Electrode for biosensor for NADH measurement and manufacturing method therefor

    公开(公告)号:US11782010B2

    公开(公告)日:2023-10-10

    申请号:US16959506

    申请日:2018-12-28

    Inventor: Kyuhong Lee

    CPC classification number: G01N27/3277

    Abstract: The present invention relates to an electrode for a biosensor for NADH measurement and a manufacturing method therefor. An electrode manufactured by the method according to the present invention enjoys the advantages of stabilizing current flow during an electric polymerization reaction, making the contact angle of the modified material remarkably small to increase the efficiency of surface modification, and being reusable several times. In addition, when applied to a biosensor for NADH measurement, the electrode of the present invention maintains sensitivity and selectivity at a high level without interference and thus easily measures a target of interest even in blood or serum that necessarily requires a pretreatment process due to the existence of a trace amount of a material to be measured. In addition, when applied to a biosensor for NADH measurement, the electrode can measure cell viability in a continuous manner and in real time, which leads to the application thereof to the cell toxicity assay field, and enables the measurement of cell viability in apoptotic cells lacking the mitochondrial function.

    NOVEL VACCINE ADJUVANT COMPOSITION INCLUDING BAVACHIN

    公开(公告)号:US20220409723A1

    公开(公告)日:2022-12-29

    申请号:US17778368

    申请日:2020-11-16

    Abstract: Provided are a vaccine adjuvant composition including, as an active ingredient, bavachin capable of improving antibody titer and enhancing cellular immunity and humoral immunity when administered together with an antigen, a vaccine preparation including the bavachin and an antigen, a method of promoting an immune response, the method including the step of administering the vaccine adjuvant composition to a subject together with a vaccine composition or before and after administration of the vaccine composition, and a vaccine adjuvant composition for promoting an immune response, the vaccine adjuvant composition including the bavachin. Since the vaccine adjuvant composition of the present invention includes bavachin isolated from an extract of Psoralea corylifolia, of which safety has been secured, it may exhibit safety and may enhance both the humoral and cellular immune responses as well as the titer of antibodies generated by antigens.

    TEMPERATURE-CHANGE SENSING SUBSTRATE COMPRISING SELF-HEALING POLYURETHANE POLYMER

    公开(公告)号:US20220373406A1

    公开(公告)日:2022-11-24

    申请号:US17773424

    申请日:2020-11-11

    Abstract: The present invention relates to a temperature-change sensing substrate comprising a self-healing polyurethane polymer. More specifically, the present invention relates to a temperature-change sensing substrate having a self-healing polyurethane polymer matrix and a plurality of pores dispersed in the matrix. The temperature-change sensing substrate according to the present invention can be applied as a temperature-change sensor for preventing the spoiling of refrigerated or frozen food and medical supplies. For example, substrate, which was opaque when stored at −60° C., −50° C., −30° C., −20° C., −10° C. and the like, becomes transparent if the temperature rises to 0° C., 10° C., 20° C., 30° C. and the like, and thus a temperature-change sensor capable of checking storage conditions through a change in light transmittance can be provided.

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