公开(公告)号：US06310185B1

公开(公告)日：2001-10-30

申请号：US08207861

申请日：1994-03-08

申请人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

发明人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

IPC分类号： C07K1630

CPC分类号： C07K16/34 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00

摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by murine atibodies specific for the Lewis Y antigen. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumour types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumours. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.

摘要翻译： 本发明提供了对抗原Lewis Y特异性的几种人源化鼠抗体的产生，其被Lewis Y抗原特异性的鼠抗体识别。 Lewis Y抗原在正常组织中表达，但在某些肿瘤类型中表达水平较高，因此抗原可用作乳腺癌，结肠癌，胃癌，食管癌，胰腺癌，十二指肠癌，肺癌，膀胱癌， 肾癌和胃和胰岛细胞神经内分泌肿瘤。 本发明还提供编码人源化Lewis Y特异性抗体的许多多核苷酸，用于产生人源化Lewis Y特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis Y特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用人源化Lewis Y特异性抗体治疗癌症的方法。

公开(公告)号：US5843448A

公开(公告)日：1998-12-01

申请号：US560024

申请日：1995-11-17

申请人： Yao-Tseng Chen ,  Elisabeth Stockert ,  Yachi Chen ,  Pilar Garin-Chesa ,  Wolfgang J. Rettig ,  Lloyd J. Old

发明人： Yao-Tseng Chen ,  Elisabeth Stockert ,  Yachi Chen ,  Pilar Garin-Chesa ,  Wolfgang J. Rettig ,  Lloyd J. Old

IPC分类号： C12N15/02 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07H21/04 ,  C07K20060101 ,  C07K7/08 ,  C07K14/47 ,  C07K14/705 ,  C07K16/30 ,  C12N5/10 ,  C12N5/20 ,  C12P21/08 ,  C12R1/91 ,  G01N33/574 ,  A61K38/10 ,  C07K14/82

CPC分类号： C07K14/4748 ,  C07K16/30 ,  A61K38/00 ,  A61K39/00

摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.

摘要翻译： 本发明涉及与肿瘤排斥抗原前体分子MAGE-1特异性结合的单克隆抗体，产生这些单克隆抗体的杂交瘤及其应用。 还描述了重组形式的MAGE-1，可用作免疫原的肽和含有肽和佐剂的免疫原性组合物。

公开(公告)号：US07795409B2

公开(公告)日：2010-09-14

申请号：US12011953

申请日：2008-01-30

申请人： Dirk Jager ,  Elisabeth Stockert ,  Barry C. Picker, legal representative ,  Matthew Scanlan ,  Cynthia H. Scanlan, legal representative ,  Ali Gure ,  Elke Jager ,  Alexander Knuth ,  Lloyd Old ,  Yao-Tseng Chen

发明人： Dirk Jager ,  Elisabeth Stockert ,  Matthew Scanlan ,  Ali Gure ,  Elke Jager ,  Alexander Knuth ,  Lloyd Old ,  Yao-Tseng Chen

IPC分类号： C07H21/02

CPC分类号： C07K14/47 ,  C07K14/4748

摘要： The invention relates to newly identified cancer associated antigens. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.

摘要翻译： 本发明涉及新鉴定的癌症相关抗原。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。

公开(公告)号：US07589180B2

公开(公告)日：2009-09-15

申请号：US10145598

申请日：2002-05-13

申请人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

发明人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

IPC分类号： C07K16/28

CPC分类号： C07K16/2863 ,  A61K39/395 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  A61K2300/00

摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

公开(公告)号：US20090220510A1

公开(公告)日：2009-09-03

申请号：US12317683

申请日：2008-12-23

申请人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gred Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

发明人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gred Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

IPC分类号： A61K39/395 ,  C07K16/18 ,  C12N15/11 ,  C12P21/00 ,  G01N33/574 ,  C12N1/21 ,  C12N1/19 ,  C12N5/06 ,  C12N5/04

CPC分类号： C07K16/2863 ,  A61K39/395 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  A61K2300/00

摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

摘要翻译： 本发明涉及特异性结合成员，特别是抗体及其活性片段，其识别异常翻译后修饰，特别是EGFR的异常糖基化形式。 本发明的结合成员，特别是抗体及其片段在正常细胞上不与野生型基因扩增结合，并且能够以不同于 连接肽。 这种抗体的例子是其VH和VL序列如SEQ ID NO：2和4以及其嵌合抗体如ch806所示的新抗体806。

公开(公告)号：US20090137782A1

公开(公告)日：2009-05-28

申请号：US10145598

申请日：2002-05-13

申请人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

发明人： Lloyd J. Old ,  Terrance Grant Johns ,  Con Panousis ,  Andrew Mark Scott ,  Christoph Renner ,  Gerd Ritter ,  Achim Jungbluth ,  Elisabeth Stockert ,  V. Peter Collins ,  Webster K. Cavenee ,  Huei-Jen Su Huang ,  Antony Wilks Burgess ,  Edouard Collins Nice

IPC分类号： C07K16/30

CPC分类号： C07K16/2863 ,  A61K39/395 ,  A61K39/39541 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/77 ,  A61K2300/00

摘要： The invention relates to specific binding members, particularly antibodies and active fragments thereof, which recognize an aberrant post-translationally modified, particularly an aberrant glycosylated form of the EGFR. The binding members, particularly antibodies and fragments thereof, of the invention do not bind to EGFR on normal cells in the absence of amplification of the wild-type gene and are capable of binding the de2-7 EGFR at an epitope which is distinct from the junctional peptide. Antibodies of this type are exemplified by the novel antibody 806 whose VH and VL sequences are illustrated as SEQ ID NOs: 2 and 4 and chimeric antibodies thereof as exemplified by ch806.

摘要翻译： 本发明涉及特异性结合成员，特别是抗体及其活性片段，其识别异常翻译后修饰，特别是EGFR的异常糖基化形式。 本发明的结合成员，特别是抗体及其片段在正常细胞上不与野生型基因扩增结合，并且能够以不同于 连接肽。 这种抗体的例子是其VH和VL序列如SEQ ID NO：2和4以及其嵌合抗体如ch806所示的新抗体806。

公开(公告)号：US07335467B2

公开(公告)日：2008-02-26

申请号：US10146473

申请日：2002-05-15

申请人： Matthew J. Scanlan ,  Ivan Gout ,  Elisabeth Stockert ,  Lloyd J. Old ,  Ali Gure ,  Yao-Tseng Chen

发明人： Matthew J. Scanlan ,  Ivan Gout ,  Elisabeth Stockert ,  Lloyd J. Old ,  Ali Gure ,  Yao-Tseng Chen

IPC分类号： C12Q1/00 ,  C12Q1/68 ,  G01N33/567 ,  G01N33/574 ,  G01N1/00 ,  G01N33/48 ,  C12P19/34

CPC分类号： G01N33/57415 ,  C12Q1/6886 ,  C12Q2600/158 ,  Y10T436/25

摘要： The invention provides methods for diagnosing cancer including breast cancer, based on the identification of certain breast cancer-associated polypeptides as antigens that elicit immune responses in breast cancer. The identified antigens can be utilized as markers for diagnosing breast cancer, and for following the course of treatment of breast cancer.

摘要翻译： 本发明提供了鉴定某些乳腺癌相关多肽作为在乳腺癌中引起免疫反应的抗原来诊断包括乳腺癌在内的癌症的方法。 鉴定的抗原可用作诊断乳腺癌的标志物，并用于跟踪乳腺癌的治疗过程。

公开(公告)号：US06830924B1

公开(公告)日：2004-12-14

申请号：US09270437

申请日：1999-03-16

申请人： Yao-Tseng Chen ,  Ali Gure ,  Solam Tsang ,  Elisabeth Stockert ,  Elke Jager ,  Alexander Knuth ,  Lloyd J. Old

发明人： Yao-Tseng Chen ,  Ali Gure ,  Solam Tsang ,  Elisabeth Stockert ,  Elke Jager ,  Alexander Knuth ,  Lloyd J. Old

IPC分类号： C12N1563

CPC分类号： C07K14/4748 ,  A61K2039/505

摘要： The invention relates to newly identified cancer associated antigens, referred to as CT7, KOC-2 and KOC-3. The invention also relates to observations regarding known molecule KOC-1. It has been discovered that each of these molecules provokes antibodies when expressed by a subject. The ramifications of this observation are also a part of this invention.

摘要翻译： 本发明涉及新鉴定的癌相关抗原，称为CT7，KOC-2和KOC-3。 本发明还涉及关于已知分子KOC-1的观察。 已经发现，当由受试者表达时，这些分子中的每一个都会引发抗体。 该观察结果也是本发明的一部分。

公开(公告)号：US06576756B2

公开(公告)日：2003-06-10

申请号：US09899651

申请日：2001-07-06

申请人： Yao-Tseng Chen ,  Ali Gure ,  Solam Tsang ,  Elisabeth Stockert ,  Elke Jäger ,  Knuth Alexander ,  Lloyd J. Old

发明人： Yao-Tseng Chen ,  Ali Gure ,  Solam Tsang ,  Elisabeth Stockert ,  Elke Jäger ,  Knuth Alexander ,  Lloyd J. Old

IPC分类号： C07H2104

CPC分类号： C07K14/4748 ,  A61K2039/505

摘要： The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.

公开(公告)号：US06518415B1

公开(公告)日：2003-02-11

申请号：US08859648

申请日：1997-05-20

申请人： Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

发明人： Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

IPC分类号： C07H2104

CPC分类号： C07K16/34 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00

摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by the murine antibody Lewis Y. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumor types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumors. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.

摘要翻译： 本发明提供对抗原Lewis Y特异性的几种人源化鼠抗体的产生，其被鼠抗体Lewis Y识别。Lewis Y抗原在正常组织中表达，但在某些肿瘤类型中表达水平较高，因此 抗原可用作乳腺癌，结肠癌，胃癌，食管癌，胰腺癌，十二指肠癌，肺癌，膀胱癌和肾癌和胃和胰岛细胞神经内分泌肿瘤的细胞标志物。 本发明还提供编码人源化Lewis Y特异性抗体的许多多核苷酸，用于产生人源化Lewis Y特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis Y特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用人源化Lewis Y特异性抗体治疗癌症的方法。