公开(公告)号：US20110207912A1

公开(公告)日：2011-08-25

申请号：US13013734

申请日：2011-01-25

Applicant: David Botstein ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Margaret Ann Roy

Inventor： David Botstein ,  Audrey Goddard ,  Austin L. Gurney ,  Kenneth J. Hillan ,  David A. Lawrence ,  Margaret Ann Roy

IPC: C07K14/50 ,  C07H21/04 ,  C12N15/63 ,  C12N1/19 ,  C12P21/02 ,  C12N5/10 ,  C12N1/21

CPC classification number: C07K14/50 ,  C07K2317/24 ,  C07K2319/00

Abstract: The present invention is directed to novel polypeptides having homology to the PRO533 protein and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention, and methods for producing the polypeptides of the present invention. The invention concerns compositions and methods for the diagnosis and treatment of neoplastic cell growth and proliferation in mammals, including humans. The invention is based on the identification of genes that are amplified in the genome of tumor cells. Such gene amplification is expected to be associated with the overexpression of the gene product and contribute to tumorigenesis and/or autocrine signaling. Accordingly, the proteins encoded by the amplified genes are believed to be useful targets for the diagnosis and/or treatment (including prevention) of certain cancers, and may act of predictors of the prognosis of tumor treatment. Furthermore, the compounds, compositions including antagonists and methods of the present invention are further expected to have therapeutic effect upon conditions characterized by FgF-19 modulation.

Abstract translation: 本发明涉及与PRO533蛋白质和编码这些多肽的核酸分子具有同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明多肽的嵌合多肽分子，与本发明的多肽结合的抗体，以及本发明多肽的制备方法 发明。 本发明涉及用于诊断和治疗哺乳动物包括人类的肿瘤细胞生长和增殖的组合物和方法。 本发明基于在肿瘤细胞基因组中扩增的基因的鉴定。 预期这种基因扩增与基因产物的过度表达有关，并且有助于肿瘤发生和/或自分泌信号传导。 因此，由扩增的基因编码的蛋白质被认为是某些癌症的诊断和/或治疗（包括预防）的有用靶标，并且可以作为肿瘤治疗预后的预测因子。 此外，进一步预期本发明的化合物，包括拮抗剂和方法的组合物对于以FgF-19调节为特征的病症具有治疗作用。

公开(公告)号：US10823098B1

公开(公告)日：2020-11-03

申请号：US16387677

申请日：2019-04-18

Applicant: Ethan E Bayer ,  Jonathan D Stoffer ,  David A Lawrence ,  William P Attard ,  Tyler Tutton

Inventor： Ethan E Bayer ,  Jonathan D Stoffer ,  David A Lawrence ,  William P Attard ,  Tyler Tutton

IPC: F02D41/22 ,  F02D41/14 ,  F02D41/00 ,  G07C5/08 ,  B60W50/14

Abstract: A low speed pre-ignition detection, mitigation, and driver notification system and method utilize a controller to analyze a knock signal from a knock sensor to detect LSPI knock of the engine and in response to detecting the LSPI knock, enrich a fuel/air ratio of the engine and limit a torque output of the engine to a level that is less than a maximum torque output of the engine, and when enriching the fuel/air ratio of the engine and limiting the torque output of the engine does not mitigate the LSPI knock, output at least one message for a driver of the vehicle instructing the driver to take remedial action to mitigate the LSPI knock.

公开(公告)号：US10584630B2

公开(公告)日：2020-03-10

申请号：US15586806

申请日：2017-05-04

Applicant: David A Lawrence ,  Ethan Bayer ,  John Bucknell

Inventor： David A Lawrence ,  Ethan Bayer ,  John Bucknell

IPC: F02B37/18 ,  F02B37/12 ,  F02D41/00 ,  F02D41/14 ,  F02B37/16 ,  F04D25/04 ,  F02D23/00

Abstract: A power-based control system and method for an engine comprising a turbocharger involve obtaining a set of parameters that each affect exhaust gas energy and using the set of parameters to (i) determine a target mass flow into the engine and a target boost for the turbocharger to achieve a torque request, (ii) determine a target power for a compressor of the turbocharger to achieve the target engine mass flow and the target turbocharger boost, (iii) determine a target pressure ratio and a target mass exhaust flow for the turbine of the turbocharger to achieve a target turbine power equal to the target compressor power, and (iv) determine a target position of the wastegate valve to achieve the target turbine pressure ratio and mass exhaust flow, and commanding a wastegate valve to the target position.

公开(公告)号：US09541018B2

公开(公告)日：2017-01-10

申请号：US14851033

申请日：2015-09-11

Applicant: Ethan E Bayer ,  Ayman Ismail ,  David A Lawrence

Inventor： Ethan E Bayer ,  Ayman Ismail ,  David A Lawrence

IPC: F01L1/34 ,  F02D41/00 ,  F02D41/14 ,  F02D13/02 ,  F02B75/22 ,  F02D41/24 ,  F01L13/00

CPC classification number: F02D41/0082 ,  F01L1/34 ,  F01L2013/111 ,  F01L2800/11 ,  F01L2820/041 ,  F01L2820/042 ,  F02B75/22 ,  F02D13/0226 ,  F02D13/0238 ,  F02D41/0085 ,  F02D41/1405 ,  F02D41/1443 ,  F02D41/1454 ,  F02D41/2451 ,  F02D41/2454 ,  F02D2041/001 ,  F02D2200/0411 ,  Y02T10/18

Abstract: An engine bank-to-bank airflow balancing technique includes calculating current and offset volumetric efficiencies of the engine and calculating a slope representing (i) a difference between the offset and current volumetric efficiencies and (ii) a difference between offset and current intake camshaft positions. Based on the respective exhaust gas oxygen concentrations, the technique involves calculating a volumetric efficiency correction corresponding to each cylinder bank and based on the slope and the volumetric efficiency corrections, calculating target intake camshaft position shifts. The technique further involves controlling offsets of the intake camshafts based on the target intake camshaft position shifts. After a predetermined number of target intake camshaft position shifts are determined and stored with respect to various combinations of engine speed and a ratio of intake manifold pressure to barometric pressure, final intake camshaft position shifts may be determined and utilized when determining the intake camshaft positions.

Abstract translation: 发动机库对空气流平衡技术包括计算发动机的当前和偏移体积效率并计算斜率，其表示（i）偏移和当前体积效率之间的差异，以及（ii）偏置和当前进气凸轮轴位置之间的差异 。 基于相应的废气氧浓度，该技术涉及计算对应于每个气缸组的体积效率校正，并且基于斜率和体积效率校正，计算目标进气凸轮轴位置偏移。 该技术还包括基于目标进气凸轮轴位置偏移来控制进气凸轮轴的偏移。 在相对于发动机转速和进气歧管压力与大气压力的比例的各种组合来确定和存储预定数量的目标进气凸轮轴位置偏移之后，可以在确定进气凸轮轴位置时确定和利用最终进气凸轮轴位置偏移。

公开(公告)号：US06854167B2

公开(公告)日：2005-02-15

申请号：US10315409

申请日：2002-12-09

Applicant: Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  Curtis Brian Williamson

Inventor： Andre M. Goineau ,  David A. Lawrence ,  Jimmy B. Henson ,  Renee G. Booths ,  Curtis Brian Williamson

IPC: D02J3/02

CPC classification number: D02J3/02 ,  D02G1/162 ,  D02J1/08

Abstract: A process for forming a continuous filament yarn having the surface tactile character of a spun yarn. The process includes passing the cohesive yarn structure through the interior of a rotating sleeve member disposed in surrounding relation to the cohesive yarn structure. The rotating sleeve member includes an abrasive inner surface of diameter greater than the cohesive yarn structure and is adapted to contact the exterior surface of the cohesive yarn structure such that at least a portion of the elongate filaments disposed at the exterior of the cohesive yarn structure are broken. Terminal ends of the broken filaments define an arrangement of outwardly projecting hairs at discrete locations disposed substantially around the circumference of the cohesive yarn structure. An apparatus for carrying out the process is also provided.

公开(公告)号：US06764679B2

公开(公告)日：2004-07-20

申请号：US09896096

申请日：2001-06-28

Applicant: Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

Inventor： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC: C07K1628

CPC classification number: A01K67/0275 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/70575 ,  C07K14/70578 ,  C07K16/2875 ,  C07K16/2878 ,  C07K2317/73 ,  C07K2319/00 ,  C12N2799/026

Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

Abstract translation: 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。

公开(公告)号：US12292341B2

公开(公告)日：2025-05-06

申请号：US17893345

申请日：2022-08-23

Applicant: Shu S Wang ,  David A Lawrence ,  Michael Barkey

Inventor： Shu S Wang ,  David A Lawrence ,  Michael Barkey

IPC: G01K7/16 ,  B60R16/03 ,  B60W20/50

Abstract: A system and method of controlling a powertrain to protect a high voltage cable by determining a temperature characteristic for a busbar, determining a temperature characteristic adjacent to a component, and determining a current through the high voltage cable. Thereafter, the method reduces an operating characteristic of the powertrain based on the temperature characteristic for the busbar, the temperature characteristic adjacent to the component, and the current.

公开(公告)号：US11286871B1

公开(公告)日：2022-03-29

申请号：US17158459

申请日：2021-01-26

Applicant: Shuonan Xu ,  David A Lawrence ,  Ethan E Bayer

Inventor： Shuonan Xu ,  David A Lawrence ,  Ethan E Bayer

IPC: F02D41/14 ,  F02D41/24 ,  F02D41/00 ,  G06N3/08

Abstract: A combustion control method and system for an engine of a vehicle comprises a controller configured to access a trained feedforward artificial neural network configured to model a volumetric efficiency (VE) of the engine based on measured engine speed, engine intake manifold absolute pressure, intake and exhaust camshaft positions, intake air temperature, and engine coolant temperature, generate a base VE of the engine using the trained feedforward artificial neural network and the measured parameters, estimate an air charge mass flowing to each cylinder of the engine based on the base VE of the engine, and control combustion in the cylinders of the engine based on the estimated air charge mass to improve at least one of combustion stability, torque response, and fuel economy.

公开(公告)号：US10788396B2

公开(公告)日：2020-09-29

申请号：US16224988

申请日：2018-12-19

Applicant: William P Attard ,  Shu Wang ,  Shuonan Xu ,  Tyler Tutton ,  Srinath Gopinath ,  David A Lawrence

Inventor： William P Attard ,  Shu Wang ,  Shuonan Xu ,  Tyler Tutton ,  Srinath Gopinath ,  David A Lawrence

IPC: G01M15/04 ,  F02P5/15 ,  F02P17/04 ,  F02D41/14

Abstract: A calibration system and method for a spark ignition engine of a vehicle involve artificially weighting engine dynamometer data in high engine load regions and using it to generate training data for an artificial neutral network (ANN). A plurality of ANNs are trained using the training data and the plurality of ANNs are then filtered based on their maximum error to obtain a filtered set of trained ANNs. A statistical analysis is performed on each of the filtered set of trained ANNs including determining a set of statistical metrics for each of the filtered set of trained ANNs and then one of the filtered set of trained ANNs having a best combination of error at high engine loads and the set of statistical error metrics is then selected. Finally, an ANN calibration is generated using the selected one of the filtered set of trained ANNs.

公开(公告)号：US20090191184A1

公开(公告)日：2009-07-30

申请号：US12287810

申请日：2008-10-14

Applicant: Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

Inventor： Avi J. Ashkenazi ,  David Botstein ,  Kelly H. Dodge ,  Audrey Goddard ,  Austin L. Gurney ,  Kyung Jin Kim ,  David A. Lawrence ,  Robert Pitti ,  Margaret A. Roy ,  Daniel B. Tumas ,  William I. Wood

IPC: A61K38/17 ,  A61K39/395

CPC classification number: C07K14/70578 ,  A01K2217/05 ,  C07H21/04

Abstract: A TNFR homolog, identified as DcR3, is provided. Nucleic acid molecules encoding DcR3, chimeric molecules and antibodies to DcR3 are also provided.

Abstract translation: 提供了标识为DcR3的TNFR同源物。 还提供了编码DcR3的核酸分子，嵌合分子和DcR3的抗体。