疗眼部疾病如干燥，非感染性角膜炎，角膜或结膜上皮不规则，眼瘢痕形成和主观刺激的方法。
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公开(公告)号：US5470881A
公开(公告)日：1995-11-28
申请号：US118265
申请日：1993-09-09
IPC分类号： A61K31/17 , A61K31/197 , A61K31/4166
CPC分类号： A61K31/4166 , A61K31/17 , A61K31/197 , Y10S514/912
摘要： A topical ophthalmic preparation utilizing a urea and/or urea derivative or mixtures thereof as the principle active ingredient within a range of about 0.01% by weight to about 30% by weight and a method of using the same. When applied to a mammalian eye affected with an abnormal ophthalmological surface problem resulting in epithelial cell loss, keratinization, and/or scarring, the present invention will heal epithelial defects, soften keratin, decrease scarring, enhance hydration, and have anti-mucolytic activity. The present invention provides a method for treating ocular conditions such as dryness, noninfectious keratitis, corneal or conjunctival epithelial irregularities, ocular scarring and subjective irritations.
摘要翻译： 使用尿素和/或尿素衍生物或其混合物作为主要活性成分的约0.01重量％至约30重量％范围内的局部眼用制剂及其使用方法。 当应用于导致上皮细胞丢失，角质化和/或瘢痕形成的异常眼科表面问题的哺乳动物眼睛时，本发明将治愈上皮缺陷，软化角蛋白，减少瘢痕形成，增强水合，并具有抗粘液分解活性。 本发明提供了治疗眼部疾病如干燥，非感染性角膜炎，角膜或结膜上皮不规则，眼瘢痕形成和主观刺激的方法。
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30.发明授权公开(公告)号：US11306401B2
公开(公告)日：2022-04-19
申请号：US15866660
申请日：2018-01-10
IPC分类号： C25B1/00 , H01B1/04 , C01B32/00 , C01B32/05 , C01B32/20 , C01B32/182 , C01B32/184 , C01B32/25 , C25B11/043 , B82Y40/00
摘要： An apparatus containing at least one electrochemical cell with an electrode structure. The electrode structure contains at least one carbide chemical compound. The carbide chemical compound may be a salt-like carbide. The electrode may contain at least one electronically conductive element different from the carbide. Carbon compositions of various forms may be formed by the methods and apparatus using the electrode structure. Large pieces of pure carbon may be produced. Post-reaction processing of the carbon may be carried out such as exfoliation.
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