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1.发明授权公开(公告)号：US06537775B1
公开(公告)日：2003-03-25
申请号：US09230652
申请日：1999-05-17
IPC分类号： C07H2104
CPC分类号： C07K14/70567 , A61K38/00
摘要： The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL. The invention also concerns models and products for treating CADASIL and related diseases.
摘要翻译： 本发明涉及参与CADASIL的Notch3基因和相应的蛋白质。 本发明特别涉及用于证明该基因突变的方法，其与开发CADASIL的风险有关。 本发明还涉及用于治疗CADASIL和相关疾病的模型和产品。
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2.发明授权Gene involved in CADASIL, method of diagnosis and therapeutic application 有权涉及CADASIL的基因，诊断和治疗应用的方法公开(公告)号：US07138234B2
公开(公告)日：2006-11-21
申请号：US10356625
申请日：2003-02-03
CPC分类号： C07K14/70567 , A61K38/00
摘要： The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL and related diseases.
摘要翻译： 本发明涉及参与CADASIL的Notch3基因和相应的蛋白质。 本发明特别涉及用于证明该基因突变的方法，其涉及发展CADASIL和相关疾病的风险。
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公开(公告)号：US06995257B1
公开(公告)日：2006-02-07
申请号：US09612226
申请日：2000-07-07
IPC分类号： C07H21/04 , C07H21/02 , G01N33/567 , G01N33/566 , C12Q1/68
CPC分类号： C07K14/70567 , A61K38/00
摘要： The invention concerns the Notch3 gene and the corresponding protein, which are involved in CADASIL. The invention concerns, in particular, methods for demonstrating mutations in this gene, which are linked to the risk of developing CADASIL. The invention also concerns models and products for treating CADASIL and related diseases.
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