公开(公告)号：US20240353310A1

公开(公告)日：2024-10-24

申请号：US18759876

申请日：2024-06-29

申请人： SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

发明人： Jin LI ,  Shiyao PAN ,  Xiaomei ZHANG ,  Chuanjian WU ,  Wenbo ZHENG ,  Bo YE

IPC分类号： G01N15/14 ,  G01N1/30 ,  G01N15/10 ,  G01N21/47 ,  G01N21/64 ,  G16H50/20

CPC分类号： G01N15/1459 ,  G01N1/30 ,  G01N21/6486 ,  G16H50/20 ,  G01N2015/1006 ,  G01N2021/4707 ,  G01N2021/4726 ,  G01N2800/26

摘要： The present invention relates to a blood cell analyzer, a method, and a use of an infection marker parameter. The blood cell analyzer comprises a sample suction device used for aspirating a blood sample to be tested of a subject, a sample preparation device used for preparing a test sample containing a part of a blood sample to be tested, a hemolytic agent, and a staining agent for identifying nucleated red blood cells, an optical detection device used for detecting an test sample to obtain optical information, and a processor. The processor obtains from the optical information at least one leukocyte characteristic parameter of at least one target particle population in a test sample, obtains an infection marker parameter for evaluating an infection status of a subject on the basis of the at least one leukocyte characteristic parameter, and outputs the infection marker parameter.

公开(公告)号：US12077805B2

公开(公告)日：2024-09-03

申请号：US16947655

申请日：2020-08-11

申请人： IP SPECIALISTS LTD.

发明人： Dana A. Marshall ,  Theodore S. McMinn ,  Dan Vadim Regelman

IPC分类号： C12Q1/04 ,  B01L3/00 ,  G01N21/51 ,  G16B50/00 ,  G16B50/30 ,  G01N21/47

CPC分类号： C12Q1/04 ,  B01L3/50255 ,  G01N21/51 ,  G16B50/00 ,  G16B50/30 ,  B01L2200/0684 ,  B01L2300/022 ,  B01L2300/043 ,  B01L2300/045 ,  B01L2300/0681 ,  G01N2021/4707 ,  G01N2021/513 ,  G01N2201/0612

摘要： An optical measurement instrument is an integrated instrument that includes an optical cavity with a light source, a sample cuvette, and an optical sensor. The instrument can be used for taking measurements of organism concentration in one or more samples. Preferably, the instrument holds multiple, individually-loaded, independent fluid samples and determines bacteria concentration via a forward-scattering signal. The instrument can incorporate onboard incubation to promote bacterial growth in the samples such that, once a certain bacterial concentration is achieved, the higher concentration sample can be used with a mass spectrometer to identify the type of bacteria. The instrument and mass spectrometer can be a part of a network for medical diagnostic testing data where data is stored in a manner that is inherently untainted by patient identifiable information.

公开(公告)号：US11977015B2

公开(公告)日：2024-05-07

申请号：US17396980

申请日：2021-08-09

申请人： NEW YORK UNIVERSITY

发明人： David G. Grier ,  David B. Ruffner ,  Aaron Yevick ,  Mark Hannel

IPC分类号： G01N15/02 ,  G01N15/0227 ,  G03H1/00 ,  G03H1/04 ,  G06V10/143 ,  G06V20/69 ,  G06V20/80 ,  B01L3/00 ,  G01N15/00 ,  G01N21/47

CPC分类号： G01N15/0227 ,  G03H1/0005 ,  G03H1/0443 ,  G06V10/143 ,  G06V20/69 ,  G06V20/80 ,  B01L3/5027 ,  G01N2015/0053 ,  G01N2015/0233 ,  G01N2015/03 ,  G01N2021/4707 ,  G03H2001/0033 ,  G03H2001/005 ,  G03H2001/0447

摘要： Systems and methods for uniquely identifying fluid-phase products by endowing them with fingerprints composed of dispersed colloidal particles, and by reading out those fingerprints on demand using Total Holographic Characterization. A library of chemically inert colloidal particles is developed that can be dispersed into soft materials, the stoichiometry of the mixture encoding user-specified information, including information about the host material. Encoded information then can be recovered by high-speed analysis of holographic microscopy images of the dispersed particles. Specifically, holograms of individual colloidal spheres are analyzed with predictions of the theory of light scattering to measure each sphere's radius and refractive index, thereby building up the distribution of particle properties one particle at a time. A complete analysis of a colloidal fingerprint requires several thousand single-particle holograms and can be completed in ten minutes.

公开(公告)号：US11965834B2

公开(公告)日：2024-04-23

申请号：US17283686

申请日：2019-09-20

申请人： Unity Semiconductor

发明人： Mayeul Durand de Gevigney

IPC分类号： G01N21/88 ,  G01N21/47 ,  G01N21/95

CPC分类号： G01N21/8806 ,  G01N21/474 ,  G01N21/9501 ,  G01N21/9506 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2021/4742 ,  G01N2021/8822

摘要： A device for dark-field optical inspection of a substrate comprises: a light source for generating an incident beam that is projected onto an inspection zone of the substrate and that is capable of being reflected in the form of diffuse radiation; at least one first and one second collecting device; and a reflecting device for directing at least a portion of the diffuse radiation originating from a focal point of collection coincident with the inspection zone in the direction of the collecting devices, with a first and second reflective zone from which a first portion of the diffuse radiation is directed toward a first focal point, which is optically conjugated with the focal point of collection, and a second portion of the diffuse radiation is reflected toward a second focal point, which is optically conjugated with the collection focal point and distinct from the first focal point of detection.

公开(公告)号：US20190187067A1

公开(公告)日：2019-06-20

申请号：US15846932

申请日：2017-12-19

申请人： Industrial Technology Research Institute

发明人： Ding-Kun Liu ,  Chia-Hung Cho

IPC分类号： G01N21/94 ,  G01N21/958 ,  G03F1/84 ,  G01N21/88

CPC分类号： G01N21/94 ,  G01N21/8422 ,  G01N21/8806 ,  G01N21/958 ,  G01N2021/3181 ,  G01N2021/4707 ,  G01N2021/4709 ,  G01N2021/8438 ,  G03F1/84

摘要： A detection system for a multilayer film is provided. The detection system for a multilayer film includes a light source device, a first image capture device, a second image capture device and an image processing device. The light source device projects a pair of parallel incident light to a transparent multilayer film obliquely. The pair of parallel incident light is projected onto the transparent multilayer film for producing and enabling a forward scattered light and a back scattered light to be projected therefrom. The first image capture device captures the back scattered light to produce a first image. The second image capture device captures the forward scattered light to produce a second image. The image processing device is coupled to the first image capture device and the second image capture device. The image processing device is used to compares and detect the differences between the second image and the first image.

公开(公告)号：US20190094056A1

公开(公告)日：2019-03-28

申请号：US15934389

申请日：2018-03-23

申请人： DEKA Products Limited Partnership

发明人： David E. Altobelli ,  Larry B. Gray ,  Derek G. Kane

IPC分类号： G01F13/00 ,  A61M15/00 ,  G01N1/22 ,  A61B5/08 ,  G01N15/02 ,  G01N15/14 ,  G01N21/53 ,  G01F1/34 ,  A61M16/00 ,  G01N21/47

CPC分类号： G01F13/006 ,  A61B5/08 ,  A61M15/0003 ,  A61M15/0065 ,  A61M15/009 ,  A61M2016/0021 ,  A61M2016/0039 ,  A61M2205/3306 ,  A61M2205/3331 ,  A61M2205/3379 ,  G01F1/34 ,  G01N1/2202 ,  G01N15/02 ,  G01N15/0205 ,  G01N15/1456 ,  G01N21/53 ,  G01N2001/2223 ,  G01N2021/4707

摘要： An apparatus comprises a detector, a pressure sensor and a processor. The detector is operable to detect light that is scattered by an aerosol that is associated with a pressure. The pressure sensor is operable to measure the pressure. The processor is coupled to the detector and to the pressure sensor, and is configured to receive at least a signal from the detector and the pressure sensor. The processor is further configured to use the received signals to calculate a volume of the first aerosol, and to output an output signal associated with the calculated volume. The various measurements can be repeated and compared, and the output signal can be a feedback signal for metering subsequent amounts of the aerosol, based on the comparison.

公开(公告)号：US20180003612A1

公开(公告)日：2018-01-04

申请号：US15196808

申请日：2016-06-29

申请人： Honeywell International Inc.

发明人： Barrett E. Cole ,  Robert P. Costello

IPC分类号： G01N15/14 ,  G01N15/06 ,  G01N15/10

CPC分类号： G01N15/1434 ,  G01N15/0205 ,  G01N15/06 ,  G01N21/53 ,  G01N2015/1043 ,  G01N2021/4707 ,  G01N2201/0637 ,  G01N2201/0642

摘要： Devices and methods for detecting particulate matter are described herein. One device includes a laser, a reflector, an ellipsoidal reflector, and a detector, wherein the laser is configured to emit a beam, the reflector is configured to reflect the beam toward the ellipsoidal reflector, and the ellipsoidal reflector has a first focal region located on a path of the reflected beam, and a second focal region located at a surface of the detector.

公开(公告)号：US20170227437A1

公开(公告)日：2017-08-10

申请号：US15423059

申请日：2017-02-02

申请人： HORIBA, Ltd.

发明人： Tetsuji YAMAGUCHI ,  Tetsuya MORI

IPC分类号： G01N15/02

CPC分类号： G01N15/0211 ,  G01N21/53 ,  G01N2015/0222 ,  G01N2015/025 ,  G01N2021/4707

摘要： Provided is a dynamic light scattering type particle size distribution measuring apparatus 100 capable of accurately measure the particle sizes of a sample obtained from slurry or the like. The dynamic light scattering type particle size distribution measuring apparatus 100 is configured to include: a filter member 6 that is interposed between any adjacent two of a light source 4, a cell 2, and a photodetector 5 and attenuates light passing therethrough; and an information processing device 8 that measures a particle size distribution multiple times with time and combines particle size distributions obtained at respective times of measurement to thereby calculate the particle size distribution of the whole of portions of the sample introduced at the respective times of measurement. In addition, the filter member 6 is also configured to be changeable to one having a different attenuation level at every time of measurement.

公开(公告)号：US09562855B1

公开(公告)日：2017-02-07

申请号：US13458650

申请日：2012-04-27

申请人： Jeong-Yeol Yoon ,  David Jinsoo You

发明人： Jeong-Yeol Yoon ,  David Jinsoo You

IPC分类号： G01N21/47 ,  G01N33/58 ,  B01L3/00 ,  G01N33/569

CPC分类号： G01N21/47 ,  B01L3/502 ,  B01L2300/0816 ,  G01N33/54313 ,  G01N33/54373 ,  G01N33/569 ,  G01N33/56911 ,  G01N33/585 ,  G01N2021/4704 ,  G01N2021/4707 ,  G01N2021/4711

摘要： Microfluidic methods and systems for detecting levels of microorganisms via Mie forward light scattering. The systems and methods of the present invention can be customized so as to optionally maximize scatter from the particle immunoagglutination and minimize that of the sample matrix, e.g., via selection of parameters particle diameter d, wavelength of incident λ, and/or scatter angle θ. Methods feature providing beads conjugated with an antibody specific for the microorganism, mixing beads with a sample to form a first mixture; providing a control mixture; irradiating the mixtures with incident light; detecting forward light scattering scattered by the first mixture at a first angle with respect to the incident light and forward scattered light scattered by the control the same first angle with respect to the incident light; determining I and I0 from the light scattering; comparing I with I0; and determining a level of the microorganism.

摘要翻译： 用于通过Mie前向光散射检测微生物水平的微流控方法和系统。 可以定制本发明的系统和方法，以便可选地使颗粒免疫凝集的散射最大化，并使样品基质的散射最小化，例如通过选择参数粒径d，入射λ的波长和/或散射角θ 。 方法特征在于提供与微生物特异性抗体缀合的珠粒，将珠子与样品混合以形成第一混合物; 提供控制混合物; 用入射光照射混合物; 检测由第一混合物散射的相对于入射光的第一角度的向前光散射，并且通过控制散射的向前散射的光相对于入射光具有相同的第一角度; 从光散射确定I和I0; 将I与I0进行比较 并确定微生物的水平。

公开(公告)号：US09347881B2

公开(公告)日：2016-05-24

申请号：US14577105

申请日：2014-12-19

申请人： Hiroshi Andoh ,  Hideharu Miki ,  Genichiro Kawamichi ,  Shigeru Morinaga ,  Kohji Tokuyama ,  Toshihide Inaba ,  Mitsuyuki Karasawa ,  Takeo Shirato

发明人： Hiroshi Andoh ,  Hideharu Miki ,  Genichiro Kawamichi ,  Shigeru Morinaga ,  Kohji Tokuyama ,  Toshihide Inaba ,  Mitsuyuki Karasawa ,  Takeo Shirato

IPC分类号： G01N21/00 ,  G01N21/49 ,  G01N21/47

CPC分类号： G01N21/49 ,  G01N21/47 ,  G01N2021/4707 ,  G01N2021/4769

摘要： A device for detecting a state of a liquid droplet discharged from each of nozzles placed in one or more rows, includes a light emitting element to emit a light beam to the liquid droplet from a nozzle in question, and a pair of light receiving elements disposed on both sides of a beam diameter of the light beam via an optical axis to receive scattered light occurring from the liquid droplet for detecting a state of the discharged liquid droplet on the basis of the scattered light. Either of the pair of the light receiving elements is selected for receiving the scattered light from the liquid droplet discharged from the nozzle according to a positional relation between the nozzle and the pair of light receiving elements.

摘要翻译： 一种用于检测从设置成一行或多行的每个喷嘴排出的液滴的状态的装置包括从所述喷嘴向液滴发射光束的发光元件和设置在一起的一对光接收元件 在光束的光束直径的两侧经由光轴接收从液滴发生的散射光，用于基于散射光检测排出液滴的状态。 选择一对光接收元件中的任一个，以根据喷嘴和一对光接收元件之间的位置关系接收来自喷嘴喷射的液滴的散射光。