公开(公告)号：US20060200097A1

公开(公告)日：2006-09-07

申请号：US10543083

申请日：2004-01-26

申请人： Mark Humayun ,  Eugene De Juan

发明人： Mark Humayun ,  Eugene De Juan

IPC分类号： A61M31/00 ,  A61M37/00

CPC分类号： A61F9/0017 ,  A61F2/16 ,  A61F2250/0068 ,  A61M5/1428 ,  A61M2210/0612

摘要： Featured are devices and methods for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. Such instillation is accomplished by providing a reservoir containing a therapeutic medium to which is fluidly coupled a cannula and inserting a portion of the cannula sub-retinally, whereby the therapeutic medium within the reservoir is coupled to and dispersed subretinally via the cannula.

摘要翻译： 特别是用于将治疗性介质施用于眼后段的装置和方法，包括滴注或处置回顾性治疗介质。 这种滴注是通过提供一种包含治疗介质的储存器来实现的，该治疗介质流体地联接套管并且插入套管的一部分，其中储存器内的治疗介质通过套管联接到并且通过插管被分散地分散。

公开(公告)号：US20050287188A1

公开(公告)日：2005-12-29

申请号：US11203981

申请日：2005-08-15

申请人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

发明人： Aron Anderson ,  Laurie Lawin ,  Byron Shen ,  Eugene de Juan ,  Signe Varner ,  Ralph Chappa

IPC分类号： A61K9/00 ,  A61K31/58 ,  A61F2/00

CPC分类号： A61K31/58 ,  A61F2310/00353 ,  A61K9/0051

摘要： The invention provides retrievable devices for sustained delivery of bioactive agent to a site within a patient, the devices including a body member having a direction of extension, a longitudinal axis along the direction of extension, and a proximal end and a distal end, wherein at least a portion of the body member deviates from the direction of extension; a cap at the proximal end of the body member; and a polymeric coated composition in contact with a surface of the body member, the polymeric coated composition including a first polymer, a second polymer, and a bioactive agent.

摘要翻译： 本发明提供了用于将生物活性剂持续递送到患者内的部位的可回收装置，所述装置包括具有延伸方向的本体构件，沿着延伸方向的纵向轴线，以及近端和远端，其中， 身体构件的至少一部分偏离延伸方向; 在主体构件的近端处的帽; 以及与本体构件的表面接触的聚合物涂覆的组合物，所述聚合物涂覆的组合物包含第一聚合物，第二聚合物和生物活性剂。

公开(公告)号：US20050277802A1

公开(公告)日：2005-12-15

申请号：US11056763

申请日：2005-02-11

申请人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

发明人： Charles Larsen ,  Richard Hillstead ,  Roelof Trip ,  Eugene de Juan ,  Mark Humayun ,  Eberhard Fritz ,  Rainer Pintaske

IPC分类号： A61N5/00 ,  A61N5/10

CPC分类号： A61N5/1017

摘要： A method for performing intraocular brachytherapy and an apparatus for performing the same is disclosed. The apparatus preferably comprises a hand-held delivery device that advances a radiation source into an associated cannula or probe that is positioned adjacent the target tissue. The handpiece provides for shielded storage of the radiation source when retracted from the cannula and includes a slider mechanism for advancing and retracting the radiation source. The radiation source is mounted to a wire that has a flexible distal end and a relatively stiffer proximal end. A positioning system for the cannula is also disclosed.

摘要翻译： 公开了一种用于进行眼内近距离放射治疗的方法及其执行装置。 该装置优选地包括将辐射源前进到与靶组织相邻定位的相关套管或探针中的手持递送装置。 所述手持件在从套管缩回时提供辐射源的屏蔽存储并且包括用于前进和后退辐射源的滑块机构。 辐射源安装到具有柔性远端和较硬的近端的导线上。 还公开了用于套管的定位系统。

公开(公告)号：US20050143363A1

公开(公告)日：2005-06-30

申请号：US10507461

申请日：2003-09-29

申请人： Eugene De Juan ,  Signe Varner

发明人： Eugene De Juan ,  Signe Varner

IPC分类号： A61K9/00 ,  A61K31/56 ,  A61K31/573

CPC分类号： A61K31/56 ,  A61K9/0048 ,  A61K31/573

摘要： Featured is a methodology for administering a therapeutic medium to the posterior segment of an eye including instilling or disposing the therapeutic medium sub-retinally. In particular embodiments, the therapeutic medium is disposed in a sub retinal space. Such instillation being accomplished by one of injection or implantation of the therapeutic medium sub-retinally or the sub-retinal space. In other aspects, the methodology further includes forming a limited retinal detachment so as to define the sub-retinal space as well as methods for treating an eye by sub-retinally administering a therapeutic medium.

摘要翻译： 特色是一种用于向眼后段施用治疗性介质的方法，包括滴注或处置回顾性治疗介质。 在具体实施方案中，将治疗介质设置在视网膜的视网膜空间中。 这种滴注是通过注射或植入视网膜或视网膜下空间的治疗介质之一完成的。 在其他方面，所述方法还包括形成有限的视网膜脱离以限定子视网膜空间以及通过次级再次施用治疗介质来治疗眼睛的方法。

公开(公告)号：US06676607B2

公开(公告)日：2004-01-13

申请号：US09754830

申请日：2001-01-03

申请人： Eugene de Juan, Jr. ,  Patrick S. Jensen

发明人： Eugene de Juan, Jr. ,  Patrick S. Jensen

IPC分类号： A61B814

CPC分类号： A61B5/6848 ,  A61B5/6885 ,  A61B8/10 ,  A61B8/12 ,  A61B8/4461 ,  A61B8/4488 ,  A61B17/00234 ,  A61B17/29 ,  A61B34/76 ,  A61B2017/00022 ,  A61B2017/00115 ,  A61B2017/00128 ,  A61B2017/00345 ,  A61B2017/00477 ,  A61B2017/00734 ,  A61B2090/0813 ,  A61F9/0017 ,  A61F9/007 ,  A61M25/00

摘要： Featured is a device that provides a mechanism for imaging structure and/or tissue of a surgical site during and after performing a microsurgical procedure such as ophthalmic surgical procedures. Also featured are methods and systems related thereto. In the imaging method of the present invention using such a device includes positioning a high frequency ultrasonic signal transmitting and receiving apparatus imaging mechanism in close proximity to the area to be scanned/imaged (e.g., surgical site), so that the high frequency ultrasonic signal penetrates the tissue/structure of the surgical site being scanned. The reflected ultrasonic signals, are processed so as to yield high quality/high resolution images of the scanned tissue/structure. Further, the high resolution images are evaluated by the surgeon during the procedure to determine if the surgical approach should be adjusted. If such a determination is made, then the planned surgical approach is adjusted to accommodate for any conditions not accounted for in the initial planning.

摘要翻译： 特色是提供用于在执行显微外科手术（例如眼科外科手术）期间和之后对外科手术部位的结构和/或组织进行成像的机构。 还有与之相关的方法和系统。 在使用这种装置的本发明的成像方法中包括将高频超声信号发射和接收装置成像机构定位在靠近待扫描/成像区域（例如手术部位）的位置，使得高频超声波信号 穿透被扫描的手术部位的组织/结构。 反射的超声波信号被处理以产生扫描的组织/结构的高质量/高分辨率图像。 此外，在手术过程中，外科医生评估高分辨率图像，以确定是否应调整手术方法。 如果做出这样的决定，则调整计划的手术方法以适应初始规划中未考虑的任何情况。

公开(公告)号：US06494314B1

公开(公告)日：2002-12-17

申请号：US09563672

申请日：2000-05-02

申请人： Andrew N. Lamborne ,  Eugene de Juan, Jr.

发明人： Andrew N. Lamborne ,  Eugene de Juan, Jr.

IPC分类号： A61M3100

CPC分类号： A61M5/002 ,  A61F9/0017 ,  A61J1/20 ,  A61J1/201 ,  A61J1/2082 ,  A61J1/2096 ,  A61M13/003 ,  A61M2209/06 ,  A61M2210/0612

摘要： A unit dose, gas-filled syringe is provided which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. The syringe is filled with a selected gas and sealed inside a container made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate sufficient to prevent the selected gas from diffusing out of the container into the atmosphere. The volume of gas in the container is greater that atmospheric pressure to prevent atmospheric contaminants from entering the container and syringe.

摘要翻译： 提供了单位剂量的充气注射器，其在使用之前填充有气体并封装在阻气材料中以增加保质期，即使气体泄漏和注射器内容物的稀释最小化。 注射器填充有选定的气体并密封在由高阻气材料制成的容器内。 容器还装有选定的气体。 容器材料被选择为具有足以防止选定气体从容器扩散进入大气中的气体透过率。 容器中的气体体积大于大气压，以防止大气污染物进入容器和注射器。

公开(公告)号：US06372753B1

公开(公告)日：2002-04-16

申请号：US09536221

申请日：2000-03-27

申请人： Peter A. Campochiaro ,  Larry A. Wheeler ,  Roshantha A. Chandraratna ,  Sunil Nagpal ,  Eugene De Juan, Jr.

发明人： Peter A. Campochiaro ,  Larry A. Wheeler ,  Roshantha A. Chandraratna ,  Sunil Nagpal ,  Eugene De Juan, Jr.

IPC分类号： A61K31435

CPC分类号： A61K31/455 ,  A61K31/192 ,  Y10S514/912

摘要： Proliferation of retinal pigment epithelium following surgery or trauma or resulting in ocular diseases associated with choroidal neovascularization, such as age related macular degeneration and histoplasmosis syndrome, is prevented by contacting retinal pigment epithelium cells with a therapeutic amount of a retinoic acid receptor (RAR agonist, preferably one with specific activity for retinoic acid receptors. Preferably the RAR agonist is also a potent antagonist of AP1-dependent gene expression. Alternatively, the proliferation of retinal pigment epithelium is ameliorated with a therapeutic amount of an AP-1 antagonist, alone or in combination with an RAR agonist. The drug can be administered by bolus injection into the vitreous cavity using a dosage from about 50 to 150 &mgr;g. Or by slow release from liposomes or an oil tamponade injected into the vitreous cavity. Formulations for preventing proliferation of retinal pigment epithelium are also provided.

摘要翻译： 通过使视网膜色素上皮细胞与治疗量的视黄酸受体（RAR激动剂，血管内皮细胞生长因子受体）接触，可防止手术或外伤后视网膜色素上皮细胞增生，或导致与脉络膜新生血管形成相关的眼部疾病，如年龄相关性黄斑变性和组织胞浆菌病综合征 优选地，具有比较活性的视黄酸受体，优选地，RAR激动剂也是AP1依赖性基因表达的有效拮抗剂，或者，视网膜色素上皮的增殖用治疗量的AP-1拮抗剂单独或在 与RAR激动剂组合，药物可以通过使用约50至150杯的剂量通过快速注射进入玻璃体腔，或通过从脂质体缓慢释放或注射到玻璃体腔中的油脂填充剂来制备。用于防止视网膜增殖的制剂 还提供了色素上皮。

公开(公告)号：US5997498A

公开(公告)日：1999-12-07

申请号：US74960

申请日：1998-05-07

申请人： Eugene de Juan, Jr.

发明人： Eugene de Juan, Jr.

IPC分类号： A61F9/007 ,  A61F9/008 ,  A61F9/011 ,  A61M37/00

CPC分类号： A61F9/008 ,  A61F9/00821 ,  A61F2009/00863 ,  A61F9/00781

摘要： In preferred aspects the invention provides an in-line humidifier, a system using such a humidifier and methods related thereto, a method for infusing a gas into an eye during retinal detachment surgical procedure and a method for treating a retinal tear. The method for infusing gas includes providing an in-line humidifier, humidifying the gas in the in-line humidifier by flowing the gas there through and infusing the humidified gas into the eye. The in-line humidifier includes a housing and a humidifier section disposed within the housing, the humidifier section including a hydroscopic material that releasably retains liquid therein. The housing includes an inlet and outlet connection in fluid communication with the housing interior. The humidifier section is disposed within the housing so the gas entering through the inlet connection flows through the humidifying section, where small quantities of the releasably retinal liquid is released by the hydroscopic material to the flowing gas, and so the humidified gas exits the housing via the outlet connection.

摘要翻译： 在优选方面，本发明提供一种在线加湿器，使用这种加湿器的系统及其相关方法，在视网膜脱离手术过程中将气体注入眼睛的方法以及治疗视网膜撕裂的方法。 用于输入气体的方法包括提供在线加湿器，通过使气体在其中流动并将加湿气体注入眼睛来加湿在线加湿器中的气体。 在线加湿器包括壳体和设置在壳体内的加湿器部分，加湿器部分包括可释放地将液体保持在其中的吸湿材料。 壳体包括与壳体内部流体连通的入口和出口连接。 加湿器部分设置在壳体内，使得通过入口连接进入的气体流过加湿部分，其中少量的可释放的视网膜液体被吸湿材料释放到流动的气体中，因此加湿气体经由 出口连接。

公开(公告)号：US5980929A

公开(公告)日：1999-11-09

申请号：US42440

申请日：1998-03-13

申请人： Eugene de Juan, Jr.

发明人： Eugene de Juan, Jr.

IPC分类号： A61K31/00 ,  A61K31/352 ,  A61K31/395 ,  A61F2/14 ,  A61F2/02

CPC分类号： A61K31/00 ,  A61K31/352 ,  A61K31/395

摘要： The present invention is directed to methods for the prophylactic and therapeutic treatment of retinal ischemia and retinal inflammation. The methods involve the administration of an inhibitor of the protein tyrosine kinase pathway to an animal, such as a mammal, in particular a human, in an amount sufficient to treat the retina for ischemia or inflammation prophylactically or therapeutically. The inhibitor of the protein tyrosine kinase pathway is preferably genistein or an analogue or prodrug thereof or a pharmaceutically acceptable salt of any of the foregoing.

摘要翻译： 本发明涉及用于预防和治疗视网膜缺血和视网膜炎症的方法。 所述方法涉及将蛋白质酪氨酸激酶途径的抑制剂施用于动物，例如哺乳动物，特别是人，其量足以预防或治疗地治疗视网膜缺血或炎症。 蛋白酪氨酸激酶途径的抑制剂优选为染料木素或其类似物或前药，或上述任一项的药学上可接受的盐。

公开(公告)号：US5563584A

公开(公告)日：1996-10-08

申请号：US152012

申请日：1993-11-15

申请人： R. Scott Rader ,  Eric H. Schallen ,  Alexander C. Walsh ,  Carl C. Awh ,  Eugene de Juan

发明人： R. Scott Rader ,  Eric H. Schallen ,  Alexander C. Walsh ,  Carl C. Awh ,  Eugene de Juan

IPC分类号： A61M5/168 ,  G08B21/00

CPC分类号： A61M5/1684 ,  Y10S128/13 ,  Y10T137/7339

摘要： A liquid level sensing and monitoring system for a medical fluid infusion system has an IV spike with a pressure sensor which contacts fluid in an infusion container such as an IV bag or bottle. When an adequate amount of fluid is in the container, the resulting pressure on the sensor is at a relatively high level; however, when the fluid reservoir is nearly depleted, the pressure on the sensor falls to a low level, thereby activating the sensor and associated control circuitry which operates an alarm or warning indicator. In lieu of the pressure sensor, the device may use a resistive or capacitive sensor. When the liquid level falls below the electrical sensor, its state changes, and the alarm circuitry is activated.

摘要翻译： 用于医疗液体输注系统的液位感测和监测系统具有IV尖峰，其具有接触诸如IV袋或瓶的输注容器中的流体的压力传感器。 当容器中有足够量的流体时，传感器上产生的压力处于较高的水平; 然而，当流体储存器几乎耗尽时，传感器上的压力下降到低水平，由此激活操作警报或警告指示器的传感器和相关联的控制电路。 代替压力传感器，该装置可以使用电阻或电容传感器。 当液位低于电传感器时，其状态改变，并且报警电路被激活。