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156 条记录 (耗时 0.051 秒)

    4-fluoro-N-indan-2-yl benzamide and its use as a pharmaceutical
    23.
    发明授权
    4-fluoro-N-indan-2-yl benzamide and its use as a pharmaceutical 有权
    4-氟-N-茚满-2-基苯甲酰胺及其作为药物的用途

    公开(公告)号：US07202278B2

    公开(公告)日：2007-04-10

    申请号：US10920395

    申请日：2004-08-18

    申请人： Paulus Wohlfart ,  Teri Suzuki ,  Ramalinga M. Dharanipragada ,  Alena Safarova ,  Armin Walser ,  Hartmut Strobel

    发明人： Paulus Wohlfart ,  Teri Suzuki ,  Ramalinga M. Dharanipragada ,  Alena Safarova ,  Armin Walser ,  Hartmut Strobel

    IPC分类号： A61K31/165 ,  A61K31/495 ,  A61K31/44 ,  A61K31/195

    CPC分类号： C07C233/65 ,  A61K31/166 ,  C07C2602/08

    摘要： A method of stimulating the expression of endothelial NO-synthase in a mammal, which method comprises administering a physiologically active amount of 4-fluoro-N-indan- 2-yl benzamide according to the formula (I) to the said mammal. Compound (I) can be used for the therapy and prophylaxis of cardiovascular diseases like stable and unstable angina pectoris, Prinzmetal angina (spasm), acute coronary syndrome, heart failure, myocardial infarction, stroke, thrombosis, peripheral artery occlusive disease PAOD, atherosclerosis, restenosis, endothelial damage after PTCA, essential hypertension, pulmonary hypertension, secondary hypertension, renovascular chronic glomerulonephritis, erectile dysfunction, ventricular arrhythmia, and the lowering of cardiovascular risk of postmenopausal women or after intake of contraceptives, the therapy and prophylaxis of diabetes and diabetes complications (nephropathy, retinopathy), angiogenesis, asthma bronchiale, chronic renal failure, cirrhosis of the liver, restricted memory performance or a restricted ability to learn.

    摘要翻译： 一种刺激哺乳动物内皮细胞NO合成酶表达的方法，该方法包括给予生理活性量的式（I）的4-氟-N-茚满-2-基苯甲酰胺，

    Process for the polymerisation of isobutene
    25.
    发明授权
    Process for the polymerisation of isobutene 失效
    异丁烯聚合方法

    公开(公告)号：US07176032B2

    公开(公告)日：2007-02-13

    申请号：US10311018

    申请日：2001-06-14

    申请人： Christian Sait ,  Gacem Benazzouz

    发明人： Christian Sait ,  Gacem Benazzouz

    IPC分类号： G01N33/44

    CPC分类号： C08F110/10 ,  Y10T436/12 ,  C08F2/00

    摘要： A process for maintaining a property P of a polyisobutene around a target value V during a continuous polymerisation of isobutene in a reactor containing a boiling liquid reaction phase in equilibrium with a gas phase above the liquid phase. The process comprises continuously introducing, into the reactor, a catalyst and a C4 hydrocarbon feed and continuously withdrawing, from the reactor, the liquid reaction phase which is subsequently subjected, continuously, to at least one purification step to isolate the polyisobutene. The property P is chosen amongst the viscosity and the average molecular mass of the polyisobutene. The property P is maintained around the target value V (i) by measuring the isobutene partial pressure (PiC4) in the gas phase of the reactor, (ii) by calculating the isobutene concentration (CiC4R2) in the boiling liquid reaction phase by means of a first model predicting the value of CiC4R2 from the measured value of PiC4 and being based on liquid/vapor equilibrium law, (iii) by calculating an instantaneous value Pinst of the property P by means of a second model predicting the value of Pinst from the calculated value of CiC4R2 and including at least one function of the isobutene polymerisation kinetics, and (iv) by varying at least one process parameter so as to make the instantaneous value Pinst tend towards the target value V.

    摘要翻译： 在含有与液相上方的气相平衡的沸腾液体反应相的反应器中异丁烯的连续聚合期间，将聚异丁烯的性质P维持在目标值V附近的方法。 该方法包括连续向反应器中引入催化剂和C 4烃原料，并从反应器中连续地将液相反应相连续地连续抽出至至少一个纯化步骤以分离聚异丁烯。 性质P选自聚异丁烯的粘度和平均分子量。 通过测量反应器气相中的异丁烯分压（PiC4），将性能P维持在目标值V（i）附近，（ii）通过计算反应器中异丁烯浓度（C 1 S 2 S 2 S 2） 沸点液体反应阶段，通过从PiC4的测量值预测CiC4 的值的第一模型，并基于液/气平衡定律，（iii）通过计算瞬时值Pinst 该性质P通过第二模型，从计算的CiC4R2R2值估计Pinst的值，并包括异丁烯聚合动力学的至少一个函数，和（iv）通过改变至少一个过程 参数，以使瞬时值Pinst趋于目标值V.

    Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof
    29.
    发明授权
    Cephaibols: novel antiparasitics from Acremonium tubakii, process for their production, and use thereof 有权
    头孢唑醇：来自Acremonium tubakii的新型抗寄生虫药，其生产方法及其用途

    公开(公告)号：US07067112B2

    公开(公告)日：2006-06-27

    申请号：US10411144

    申请日：2003-04-11

    申请人： Laszlo Vertesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

    发明人： Laszlo Vertesy ,  Michael Kurz ,  Matthias Schiell ,  Joachim Hofmann

    IPC分类号： A61K49/00 ,  A61K38/10 ,  C07K7/08

    CPC分类号： C07K7/08 ,  A61K38/00

    摘要： The invention relates to compounds of the formula I AcPhe-Aib-Aib-Aib-x-w-Leu-y-Aib-Hyp-Gln-z-Hyp-Aib-Pro-R   (I) in which R is Phe-ol or Phe-al and w, x, y, and z have the following meanings: a) w is Gly or Ala; x is Aib and y and z are Iva; b) w is Gly; x, y and z are Iva; c) w is Gly; x and z are Aib and y is Iva; d) w is Gly; x, y and z are Aib; or e) w is Gly; x and y are Aib and z is Iva; or of the formula II AcPhe-Iva-Gln-Aib-lle-Thr-Aib-Leu-Aib-x-Gln-Aib-Hyp-Aib-Pro-Phe-Ser,   (II) wherein x is Hyp or Pro, which are synthesized by Acremonium tubakii FH 1685 DSM 12774 during fermentation and released into the culture medium, a process for the isolation of the cephaibols from the culture medium, and their purification, and the use of the cephaibols as pharmacologically active compounds, in particular for the control of parasites.

    摘要翻译： 本发明涉及式I化合物<？in-line-formula description =“In-line Formulas”end =“lead”→AcPhe-Aib-Aib-Aib-xw-Leu-y-Aib-Hyp-Gln -z-Hyp-Aib-Pro-R（I）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中R是Phe-ol或Phe-al，w，x ，y和z具有以下含义：a）w是Gly或Ala; x是Aib，y和z是Iva; b）w是Gly; x，y和z是Iva; c）w是Gly; x和z是Aib，y是Iva; d）w是Gly; x，y和z是Aib; 或e）w是Gly; x和y是Aib，z是Iva; AcPhe-Iva-Gln-Aib-Lle-Thr-Aib-Leu-Aib-x-Gln-Aib，或者式II <？in-line-formula description =“In-line Formulas”end =“lead” -Hyp-Aib-Pro-Phe-Ser，（II）<？在线公式描述=“在线公式”end =“tail”？>其中x是Hyp或Pro，它们是由Acremonium tubakii FH 1685 DSM 12774在发酵过程中释放到培养基中，从培养基中分离头孢胆素的方法及其纯化，以及将头孢唑醇用作药物活性化合物，特别是用于控制寄生虫的方法。

    Nephelometric detection unit with optical in-process control
    30.
    发明授权
    Nephelometric detection unit with optical in-process control 有权
    具有光学过程控制的比浊法检测单元

    公开(公告)号：US07050167B2

    公开(公告)日：2006-05-23

    申请号：US10717594

    申请日：2003-11-19

    申请人： Paul Meller

    发明人： Paul Meller

    IPC分类号： G01N21/51

    CPC分类号： G01N21/474 ,  G01N21/51 ,  G01N2021/4707

    摘要： The present invention relates to the field of the use of automated measurement systems in analysis and in in-vitro diagnosis. In particular, the apparatus described enables automatic quality control and validation of characteristic process engineering parameters, in particular characteristic optical parameters, during the measurement of scattered light signals.

    摘要翻译： 本发明涉及在分析和体外诊断中使用自动测量系统的领域。 特别地，所描述的装置能够在散射光信号的测量期间自动质量控制和确认特征过程工程参数，特别是特征光学参数。