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    2-Quinazolinone compounds and methods of use
    21.
    发明申请
    2-Quinazolinone compounds and methods of use 失效
    2-喹唑啉酮化合物及其使用方法

    公开(公告)号：US20080032973A1

    公开(公告)日：2008-02-07

    申请号：US11879243

    申请日：2007-07-16

    Applicant: Fang-Tsao Hong ,  Kelvin Sham ,  Seifu Tadesse ,  Andrew Tasker

    Inventor： Fang-Tsao Hong ,  Kelvin Sham ,  Seifu Tadesse ,  Andrew Tasker

    IPC: C07D239/80 ,  A61K31/517 ,  A61K31/519 ,  A61K31/5377 ,  A61P19/00 ,  C07D413/14 ,  C07D471/04 ,  C07D413/02 ,  A61P3/00 ,  A61P31/12 ,  A61P7/00

    CPC classification number: C07D471/04 ,  C07D239/82

    Abstract: The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including inflammation and related conditions. The compounds have a general Formula I wherein A1, A2, B, s, T, R1, R2, R3 and R4 are defined herein. The invention also comprises pharmaceutical compositions including one or more compounds of Formula I, methods of use such as treatment of kinase mediated diseases by administering the compounds of Formula I or compositions including the compounds of Formula I, and intermediates and processes useful for the preparation of compounds of Formula I.

    Abstract translation: 本发明包括一类新的可用于预防和治疗蛋白激酶介导的疾病，包括炎症和相关病症的化合物。 化合物具有通式I，其中A 1，A 2，B，s，T，R 1，R 2， / SUP>，R 3和R 4在本文中定义。 本发明还包括药物组合物，其包含一种或多种式I化合物，使用方法，例如通过施用式I化合物或包含式I化合物的组合物治疗激酶介导的疾病，以及可用于制备 式Ⅰ的化合物。

    Substituted heterocyclic compounds and methods of use
    23.
    发明申请
    Substituted heterocyclic compounds and methods of use 审中-公开
    取代的杂环化合物及其使用方法

    公开(公告)号：US20050288502A1

    公开(公告)日：2005-12-29

    申请号：US11166423

    申请日：2005-06-24

    Applicant: Denise Andersen ,  Michael Frohn ,  Fang-Tsao Hong ,  Longbin Liu ,  Patricia Lopez

    Inventor： Denise Andersen ,  Michael Frohn ,  Fang-Tsao Hong ,  Longbin Liu ,  Patricia Lopez

    IPC: A61K31/53 ,  C07D471/02 ,  C07D471/04 ,  C07D487/04

    CPC classification number: C07D471/04 ,  C07D487/04

    Abstract: The present invention relates to triazolopyrimidines, imidazolopyrimidines and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic B cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

    Abstract translation: 本发明涉及三唑并嘧啶，咪唑并嘧啶及其衍生物及其药学上可接受的盐。 还包括治疗炎症，类风湿性关节炎，佩吉特病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺B细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征 （ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉变性，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病 ，中风，心肌梗塞，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV-1，HIV-2，HIV-3，巨细胞病毒 ），流感病毒，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的如上所述的化合物。

    Substituted heterocyclic compounds and methods of use
    24.
    发明申请
    Substituted heterocyclic compounds and methods of use 失效
    取代的杂环化合物及其使用方法

    公开(公告)号：US20050187223A1

    公开(公告)日：2005-08-25

    申请号：US11041151

    申请日：2005-01-21

    Applicant: Michael Frohn ,  Fang-Tsao Hong ,  Longbin Liu ,  Patricia Lopez ,  Aaron Siegmund ,  Seifu Tadesse ,  Nuria Tamayo

    Inventor： Michael Frohn ,  Fang-Tsao Hong ,  Longbin Liu ,  Patricia Lopez ,  Aaron Siegmund ,  Seifu Tadesse ,  Nuria Tamayo

    IPC: A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  C07D471/04 ,  C07D487/04

    CPC classification number: C07D487/04 ,  C07D471/04

    Abstract: The present invention relates to pyrimidinones and pyridones and derivatives thereof, and pharmaceutically acceptable salts thereof. Also included is a method of treatment of inflammation, rheumatoid arthritis, Pagets disease, osteoporosis, multiple myeloma, uveititis, acute or chronic myelogenous leukemia, pancreatic β cell destruction, osteoarthritis, rheumatoid spondylitis, gouty arthritis, inflammatory bowel disease, adult respiratory distress syndrome (ARDS), psoriasis, Crohn's disease, allergic rhinitis, ulcerative colitis, anaphylaxis, contact dermatitis, asthma, muscle degeneration, cachexia, Reiter's syndrome, type I diabetes, type II diabetes, bone resorption diseases, graft vs. host reaction, Alzheimer's disease, stroke, myocardial infarction, ischemia reperfusion injury, atherosclerosis, brain trauma, multiple sclerosis, cerebral malaria, sepsis, septic shock, toxic shock syndrome, fever, myalgias due to HIV-1, HIV-2, HIV-3, cytomegalovirus (CMV), influenza, adenovirus, the herpes viruses or herpes zoster infection in a mammal comprising administering an effective amount a compound as described above.

    Abstract translation: 本发明涉及嘧啶酮和吡啶酮及其衍生物及其药学上可接受的盐。 还包括治疗炎症，类风湿性关节炎，斑节病，骨质疏松症，多发性骨髓瘤，葡萄膜炎，急性或慢性骨髓性白血病，胰腺β细胞破坏，骨关节炎，类风湿性脊椎炎，痛风性关节炎，炎性肠病，成人呼吸窘迫综合征 （ARDS），牛皮癣，克罗恩病，过敏性鼻炎，溃疡性结肠炎，过敏反应，接触性皮炎，哮喘，肌肉变性，恶病质，赖特综合征，I型糖尿病，II型糖尿病，骨吸收疾病，移植物抗宿主反应，阿尔茨海默病 ，中风，心肌梗塞，缺血再灌注损伤，动脉粥样硬化，脑外伤，多发性硬化，脑疟疾，败血症，败血性休克，中毒性休克综合征，发热，HIV-1，HIV-2，HIV-3，巨细胞病毒 ），流感病毒，腺病毒，哺乳动物中的疱疹病毒或带状疱疹感染，包括给予有效量的如上所述的化合物。

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