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    Tissue adhesive based on nitrogen-modified aspartates
    27.
    发明授权
    Tissue adhesive based on nitrogen-modified aspartates 有权
    基于氮改性天冬氨酸的组织粘合剂

    公开(公告)号：US09421298B2

    公开(公告)日：2016-08-23

    申请号：US13984186

    申请日：2012-02-06

    Applicant: Heike Heckroth ,  Christoph Eggert

    Inventor： Heike Heckroth ,  Christoph Eggert

    IPC: C08L75/02 ,  C08L75/04 ,  C09D175/02 ,  C08G18/10 ,  A61L24/04 ,  C08G18/38 ,  C08G18/42 ,  C08G18/73 ,  A61L24/00

    CPC classification number: A61L24/046 ,  A61L24/0015 ,  C08G18/10 ,  C08G18/3821 ,  C08G18/4252 ,  C08G18/73 ,  C08L75/04

    Abstract: The invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers which can be obtained by reacting aliphatic isocyanates A1) with polyols A2) that can have a number-average molecular weight of =400 g/mol and an average OH functionality of 2 to 6 in particular; and as component B) amino-functional aspartic acid esters of the general formula (I) in which X is an organic group containing a secondary amino function, R1, R2 are the same or different organic groups that do not have Zerewitinoff-active hydrogen, and n is a whole number of at least 2, in particular for sealing, bonding, gluing, or covering cell tissue. The invention also relates to a metering system for the polyurea system according to the invention.

    Abstract translation: 本发明涉及一种包含作为组分A）异氰酸酯官能的预聚物的聚脲体系，该异氰酸酯官能的预聚物可通过使脂族异氰酸酯A1）与数均分子量为400g / mol和平均OH官能度的多元醇A2） 特别是2到6; 和作为组分B）通式（I）的氨基官能天冬氨酸酯，其中X是含有仲氨基官能团的有机基团，R 1，R 2是相同或不同的不具有齐维诺芬活性氢的有机基团， 并且n是至少为2的整数，特别是用于密封，粘合，胶合或覆盖细胞组织。 本发明还涉及根据本发明的聚脲系统的计量系统。

    MEDICAL ADHESIVE FOR STEMMING BLEEDING
    28.
    发明申请
    MEDICAL ADHESIVE FOR STEMMING BLEEDING 有权
    医用胶粘剂

    公开(公告)号：US20140065091A1

    公开(公告)日：2014-03-06

    申请号：US14112368

    申请日：2012-04-17

    Applicant: Heike Heckroth ,  Christoph Eggert

    Inventor： Heike Heckroth ,  Christoph Eggert

    IPC: A61L24/04

    CPC classification number: A61L24/046 ,  A61L24/0015 ,  C08G18/10 ,  C08G18/12 ,  C08G18/73 ,  C08G18/3821 ,  C08L75/02

    Abstract: The present invention relates to a polyurea system comprising as component A) isocyanate-functional prepolymers obtainable by reaction of aliphatic isocyanates A1) with polyols A2), which in particular can have a number-average molecular weight of ≧400 g/mol and a mean OH functionality of from 2 to 6, as component B) an amino-functional compound of the general formula (I) in which X is an organic radical containing a secondary amino function, Y is an organic radical that contains a tertiary amino group and does not contain Zerewitinoff-active hydrogen, R1 is a CH2—COOR3 radical in which R3 is an organic radical that does not contain Zerewitinoff-active hydrogen, a linear or branched C1- to C4-alkyl radical, a cyclopentyl radical, a cyclohexyl radical or H, R2 is an organic radical that does not contain Zerewitinoff-active hydrogen, a is 1 or 2, b is 1 or 2, and a+b=2 or 3, for stemming the escape of blood, and to a metering system for the polyurea system according to the invention.

    Abstract translation: 本发明涉及包含作为组分A）的异氰酸酯官能的预聚物本发明涉及通过脂族异氰酸酯A1）与多元醇A2）的反应得到的异氰酸酯官能的预聚物，其特别是其数均分子量> 400g / mol， 平均OH官能度为2至6，作为组分B）通式（I）的氨基官能化合物，其中X为含有仲氨基官能团的有机基团，Y为含有叔氨基的有机基团， 不含Zerewitinoff活性氢，R1是CH2-COOR3基团，其中R3是不含有Zerewitinoff活性氢的有机基团，直链或支链C 1 -C 4烷基，环戊基，环己基 或H，R2是不含Zerewitinoff活性氢的有机基团，a是1或2，b为1或2，a + b = 2或3，用于阻止血液的逸出，并且计量系统 对于根据本发明的聚脲系统。

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