公开(公告)号：US09648875B2

公开(公告)日：2017-05-16

申请号：US14347446

申请日：2011-10-28

Applicant: David William Koenig ,  Douglas Robert Hoffman ,  Yang Huang ,  Aimin He

Inventor： David William Koenig ,  Douglas Robert Hoffman ,  Yang Huang ,  Aimin He

IPC: A01N33/24 ,  A01N59/00 ,  A01N37/16 ,  A01N37/10 ,  A01N25/06 ,  A01N25/30 ,  A47K10/32 ,  A61K8/02 ,  A61K9/70 ,  A61Q17/00 ,  A01N25/08

CPC classification number: A01N33/24 ,  A01N25/08 ,  A01N37/10 ,  A01N59/00 ,  A47K2010/3266 ,  A61K8/0208 ,  A61K9/7007 ,  A61Q17/005 ,  A01N25/30 ,  A01N37/16

Abstract: Formulations and wipes for imparting a sporicide to a surface are disclosed herein. To achieve the sporicidal efficacy of the product, a synergistic amount of an amine oxide surfactant and a mixture of oxidants is incorporated into the formulation. The operative sporicidal formulation contains a solvent, an amine oxide surfactant, a water soluble oxidant and a water insoluble oxidant. Typically, the formulation can contain about 0.05 to about 3.7 percent (by weight of the formulation) of an amine oxide surfactant, about 0.5 to about 4 percent (by weight of the formulation) of a water soluble oxidant, and about 0.1 to about 6 percent (by weight of the formulation) of a water insoluble oxidant.

公开(公告)号：US20140170674A1

公开(公告)日：2014-06-19

申请号：US13730805

申请日：2012-12-28

Applicant: Aimin He

Inventor： Aimin He

IPC: G01N33/558 ,  G01N33/543

CPC classification number: G01N33/558

Abstract: This invention discloses an immunochromatographic assay device to detect and quantify analytes. The device utilizes up-converting luminescent probes to detect time-resolved luminescence signals. Because the unconverting luminescent probes can have relatively long emission lifetime, background interference from sample autofluorescence and light scattering from excitation source can be easily eliminated through delayed luminescence detection. Furthermore, the up-converting luminescent probes can be excited by near Infrared (IR) or IR light sources. In comparing with UV and visible lights, the near IR and IR lights can penetrate deeper into sample matrices and more effectively excite the probes, but not the sample matrices, resulting in less background and higher detection sensitivity. A simple and low cost reader can be designed to measure the delayed up-converting luminescence of long lifetime that does not use expensive optical filters and mirrors.

Abstract translation: 本发明公开了一种用于检测和定量分析物的免疫色谱测定装置。 该器件利用上转换发光探针来检测时间分辨发光信号。 因为未转换的发光探针具有相对长的发光寿命，所以通过延迟发光检测可以容易地消除来自样品自发荧光的背景干扰和来自激发源的光散射。 此外，上转换发光探针可以被近红外（IR）或红外光源激发。 与紫外光和可见光相比，近红外和红外光可以更深地渗透到样品基质中，更有效地激发探针，而不是样品基质，导致较少的背景和更高的检测灵敏度。 可以设计简单且低成本的读取器来测量不使用昂贵的光学滤波器和反射镜的长寿命的延迟上变换发光。

公开(公告)号：US08518311B2

公开(公告)日：2013-08-27

申请号：US12668255

申请日：2007-08-22

Applicant: Aimin He ,  James H. Wang ,  Vasily A. Topolkaraev ,  Gregory J. Wideman ,  Doris Palfery

Inventor： Aimin He ,  James H. Wang ,  Vasily A. Topolkaraev ,  Gregory J. Wideman ,  Doris Palfery

IPC: D01D5/32 ,  D01D5/34 ,  D01F8/14 ,  D04H3/00

CPC classification number: D01F8/14 ,  A61F13/15252 ,  B32B5/16 ,  B32B27/12 ,  B32B27/36 ,  B32B2307/7163 ,  D01F6/92 ,  D04H3/03 ,  D04H3/16 ,  D04H13/00 ,  Y10T428/2929 ,  Y10T442/697

Abstract: A biodegradable, substantially continuous filament is provided. The filament contains a first component formed from at least one high melting polyester and a second component formed from at least one low melting polyester. The low melting point polyester is an aliphatic-aromatic copolyester formed by melt blending a polymer and an alcohol to initiate an alcoholysis reaction that results in a copolyester having one or more hydroxyalkyl or alkyl terminal groups. By selectively controlling the alcoholysis conditions (e.g., alcohol and copolymer concentrations, catalysts, temperature, etc.), a modified aliphatic-aromatic copolyester may be achieved that has a molecular weight lower than the starting aliphatic-aromatic polymer. Such lower molecular weight polymers also have the combination of a higher melt flow index and lower apparent viscosity, which is useful in the formation of substantially continuous filaments.

Abstract translation: 提供了可生物降解的，基本连续的细丝。 长丝包含由至少一种高熔点聚酯形成的第一组分和由至少一种低熔点聚酯形成的第二组分。 低熔点聚酯是通过熔融共混聚合物和醇以引发醇解反应形成的脂族 - 芳族共聚酯，其导致共聚酯具有一个或多个羟烷基或烷基端基。 通过选择性地控制醇解条件（例如醇和共聚物浓度，催化剂，温度等），可以实现具有低于起始脂族 - 芳族聚合物的分子量的改性脂族 - 芳族共聚酯。 这种低分子量聚合物还具有较高的熔体流动指数和较低的表观粘度的组合，其可用于形成基本连续的长丝。

公开(公告)号：US20130171624A1

公开(公告)日：2013-07-04

申请号：US13730814

申请日：2012-12-28

Applicant: Aimin He

Inventor： Aimin He

IPC: G01N33/58

CPC classification number: G01N33/582 ,  G01N33/54326 ,  G01N2458/40

Abstract: This invention describes a general magnetic binding assay method to detect the presence and quantity of analyte in a sample. The method uses magnetic particles for separating and concentrating analytes of interest from complex samples and use time-resolved up-converting fluorescence detection technique to provide highly sensitive detection without using expensive optical components such as band-pass filters. The method uses pulsed long wavelength light for excitation and time-delayed luminescence detection, resulting in little interferences from sample matrices. Furthermore, the usage of long wavelength excitation light requires simpler sample preparation and clean-up such as removal of red blood cells, which otherwise will significantly interfere with excitation efficiency of the fluorescence probes.

Abstract translation: 本发明描述了用于检测样品中分析物的存在和量的一般磁结合测定方法。 该方法使用磁性颗粒从复杂样品中分离和浓缩感兴趣的分析物，并使用时间分辨上变换荧光检测技术，以提供高灵敏度检测，而不使用昂贵的光学组件，如带通滤光片。 该方法使用脉冲长波长光进行激发和时间延迟的发光检测，导致样品基质几乎没有干扰。 此外，长波长激发光的使用需要更简单的样品制备和清除，例如去除红细胞，否则将显着干扰荧光探针的激发效率。

公开(公告)号：US08461262B2

公开(公告)日：2013-06-11

申请号：US13553912

申请日：2012-07-20

Applicant: Ryan J. McEneany ,  Vasily A. Topolkaraev ,  Aimin He

Inventor： Ryan J. McEneany ,  Vasily A. Topolkaraev ,  Aimin He

IPC: C08L67/00 ,  C08L67/04 ,  C08G63/08

CPC classification number: C08L67/04 ,  C08L71/02 ,  D01F1/10 ,  D01F6/625 ,  D01F6/92 ,  Y10T428/2913 ,  C08L23/26

Abstract: A biodegradable fiber that is formed from a thermoplastic composition that contains polylactic acid, a plasticizer, and a compatibilizer is provided. The compatibilizer includes a polymer that is modified with a polar compound that is compatible with the plasticizer and a non-polar component provided by the polymer backbone that is compatible with polylactic acid. Such functionalized polymers may thus stabilize each of the polymer phases and reduce plasticizer migration. By reducing the plasticizer migration, the composition may remain ductile and soft. Further, addition of the functionalized polymer may also promote improved bonding and initiate crystallization faster than conventional polylactic acid fibers. The polar compound includes an organic acid, an anhydride of an organic acid, an amide of an organic acid, or a combination thereof. Such compounds are believed to be more compatible with the generally acidic nature of the polylactic acid fibers.

Abstract translation: 提供由含有聚乳酸，增塑剂和增容剂的热塑性组合物形成的生物可降解纤维。 增容剂包括用与增塑剂相容的极性化合物改性的聚合物和由与聚乳酸相容的聚合物主链提供的非极性组分。 这样的官能化聚合物因此可以稳定每个聚合物相并减少增塑剂迁移。 通过减少增塑剂迁移，组合物可保持延展性和柔软性。 此外，官能化聚合物的添加还可以促进改进的粘合并且比常规聚乳酸纤维更快地引发结晶。 极性化合物包括有机酸，有机酸的酸酐，有机酸的酰胺或其组合。 据信这些化合物与聚乳酸纤维的普遍酸性特性更相容。

公开(公告)号：US20100323575A1

公开(公告)日：2010-12-23

申请号：US12741665

申请日：2007-12-13

Applicant: Aimin He ,  Vasily A. Topolkaraev

Inventor： Aimin He ,  Vasily A. Topolkaraev

IPC: D04H13/00 ,  C08L67/00

CPC classification number: D01F6/92 ,  D01D5/08 ,  D01D5/0985 ,  D01F8/14 ,  D04H1/4282 ,  D04H1/4326 ,  D04H1/435 ,  D04H1/4382 ,  D04H1/74 ,  D04H3/011 ,  D04H3/016 ,  D04H3/02 ,  D04H13/00 ,  Y10T442/60 ,  Y10T442/68 ,  Y10T442/681

Abstract: A biodegradable fiber for use in forming a nonwoven web is provided. The fiber is formed from a thermoplastic composition comprising at least one polylactic acid in an amount from about 75 wt. % to about 99 wt. % and at least one polyether copolymer in an amount from about 1 wt. % to about 25 wt. %, wherein the polyether copolymer contains from about 40 mol. % to about 95 mol. % of a repeating unit (A) having the following formula. wherein, x is an integer from 1 to 250, the polyether copolymer further containing from about 5 mol. % to about 60 mol. % of a repeating unit (B) having the following formula. wherein, n is an integer from 3 to 20; and y is an integer from 1 to 150. Such polyether copolymers have been found to improve a variety of characteristics of the resulting thermoplastic composition, including its ability to be melt processed into fibers and webs, as well as its sensitivity to moisture.

Abstract translation: 提供了用于形成非织造纤维网的可生物降解纤维。 纤维由热塑性组合物形成，该热塑性组合物包含至少一种约75wt。 ％至约99wt。 ％和至少一种聚醚共聚物，其量为约1wt。 ％至约25wt。 ％，其中聚醚共聚物含有约40mol。 ％至约95mol。 ％的具有下式的重复单元（A）。 其中，x为1至250的整数，所述聚醚共聚物还含有约5mol。 ％至约60mol。 ％的具有下式的重复单元（B）。 其中n为3至20的整数; 并且y是1至150的整数。已经发现，这种聚醚共聚物可以改善所得热塑性组合物的各种特性，包括其熔融加工成纤维和纤维网的能力，以及其对水分的敏感性。

公开(公告)号：US20090305594A1

公开(公告)日：2009-12-10

申请号：US12136090

申请日：2008-06-10

Applicant: Aimin He ,  Vasily A. Topolkaraev ,  Alan E. Wright ,  Gregory J. Wideman

Inventor： Aimin He ,  Vasily A. Topolkaraev ,  Alan E. Wright ,  Gregory J. Wideman

IPC: C08F283/01 ,  D04H13/00

CPC classification number: D01F6/62 ,  C08F283/01 ,  C08L67/02 ,  C08L71/02 ,  D01F6/66 ,  D04H1/56 ,  D04H1/565 ,  Y10T442/60 ,  Y10T442/68 ,  Y10T442/681 ,  Y10T442/696 ,  C08L2666/22

Abstract: A method for forming a fiber is provided. The method comprises supplying at least one aromatic polyester to a melt processing device and modifying the aromatic polyester with at least one polyether copolymer within the device to form a thermoplastic composition having a melt flow rate that is greater than the melt flow rate of the aromatic polyester. The polyether copolymer contains a repeating unit (A) having the following formula: C2H4Ox   (A) wherein, x is an integer from 1 to 250, the polyether copolymer further containing a repeating unit (B) having the following formula: CnH2nOy   (B) wherein, n is an integer from 3 to 20; and y is an integer from 1 to 150.

Abstract translation: 提供了一种形成纤维的方法。 该方法包括向熔融加工装置供应至少一种芳族聚酯，并在装置内用至少一种聚醚共聚物改性芳族聚酯以形成熔体流动速率大于芳族聚酯的熔体流动速率的热塑性组合物 。 聚醚共聚物含有具有下式的重复单元（A）：其中，x为1〜250的整数，聚醚共聚物还含有具有下式的重复单元（B）： C n H 2n O（B）其中，n为3至20的整数; y为1〜150的整数。