公开(公告)号：US20230386176A1

公开(公告)日：2023-11-30

申请号：US18031972

申请日：2021-10-19

Applicant: BIOMERIEUX ,  BIOASTER

Inventor： Pierre MAHÉ ,  Meriem EL AZAMI ,  Elodie DEGOUT-CHARMETTE ,  Zohreh SEDAGHAT ,  Quentin JOSSO ,  Fabian ROL

IPC: G06V10/764 ,  G06T7/11 ,  G06V10/24 ,  G06V10/771 ,  G06V20/69

CPC classification number: G06V10/764 ,  G06T7/11 ,  G06V10/24 ,  G06V10/771 ,  G06V20/69 ,  G06V2201/07 ,  G06T2207/20084 ,  G06T2207/20132

Abstract: A method for classifying at least one input image representing a target particle in a sample involves implementing, by data processing a client, steps of: (B) extracting a characteristic map of the target particle from the input image; (c) reducing the number of variables in the extracted characteristic map, using the t-SNE algorithm; (d) classifying, unsupervised, the input image based on the characteristic map having a reduced number of variables.

公开(公告)号：US20230313326A1

公开(公告)日：2023-10-05

申请号：US18014934

申请日：2021-07-05

Applicant: BIOMÉRIEUX ,  BIOASTER

Inventor： Laurence VACHOT ,  François MALLET ,  Guillaume MONNERET ,  Virginie MOUCADEL ,  Alexandre PACHOT ,  Estelle PERONNET ,  Thomas RIMMELÉ ,  Julien TEXTORIS ,  Fabienne VENET

IPC: C12Q1/70 ,  C12Q1/689

CPC classification number: C12Q1/702 ,  C12Q1/689 ,  C12Q2600/158 ,  C12Q2600/118

Abstract: An in vitro or ex vivo method for determining the risk of complication in a patient, including a step of measuring the expression of C3AR1 in a biological sample from the patient.

公开(公告)号：US20220356459A1

公开(公告)日：2022-11-10

申请号：US17745205

申请日：2022-05-16

Applicant: Da Volterra ,  Bioaster

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/86 ,  A61K31/407 ,  A61K31/496 ,  A61K31/546 ,  A61K38/50

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

公开(公告)号：US20220333201A1

公开(公告)日：2022-10-20

申请号：US17764323

申请日：2020-09-25

Applicant: BIOMÉRIEUX ,  BIOASTER ,  HOSPICES CIVILS DE LYON

Inventor： Laurence VACHOT ,  François MALLET ,  Guillaume MONNERET ,  Virginie MOUCADEL ,  Alexandre PACHOT ,  Estelle PERONNET ,  Thomas RIMMELÉ ,  Julien TEXTORIS ,  Fabienne VENET

IPC: C12Q1/6883 ,  G16H50/30

Abstract: An in vitro or ex vivo method for determining the risk of occurrence of a healthcare-associated infection in a patient, including a step of measuring the expression of CX3CR1, in a biological sample of said patient.

公开(公告)号：US11365403B2

公开(公告)日：2022-06-21

申请号：US16757968

申请日：2018-10-24

Applicant: Da Volterra ,  Bioaster

Inventor： Jean De Gunzburg ,  Jean-Denis Docquier

IPC: C12N9/84 ,  C12N1/21 ,  A61K38/50 ,  C12N9/86 ,  A61K31/407 ,  A61K31/496 ,  A61K31/546 ,  A61K38/00

Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.

公开(公告)号：US20210373004A1

公开(公告)日：2021-12-02

申请号：US17294327

申请日：2019-11-18

Applicant: BIOASTER

Inventor： Patrick LECINE ,  Christophe VEDRINE ,  Adrien LUGARI

IPC: G01N33/543 ,  G01N33/68

Abstract: A support for a multiplex binding experiment is functionalized with at least two different polypeptides. The polypeptides are provided in a reaction mixture along with their cognate binding partners. The polypeptides have high affinity for their cognate binding partners provided in the reaction mixture. The polypeptides and their cognate binding partners can be used in immunoassays.