公开(公告)号：US20230033749A1

公开(公告)日：2023-02-02

申请号：US17728485

申请日：2022-04-25

Applicant: Georgetown University ,  The Board of Regents of the University of Oklahoma

Inventor： Milton L. Brown ,  Yali Kong ,  Courtney Houchen ,  Sripathi M. Sureban ,  Parthasarathy Chandrakesan

IPC: A61K31/454 ,  A61P39/00 ,  A61K31/4184

Abstract: Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

公开(公告)号：US11530239B2

公开(公告)日：2022-12-20

申请号：US17192152

申请日：2021-03-04

Applicant: The Board of Regents of the University of Oklahoma

Inventor： David C. Kem ,  Xichun Yu ,  Hongliang Li ,  LaTasha B. Craig

IPC: C07K7/06 ,  C07K7/08 ,  C07K14/71 ,  C07K5/10 ,  A61P35/00 ,  A61P5/02 ,  A61P15/08 ,  A61K38/00

Abstract: The disclosure is directed in non-limiting embodiments to compounds, compositions, and methods of treating conditions and diseases associated with activation of the gonadotropin GnRH receptor (GnRHR), particularly those involving GnRHR activating autoantibodies (GnRHR AAbs). In one non-limiting embodiment, the disease is Polycystic Ovary Syndrome (PCOS). The therapeutic compounds in at least certain embodiments include peptides which at least partially comprise D-amino acids, such as retro-inverso D-amino acid (RID) peptides, which are able to bind with high affinity to GnRHR AAbs.

公开(公告)号：US11446365B2

公开(公告)日：2022-09-20

申请号：US16331634

申请日：2018-08-09

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Roger G. Harrison, Jr. ,  Patrick H. McKernan

IPC: A61K38/51 ,  A61K47/60 ,  A61K45/06 ,  C12N9/88 ,  A61K31/223

Abstract: A method, composition, and kit for treating a malarial infection in a subject by using an enzyme conjugate comprising a variant cystathione-gamma-lyase and a targeting ligand which binds to erythrocytes infected with Plasmodium pathogens. The variant cystathione-gamma-lyase has methioninase activity. Also disclosed is a method of treating Plasmodium-infected blood by exposing the infected blood with the enzyme conjugate.

公开(公告)号：US20220277902A1

公开(公告)日：2022-09-01

申请号：US17631229

申请日：2020-07-29

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Zhisheng Shi ,  Jijun Qiu

IPC: H01G9/20 ,  H01L51/42 ,  H01L51/44

Abstract: A solar cell having a transparent conducting layer disposed upon a substrate, an electron transporting layer (ETL) disposed upon the transparent conducting layer, a perovskite layer disposed upon the ETL layer, an inorganic dichalcogenide material disposed upon the perovskite layer, and a conducting material disposed upon the dichalcogenide material, the dichalcogenide material and the conducting material together comprising a dichalcogenide composite electrode. In another embodiment, the solar cell has a first conducting material disposed upon a substrate, an inorganic dichalcogenide material disposed upon the first conducting material forming a dichalcogenide composite electrode, a perovskite layer disposed upon the dichalcogenide composite electrode, an ETL disposed upon the perovskite layer, and a second conducting material disposed upon the ETL.

公开(公告)号：US20220228339A1

公开(公告)日：2022-07-21

申请号：US17581304

申请日：2022-01-21

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Blake A. Herren ,  Yingtao Liu ,  M. Cengiz Altan ,  Mrinal C. Saha

IPC: E02B15/04 ,  E02B15/10

Abstract: A sorbent-based oil skimmer is configured to collect oil from an oil layer and passively deposit the oil in an encasing, where the oil can be continuously or periodically removed. The oil skimmer includes an encasing and a sponge that is partially enclosed within the encasing. The sponge has a top sheet in contact with the oil layer and a shell connected to the top sheet, where the shell extends into the encasing. Oil collected by the top sheet is conveyed through the shell, where it is deposited into the encasing under the force of gravity. In some applications, the sponge is manufactured from a silicone-based polymer that has been impregnated with carbonaceous material. The skimmer may optionally include counterweights, ballast tanks, buoyancy adjustment systems and propulsion modules.

公开(公告)号：US20220225127A1

公开(公告)日：2022-07-14

申请号：US17617505

申请日：2020-06-11

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Ali Imran ,  Hasan Farooq ,  Ahmad Asghar

IPC: H04W24/02 ,  H04B17/309

Abstract: An apparatus comprises: a memory; and a processor coupled to the memory and configured to: build a prediction model that predicts next cells of UEs in a future time step of a mobile network; map the next cells to future user locations; determine future loads of BSs in the mobile network based on the future user locations; determine an optimization of the mobile network using the future loads; and implement the optimization by instructing the BSs to adjust a parameter in the future time step.

公开(公告)号：US20220202924A1

公开(公告)日：2022-06-30

申请号：US17694639

申请日：2022-03-14

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Terrence L. Stull ,  Daniel J. Morton ,  Thomas W. Seale ,  Paul W. Whitby

IPC: A61K39/102 ,  A61K9/00 ,  C07K14/285

Abstract: Immunogenic peptides, fusion polypeptides, and carrier molecules which include the immunogenic peptides, and immunogenic compositions which include these immunogenic peptides, fusion polypeptides, and/or carrier molecules bearing the peptides, and which are able to elicit antibody production against Haemophilus influenzae (Hi), are disclosed. Also disclosed are methods of their use in causing an antibody response against one or more strains of Hi.

公开(公告)号：US11357972B2

公开(公告)日：2022-06-14

申请号：US16955238

申请日：2018-12-14

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Sunny Po ,  Benjamin Scherlag ,  Stavros Stavrakis ,  Paul Garabelli ,  David Albert

IPC: A61N1/04 ,  A61N1/08 ,  A61N1/36 ,  A61N1/362 ,  A61N1/365

Abstract: Methods and systems for alleviating disorders and complications associated with autonomic nervous system dysfunction. The approach generally includes measuring heart rate signals from a subject to measure heart rate variability and determine a heart rate variability threshold, determining that the subject is experiencing autonomic nervous system dysfunction, and alerting the subject to stimulate the auricular branch of the vagus nerve with an ear device.

公开(公告)号：US20220162157A1

公开(公告)日：2022-05-26

申请号：US17666692

申请日：2022-02-08

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Weidong Wang ,  Venkateswararao Eeda

IPC: C07C233/73 ,  C07D317/54

Abstract: Benzylamino-oxoethyl benzamide compounds for use in treating diseases and conditions associated with abnormal cell function related to endoplasmic reticulum (ER) stress. For example, the compounds can be used as suppressors of ER stress-induced pancreatic β-cell dysfunction and death, for example in the treatment of Type 1 and Type 2 diabetes. The compounds can also be used in treatments for chronic heart disease, neurodegenerative diseases, retinal degeneration, and other metabolic disorders associated with ER stress.

公开(公告)号：US11337968B2

公开(公告)日：2022-05-24

申请号：US16097353

申请日：2017-04-28

Applicant: The Board of Regents of the University of Oklahoma

Inventor： Jian-xing Ma ,  Elizabeth Moran ,  Guotao Deng ,  Adam S. Duerfeldt

IPC: A61K31/47 ,  A61K9/00 ,  A61P27/02

Abstract: Compositions containing a phenylquinoline derivative compound having peroxisome proliferator-activated receptor a (PPARα) agonistic activity, and methods of their use in enhancing PPARα activity in retinal cells, and in treating ocular disorders or conditions, such as but not limited to retinal inflammation, retinal neovascularization, retinal vascular leakage, retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, and diabetic macular edema are disclosed.