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    METHOD AND APPARATUS FOR SENSING
    2.
    发明申请
    METHOD AND APPARATUS FOR SENSING 审中-公开

    公开(公告)号：US20140131557A1

    公开(公告)日：2014-05-15

    申请号：US14130932

    申请日：2012-09-03

    申请人： Peter Collins

    发明人： Peter Collins

    IPC分类号： G01V8/20

    CPC分类号： G01V8/20 ,  B66B13/26

    摘要： A method of and apparatus for, detecting an intrusion into a volume defined relative to a path across an opening along which path a closure member for the opening can be controllably displaced to define a gap in the opening, the gap being bounded on one side by the closure member and on the other side to the one side by a boundary member; the volume including at least one threshold region on at least one side of the path; the volume having as a base the threshold region and rising above the threshold region; a first group of at least two emitters of electromagnetic signals located on either the closure member or the boundary and directed into the volume and a second group of at least two receivers for electromagnetic signals located on the opposite side of the gap to the emitters; emissions from the emitters being directed into the volume but not directly towards the receivers; the emitters and receivers forming part of a network including processing means which form a compound sensor for use in monitoring operation of the closure member and for defining sensitivity to an intrusion into a region or regions of the volume; each emitter being adapted to direct a primary beam of e.m. radiation into the volume; each receiver being adapted to receive a secondary beam generated by the reflection of a primary beam from a target intruding into the volume; the method comprising the steps of: causing at least one of the emitters to emit a primary beam along a first axis into the volume; allowing at least one of the receivers to receive a secondary beam of radiation along a second axis from the volume; the secondary beam being generated by reflection of a primary beam from a target intruding into the volume; the secondary beam being generated in the volume by way of but not constituted by, the or any primary beam from an emitter; and enabling one or more of the receivers to provide an output signal into the network of the compound receiver characteristic of the, or each, secondary beam detected by at least one of the receivers in the second group; and providing that where the compound sensor serves to establish: that when an excess gain ratio is relatively small in an output signal from a single receiver caused by reception by the receiver of a secondary beam and the size of the gap is relatively large then the compound sensor functions so as to increase sensitivity of detection existing within a given predetermined region of the volume by comparison with sensitivity in another region or regions in the volume; that when an excess gain ratio is relatively large in an output signal from a single receiver caused by reception by the receiver of a secondary beam and the size of the gap is reducing or small then the sensor functions so as to increase sensitivity of detection within more than one region of the volume by comparison with sensitivity in another region or regions in the volume.

    MULTIWELL STRIPS
    3.
    发明申请
    MULTIWELL STRIPS 审中-公开

    公开(公告)号：US20130029343A1

    公开(公告)日：2013-01-31

    申请号：US13579834

    申请日：2011-02-21

    申请人： Paul Day ,  Peter Collins ,  Thomas Lernbecher

    发明人： Paul Day ,  Peter Collins ,  Thomas Lernbecher

    IPC分类号： C12Q1/00 ,  B29C45/12 ,  C12Q1/02 ,  B01L3/00 ,  C12Q1/68 ,  G01N33/566

    CPC分类号： B01L3/50855 ,  B01L3/50851 ,  B01L2200/12 ,  B01L2300/021 ,  B01L2300/0829 ,  B01L2300/0858 ,  B29C45/16

    摘要： The present invention relates to a multiwell strip comprising a frame portion consisting of a first stiff material, and a plurality of wells arranged in a line and consisting of a second material, which is not as stiff as the first material. Furthermore, the present invention relates to a multiwell-frame for obtaining a multiwell strip according to the present invention and methods for producing a multiwell strip according to the present invention.

    摘要翻译： 本发明涉及一种多孔条，其包括由第一刚性材料构成的框架部分和布置成一条直线并由第二材料构成的多个孔，该第二材料不像第一材料那么刚硬。 此外，本发明涉及一种用于获得根据本发明的多孔板的多孔框架以及用于制造根据本发明的多孔板的方法。

    SEALING MULTIWELL PLATES
    4.
    发明申请
    SEALING MULTIWELL PLATES 审中-公开
    密封多层板

    公开(公告)号：US20120058516A1

    公开(公告)日：2012-03-08

    申请号：US13203656

    申请日：2010-03-02

    申请人： Peter Collins

    发明人： Peter Collins

    IPC分类号： C12P19/34 ,  B32B38/10 ,  B01L99/00 ,  B32B37/06

    CPC分类号： B01L3/50853 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2300/041 ,  B01L2300/0829

    摘要： The present invention relates to a heat sealable member comprising a sheet of heat sealable material to a multiwell plate, wherein the sheet is mounted in a frame, and wherein said frame is sized to fit over a multiwell plate so that the sheet is contacted with at least one of the rims of the top of the plate and the individual wells; as well as to the use of the heat sealable member with automatic plate handling apparatus, especially in PCR processes. The present invention further relates to a method for sealing multiwell plates.

    摘要翻译： 本发明涉及一种可热封构件，其包括一片可热密封材料到多孔板，其中该片安装在框架中，并且其中所述框架的尺寸适于装配在多孔板上，使得片材与 板块顶部和个别井中的至少一个边缘; 以及使用具有自动板处理装置的可热封构件，特别是在PCR工艺中。 本发明还涉及密封多孔板的方法。

    Air displacing device
    5.
    发明授权
    Air displacing device 失效
    排气装置

    公开(公告)号：US08128465B2

    公开(公告)日：2012-03-06

    申请号：US12147706

    申请日：2008-06-27

    申请人： Peter Collins

    发明人： Peter Collins

    IPC分类号： F24F7/02

    CPC分类号： A47K10/48

    摘要： An air displacing device for transferring air from a first location to a second location comprising a housing including a fan, a prime mover for the fan, means defining an air inlet to receive air from the first location, and an air outlet to deliver air to the second location and a duct for air through the housing from the inlet to the outlet, the fan being operable by way of the prime mover to cause air to be displaced along the duct from the inlet to the outlet, the housing serving to define a datum plane characterized in that the housing has external members adapted for displacement between a first, standby, configuration where the projection of the housing from the datum plane is a minimum and so the volume of the housing is a minimum and a second, working, configuration where the projection of the housing from the datum plane is a maximum and so the volume of the housing is a maximum. The invention is particularly applicable for hand driers but is also applicable to other air moving devices such as vacuum cleaners, air conditioning units and drying apparatus for objects other than hands.

    摘要翻译： 一种用于将空气从第一位置传送到第二位置的空气移动装置，包括壳体，壳体包括风扇，用于风扇的原动机，限定用于从第一位置接收空气的空气入口的装置，以及将空气输送到 所述第二位置和用于通过所述壳体从入口到出口的空气的通道，所述风扇可通过所述原动机操作，以使空气沿着所述管道从所述入口移动到所述出口，所述壳体用于限定一个 其特征在于，所述壳体具有适于在第一待机配置之间的位移的外部构件，其中所述壳体从所述基准平面的突出部是最小的，并且因此所述壳体的体积是最小的，而所述壳体的第二， 其中壳体从基准平面的突出是最大的，因此壳体的体积是最大的。 本发明特别适用于手动干燥机，但也适用于除手以外的其他空气移动装置，例如真空吸尘器，空调机组和干燥装置。

    Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines
    6.
    发明申请
    Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines 失效
    减毒，人 - 牛嵌合呼吸道合胞体病毒疫苗的生产

    公开(公告)号：US20070184069A1

    公开(公告)日：2007-08-09

    申请号：US11203620

    申请日：2005-08-11

    申请人： Ursula Buchholz ,  Peter Collins ,  Brian Murphy ,  Stephen Whitehead ,  Christine Krempl

    发明人： Ursula Buchholz ,  Peter Collins ,  Brian Murphy ,  Stephen Whitehead ,  Christine Krempl

    IPC分类号： A61K39/155 ,  C07H21/04 ,  C12N7/00 ,  C12N15/86

    CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/544 ,  C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2840/203

    摘要： Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete “background” RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment including a protein or portion thereof. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.

    摘要翻译： 嵌合人 - 牛呼吸道合胞病毒（RSV）在人类和其他哺乳动物中具有感染性和减毒性，并且可用于引发抗RSV免疫应答的疫苗制剂中。 还提供了分离的多核苷酸分子和掺入嵌合RSV基因组或抗原组的载体，其包括部分或完整的人或牛RSV“背景”基因组或与一个或多个异源基因或基因组片段 不同的RSV菌株。 本发明的嵌合人类牛RSV包括部分或完整的“背景”RSV基因组或在与一个或多个异源基因或基因组片段组合的人或牛RSV病毒株或亚组病毒之后衍生或构图的部分或完整的“背景” 的不同RSV株或亚组病毒形成人 - 牛嵌合RSV基因组或抗原组。 在本发明的优选方面，嵌合RSV包含与来自人RSV的一个或多个异源基因或基因组片段组合的部分或完整的牛RSV背景基因组或反义基因组。 感兴趣的基因包括任何NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因或包含蛋白质或其部分的基因组片段。 在本发明的人 - 牛嵌合RSV内提供了多种额外的突变和核苷酸修饰，以产生所需的表型和结构效果。

    Detection of negative-strand RNA viruses
    8.
    发明授权
    Detection of negative-strand RNA viruses 有权
    检测负链RNA病毒

    公开(公告)号：US06270958B1

    公开(公告)日：2001-08-07

    申请号：US09253445

    申请日：1999-02-19

    申请人： Paul D. Olivo ,  Sondra Schlesinger ,  Mark E. Peeples ,  Peter Collins

    发明人： Paul D. Olivo ,  Sondra Schlesinger ,  Mark E. Peeples ,  Peter Collins

    IPC分类号： C12Q170

    CPC分类号： C12Q1/6897 ,  C12N2503/00 ,  C12N2510/00 ,  Y10S435/81 ,  Y10S435/975

    摘要： A diagnostic assay for detecting a negative-strand RNA virus in a sample and a genetically engineered cell for use in the assay are disclosed. The cell expresses a heterologous DNA-dependent RNA polymerase that synthesizes a minigenome or miniantigenome of the RNA virus from a cDNA template present in the cell. The cell also expresses the nucleocapsid proteins of the negative-strand virus that are necessary for replication of the minigenome or miniantigenome. Infection of the cell by the negative-strand virus results in expression of a reporter gene product encoded by the miniantigenome.

    摘要翻译： 公开了用于检测样品中的负链RNA病毒的诊断测定法和用于测定中的遗传工程细胞。 细胞表达异源DNA依赖性RNA聚合酶，其从存在于细胞中的cDNA模板合成RNA病毒的小基因组或微型基因组。 细胞还表达了负链病毒的核衣壳蛋白，其是复制小基因组或微型基因组所必需的。 通过负链病毒感染细胞导致由本发明组编码的报告基因产物的表达。