公开(公告)号：US6081256A

公开(公告)日：2000-06-27

申请号：US164884

申请日：1998-10-01

申请人： Martin Herget ,  Diana Martin

发明人： Martin Herget ,  Diana Martin

IPC分类号： G06F3/0484 ,  G09G5/08

CPC分类号： G06F3/04847

摘要： In a method for reading in a data value that is entered with a pointer actuator a data value as well as a place value (i.e., 10.sup.x where x is arbitrary) is prescribed, a control motion is read in, at least a first motion value or a second motion value dependent on the control motion is determined, and the place value is modified if necessary dependent on the first motion value and the data value is modified if necessary dependent on the second motion value and the current place value. With such a method, data values can be entered fast and comfortably with a pointer in a large value range and with high precision.

摘要翻译： 在用于读取使用指针致动器输入的数据值的方法中，规定数据值以及位置值（即，x是任意的10x），控制运动被读入至少第一运动值 或者取决于控制运动的第二运动值被确定，并且如果必要，则根据第一运动值修改位置值，并且如果需要，则根据第二运动值和当前位置值修改数据值。 通过这样的方法，可以用大的值范围内的指针和高精度快速且舒适地输入数据值。

公开(公告)号：US08942440B2

公开(公告)日：2015-01-27

申请号：US12010026

申请日：2008-01-18

申请人： Diana Martin ,  Sebastian Schmidt

发明人： Diana Martin ,  Sebastian Schmidt

IPC分类号： G06K9/00 ,  G06F19/00

CPC分类号： G06F19/321 ,  G06F19/00 ,  Y10S128/92 ,  Y10S128/922

摘要： A method for image acquisition is disclosed. In an embodiment, the method includes acquiring, by a first imaging method, first image data of an object to be examined; acquiring, by a second imaging method, second image data of the object to be examined; generating an image file, the file format of which allows different logical layers of image data to be stored, in such a manner that the image file generated contains the acquired first image data in a first logical layer in the intended layer format and the acquired second image data in a second logical layer.

摘要翻译： 公开了一种用于图像采集的方法。 在一个实施例中，该方法包括通过第一成像方法获取被检查对象的第一图像数据; 通过第二成像方法获取待检查对象的第二图像数据; 生成其文件格式允许存储图像数据的不同逻辑层的图像文件，使得所生成的图像文件包含以所需图层格式的第一逻辑层中获取的第一图像数据，并且获取的第二图像文件 第二逻辑层中的图像数据。

公开(公告)号：US20090043189A1

公开(公告)日：2009-02-12

申请号：US12222209

申请日：2008-08-05

申请人： Ralf Ladebeck ,  Diana Martin ,  Sebastian Schmidt

发明人： Ralf Ladebeck ,  Diana Martin ,  Sebastian Schmidt

IPC分类号： A61B5/05

CPC分类号： G01R33/481 ,  A61B6/037 ,  G01R33/421 ,  G01R33/4215 ,  G01R33/422 ,  G01T1/1603

摘要： A combined positron emission tomography/magnetic resonance imaging apparatus, in a trailer housing is disclosed, for imaging organs of an examination object in an examination space. In at least one embodiment, the positron emission tomography/magnetic resonance imaging apparatus includes a positron emission tomography apparatus with at least one radiation detector and a magnetic resonance imaging apparatus with at least one main magnetic field coil for generating a main magnetic field, at least one gradient coil for generating a magnetic gradient field, and a radio-frequency antenna device for transmitting excitation pulses and receiving magnetic resonance signals from the examination space, the radiation detector and the at least one gradient coil being arranged coaxially and at substantially the same axial height. In order to create a mobile MRI/PET apparatus which is designed as compactly as possible and, firstly, satisfies the radiation protection requirements for protecting the surroundings of the measurement apparatus to the best possible extent and, secondly, excludes interfering environmental influences on the measurement apparatus, a shielding arrangement with at least one shielding element for attenuating the main magnetic field and the gradient field and also the annihilation radiation outside the trailer housing is provided in at least one embodiment.

摘要翻译： 公开了一种组合的正电子发射断层摄影/磁共振成像装置，用于在检查空间中成像检查对象的器官。 在至少一个实施例中，正电子发射断层摄影/磁共振成像装置包括具有至少一个辐射检测器和磁共振成像装置的正电子发射断层摄影装置，该装置具有至少一个用于产生主磁场的主磁场线圈，至少 用于产生磁梯度场的一个梯度线圈和用于从检查空间传输激励脉冲和接收磁共振信号的射频天线装置，辐射检测器和至少一个梯度线圈同轴并且基本相同的轴向 高度。 为了创建尽可能紧凑地设计的移动MRI / PET装置，首先满足最大限度地保护测量装置的周围的辐射防护要求，其次，排除对测量的干扰环境影响 在至少一个实施例中提供了一种屏蔽装置，其具有用于衰减主磁场和梯度场的至少一个屏蔽元件以及拖车壳体外部的湮灭辐射。

公开(公告)号：US20090030304A1

公开(公告)日：2009-01-29

申请号：US12219609

申请日：2008-07-24

申请人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

发明人： Thorsten Feiweier ,  Diana Martin ,  Gunther Platsch ,  Sebastian Schmidt ,  Kristin Schmiedehausen ,  Michael Szimtenings

IPC分类号： A61B5/055

CPC分类号： A61K49/0004 ,  A61B5/4064 ,  A61B5/4088 ,  A61B6/037 ,  A61B6/5247

摘要： A computerized method is disclosed for detecting a brain region with neurodegenerative change and also a brain region with vascular change in the brain of a patient and also an imaging arrangement suitable for this. In at least one embodiment, the method includes recording a first data record of the brain via positron emission tomography and a second data record of the brain via magnetic resonance imaging; reconstructing a PET image from the first data record and an MRI image from the second data record; identifying evidence for a brain region with vascular change in the MRI image; segmenting the MRI image into gray matter and white matter; identifying a brain region with neurodegenerative change in the PET image; and superposing the PET image and the segmented MRI image to determine whether the brain region with neurodegenerative change is present in gray matter or in white matter, the recording of the first data record and the second data record being carried out in quick succession without repositioning the patient or is even carried out simultaneously.

摘要翻译： 公开了一种用于检测具有神经变性变化的脑区域以及患者脑部血管变化的脑区域的计算机化方法，以及适合于此的成像装置。 在至少一个实施例中，该方法包括通过正电子发射断层摄影和脑的第二数据记录经由磁共振成像记录脑的第一数据记录; 从第一数据记录重建PET图像和从第二数据记录重建MRI图像; 识别MRI图像中具有血管变化的脑区域的证据; 将MRI图像分割成灰质和白质; 识别PET图像中具有神经变性变化的脑区域; 并叠加PET图像和分割的MRI图像，以确定具有神经变性变化的脑区域是否存在于灰质物质或白质中，第一数据记录和第二数据记录的记录被快速连续进行而不重新定位 病人或甚至同时进行。

公开(公告)号：US20080181480A1

公开(公告)日：2008-07-31

申请号：US12010026

申请日：2008-01-18

申请人： Diana Martin ,  Sebastian Schmidt

发明人： Diana Martin ,  Sebastian Schmidt

IPC分类号： G06K9/00

CPC分类号： G06F19/321 ,  G06F19/00 ,  Y10S128/92 ,  Y10S128/922

摘要： A method for image acquisition is disclosed. In an embodiment, the method includes acquiring, by a first imaging method, first image data of an object to be examined; acquiring, by a second imaging method, second image data of the object to be examined; generating an image file, the file format of which allows different logical layers of image data to be stored, in such a manner that the image file generated contains the acquired first image data in a first logical layer in the intended layer format and the acquired second image data in a second logical layer.

摘要翻译： 公开了一种用于图像采集的方法。 在一个实施例中，该方法包括通过第一成像方法获取被检查对象的第一图像数据; 通过第二成像方法获取待检查对象的第二图像数据; 生成其文件格式允许存储图像数据的不同逻辑层的图像文件，使得所生成的图像文件包含以所需图层格式的第一逻辑层中获取的第一图像数据，并且获取的第二图像文件 第二逻辑层中的图像数据。

公开(公告)号：US20080174310A1

公开(公告)日：2008-07-24

申请号：US12003138

申请日：2007-12-20

申请人： Diana Martin ,  Sebastian Schmidt

发明人： Diana Martin ,  Sebastian Schmidt

IPC分类号： G01R33/48 ,  A61B5/055

CPC分类号： G01R33/481 ,  A61B2090/365 ,  G01T1/1603

摘要： A method is disclosed for operating a hybrid medical imaging unit including a first imaging device of relatively high spatial resolution and a second nuclear medicine imaging device of relatively high sensitivity that respectively acquire imaging measurement signals from a common examination volume. In an embodiment of the method, during the current measurement signal acquisition of the second imaging device, the continuously acquired measurement signals are used to determine a region in the examination volume in which a region referred measurement signal acquisition is subsequently performed by the first examination device with use of a region referred measurement protocol.

摘要翻译： 公开了一种用于操作混合医疗成像单元的方法，所述混合医学成像单元包括相对高的空间分辨率的第一成像装置和相对高灵敏度的第二核医学成像装置，其分别从共同检查体积获取成像测量信号。 在该方法的一个实施例中，在第二成像装置的当前测量信号采集期间，使用连续获取的测量信号来确定检查卷中的区域，其中随后由第一检查装置执行测量信号获取的区域 使用区域参考测量协议。

公开(公告)号：US20080033279A1

公开(公告)日：2008-02-07

申请号：US11882693

申请日：2007-08-03

申请人： Ralf Ladebeck ,  Diana Martin ,  Norbert Rietsch

发明人： Ralf Ladebeck ,  Diana Martin ,  Norbert Rietsch

IPC分类号： A61B5/055 ,  G01T1/164

CPC分类号： G01R33/481 ,  A61B6/037 ,  G01T1/1603

摘要： A device is disclosed for superposed MRI and PET imaging and includes an MRI tube that has a first field of view along its longitudinal direction, and a multiplicity of PET detection units arranged opposite one another in pairs about the longitudinal direction. In at least one embodiment the many PET detection units define a second field of view along the longitudinal direction, and their arrangement density along the longitudinal direction is optimized such that the second field of view substantially corresponds to the first field of view.

摘要翻译： 公开了一种用于重叠的MRI和PET成像的装置，并且包括沿着其纵向方向具有第一视场的MRI管和多个相对于纵向方向成对布置的PET检测单元。 在至少一个实施例中，许多PET检测单元沿着纵向方向限定第二视场，并且优化其沿着纵向方向的排列密度，使得第二视场基本上对应于第一视场。

公开(公告)号：US09063203B2

公开(公告)日：2015-06-23

申请号：US12153557

申请日：2008-05-21

申请人： Diana Martin ,  Wolfgang Bielmeier

发明人： Diana Martin ,  Wolfgang Bielmeier

IPC分类号： A61B5/055 ,  G01R33/48 ,  A61B6/03 ,  A61B6/00 ,  G01T1/16 ,  A61B6/02 ,  G01T1/161 ,  G01R33/54

CPC分类号： G01R33/481 ,  A61B6/037 ,  A61B6/5247 ,  A61B6/545 ,  G01R33/543 ,  G01T1/1603

摘要： A method is disclosed for determining at least one PET parameter for a PET examination in a combined magnetic resonance/PET scanner designed for isocentric measurement. In at least one embodiment, at least one acquisition time for the PET examination is determined as a PET parameter from magnetic resonance data, recorded for determining patient-specific examination parameters for a magnetic resonance examination, and/or from at least one patient-specific information value derived therefrom, and is displayed and/or used for controlling the scanner.

摘要翻译： 公开了一种用于在为等中心测量设计的组合磁共振/ PET扫描仪中确定用于PET检查的至少一个PET参数的方法。 在至少一个实施例中，PET检查的至少一个采集时间被确定为来自磁共振数据的PET参数，记录用于确定用于磁共振检查的患者特异性检查参数，和/或从至少一个患者特异性 从其导出的信息值，并显示和/或用于控制扫描仪。

公开(公告)号：US08784827B2

公开(公告)日：2014-07-22

申请号：US12991689

申请日：2008-05-09

申请人： Thomas Zürcher ,  Juan José Bernal ,  Cayetano von Kobbe ,  Ignacio Jiménez Torres ,  Ana Diaz Blázquez ,  Diana Martin Lorenzo ,  Gloria Calderita Lucas ,  Arcadio Garcia de Castro

发明人： Thomas Zürcher ,  Juan José Bernal ,  Cayetano von Kobbe ,  Ignacio Jiménez Torres ,  Ana Diaz Blázquez ,  Diana Martin Lorenzo ,  Gloria Calderita Lucas ,  Arcadio Garcia de Castro

IPC分类号： A61K39/00 ,  A61K39/12 ,  C07K14/005

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K2039/5256 ,  A61K2039/5258 ,  C07K2319/40 ,  C12N2720/10022 ,  C12N2720/10023

摘要： The field of the invention refers to chimeric Virus Like Particles (VLP) derived from Birnavirus chimeric VP2 protein. In particular, the invention refers to chimeric VP2 fusion proteins which incorporate insertions and/or substitutions with one or more amino acids or particular peptide of interest while maintaining the capacity to assemble in the form of VLP. The invention identifies particular insertion and/or substitutions sites within VP2 P loop regions and outside said P loop regions. The invention also incorporates methods for the identification of preferred insertion and substitution sites within VP2 for the incorporation of particular amino acids and peptides of interest. The resulting chimeric VLP are of interest in the design of therapeutic and prophylactic vaccines as well as in the design of drug delivery systems, carriers for DNA and RNA in gene therapy, as targeted agents, in the development of antitoxins, and as diagnostic reagents.

摘要翻译： 本发明的领域是指衍生自Birnavirus嵌合VP2蛋白的嵌合病毒样颗粒（VLP）。 特别地，本发明涉及嵌合VP2融合蛋白，其掺入一个或多个氨基酸或特定感兴趣肽的插入和/或取代，同时保持以VLP形式组装的能力。 本发明鉴定VP2P环区域内的所述P环区域内的特定插入和/或取代位点。 本发明还包括用于鉴定VP2内优选的插入和取代位点以便并入特定的目的氨基酸和肽的方法。 所产生的嵌合VLP在治疗和预防性疫苗的设计以及药物递送系统的设计，基因治疗中的DNA和RNA的载体，靶向剂，抗毒素的开发和诊断试剂方面都是感兴趣的。

公开(公告)号：US08433111B2

公开(公告)日：2013-04-30

申请号：US12076611

申请日：2008-03-20

申请人： Diana Martin ,  Sebastian Schmidt

发明人： Diana Martin ,  Sebastian Schmidt

IPC分类号： G06F17/30 ,  A61B5/00

CPC分类号： A61B5/055 ,  A61B5/0035 ,  A61B5/7285 ,  A61B6/00 ,  A61B6/037 ,  A61B6/5235 ,  A61B6/5247 ,  A61B6/541 ,  G06F19/00 ,  G06F19/321

摘要： A method for image data recording with a medical modality is provided. Protocols for image data recording using the at least two different image recording techniques are provisioned in a common database. The protocols are organized on the basis of body regions and/or clinical pictures. A body region and/or a clinical picture are selected and at least one protocol is displayed as a function of the selection. At least one display protocol for image data recording from the database is selected by a user and/or automatically, and image data is recorded as a function of the at least one selected protocol.

摘要翻译： 提供了一种具有医疗模式的图像数据记录方法。 使用至少两种不同的图像记录技术的用于图像数据记录的协议被提供在公共数据库中。 协议是根据身体区域和/或临床图片进行组织的。 选择身体区域和/或临床图像，并且根据选择显示至少一个协议。 至少一个用于从数据库进行图像数据记录的显示协议由用户选择和/或自动，并且根据至少一个所选择的协议来记录图像数据。