公开(公告)号：US20240167172A1

公开(公告)日：2024-05-23

申请号：US18138116

申请日：2023-04-23

申请人： Dioxycle

发明人： Sarah Lamaison ,  Jonathan Maistrello ,  Ruperto G Mariano ,  Bastien Faure ,  David Wakerley ,  Lindsay Leveen

IPC分类号： C25B3/25 ,  C01B32/942 ,  C07C1/32 ,  C21B13/12

CPC分类号： C25B3/25 ,  C01B32/942 ,  C07C1/325 ,  C21B13/12 ,  C01B2210/0006 ,  C21B2100/40 ,  C21B2100/80

摘要： Methods and systems for the valorization of carbon monoxide emissions from electric arc furnaces into highly valuable low-carbon footprint chemicals using carbon monoxide electrolysis are disclosed herein are disclosed. A disclosed method includes operating an electric arc furnace, generating, via operation of the electric arc furnace, a volume of carbon monoxide, supplying the volume of carbon monoxide to a cathode area of a carbon monoxide electrolyzer to be used as a reduction substrate, and generating, using the carbon monoxide electrolyzer, the reduction substrate, and an oxidation substrate, a volume of generated chemicals. The volume of generated chemicals is at least one of: a volume of hydrocarbons, a volume of organic acids, a volume of alcohol, a volume of olefins and a volume of N-rich organic compounds.

公开(公告)号：US20160145276A1

公开(公告)日：2016-05-26

申请号：US14930860

申请日：2015-11-03

申请人： The Florida State University Research Foundation, Inc.

发明人： Igor V. Alabugin ,  Kamalkishore Pati

IPC分类号： C07F7/22 ,  C07C1/32

CPC分类号： C07C1/325 ,  C07C17/26 ,  C07C41/18 ,  C07C45/67 ,  C07C253/30 ,  C07C2603/40 ,  C07C2603/54 ,  C07D221/18 ,  C07D317/70 ,  C07C13/66 ,  C07C13/62 ,  C07C255/54 ,  C07C255/52 ,  C07C25/22 ,  C07C22/08 ,  C07C43/21 ,  C07C49/84

摘要： The present disclosure is directed to a traceless directing group in a radical cascade. The chemo- and regioselectivity of the initial attack in skipped oligoalkynes is controlled by a propargyl alkoxy moiety. Radical translocations lead to the boomerang return of radical center to the site of initial attack where it assists to the elimination of the directing functionality via β-scission in the last step of the cascade. In some aspects, the reaction of the present invention is catalyzed by a stannane moiety, which allows further via facile reactions with electrophiles as well as Stille and Suzuki cross-coupling reactions. This selective radical transformation opens a new approach for the controlled transformation of skipped oligoalkynes into polycyclic ribbons of tunable dimensions.

摘要翻译： 本公开涉及一种无级联的无级引导组。 跳过的寡聚炔烃的初始攻击的化学和区域选择性由炔丙基烷氧基部分控制。 激进的易位导致自由基中心返回到初始攻击的地点，从而有助于在级联的最后一个步骤中消除引导功能。 在一些方面，本发明的反应由锡烷部分催化，其允许进一步通过亲电子反应以及Stille和Suzuki交叉偶联反应。 这种选择性的基因转换开辟了一种新方法，可以将跳过的寡核苷酸控制转化为可调节尺寸的多环带。

公开(公告)号：US08426535B2

公开(公告)日：2013-04-23

申请号：US12801741

申请日：2010-06-23

申请人： George Johan Peter Britovsek ,  Steven A. Cohen ,  Vernon Charles Gibson

发明人： George Johan Peter Britovsek ,  Steven A. Cohen ,  Vernon Charles Gibson

IPC分类号： C08F4/50 ,  C08F4/76 ,  C08F4/80 ,  B01J31/00 ,  B01J31/28

CPC分类号： C07C1/325 ,  C07F3/06 ,  C08F4/65922 ,  C08F4/65925 ,  C08F4/65927 ,  C08F10/00 ,  C08F10/02 ,  C08F210/16 ,  C07C11/02 ,  C08F4/65912 ,  C08F210/14 ,  C08F2500/03 ,  C08F4/60089 ,  C08F4/7042 ,  C08F4/64013 ,  C08F4/69293 ,  C08F4/64048

摘要： A process is disclosed for the preparation of zinc alkyl chain growth products via a catalyzed chain growth reaction of an alpha-olefin on a zinc alkyl, wherein the chain growth catalyst system employs a group 3-10 transition metal, or a group 3 main group metal, or a lanthanide or actinide complex, and optionally a suitable activator. The products can be further converted into alpha-olefins by olefin displacement of the grown alkyls as alpha-olefins from the zinc alkyl chain growth product, or into primary alcohols, by oxidation of the resulting zinc alkyl chain growth product to form alkoxide compounds, followed by hydrolysis of the alkoxides.

公开(公告)号：US08067631B2

公开(公告)日：2011-11-29

申请号：US12090642

申请日：2006-10-06

申请人： Masaaki Suzuki ,  Takamitsu Hosoya

发明人： Masaaki Suzuki ,  Takamitsu Hosoya

IPC分类号： C07C69/74 ,  C07C45/00 ,  C07C35/00 ,  C07C11/02

CPC分类号： C07C45/673 ,  C07B59/00 ,  C07B2200/05 ,  C07C1/325 ,  C07C29/32 ,  C07C67/343 ,  C07C2531/24 ,  C07C47/21 ,  C07C49/603 ,  C07C69/587 ,  C07C33/03

摘要： To provide a method of rapid methylation of alkenes, which is applicable to the preparation of a PET tracer and which enables alkenes to be methylated through cross coupling between SP2 (alkenyl) and SP3 (alkyl) carbon atoms rapidly and in a high yield. Methyl iodide and an alkenyltrialkylstannane are subjected to cross coupling in an aprotic polar solvent in the presence of a palladium complex having a valence of 0, a phosphine ligand, a cuprous halide, and a carbonate and/or alkali metal fluoride.

摘要翻译： 提供烯烃快速甲基化的方法，其适用于制备PET示踪剂，并且通过SP2（烯基）和SP3（烷基）碳原子之间的快速和高收率的交叉偶联使烯烃能甲基化。 甲基碘和烯基三烷基锡烷在非质子极性溶剂中，在化合价为0的钯络合物，膦配位体，卤化亚铜和碳酸盐和/或碱金属氟化物的存在下进行交联。

公开(公告)号：US20110152523A1

公开(公告)日：2011-06-23

申请号：US12737288

申请日：2009-03-10

申请人： Masaharu Nakamura ,  Takuji Hatakeyama ,  Yu-ichi Fujiwara

发明人： Masaharu Nakamura ,  Takuji Hatakeyama ,  Yu-ichi Fujiwara

IPC分类号： C07F9/6509 ,  B01J31/30 ,  C07F9/50 ,  C07C1/20

CPC分类号： C07F9/650994 ,  B01J31/2419 ,  B01J2231/4233 ,  B01J2531/842 ,  C07B37/04 ,  C07C1/325 ,  C07C1/327 ,  C07F9/5027 ,  C07F15/025

摘要： The present invention provides a process for efficiently producing an alkylated aromatic compound in good yield, by a cross-coupling reaction between an alkyl halide and an aromatic magnesium reagent. A process for producing an aromatic compound represented by Formula (1): R—Ar′  (1) wherein R is a hydrocarbon group, and Ar′ is an aryl group; the process comprising: reacting a compound represented by Formula (2): R—X  (2) wherein X is a halogen atom, and R is as defined above, with a magnesium reagent represented by Formula (3): Ar′—MgY  (3) wherein Y is a halogen atom, and Ar′ is as defined above, in the presence of a catalyst for cross-coupling reactions comprising an iron compound and a bisphosphine compound represented by Formula (4): wherein Q is a divalent group derived from an aromatic ring by removing two hydrogen (H) atoms on adjacent carbon atoms; and each Ar is independently an aryl group.

摘要翻译： 本发明提供了通过烷基卤和芳族镁试剂之间的交叉偶联反应，以高产率有效地制备烷基化芳族化合物的方法。 一种由式（1）表示的芳族化合物的制备方法：R-Ar'（1）其中R是烃基，Ar'是芳基; 该方法包括：使由式（2）表示的化合物：其中X是卤素原子的R-X（2）和R如上所定义，与式（3）表示的镁试剂反应：Ar'-MgY（ 3）其中Y是卤素原子，Ar'如上定义，在含有铁化合物和由式（4）表示的双膦化合物的交叉偶联反应催化剂存在下，其中Q是二价基团衍生物 通过在相邻碳原子上除去两个氢（H）原子而从芳香环; 并且每个Ar独立地为芳基。

公开(公告)号：US20080154035A1

公开(公告)日：2008-06-26

申请号：US11778944

申请日：2007-07-17

申请人： Phil Ho LEE ,  Kooyeon LEE ,  Dong SEOMOON ,  Hyunseok KIM

发明人： Phil Ho LEE ,  Kooyeon LEE ,  Dong SEOMOON ,  Hyunseok KIM

IPC分类号： C07C1/00 ,  C07C253/30 ,  C07C315/04 ,  C07C67/00 ,  C07C69/76 ,  C07D209/10 ,  C07D267/04 ,  C07D267/22

CPC分类号： C07C67/317 ,  C07C1/325 ,  C07C13/465 ,  C07C67/327 ,  C07C253/30 ,  C07C315/04 ,  C07C2601/08 ,  C07C2602/08 ,  C07C2602/10 ,  C07C2603/24 ,  C07D209/08 ,  C07D267/04 ,  C07D267/22 ,  C07C69/74 ,  C07C69/753 ,  C07C69/757 ,  C07C317/12 ,  C07C317/44 ,  C07C255/47

摘要： The present invention relates to a coupling method between intramolecular carbon using the intramolecular cyclization reaction in situ of an allyl-indium compound derived from an allyl derivative containing an unsaturated hydrocarbon compound and indium, in presence of a transition metal compound catalyst. More particularly, the present invention relates to a coupling method between intramolecular carbon for preparing a cyclic compound having a vinyl group as a substituent by bonding a carbon in an allyl derivative containing an unsaturated hydrocarbon compound and a carbon in the unsaturated hydrocarbon compound via intramolecular cyclization reaction in situ of an allyl-indium compound as a coupling agent derived from the allyl derivative containing the unsaturated hydrocarbon and indium (In), in presence of a palladium catalyst.

摘要翻译： 本发明涉及在过渡金属化合物催化剂存在下，使用衍生自含有不饱和烃化合物的烯丙基衍生物的烯丙基衍生物的烯丙基铟化合物的原位分子内环化反应的分子内碳的偶联方法。 更具体地说，本发明涉及通过分子内环化将不饱和烃化合物的烯丙基衍生物和不饱和烃化合物中的碳键合成碳而制备具有乙烯基作为取代基的环状化合物的分子内碳的耦合方法 在钯催化剂的存在下，烯丙基铟化合物作为源自含有不饱和烃和铟的烯丙基衍生物（In）的偶联剂原位反应。

公开(公告)号：US20070098616A1

公开(公告)日：2007-05-03

申请号：US10580699

申请日：2004-11-26

申请人： Shin Masaoka ,  Hideyuki Iwazaki

发明人： Shin Masaoka ,  Hideyuki Iwazaki

IPC分类号： C01B35/00 ,  C01B25/00

CPC分类号： B01J31/32 ,  B01J31/0268 ,  B01J31/04 ,  B01J31/146 ,  B01J31/2234 ,  B01J31/24 ,  B01J31/2404 ,  B01J31/26 ,  B01J31/28 ,  B01J2231/4205 ,  B01J2231/4283 ,  B01J2531/72 ,  B01J2531/821 ,  B01J2531/822 ,  B01J2531/824 ,  B01J2531/828 ,  B01J2531/84 ,  C07C1/325 ,  C07C1/326 ,  C07C29/32 ,  C07C41/16 ,  C07C45/68 ,  C07C67/343 ,  C07C209/10 ,  C07C213/08 ,  C07C227/08 ,  C07C253/30 ,  C07F9/54 ,  C07C49/782 ,  C07C49/796 ,  C07C69/612 ,  C07C69/618 ,  C07C211/54 ,  C07C215/68 ,  C07C229/44 ,  C07C255/41 ,  C07C255/49 ,  C07C33/483 ,  C07C33/30 ,  C07C43/263 ,  C07C43/275

摘要： The invention relates to a phosphonium borate compound represented by Formula (I) (hereinafter, the compound (I)). The invention has objects of providing (A) a novel process whereby the compound is produced safely on an industrial scale, by simple reaction operations and in a high yield; (B) a novel compound that is easily handled; and (C) novel use as catalyst. Formula (I): (R1)(R2)(R3)PH.BAr4  (I) wherein R1, R2, R3 and Ar are as defined in the specification. The process (A) includes reacting a phosphine with a) HCl or b) H2SO4 to produce a) a hydrochloride or b) a sulfate; and reacting the salt with a tetraarylborate compound. The compound (B) has for example a secondary or tertiary alkyl group as R1 and is easily handled in air without special attention. The use (C) is characterized in that the compound (I) is used instead of an unstable phosphine compound of a transition metal complex catalyst for catalyzing C—C bond, C—N bond and C—O bond forming reactions and the compound produces an effect that is equal to that achieved by the transition metal complex catalyst.

摘要翻译： 本发明涉及由式（I）表示的硼酸鏻化合物（以下称为化合物（I））。 本发明的目的是提供（A）通过简单的反应操作和高产率使化合物在工业规模上安全生产的新方法; （二）易于处理的新型化合物; 和（C）新型用作催化剂。 公式（I）：（R＆lt; 1＆lt; 1＆gt;）（R 2）（R 2） （I）<βin-line-formula description =“In-line Formulas”end =“tail”？>其中R ^{1 ，R 2，R 3和Ar如说明书中所定义。 方法（A）包括使膦与a）HCl或b）H 2 SO 4 4反应以产生a）盐酸盐或b）硫酸盐; 并使该盐与四芳基硼酸盐化合物反应。 化合物（B）具有例如作为R 1的仲或叔烷基，并且容易在空气中处理而没有特别注意。 使用（C）的特征在于，使用化合物（I）代替用于催化CC键，CN键和CO键形成反应的过渡金属络合物催化剂的不稳定膦化合物，并且该化合物产生等于 这通过过渡金属络合物催化剂实现。}

公开(公告)号：US20040049071A1

公开(公告)日：2004-03-11

申请号：US10442664

申请日：2003-05-21

发明人： Dennis Patrick Curran ,  Zhiyong Luo

IPC分类号： C12P007/40 ,  C07C029/74

CPC分类号： C07D207/333 ,  C07B37/04 ,  C07B61/00 ,  C07B63/00 ,  C07C1/325 ,  C07C17/02 ,  C07C45/46 ,  C07D307/46 ,  C07D333/22 ,  C07C15/52 ,  C07C23/10 ,  C07C22/04 ,  C07C49/84

摘要： A method of obtaining an enantioenriched organic compound comprising the steps of: 1) generating from a starting racemic, non-enantiopure or achiral compound a first mixture comprising at least one fluorous-tagged compound and at least one other non-fluorous tagged compound, at least one of these two compounds being enantioenriched relative to the starting compound; 2) contacting a first non-fluorous phase including the first mixture with a fluorous phase at a first phase interface, the fluorous-tagged compound distributing between the first non-fluorous phase and the fluorous phase; and 3) contacting the fluorous phase with a second non-fluorous phase at a second phase interface. The method further includes the step of having a third compound in the second non-fluorous phase that reacts with the fluorous-tagged compound to produce a second compound and the step of generating the first mixture by chemical or enzymatic kinetic resolution of a racemic or non-enantiopure compound.

摘要翻译： 一种获得对映体有机化合物的方法，包括以下步骤：1）从起始外消旋非对映体纯或非手性化合物产生包含至少一种含氟标记化合物和至少一种其它非氟标记化合物的第一混合物， 这两种化合物中的至少一种相对于起始化合物具有对映体; 2）在第一相界面处将包含第一混合物的第一非氟相与氟相接触，分配在第一非氟相和氟相之间的含氟标记化合物; 和3）在第二相界面处将氟相与第二非氟相接触。 所述方法还包括使所述第二非氟相中的第三化合物与所述含氟标记的化合物反应以产生第二化合物的步骤，以及通过化学或酶动力学拆分外消旋或非 - - 昂贵化合物。

公开(公告)号：US06610871B1

公开(公告)日：2003-08-26

申请号：US09763963

申请日：2001-05-03

申请人： Frank Duebner ,  Paul Knochel

发明人： Frank Duebner ,  Paul Knochel

IPC分类号： C07F1700

CPC分类号： C07F17/02 ,  C07B53/00 ,  C07B2200/07 ,  C07C1/325 ,  C07C17/00 ,  C07C41/30 ,  C07C67/293 ,  C07C69/007 ,  C07C69/155 ,  C07C43/15

摘要： An allylic compound is reacted with an organozinc compound Zn(R6)2 to eliminate a group (the leaving group) from the allylic compound and to add a group from the organozinc compound to it in the presence of a copper salt catalyst and a chiral organic ligand for the copper. A novel ferrocenyl compound and a novel copper complex of the ferrocenyl compound and copper are also described.

摘要翻译： 使烯丙基化合物与有机锌化合物Zn（R6）2反应，以除去烯丙基化合物的基团（离去基团），并在铜盐催化剂和手性有机物存在下，从有机锌化合物中加入基团 铜配体。 还描述了二茂铁基化合物和铜的新型二茂铁基化合物和新型铜络合物。

公开(公告)号：US06566572B2

公开(公告)日：2003-05-20

申请号：US09788550

申请日：2001-02-21

申请人： Kuniaki Okamoto ,  Tomimasa Kurita ,  Atsunori Sano

发明人： Kuniaki Okamoto ,  Tomimasa Kurita ,  Atsunori Sano

IPC分类号： C07C128

CPC分类号： C07C1/327 ,  C07C1/321 ,  C07C1/325 ,  C07C1/326 ,  C07C1/328 ,  C07C2603/24 ,  C07C15/28

摘要： 9,10-Diphenylanthracene, which can be produced applicably for industrial use in one or two process steps by subjecting a 9,10-dihalogenoanthracene and a metal or half-metal phenyl compound to a cross-coupling reaction.