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公开(公告)号：US20120282622A1
公开(公告)日：2012-11-08
申请号：US13547954
申请日：2012-07-12
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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公开(公告)号：US08110594B2
公开(公告)日：2012-02-07
申请号：US11730168
申请日：2007-03-29
申请人： Michael E. Jung , Dongwon Yoo , Charles L. Sawyers , Chris Tran , John Wongvipat
发明人： Michael E. Jung , Dongwon Yoo , Charles L. Sawyers , Chris Tran , John Wongvipat
IPC分类号： A61K31/4166 , C07D233/86
CPC分类号： C07D235/02 , A61K31/4166 , A61K31/4184 , C07D233/86
摘要： The present invention relates to diarylthiohydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
摘要翻译： 本发明涉及二芳基硫代乙内酰脲化合物及其合成方法，并用于治疗激素难治性前列腺癌。
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23.发明申请MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571 审中-公开与STI-571相关的BCR-ABL酪氨酸激酶相关突变公开(公告)号：US20120021425A1
公开(公告)日：2012-01-26
申请号：US13248921
申请日：2011-09-29
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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24.发明授权公开(公告)号：US07718684B2
公开(公告)日：2010-05-18
申请号：US10590445
申请日：2005-02-23
IPC分类号： A01N43/50 , C07D293/00 , C07D409/00
CPC分类号： A61K31/426
摘要： A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds.
摘要翻译： 雄激素受体（AR）mRNA的适度（2-5倍）增加是与抗雄激素治疗发展抵抗力的唯一表达变化。 增加的AR水平通过放大来自低水平的残留配体的信号输出并改变对拮抗剂的正常反应来赋予抗雄激素抗性。 本发明提供用于检查新的治疗方式的基于细胞的测定法，并提供新的抗雄激素化合物的设计。
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25.发明申请Mutations in the BCR-ABL tyrosine kinase associated with resistance to ST1-571 有权与ST1-571抗性相关的BCR-ABL酪氨酸激酶突变公开(公告)号：US20100055687A1
公开(公告)日：2010-03-04
申请号：US12381448
申请日：2009-03-11
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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公开(公告)号：US07595431B2
公开(公告)日：2009-09-29
申请号：US11531212
申请日：2006-09-12
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
摘要： The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
摘要翻译： 本发明提供了具有局部晚期或转移性前列腺癌的人前列腺异种移植物的免疫缺陷小鼠及其用途。
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27.发明申请Mutations in the BCR-ABL tyrosine kinase associated with resistance to STI-571 有权与STI-571抗性相关的BCR-ABL酪氨酸激酶突变公开(公告)号：US20090155787A1
公开(公告)日：2009-06-18
申请号：US12080596
申请日：2008-04-04
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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公开(公告)号：US07053263B2
公开(公告)日：2006-05-30
申请号：US10022115
申请日：2001-12-14
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
摘要： The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
摘要翻译： 本发明提供了具有局部晚期或转移性前列腺癌的人前列腺异种移植物的免疫缺陷小鼠及其用途。
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公开(公告)号：US06828471B2
公开(公告)日：2004-12-07
申请号：US10062925
申请日：2002-01-30
IPC分类号： A01K6700
CPC分类号： A01K67/0271 , A01K2227/105 , A01K2267/0331 , A61K49/0008
摘要： The present invention provides an immune deficient mouse having a human prostate xenograft of locally advanced or metastatic prostate cancer and uses thereof.
摘要翻译： 本发明提供了具有局部晚期或转移性前列腺癌的人前列腺异种移植物的免疫缺陷小鼠及其用途。
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30.发明申请ANDROGEN RECEPTOR MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND ANDROGEN RECEPTOR-ASSOCIATED DISEASES 有权用于治疗前列腺癌和雄激素受体相关疾病的雄激素受体调节剂公开(公告)号：US20130072511A1
公开(公告)日：2013-03-21
申请号：US13615085
申请日：2012-09-13
申请人： Michael E. Jung , Charles L. Sawyers , Samedy Ouk , Chris Tran , John Wongvipat
发明人： Michael E. Jung , Charles L. Sawyers , Samedy Ouk , Chris Tran , John Wongvipat
IPC分类号： A61K31/4439 , A61P35/00 , C07D401/04
CPC分类号： A61K31/4439 , A61K9/48 , C07D401/04
摘要： Described herein, inter alia, are compounds useful for the prevention or treatment of hyperproliferative diseases or disorders.
摘要翻译： 本文所描述的是可用于预防或治疗过度增殖性疾病或病症的化合物。
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